{"id":"https://openalex.org/W2157397404","doi":"https://doi.org/10.2337/db10-1331","title":"Identification of Metabolic Modifiers That Underlie Phenotypic Variations in Energy-Balance Regulation","display_name":"Identification of Metabolic Modifiers That Underlie Phenotypic Variations in Energy-Balance Regulation","publication_year":2011,"publication_date":"2011-02-08","ids":{"openalex":"https://openalex.org/W2157397404","doi":"https://doi.org/10.2337/db10-1331","mag":"2157397404","pmid":"https://pubmed.ncbi.nlm.nih.gov/21300845"},"language":"en","primary_location":{"id":"doi:10.2337/db10-1331","doi":"https://doi.org/10.2337/db10-1331","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db10-1331","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.2337/db10-1331","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101415600","display_name":"Chia Lin Chang","orcid":"https://orcid.org/0000-0001-6408-9284","observed_orcids":["https://orcid.org/0000-0001-6408-9284"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia Lin Chang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Kweishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Kweishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059360459","display_name":"James J. Cai","orcid":"https://orcid.org/0000-0002-8081-6725","observed_orcids":["https://orcid.org/0000-0002-8081-6725"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Cai","raw_affiliation_strings":["Department of Biology, Stanford University, Stanford, California","Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University, Stanford, California","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103253078","display_name":"Po Jen Cheng","orcid":"https://orcid.org/0000-0002-8587-8626","observed_orcids":["https://orcid.org/0000-0002-8587-8626"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po Jen Cheng","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Kweishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Kweishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108219074","display_name":"Ho Yen Chueh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ho Yen Chueh","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Kweishan, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Kweishan, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210116208"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042806677","display_name":"Sheau Yu Hsu","orcid":"https://orcid.org/0000-0001-6690-9864","observed_orcids":["https://orcid.org/0000-0001-6690-9864"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sheau Yu Teddy Hsu","raw_affiliation_strings":["Reproductive Biology and Stem Cell Research Program, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Biology and Stem Cell Research Program, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5042806677"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":1.0993,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.78233058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60","issue":"3","first_page":"726","last_page":"734"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-dependent-insulinotropic-polypeptide","display_name":"glucose-dependent insulinotropic polypeptide","score":0.875},{"id":"https://openalex.org/keywords/regulatory-single-nucleotide-polymorphisms","display_name":"regulatory single nucleotide polymorphisms","score":0.8790000081062317},{"id":"https://openalex.org/keywords/energy-balance-regulation","display_name":"energy balance regulation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/enteroinsular-axis","display_name":"enteroinsular axis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.6650000214576721},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.3869999945163727},{"id":"https://openalex.org/keywords/serum-glucose","display_name":"serum glucose","score":0.6589999794960022},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.5870000123977661},{"id":"https://openalex.org/keywords/gip-receptor","display_name":"GIP receptor","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7134793400764465},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6610994338989258},{"id":"https://openalex.org/C2777423268","wikidata":"https://www.wikidata.org/wiki/Q3663116","display_name":"Energy balance","level":2,"score":0.5991560220718384},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.5623459815979004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4946443736553192},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.4778311252593994},{"id":"https://openalex.org/C2991986269","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic regulation","level":3,"score":0.42471209168434143},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33165180683135986},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2759553790092468},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2619144022464752},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.16147825121879578},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1613864302635193},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10759532451629639},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09190437197685242}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005749","descriptor_name":"Gastric Inhibitory Polypeptide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005749","descriptor_name":"Gastric Inhibitory Polypeptide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005749","descriptor_name":"Gastric Inhibitory Polypeptide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016640","descriptor_name":"Diabetes, Gestational","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016640","descriptor_name":"Diabetes, Gestational","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016640","descriptor_name":"Diabetes, Gestational","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.2337/db10-1331","doi":"https://doi.org/10.2337/db10-1331","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db10-1331","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:21300845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21300845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2296508","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3046833","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3046833","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3046833","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1021.3032","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1021.3032","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diabetes.diabetesjournals.org/content/diabetes/60/3/726.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.724.2276","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.724.2276","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://people.tamu.edu/%7Ejcai/pdf/20.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2337/db10-1331","doi":"https://doi.org/10.2337/db10-1331","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db10-1331","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2488654488","display_name":null,"funder_award_id":"R01 DK070652","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6070397969","display_name":null,"funder_award_id":"DK-70652","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1506095972","https://openalex.org/W1541471661","https://openalex.org/W1995148706","https://openalex.org/W2005493813","https://openalex.org/W2010357255","https://openalex.org/W2013478069","https://openalex.org/W2015578131","https://openalex.org/W2017914974","https://openalex.org/W2019129011","https://openalex.org/W2025253353","https://openalex.org/W2029121047","https://openalex.org/W2038322995","https://openalex.org/W2039135009","https://openalex.org/W2039435867","https://openalex.org/W2047366062","https://openalex.org/W2047495447","https://openalex.org/W2061672417","https://openalex.org/W2085122736","https://openalex.org/W2093032802","https://openalex.org/W2095816689","https://openalex.org/W2097008225","https://openalex.org/W2098460741","https://openalex.org/W2106187022","https://openalex.org/W2107916366","https://openalex.org/W2116937342","https://openalex.org/W2119110311","https://openalex.org/W2119279196","https://openalex.org/W2121301862","https://openalex.org/W2130872718","https://openalex.org/W2133931993","https://openalex.org/W2135092079","https://openalex.org/W2135370544","https://openalex.org/W2139487710","https://openalex.org/W2141642891","https://openalex.org/W2146466098","https://openalex.org/W2147575903","https://openalex.org/W2151192621","https://openalex.org/W2153554912","https://openalex.org/W2155445544","https://openalex.org/W2155670634","https://openalex.org/W2156008071","https://openalex.org/W2156866331","https://openalex.org/W2156918287","https://openalex.org/W2162530578","https://openalex.org/W2166734039","https://openalex.org/W2167852412","https://openalex.org/W2171750333","https://openalex.org/W2171777347","https://openalex.org/W2171874894","https://openalex.org/W2171981572","https://openalex.org/W2296261114","https://openalex.org/W2490762048","https://openalex.org/W2885727518","https://openalex.org/W2988522900","https://openalex.org/W4240575174","https://openalex.org/W4251304755","https://openalex.org/W4301356399","https://openalex.org/W6632376585"],"related_works":["https://openalex.org/W1840542775","https://openalex.org/W2416830231","https://openalex.org/W179926425","https://openalex.org/W2386367800","https://openalex.org/W3003578468","https://openalex.org/W1518773297","https://openalex.org/W17768695","https://openalex.org/W3171896139","https://openalex.org/W2410795314","https://openalex.org/W2052383327"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Although":[1],"recent":[2],"studies":[3,136,168],"have":[4,137,152,173,181,190],"shown":[5,138,182],"that":[6,13,20,32,48,52,80,104,139,183,215,228,244,264],"human":[7,123],"genomes":[8],"contain":[9],"hundreds":[10],"of":[11,16,107,122,146,169,195,219,229,275],"loci":[12,97],"exhibit":[14],"signatures":[15],"positive":[17],"selection,":[18],"variants":[19,38,248],"are":[21,224],"associated":[22],"with":[23,159,185],"adaptation":[24],"in":[25,35,44,69,84,89,252],"energy-balance":[26],"regulation":[27],"remain":[28],"elusive.":[29],"We":[30],"reasoned":[31],"the":[33,118,132,266],"difficulty":[34],"identifying":[36],"such":[37],"could":[39],"be":[40,62],"due":[41],"to":[42,64],"heterogeneity":[43],"selection":[45],"pressure":[46],"and":[47,56,115,254],"an":[49,203,232],"integrative":[50],"approach":[51],"incorporated":[53],"experiment-based":[54],"evidence":[55,106,274],"population":[57],"genetics-based":[58],"statistical":[59],"judgments":[60],"would":[61],"needed":[63],"reveal":[65],"important":[66],"metabolic":[67,78],"modifiers":[68,79],"humans.":[70],"RESEARCH":[71],"DESIGN":[72],"AND":[73],"METHODS:":[74],"To":[75],"identify":[76],"common":[77,245,267],"underlie":[81],"phenotypic":[82,269],"variation":[83,270],"diabetes-associated":[85],"or":[86,91],"obesity-associated":[87],"traits":[88],"humans,":[90],"both,":[92],"we":[93,213],"screened":[94],"207":[95],"candidate":[96],"for":[98,178,209],"regulatory":[99,246],"single":[100],"nucleotide":[101],"polymorphisms":[102],"(SNPs)":[103],"exhibited":[105],"gene-environmental":[108,277],"interactions.":[109,278],"RESULTS:":[110],"Three":[111],"SNPs":[112,149],"(rs3895874,":[113],"rs3848460,":[114],"rs937301)":[116],"at":[117,131,162],"5'":[119],"gene":[120],"region":[121],"GIP":[124,140,247,253],"were":[125],"identified":[126,265],"as":[127],"prime":[128],"metabolic-modifier":[129],"candidates":[130],"enteroinsular":[133],"axis.":[134],"Functional":[135],"promoter":[141],"reporters":[142],"carrying":[143,202,221,231],"derived":[144],"alleles":[145,161],"these":[147],"three":[148],"(haplotype":[150,165],"GIP(-1920A))":[151],"significantly":[153,191,225],"lower":[154,192],"transcriptional":[155],"activities":[156],"than":[157,200,227],"those":[158,201,230],"ancestral":[160,204,233],"corresponding":[163],"positions":[164],"GIP(-1920G)).":[166],"Consistently,":[167],"pregnant":[170],"women":[171],"who":[172],"undergone":[174],"a":[175,186,210,250,261],"screening":[176],"test":[177],"gestational":[179],"diabetes":[180],"patients":[184,220],"homozygous":[187],"GIP(-1920A/A)":[188,222],"genotype":[189],"serum":[193,216],"concentrations":[194,218],"glucose-dependent":[196],"insulinotropic":[197],"polypeptide":[198],"(GIP)":[199],"GIP(-1920G)":[205,234],"haplotype.":[206],"After":[207],"controlling":[208],"GIPR":[211],"variation,":[212],"showed":[214],"glucose":[217,255],"homozygotes":[223],"higher":[226],"haplotype":[235],"(odds":[236],"ratio":[237],"3.53).":[238],"CONCLUSIONS:":[239],"Our":[240],"proof-of-concept":[241],"study":[242,258],"indicates":[243],"impart":[249],"difference":[251],"metabolism.":[256],"The":[257],"also":[259],"provides":[260],"rare":[262],"example":[263],"variant-common":[268],"pattern":[271],"based":[272],"on":[273],"moderate":[276]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}