{"id":"https://openalex.org/W2157255393","doi":null,"title":"The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion","display_name":"The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2157255393","mag":"2157255393"},"language":"en","primary_location":{"id":"pmh:oai:lup.lub.lu.se:0c909ccc-af83-45f7-bcea-bfe798a34a39","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/548212","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lup.lub.lu.se/record/548212","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010347051","display_name":"Erik Flodgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Erik Flodgren","raw_affiliation_strings":["Medicine, Lund"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Lund","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010347051"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpr40","display_name":"GPR40","score":0.9990000128746033},{"id":"https://openalex.org/keywords/free-fatty-acid-receptors","display_name":"free fatty acid receptors","score":0.972000002861023},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7020000219345093},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7829999923706055},{"id":"https://openalex.org/keywords/pancreatic-alpha-cells","display_name":"alpha cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/glucagon-secretion","display_name":"glucagon secretion","score":1.0},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C32670627","wikidata":"https://www.wikidata.org/wiki/Q18026423","display_name":"Free fatty acid receptor 1","level":4,"score":0.9921697378158569},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.744657039642334},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7106578946113586},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5295551419258118},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5277605056762695},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.521143913269043},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5048864483833313},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.48528310656547546},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.47943323850631714},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4752602279186249},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.44637900590896606},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.43596506118774414},{"id":"https://openalex.org/C21387880","wikidata":"https://www.wikidata.org/wiki/Q24781050","display_name":"Free fatty acid receptor","level":4,"score":0.4347701668739319},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42195069789886475},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.41810351610183716},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34366950392723083},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2924741506576538},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1962248980998993},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17329567670822144},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.11902812123298645},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:lup.lub.lu.se:0c909ccc-af83-45f7-bcea-bfe798a34a39","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/548212","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2157255393","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/search/ws/files/4513899/548213.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:lup.lub.lu.se:0c909ccc-af83-45f7-bcea-bfe798a34a39","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/548212","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":145,"referenced_works":["https://openalex.org/W6013967","https://openalex.org/W199167747","https://openalex.org/W1499384204","https://openalex.org/W1545792116","https://openalex.org/W1561454056","https://openalex.org/W1568965788","https://openalex.org/W1573318520","https://openalex.org/W1592327102","https://openalex.org/W1603274157","https://openalex.org/W1826492881","https://openalex.org/W1852077611","https://openalex.org/W1946195950","https://openalex.org/W1966118942","https://openalex.org/W1966465836","https://openalex.org/W1968863211","https://openalex.org/W1971639453","https://openalex.org/W1971701221","https://openalex.org/W1974959407","https://openalex.org/W1975370433","https://openalex.org/W1979010452","https://openalex.org/W1981153465","https://openalex.org/W1983991331","https://openalex.org/W1984519947","https://openalex.org/W1984875108","https://openalex.org/W1989346288","https://openalex.org/W1989911135","https://openalex.org/W1995573327","https://openalex.org/W1995713589","https://openalex.org/W1999927420","https://openalex.org/W2001158976","https://openalex.org/W2005126850","https://openalex.org/W2006859748","https://openalex.org/W2008385479","https://openalex.org/W2008895832","https://openalex.org/W2009557514","https://openalex.org/W2013145654","https://openalex.org/W2017783641","https://openalex.org/W2019925176","https://openalex.org/W2020286683","https://openalex.org/W2021976026","https://openalex.org/W2022048961","https://openalex.org/W2022336683","https://openalex.org/W2030903086","https://openalex.org/W2031414916","https://openalex.org/W2036848107","https://openalex.org/W2037802736","https://openalex.org/W2039531356","https://openalex.org/W2041888630","https://openalex.org/W2042203830","https://openalex.org/W2042311529","https://openalex.org/W2042535492","https://openalex.org/W2042891307","https://openalex.org/W2043606482","https://openalex.org/W2044569784","https://openalex.org/W2047922146","https://openalex.org/W2050051162","https://openalex.org/W2050161272","https://openalex.org/W2051770908","https://openalex.org/W2053984056","https://openalex.org/W2054500001","https://openalex.org/W2056860785","https://openalex.org/W2065504943","https://openalex.org/W2066113694","https://openalex.org/W2067096633","https://openalex.org/W2068094755","https://openalex.org/W2071230707","https://openalex.org/W2073960217","https://openalex.org/W2074665881","https://openalex.org/W2075103181","https://openalex.org/W2075246806","https://openalex.org/W2075716614","https://openalex.org/W2076511407","https://openalex.org/W2077032611","https://openalex.org/W2077107304","https://openalex.org/W2077737366","https://openalex.org/W2077864709","https://openalex.org/W2079088793","https://openalex.org/W2080117039","https://openalex.org/W2080483538","https://openalex.org/W2082319637","https://openalex.org/W2084862721","https://openalex.org/W2087357268","https://openalex.org/W2088888731","https://openalex.org/W2089540591","https://openalex.org/W2090707240","https://openalex.org/W2092438517","https://openalex.org/W2093478842","https://openalex.org/W2095225735","https://openalex.org/W2095268130","https://openalex.org/W2096273239","https://openalex.org/W2099129407","https://openalex.org/W2100687361","https://openalex.org/W2102964449","https://openalex.org/W2103637713","https://openalex.org/W2105072053","https://openalex.org/W2105497606","https://openalex.org/W2107718435","https://openalex.org/W2108169012","https://openalex.org/W2108709856","https://openalex.org/W2109014958","https://openalex.org/W2109421395","https://openalex.org/W2110839026","https://openalex.org/W2110952210","https://openalex.org/W2112946160","https://openalex.org/W2113307670","https://openalex.org/W2117584722","https://openalex.org/W2120282127","https://openalex.org/W2121833464","https://openalex.org/W2122568821","https://openalex.org/W2122905319","https://openalex.org/W2124971376","https://openalex.org/W2128167237","https://openalex.org/W2128326754","https://openalex.org/W2130185420","https://openalex.org/W2135514341","https://openalex.org/W2136424540","https://openalex.org/W2137842897","https://openalex.org/W2138907486","https://openalex.org/W2140419064","https://openalex.org/W2141063928","https://openalex.org/W2141658656","https://openalex.org/W2143235617","https://openalex.org/W2144273086","https://openalex.org/W2145490597","https://openalex.org/W2146170191","https://openalex.org/W2149423178","https://openalex.org/W2149963584","https://openalex.org/W2153321120","https://openalex.org/W2155993440","https://openalex.org/W2159036864","https://openalex.org/W2159581380","https://openalex.org/W2160154061","https://openalex.org/W2162664501","https://openalex.org/W2163216300","https://openalex.org/W2164849270","https://openalex.org/W2166179667","https://openalex.org/W2168808956","https://openalex.org/W2168909179","https://openalex.org/W2170428376","https://openalex.org/W2171148217","https://openalex.org/W2171241319","https://openalex.org/W2172302895","https://openalex.org/W2334337188","https://openalex.org/W2341209355","https://openalex.org/W3025317614"],"related_works":["https://openalex.org/W2089163597","https://openalex.org/W2141129143","https://openalex.org/W1995573327","https://openalex.org/W1983654296","https://openalex.org/W2128326754","https://openalex.org/W2367805096","https://openalex.org/W1996947378","https://openalex.org/W2080410583","https://openalex.org/W2327320240","https://openalex.org/W2080483538"],"abstract_inverted_index":{"Type":[0],"2":[1],"diabetes":[2],"(T2D)":[3],"is":[4,50,239],"a":[5,43,76,94,105,144,209],"serious":[6],"condition":[7],"of":[8,35,48,58,71,89,121,136,174,179,193,211,216,235,245],"growing":[9],"proportions.":[10],"Developing":[11],"via":[12,248],"an":[13,53],"increasing":[14],"imbalance":[15],"between":[16,82,133],"insulin":[17,24,122,148],"sensitivity":[18],"in":[19,55,78,108,118,143,232],"the":[20,32,37,56,63,69,79,130,177,190,233],"peripheral":[21],"tissues":[22],"and":[23,84,138,147,226,237],"release":[25,149],"from":[26,150,159,185,213],"pancreatic":[27,109,152],"beta-cells,":[28],"it":[29,92,238],"ultimately":[30],"renders":[31],"individual":[33],"incapable":[34],"regulating":[36],"blood":[38],"glucose":[39],"concentration,":[40],"e.g.":[41],"after":[42,163],"meal.":[44],"The":[45],"increased":[46,156],"prevalence":[47,57],"T2D":[49,83,236],"associated":[51],"with":[52,60],"increase":[54],"obesity,":[59],"obesity":[61],"being":[62],"single":[64],"largest":[65],"risk":[66],"factor":[67],"for":[68,96],"development":[70,234],"T2D.":[72],"This":[73,124],"work":[74],"describes":[75],"molecule":[77],"border":[80],"zone":[81],"obesity.":[85],"Our":[86],"initial":[87],"characterization":[88],"GPR40":[90,114,137,175,199,218],"identified":[91],"as":[93],"receptor":[95],"medium-":[97],"to":[98,115,202],"long-chain":[99],"free":[100],"fatty":[101],"acids":[102],"(FFAs).":[103],"With":[104],"marked":[106],"expression":[107],"beta-cell":[110,145],"lines,":[111],"we":[112,128,164],"expected":[113],"be":[116],"involved":[117],"FFA-mediated":[119],"augmentation":[120],"release.":[123],"was":[125,161],"confirmed":[126],"when":[127],"examined":[129],"dose-response":[131],"relationship":[132],"FFA":[134,180],"stimulation":[135,181],"both":[139,186,224],"intracellular":[140],"second":[141],"messengers":[142],"line":[146],"isolated":[151],"islets.":[153],"A":[154],"similarly":[155],"glucagon":[157],"secretion":[158,184],"alpha-cells":[160],"demonstrated":[162],"established":[165],"that":[166,197,228,241],"these":[167],"cells":[168],"also":[169],"express":[170],"GPR40.":[171,249],"Antisense":[172],"knock-down":[173],"abolished":[176],"effect":[178],"on":[182,223],"hormone":[183],"cell":[187],"types.":[188],"In":[189],"final":[191],"part":[192,244],"this":[194],"work,":[195],"FFAs":[196,220],"activate":[198],"were":[200],"shown":[201],"negatively":[203],"regulate":[204],"its":[205],"mRNA":[206],"expression,":[207],"indicating":[208],"mechanism":[210],"protection":[212],"detrimental":[214],"effects":[215,222],"sustained":[217],"stimulation.":[219],"mediate":[221],"alpha-":[225],"beta-cells":[227],"are":[229],"potentially":[230],"harmful":[231],"possible":[240],"at":[242],"least":[243],"those":[246],"occur":[247]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
