{"id":"https://openalex.org/W2157405158","doi":"https://doi.org/10.1152/ajprenal.00454.2005","title":"Dynamics of mobilization and homing of endothelial progenitor cells after acute renal ischemia: modulation by ischemic preconditioning","display_name":"Dynamics of mobilization and homing of endothelial progenitor cells after acute renal ischemia: modulation by ischemic preconditioning","publication_year":2006,"publication_date":"2006-02-15","ids":{"openalex":"https://openalex.org/W2157405158","doi":"https://doi.org/10.1152/ajprenal.00454.2005","mag":"2157405158","pmid":"https://pubmed.ncbi.nlm.nih.gov/16478972"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.00454.2005","doi":"https://doi.org/10.1152/ajprenal.00454.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00454.2005","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081945237","display_name":"Daniel Patschan","orcid":"https://orcid.org/0000-0002-6914-5254","observed_orcids":["https://orcid.org/0000-0002-6914-5254","https://orcid.org/0000-0002-5232-9540"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Patschan","raw_affiliation_strings":["Department of Medicine, New York Medical College BSB, R-C21, Valhalla, NY 10595, USA. d.patschan@gmx.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York Medical College BSB, R-C21, Valhalla, NY 10595, USA. d.patschan@gmx.de","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086755749","display_name":"Krystina Krupincza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krystina Krupincza","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035843496","display_name":"Susann A. Patschan","orcid":"https://orcid.org/0000-0002-2286-7356","observed_orcids":["https://orcid.org/0000-0002-2286-7356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susann Patschan","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100657224","display_name":"Zhongtao Zhang","orcid":"https://orcid.org/0000-0002-1910-4753","observed_orcids":["https://orcid.org/0000-0002-1910-4753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhongtao Zhang","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083440871","display_name":"Carl V. Hamby","orcid":"https://orcid.org/0000-0001-5434-8051","observed_orcids":["https://orcid.org/0000-0001-5434-8051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl Hamby","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050906977","display_name":"Michael S. Goligorsky","orcid":"https://orcid.org/0000-0003-0561-4469","observed_orcids":["https://orcid.org/0000-0003-0561-4469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael S. Goligorsky","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1439,"has_fulltext":false,"cited_by_count":155,"citation_normalized_percentile":{"value":0.92823853,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"291","issue":"1","first_page":"F176","last_page":"F185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6234999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6234999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.2971000075340271,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.05050000175833702,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-renal-ischemia","display_name":"acute renal ischemia","score":0.968999981880188},{"id":"https://openalex.org/keywords/ischemic-preconditioning","display_name":"ischemic preconditioning","score":0.9919999837875366},{"id":"https://openalex.org/keywords/epc-mobilization","display_name":"EPC mobilization","score":0.921999990940094},{"id":"https://openalex.org/keywords/epc-homing","display_name":"EPC homing","score":0.921999990940094},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.9509999752044678},{"id":"https://openalex.org/keywords/renal-artery-clamping","display_name":"renal artery clamping","score":0.5559999942779541},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.8105111122131348},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7853701114654541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6670824289321899},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.645551860332489},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5614427924156189},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5110677480697632},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.49893712997436523},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.45982009172439575},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.449063241481781},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.42725762724876404},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.35519346594810486},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33782875537872314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20120832324028015},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10495635867118835},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001775","descriptor_name":"Blood Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007679","descriptor_name":"Kidney Medulla","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007679","descriptor_name":"Kidney Medulla","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042787","descriptor_name":"Receptor, TIE-2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajprenal.00454.2005","doi":"https://doi.org/10.1152/ajprenal.00454.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00454.2005","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmid:16478972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16478972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Renal physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.323.3722","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.3722","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajprenal.physiology.org/content/early/2006/02/14/ajprenal.00454.2005.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2681609294","display_name":"Endothelial dysfunction in acute renal ischemia","funder_award_id":"R01DK052783","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W14681177","https://openalex.org/W1586474677","https://openalex.org/W1592390749","https://openalex.org/W1965693998","https://openalex.org/W1967035072","https://openalex.org/W1977437881","https://openalex.org/W1977442297","https://openalex.org/W1980152243","https://openalex.org/W1996723509","https://openalex.org/W1998581885","https://openalex.org/W1999579644","https://openalex.org/W1999668340","https://openalex.org/W2001032948","https://openalex.org/W2010401334","https://openalex.org/W2020613339","https://openalex.org/W2035857494","https://openalex.org/W2045010231","https://openalex.org/W2053704719","https://openalex.org/W2093366031","https://openalex.org/W2094742966","https://openalex.org/W2098743872","https://openalex.org/W2104188822","https://openalex.org/W2110204147","https://openalex.org/W2110667326","https://openalex.org/W2122138696","https://openalex.org/W2123934795","https://openalex.org/W2130761693","https://openalex.org/W2135069917","https://openalex.org/W2137484316","https://openalex.org/W2144924351","https://openalex.org/W2145639716","https://openalex.org/W2151517451","https://openalex.org/W2156203281","https://openalex.org/W2159538020","https://openalex.org/W2164506013"],"related_works":["https://openalex.org/W1977164550","https://openalex.org/W7096361051","https://openalex.org/W2587372283","https://openalex.org/W2082919573","https://openalex.org/W3031477135","https://openalex.org/W2018487009","https://openalex.org/W2007431915","https://openalex.org/W3044365281","https://openalex.org/W2131035876","https://openalex.org/W1987273686"],"abstract_inverted_index":{"Endothelial":[0],"progenitor":[1],"cells":[2,81,202,219,309],"(EPCs)":[3],"have":[4],"been":[5],"shown":[6],"to":[7,27,37,53,180,231,237,269],"participate":[8],"in":[9,25,43,110,154,185,197,204,208,247,253,299,327],"tissue":[10],"repair":[11],"under":[12],"diverse":[13],"physiological":[14],"and":[15,41,69,78,170,235,295,304],"pathological":[16],"conditions.":[17],"It":[18],"is":[19,286],"unknown":[20],"whether":[21],"EPCs":[22,123,162,298,326],"are":[23],"mobilized":[24,278],"response":[26],"acute":[28,47,241],"renal":[29,48,55,242,251,258,301,318],"injury.":[30],"The":[31,119],"aim":[32],"of":[33,46,76,121,147,157,190,200,217,224,250,277,284,291,297,307,323],"this":[34],"study":[35],"was":[36,86,98,124,183,233],"characterize":[38],"EPC":[39,108,178],"mobilization":[40,290],"homing":[42,179],"the":[44,74,83,95,103,111,144,181,191,198,205,221,248,270,281,289,292,300,311,321,324,328],"course":[45],"ischemia.":[49,214,243],"Mice":[50],"were":[51,114,163],"subjected":[52,230],"unilateral":[54],"artery":[56],"clamping":[57],"(UC)":[58],"for":[59,116],"25":[60],"min.":[61],"At":[62],"10":[63],"min,":[64],"3,":[65],"6,":[66],"24":[67],"h,":[68,172],"7":[70,100,212],"days":[71,101],"after":[72,131,166,213,317],"UC,":[73],"pool":[75,146,294],"circulating":[77,122,145,158],"splenic":[79,161,293],"CD34+/Flk-1+":[80],"within":[82],"monocytic":[84],"population":[85,216],"detected":[87],"by":[88,210],"flow":[89],"cytometry.":[90],"For":[91,107],"ischemic":[92,105],"preconditioning":[93],"(IPC),":[94],"first":[96],"UC":[97,132,152,167],"performed":[99,150],"before":[102,151],"repeated":[104],"episode.":[106],"detection":[109],"kidney,":[112],"cryosections":[113],"stained":[115],"c-Kit+/Tie-2+":[117,201,218],"cells.":[118],"number":[120,199],"not":[125,141,174],"significantly":[126,142,164],"affected":[127],"at":[128,168,175],"any":[129],"time":[130],"compared":[133],"with":[134,240,288],"sham-operated":[135],"or":[136],"control":[137],"mice.":[138],"IPC":[139,186,232,285],"did":[140],"change":[143],"EPCs.":[148,159],"Splenectomy":[149],"resulted":[153,246],"a":[155,194,274],"surge":[156],"Accordingly,":[160],"increased":[165],"3":[169],"6":[171],"but":[173],"later":[176],"times.":[177],"spleen":[182],"absent":[184],"animals.":[187],"Immunohistochemical":[188],"analysis":[189],"kidneys":[192],"showed":[193],"sixfold":[195],"increase":[196],"localized":[203],"medullopapillary":[206,222,302,312],"region":[207],"mice":[209,229,239],"day":[211],"Enriched":[215],"from":[220,310],"parenchyma":[223,313],"Tie-2green":[225],"fluorescent":[226],"protein":[227],"chimeric":[228],"isolated":[234],"transplanted":[236],"wild-type":[238],"This":[244],"procedure":[245],"improvement":[249],"function":[252],"recipients.":[254],"In":[255],"conclusion,":[256],"1)":[257],"ischemia":[259],"rapidly":[260],"(within":[261],"3-6":[262],"h)":[263],"mobilizes":[264],"EPCs,":[265],"which":[266],"transiently":[267],"home":[268],"spleen,":[271],"acting":[272],"as":[273],"temporary":[275],"reservoir":[276],"EPCs;":[279],"2)":[280],"late":[282],"phase":[283],"associated":[287],"accumulation":[296],"region;":[303],"3)":[305],"transplantation":[306],"EPC-enriched":[308],"afforded":[314],"partial":[315],"renoprotection":[316],"ischemia,":[319],"suggesting":[320],"role":[322],"recruited":[325],"functional":[329],"rescue.":[330]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
