{"id":"https://openalex.org/W2157290796","doi":"https://doi.org/10.1200/jco.2010.31.8311","title":"Second Primary Cancers After an Index Head and Neck Cancer: Subsite-Specific Trends in the Era of Human Papillomavirus\u2013Associated Oropharyngeal Cancer","display_name":"Second Primary Cancers After an Index Head and Neck Cancer: Subsite-Specific Trends in the Era of Human Papillomavirus\u2013Associated Oropharyngeal Cancer","publication_year":2010,"publication_date":"2010-12-28","ids":{"openalex":"https://openalex.org/W2157290796","doi":"https://doi.org/10.1200/jco.2010.31.8311","mag":"2157290796","pmid":"https://pubmed.ncbi.nlm.nih.gov/21189382","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3056657"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2010.31.8311","doi":"https://doi.org/10.1200/jco.2010.31.8311","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.31.8311","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3056657","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084443648","display_name":"Luc G.T. Morris","orcid":"https://orcid.org/0000-0002-4417-2280","observed_orcids":["https://orcid.org/0000-0002-4417-2280"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luc G.T. Morris","raw_affiliation_strings":["From the Memorial Sloan-Kettering Cancer Center; Mount Sinai School of Medicine; and New York University School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Memorial Sloan-Kettering Cancer Center; Mount Sinai School of Medicine; and New York University School of Medicine, New York, NY","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I57206974","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035973740","display_name":"Andrew Gregory Sikora","orcid":"https://orcid.org/0000-0002-8357-8435","observed_orcids":["https://orcid.org/0000-0002-8357-8435"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew G. Sikora","raw_affiliation_strings":["From the Memorial Sloan-Kettering Cancer Center; Mount Sinai School of Medicine; and New York University School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Memorial Sloan-Kettering Cancer Center; Mount Sinai School of Medicine; and New York University School of Medicine, New York, NY","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I57206974","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078966058","display_name":"Snehal G. Patel","orcid":"https://orcid.org/0000-0001-9775-5132","observed_orcids":["https://orcid.org/0000-0001-9775-5132"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Snehal G. Patel","raw_affiliation_strings":["From the Memorial Sloan-Kettering Cancer Center; Mount Sinai School of Medicine; and New York University School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Memorial Sloan-Kettering Cancer Center; Mount Sinai School of Medicine; and New York University School of Medicine, New York, NY","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I57206974","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041461230","display_name":"Richard B. Hayes","orcid":"https://orcid.org/0000-0002-0918-661X","observed_orcids":["https://orcid.org/0000-0002-0918-661X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard B. Hayes","raw_affiliation_strings":["From the Memorial Sloan-Kettering Cancer Center; Mount Sinai School of Medicine; and New York University School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Memorial Sloan-Kettering Cancer Center; Mount Sinai School of Medicine; and New York University School of Medicine, New York, NY","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I57206974","https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075136197","display_name":"Ian Ganly","orcid":"https://orcid.org/0000-0001-7636-5426","observed_orcids":["https://orcid.org/0000-0001-7636-5426"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Ganly","raw_affiliation_strings":["From the Memorial Sloan-Kettering Cancer Center; Mount Sinai School of Medicine; and New York University School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Memorial Sloan-Kettering Cancer Center; Mount Sinai School of Medicine; and New York University School of Medicine, New York, NY","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I57206974","https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.5388,"has_fulltext":false,"cited_by_count":357,"citation_normalized_percentile":{"value":0.98373769,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"29","issue":"6","first_page":"739","last_page":"746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.15880000591278076,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/second-primary-malignancy","display_name":"second primary malignancy","score":0.9120000004768372},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hpv-positive-oropharyngeal-cancer","display_name":"HPV-positive oropharyngeal cancer","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hypopharyngeal-cancer","display_name":"hypopharyngeal cancer","score":0.9079999923706055},{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8579999804496765},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/standardized-incidence-ratio","display_name":"standardized incidence ratio","score":0.6869999766349792},{"id":"https://openalex.org/keywords/excess-absolute-risk","display_name":"excess absolute risk","score":0.7990000247955322},{"id":"https://openalex.org/keywords/seer","display_name":"SEER","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8964747190475464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6573573350906372},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.621828019618988},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5889406204223633},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5886346697807312},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5834634304046631},{"id":"https://openalex.org/C2779196318","wikidata":"https://www.wikidata.org/wiki/Q1393463","display_name":"Hypopharyngeal cancer","level":3,"score":0.5595786571502686},{"id":"https://openalex.org/C108516343","wikidata":"https://www.wikidata.org/wiki/Q189553","display_name":"Otorhinolaryngology","level":2,"score":0.49880266189575195},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4970610439777374},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.49244245886802673},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.45032209157943726},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4422942101955414},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28731203079223633},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009959","descriptor_name":"Oropharyngeal Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018426","descriptor_name":"SEER Program","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1200/jco.2010.31.8311","doi":"https://doi.org/10.1200/jco.2010.31.8311","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.31.8311","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2286579","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3056657","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3056657","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3056657","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Oncol","raw_type":"Text"},{"id":"pmid:21189382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21189382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2286579","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3056657","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6130476866","display_name":"Head and Neck Training Program in Surgical Oncology","funder_award_id":"T32CA009685","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W44067190","https://openalex.org/W303557043","https://openalex.org/W654183974","https://openalex.org/W1974452235","https://openalex.org/W1990428381","https://openalex.org/W1991949008","https://openalex.org/W1992544851","https://openalex.org/W2012068909","https://openalex.org/W2015550806","https://openalex.org/W2016336976","https://openalex.org/W2020135926","https://openalex.org/W2025383700","https://openalex.org/W2032592259","https://openalex.org/W2033216090","https://openalex.org/W2034303744","https://openalex.org/W2041949509","https://openalex.org/W2047810541","https://openalex.org/W2058499374","https://openalex.org/W2061002561","https://openalex.org/W2066621103","https://openalex.org/W2069438110","https://openalex.org/W2075008733","https://openalex.org/W2077618811","https://openalex.org/W2102282815","https://openalex.org/W2110664940","https://openalex.org/W2122054636","https://openalex.org/W2126671243","https://openalex.org/W2127605299","https://openalex.org/W2132087081","https://openalex.org/W2138271749","https://openalex.org/W2139671250","https://openalex.org/W2142131287","https://openalex.org/W2148818765","https://openalex.org/W2149166037","https://openalex.org/W2150972670","https://openalex.org/W2155905452","https://openalex.org/W2158922990","https://openalex.org/W2160022977","https://openalex.org/W2161384987","https://openalex.org/W2170225028","https://openalex.org/W2170614078","https://openalex.org/W2237853490","https://openalex.org/W2249586559","https://openalex.org/W2268494163","https://openalex.org/W2464569425","https://openalex.org/W2724744060","https://openalex.org/W4299993961"],"related_works":["https://openalex.org/W1894899463","https://openalex.org/W2319203106","https://openalex.org/W1513874753","https://openalex.org/W947692162","https://openalex.org/W2111833313","https://openalex.org/W2884329198","https://openalex.org/W1920821432","https://openalex.org/W4396582579","https://openalex.org/W4399487552","https://openalex.org/W4312186884"],"abstract_inverted_index":{"PURPOSE:":[0],"Patients":[1],"with":[2,71,121,181,191,209,224,264],"head":[3,23],"and":[4,24,28,41,43,53,77,102,137,162,184,193,228,245],"neck":[5,25],"squamous":[6],"cell":[7],"carcinoma":[8],"(HNSCC)":[9],"are":[10],"at":[11,99],"elevated":[12],"risk":[13,40,48,83,94,100,110,147,203,227,252,262,272],"of":[14,21,57,68,125,148,230,237,253,274],"second":[15,126],"primary":[16,127],"malignancies":[17],"(SPM),":[18],"most":[19,175],"commonly":[20],"the":[22,55,74,123,138,198,226,238,242,249,258,270],"(HN),":[26],"lung,":[27],"esophagus.":[29],"Our":[30],"objectives":[31],"were":[32,111],"to":[33,44,105,135,235,269],"identify":[34],"HNSCC":[35,72],"subsite-specific":[36],"differences":[37],"in":[38,47,73,108,215],"SPM":[39,82,109,149,177,202,231,261],"distribution":[42,229],"describe":[45],"trends":[46],"over":[49],"3":[50],"decades,":[51],"before":[52],"during":[54,257],"era":[56],"human":[58],"papillomavirus":[59],"(HPV)":[60],"-associated":[61],"oropharyngeal":[62,210,265],"SCC.":[63],"METHODS:":[64],"Population-based":[65],"cohort":[66],"study":[67],"75,087":[69],"patients":[70,120,180,190,208,223],"Surveillance,":[75],"Epidemiology,":[76],"End":[78],"Results":[79],"(SEER)":[80],"program.":[81],"was":[84,130,140,150,187,197],"quantified":[85],"by":[86,113],"using":[87,114],"standardized":[88],"incidence":[89],"ratios":[90],"(SIRs),":[91],"excess":[92,251],"absolute":[93],"(EAR)":[95],"per":[96,143,159,171],"10,000":[97,144,160,172],"person-years":[98],"(PYR),":[101],"number":[103],"needed":[104],"observe.":[106],"Trends":[107],"analyzed":[112],"joinpoint":[115],"log-linear":[116],"regression.":[117],"RESULTS:":[118],"In":[119,222],"HNSCC,":[122,225],"SIR":[124],"solid":[128],"tumor":[129],"2.2":[131],"(95%":[132],"CI,":[133],"2.1":[134],"2.2),":[136],"EAR":[139],"167.7":[141],"cancers":[142,247],"PYR.":[145],"The":[146,174],"highest":[151,250],"for":[152,164,179,189],"hypopharyngeal":[153,194],"SCC":[154,166,186,211,266],"(SIR,":[155,167],"3.5;":[156],"EAR,":[157,169,216],"307.1":[158],"PYR)":[161],"lowest":[163,271],"laryngeal":[165,192],"1.9;":[168],"147.8":[170],"PYR).":[173],"common":[176],"site":[178],"oral":[182],"cavity":[183],"oropharynx":[185,246],"HN;":[188],"cancer,":[195],"it":[196],"lung.":[199],"Since":[200,255],"1991,":[201],"has":[204,267],"decreased":[205],"significantly":[206,233],"among":[207],"(annual":[212],"percentage":[213],"change":[214],"-4.6%;":[217],"P":[218],"=":[219],".03).":[220],"CONCLUSION:":[221],"differ":[232],"according":[234],"subsite":[236],"index":[239],"cancer.":[240],"Before":[241],"1990s,":[243],"hypopharynx":[244],"carried":[248],"SPM.":[254],"then,":[256],"HPV":[259],"era,":[260],"associated":[263],"declined":[268],"level":[273],"any":[275],"subsite.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":31},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}