{"id":"https://openalex.org/W2157357302","doi":"https://doi.org/10.2174/1871527312666131223110147","title":"Humanin: A Possible Linkage Between Alzheimer\u2019s Disease and Type 2 Diabetes","display_name":"Humanin: A Possible Linkage Between Alzheimer\u2019s Disease and Type 2 Diabetes","publication_year":2014,"publication_date":"2014-05-31","ids":{"openalex":"https://openalex.org/W2157357302","doi":"https://doi.org/10.2174/1871527312666131223110147","mag":"2157357302","pmid":"https://pubmed.ncbi.nlm.nih.gov/24365186"},"language":"en","primary_location":{"id":"doi:10.2174/1871527312666131223110147","doi":"https://doi.org/10.2174/1871527312666131223110147","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1871527312666131223110147","pdf_url":null,"source":{"id":"https://openalex.org/S148418319","display_name":"CNS & Neurological Disorders - Drug Targets","issn_l":"1568-007X","issn":["1568-007X","1871-5273","1996-3181","2212-5299"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS & Neurological Disorders - Drug Targets","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037351048","display_name":"Hamidreza Mahboobi","orcid":"https://orcid.org/0000-0002-3491-8050","observed_orcids":["https://orcid.org/0000-0002-3491-8050","https://orcid.org/0009-0007-3599-7903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hamidreza Mahboobi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074885517","display_name":"Javad Golmirzaei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javad Golmirzaei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045095239","display_name":"Siew Hua Gan","orcid":"https://orcid.org/0000-0001-6470-3651","observed_orcids":["https://orcid.org/0000-0001-6470-3651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Siew Gan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018618633","display_name":"Mehrdad Jalalian","orcid":"https://orcid.org/0000-0002-3349-3142","observed_orcids":["https://orcid.org/0000-0002-3349-3142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehrdad Jalalian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040140025","display_name":"Mohammad Amjad Kamal","orcid":"https://orcid.org/0000-0003-0088-0565","observed_orcids":["https://orcid.org/0000-0003-0088-0565"]},"institutions":[{"id":"https://openalex.org/I4210128695","display_name":"Hormozgan University of Medical Sciences","ror":"https://ror.org/037wqsr57","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210128695"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mohammad Kamal","raw_affiliation_strings":["Hamidreza Mahboobi, Hormozgan University of Medical Sciences (HUMS), Bandar Abbas, Hormozgan, Iran. hamidrezamahboobi@yahoo.com","Hamidreza Mahboobi, Hormozgan University of Medical Sciences (HUMS), Bandar Abbas, Hormozgan, Iran.,Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamidreza Mahboobi, Hormozgan University of Medical Sciences (HUMS), Bandar Abbas, Hormozgan, Iran. hamidrezamahboobi@yahoo.com","institution_ids":["https://openalex.org/I4210128695"]},{"raw_affiliation_string":"Hamidreza Mahboobi, Hormozgan University of Medical Sciences (HUMS), Bandar Abbas, Hormozgan, Iran.,Iran","institution_ids":["https://openalex.org/I4210128695"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040140025"],"corresponding_institution_ids":["https://openalex.org/I4210128695"],"apc_list":null,"apc_paid":null,"fwci":1.1011,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.72605741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"3","first_page":"543","last_page":"552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/humanin","display_name":"humanin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.75},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9980000257492065},{"id":"https://openalex.org/keywords/amyloid-deposition","display_name":"amyloid deposition","score":0.9679999947547913},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9290000200271606},{"id":"https://openalex.org/keywords/lipid-metabolism-disorders","display_name":"lipid metabolism disorders","score":0.7879999876022339},{"id":"https://openalex.org/keywords/chronic-low-grade-inflammation","display_name":"low-grade inflammation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/mitochondrial-derived-peptides","display_name":"mitochondrial peptides","score":0.5680000185966492},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9679999947547913},{"id":"https://openalex.org/keywords/il-1-inhibitors","display_name":"IL-1 inhibitors","score":0.8529999852180481},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6917733550071716},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6528526544570923},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.6391311883926392},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6365399956703186},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5573868155479431},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5503319501876831},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5320224761962891},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5215280055999756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5081453323364258},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4755232632160187},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4690069854259491},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.46204042434692383},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.454505980014801},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4206758141517639},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31123918294906616},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30887019634246826},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29238373041152954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27128565311431885}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1871527312666131223110147","doi":"https://doi.org/10.2174/1871527312666131223110147","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1871527312666131223110147","pdf_url":null,"source":{"id":"https://openalex.org/S148418319","display_name":"CNS & Neurological Disorders - Drug Targets","issn_l":"1568-007X","issn":["1568-007X","1871-5273","1996-3181","2212-5299"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS & Neurological Disorders - Drug Targets","raw_type":"journal-article"},{"id":"pmid:24365186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24365186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS & neurological disorders drug targets","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2132014056","https://openalex.org/W7215846450","https://openalex.org/W4389464102","https://openalex.org/W3215775505","https://openalex.org/W1968392277","https://openalex.org/W2409064412","https://openalex.org/W4406232213","https://openalex.org/W2026332499","https://openalex.org/W2606042337","https://openalex.org/W3046232753"],"abstract_inverted_index":{"The":[0],"prevalence":[1],"of":[2,20,92],"Alzheimer's":[3],"disease":[4],"(AD)":[5],"is":[6,22,36],"higher":[7],"among":[8],"type":[9],"2":[10],"diabetes":[11],"mellitus":[12],"(T2DM)":[13],"patients.":[14],"In":[15],"T2DM":[16,54,110,121,144],"patients,":[17],"the":[18,48],"progression":[19],"AD":[21,32,52,100,108,123,142,161],"more":[23],"rapid.":[24],"Furthermore,":[25],"several":[26],"pathophysiological":[27],"pathways":[28,91,105,139],"are":[29,89,155],"common":[30,90,104,114,140],"to":[31,66,125,141],"and":[33,53,76,85,95,101,109,112,122,129,143,153,162],"T2DM.":[34,102,163],"Humanin":[35,45],"a":[37],"recently":[38],"introduced,":[39],"mitochondrial-derived":[40],"peptide":[41],"with":[42,69],"neuroprotective":[43],"effects.":[44],"can":[46],"alter":[47,138],"mechanisms":[49],"involved":[50],"in":[51,73,99],"pathogenesis.":[55,145],"Insulin":[56],"resistance":[57],"as":[58,60,150],"well":[59],"oxidative":[61,93],"stress":[62,94],"has":[63],"been":[64],"shown":[65],"be":[67],"associated":[68],"increased":[70],"amyloid":[71],"deposition":[72],"brain":[74],"neurons":[75],"islet":[77],"beta":[78],"cells.":[79],"Moreover,":[80],"advanced":[81],"glycation":[82],"end":[83],"products":[84],"lipid":[86],"metabolism":[87],"disorders":[88],"low-grade":[96],"systemic":[97],"inflammation":[98],"These":[103],"may":[106,137],"explain":[107],"pathogenesis":[111],"suggest":[113],"treatments":[115],"for":[116,120,159],"both":[117,160],"diseases.":[118],"Treatments":[119],"attempt":[124],"slow":[126],"cognitive":[127],"decline,":[128],"recent":[130],"investigations":[131],"have":[132],"focused":[133],"on":[134],"agents":[135],"that":[136],"Non-steroidal":[146],"antiinflammatory":[147],"drugs,":[148],"such":[149],"interleukin-1":[151],"antagonists":[152],"statins,":[154],"possible":[156],"drug":[157],"candidates":[158]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}