{"id":"https://openalex.org/W2157283041","doi":"https://doi.org/10.4049/jimmunol.1301603","title":"The Exonuclease Trex1 Restrains Macrophage Proinflammatory Activation","display_name":"The Exonuclease Trex1 Restrains Macrophage Proinflammatory Activation","publication_year":2013,"publication_date":"2013-11-12","ids":{"openalex":"https://openalex.org/W2157283041","doi":"https://doi.org/10.4049/jimmunol.1301603","mag":"2157283041","pmid":"https://pubmed.ncbi.nlm.nih.gov/24218451"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1301603","doi":"https://doi.org/10.4049/jimmunol.1301603","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1301603","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zenodo.org/record/3441352","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042421432","display_name":"Selma Pereira\u2010Lopes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Selma Pereira-Lopes","raw_affiliation_strings":["Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona , 08028 Barcelona,","*Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona, 08028 Barcelona, Spain; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona , 08028 Barcelona,","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"*Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona, 08028 Barcelona, Spain; and","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033557420","display_name":"Teja Celhar","orcid":"https://orcid.org/0000-0003-1384-0941","observed_orcids":["https://orcid.org/0000-0003-1384-0941"]},"institutions":[{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Teja Celhar","raw_affiliation_strings":["Singapore Immunology Network, Immunos , Singapore 138648,","\u2020Singapore Immunology Network, Immunos, Singapore 138648, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Immunos , Singapore 138648,","institution_ids":["https://openalex.org/I2800824516"]},{"raw_affiliation_string":"\u2020Singapore Immunology Network, Immunos, Singapore 138648, Singapore","institution_ids":["https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032369755","display_name":"Gloria Sans-Fons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gloria Sans-Fons","raw_affiliation_strings":["Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona , 08028 Barcelona,","*Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona, 08028 Barcelona, Spain; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona , 08028 Barcelona,","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"*Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona, 08028 Barcelona, Spain; and","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Serra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Serra","raw_affiliation_strings":["Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona , 08028 Barcelona,","*Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona, 08028 Barcelona, Spain; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona , 08028 Barcelona,","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"*Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona, 08028 Barcelona, Spain; and","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057282202","display_name":"Anna\u2010Marie Fairhurst","orcid":"https://orcid.org/0000-0002-8950-6192","observed_orcids":["https://orcid.org/0000-0002-8950-6192"]},"institutions":[{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Anna-Marie Fairhurst","raw_affiliation_strings":["Singapore Immunology Network, Immunos , Singapore 138648,","\u2020Singapore Immunology Network, Immunos, Singapore 138648, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Immunos , Singapore 138648,","institution_ids":["https://openalex.org/I2800824516"]},{"raw_affiliation_string":"\u2020Singapore Immunology Network, Immunos, Singapore 138648, Singapore","institution_ids":["https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039868810","display_name":"Jorge Lloberas","orcid":"https://orcid.org/0000-0001-7075-4201","observed_orcids":["https://orcid.org/0000-0001-7075-4201"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jorge Lloberas","raw_affiliation_strings":["Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona , 08028 Barcelona,","*Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona, 08028 Barcelona, Spain; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona , 08028 Barcelona,","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"*Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona, 08028 Barcelona, Spain; and","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024300705","display_name":"Antonio Celada","orcid":"https://orcid.org/0000-0003-3883-2171","observed_orcids":["https://orcid.org/0000-0003-3883-2171"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio Celada","raw_affiliation_strings":["Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona , 08028 Barcelona,","*Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona, 08028 Barcelona, Spain; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona , 08028 Barcelona,","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"*Grupo Biolog\u00eda del Macr\u00f3fago, Departamento de Fisiolog\u00eda e Inmunolog\u00eda, Universitat de Barcelona, 08028 Barcelona, Spain; and","institution_ids":["https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.4739,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.94795296,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"191","issue":"12","first_page":"6128","last_page":"6135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.4602000117301941,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.4602000117301941,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.36230000853538513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.08169999718666077,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trex1","display_name":"TREX1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/proinflammatory-response","display_name":"pro-inflammatory response","score":0.7710000276565552},{"id":"https://openalex.org/keywords/aicardi-goutieres-syndrome","display_name":"Aicardi-Gouti\u00e8res syndrome","score":0.9150000214576721},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tlr7","display_name":"TLR7","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.968999981880188},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.9459999799728394},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.939736008644104},{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.6634198427200317},{"id":"https://openalex.org/C2777501222","wikidata":"https://www.wikidata.org/wiki/Q411664","display_name":"Exonuclease","level":4,"score":0.5645979046821594},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.5304457545280457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5102086067199707},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5082983374595642},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5025982856750488},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4944431781768799},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.42539915442466736},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.39853423833847046},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3897472620010376},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2249535322189331},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.1950339376926422},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19293475151062012},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15339669585227966},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11889374256134033},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.11235466599464417},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005090","descriptor_name":"Exodeoxyribonucleases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D005090","descriptor_name":"Exodeoxyribonucleases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005090","descriptor_name":"Exodeoxyribonucleases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007739","descriptor_name":"L Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.1301603","doi":"https://doi.org/10.4049/jimmunol.1301603","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1301603","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:24218451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24218451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:zenodo.org:3441352","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/3441352","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2493820186","doi":null,"is_oa":false,"landing_page_url":"https://www.uab.edu/medicine/rheumatology/images/WC_-_Pereira-Lopes_et_al_2013.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:zenodo.org:3441352","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/3441352","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W86026435","https://openalex.org/W1532341958","https://openalex.org/W1537320491","https://openalex.org/W1542734258","https://openalex.org/W1599982743","https://openalex.org/W1916121669","https://openalex.org/W1967046222","https://openalex.org/W1969888906","https://openalex.org/W1970436496","https://openalex.org/W1974934750","https://openalex.org/W1976781795","https://openalex.org/W1986678799","https://openalex.org/W1988429158","https://openalex.org/W1993231465","https://openalex.org/W1993518566","https://openalex.org/W2002421735","https://openalex.org/W2018721405","https://openalex.org/W2021273693","https://openalex.org/W2043959346","https://openalex.org/W2056846025","https://openalex.org/W2059990804","https://openalex.org/W2061883989","https://openalex.org/W2068583506","https://openalex.org/W2075809855","https://openalex.org/W2076690763","https://openalex.org/W2077636159","https://openalex.org/W2077671923","https://openalex.org/W2088920057","https://openalex.org/W2092235636","https://openalex.org/W2094472716","https://openalex.org/W2100587126","https://openalex.org/W2109491705","https://openalex.org/W2116778443","https://openalex.org/W2121575076","https://openalex.org/W2124000892","https://openalex.org/W2124788364","https://openalex.org/W2127924870","https://openalex.org/W2128251228","https://openalex.org/W2145812105","https://openalex.org/W2159647486","https://openalex.org/W2160655220","https://openalex.org/W2167317609","https://openalex.org/W2171946670"],"related_works":["https://openalex.org/W2493820186","https://openalex.org/W7043825372","https://openalex.org/W3008986862","https://openalex.org/W1936648860","https://openalex.org/W1998158993","https://openalex.org/W2255106017","https://openalex.org/W1975815091","https://openalex.org/W3143532449","https://openalex.org/W2278223575","https://openalex.org/W2520029746"],"abstract_inverted_index":{"The":[0],"three-prime":[1],"repair":[2],"exonuclease":[3,10],"1":[4],"(TREX1)":[5],"is":[6,75],"the":[7,22,31,72,95,147,174],"most":[8],"abundant":[9],"in":[11,15,41,67,78,80,94,165,179],"mammalian":[12],"cells.":[13],"Mutations":[14],"Trex1":[16,74,148,169],"gene":[17],"are":[18],"being":[19],"linked":[20],"to":[21,82,127,173],"development":[23],"of":[24,30,48,97,121,146,153,176],"Aicardi-Gouti\u00e8res":[25],"syndrome,":[26],"an":[27,101,113,134,143],"inflammatory":[28,65,155,177],"disease":[29],"brain,":[32],"and":[33,40,87,116,123,157],"systemic":[34],"lupus":[35],"erythematosus.":[36],"In":[37,56],"clinical":[38],"cases":[39],"a":[42,53,150,162],"Trex1-deficient":[43],"murine":[44],"model,":[45],"chronic":[46],"production":[47],"type":[49],"I":[50],"IFN":[51],"plays":[52],"pathogenic":[54],"role.":[55],"this":[57],"study,":[58],"we":[59],"demonstrate":[60,158],"that":[61,159],"Trex1(-/-)":[62,110],"mice":[63],"present":[64],"signatures":[66],"many":[68],"different":[69],"organs,":[70],"including":[71,85],"brain.":[73],"highly":[76],"induced":[77],"macrophages":[79,99,111,160],"response":[81],"proinflammatory":[83,103,108],"stimuli,":[84],"TLR7":[86],"TLR9":[88],"ligands.":[89],"Our":[90],"findings":[91],"show":[92],"that,":[93],"absence":[96],"Trex1,":[98],"displayed":[100],"exacerbated":[102],"response.":[104],"More":[105],"specifically,":[106],"following":[107],"stimulation,":[109],"exhibited":[112],"increased":[114,124],"TNF-\u03b1":[115],"IFN-\u03b1":[117],"production,":[118],"higher":[119],"levels":[120],"CD86,":[122],"Ag":[125],"presentation":[126],"CD4(+)":[128],"T":[129,137],"cells,":[130],"as":[131,133,149],"well":[132],"impaired":[135],"apoptotic":[136],"cell":[138],"clearance.":[139],"These":[140],"results":[141],"evidence":[142],"unrevealed":[144],"function":[145],"negative":[151],"regulator":[152],"macrophage":[154],"activation":[156],"play":[161],"major":[163],"role":[164],"diseases":[166],"associated":[167],"with":[168],"mutations,":[170],"which":[171],"contributes":[172],"understanding":[175],"signature":[178],"these":[180],"diseases.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}