{"id":"https://openalex.org/W2157208997","doi":"https://doi.org/10.1093/annhyg/46.suppl_1.242","title":"The Importance of Surface Area and Specific Reactivity in the Acute Pulmonary Inflammatory Response to Particles","display_name":"The Importance of Surface Area and Specific Reactivity in the Acute Pulmonary Inflammatory Response to Particles","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W2157208997","doi":"https://doi.org/10.1093/annhyg/46.suppl_1.242","mag":"2157208997"},"language":"en","primary_location":{"id":"doi:10.1093/annhyg/46.suppl_1.242","doi":"https://doi.org/10.1093/annhyg/46.suppl_1.242","is_oa":false,"landing_page_url":"https://doi.org/10.1093/annhyg/46.suppl_1.242","pdf_url":null,"source":{"id":"https://openalex.org/S206992039","display_name":"The Annals of Occupational Hygiene","issn_l":"0003-4878","issn":["0003-4878","1475-3162"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of Occupational Hygiene","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066651509","display_name":"Rodger Duffin","orcid":"https://orcid.org/0000-0002-3425-9745","observed_orcids":["https://orcid.org/0000-0002-3425-9745"]},"institutions":[{"id":"https://openalex.org/I251738","display_name":"Edinburgh Napier University","ror":"https://ror.org/03zjvnn91","country_code":"GB","type":"education","lineage":["https://openalex.org/I251738"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"R. Duffin","raw_affiliation_strings":["Elegi/Colt Research Laboratories, Department of Respiratory Medicine, Division of Clinical and Radiological Sciences, University of Edinburgh Edinburgh, UK","School of Life Sciences, Napier University Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elegi/Colt Research Laboratories, Department of Respiratory Medicine, Division of Clinical and Radiological Sciences, University of Edinburgh Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"School of Life Sciences, Napier University Edinburgh, UK","institution_ids":["https://openalex.org/I251738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112968137","display_name":"C. Lang Tran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129077","display_name":"Institute of Occupational Medicine","ror":"https://ror.org/03r6k1a05","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210129077"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. L. Tran","raw_affiliation_strings":["Institute of Occupational Medicine 8 Roxburgh Place, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Occupational Medicine 8 Roxburgh Place, Edinburgh, UK","institution_ids":["https://openalex.org/I4210129077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000022879","display_name":"Anna Clouter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I251738","display_name":"Edinburgh Napier University","ror":"https://ror.org/03zjvnn91","country_code":"GB","type":"education","lineage":["https://openalex.org/I251738"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Clouter","raw_affiliation_strings":["School of Life Sciences, Napier University Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Napier University Edinburgh, UK","institution_ids":["https://openalex.org/I251738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107842900","display_name":"David M. Brown","orcid":"https://orcid.org/0000-0002-6013-2713","observed_orcids":["https://orcid.org/0000-0002-6013-2713"]},"institutions":[{"id":"https://openalex.org/I251738","display_name":"Edinburgh Napier University","ror":"https://ror.org/03zjvnn91","country_code":"GB","type":"education","lineage":["https://openalex.org/I251738"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. M. Brown","raw_affiliation_strings":["School of Life Sciences, Napier University Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Napier University Edinburgh, UK","institution_ids":["https://openalex.org/I251738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050425677","display_name":"William MacNee","orcid":"https://orcid.org/0000-0002-3692-1448","observed_orcids":["https://orcid.org/0000-0002-3692-1448"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. MacNee","raw_affiliation_strings":["Elegi/Colt Research Laboratories, Department of Respiratory Medicine, Division of Clinical and Radiological Sciences, University of Edinburgh Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elegi/Colt Research Laboratories, Department of Respiratory Medicine, Division of Clinical and Radiological Sciences, University of Edinburgh Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008390045","display_name":"Vicki Stone","orcid":"https://orcid.org/0000-0001-8346-7471","observed_orcids":["https://orcid.org/0000-0001-8346-7471"]},"institutions":[{"id":"https://openalex.org/I251738","display_name":"Edinburgh Napier University","ror":"https://ror.org/03zjvnn91","country_code":"GB","type":"education","lineage":["https://openalex.org/I251738"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"V. Stone","raw_affiliation_strings":["Elegi/Colt Research Laboratories, Department of Respiratory Medicine, Division of Clinical and Radiological Sciences, University of Edinburgh Edinburgh, UK","School of Life Sciences, Napier University Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elegi/Colt Research Laboratories, Department of Respiratory Medicine, Division of Clinical and Radiological Sciences, University of Edinburgh Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"School of Life Sciences, Napier University Edinburgh, UK","institution_ids":["https://openalex.org/I251738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034736085","display_name":"Ken Donaldson","orcid":"https://orcid.org/0000-0002-2093-1852","observed_orcids":["https://orcid.org/0000-0002-2093-1852"]},"institutions":[{"id":"https://openalex.org/I251738","display_name":"Edinburgh Napier University","ror":"https://ror.org/03zjvnn91","country_code":"GB","type":"education","lineage":["https://openalex.org/I251738"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. Donaldson","raw_affiliation_strings":["Elegi/Colt Research Laboratories, Department of Respiratory Medicine, Division of Clinical and Radiological Sciences, University of Edinburgh Edinburgh, UK","School of Life Sciences, Napier University Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elegi/Colt Research Laboratories, Department of Respiratory Medicine, Division of Clinical and Radiological Sciences, University of Edinburgh Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"School of Life Sciences, Napier University Edinburgh, UK","institution_ids":["https://openalex.org/I251738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066651509"],"corresponding_institution_ids":["https://openalex.org/I251738","https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":6.0141,"has_fulltext":false,"cited_by_count":187,"citation_normalized_percentile":{"value":0.96553469,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/particle-surface-area","display_name":"particle surface area","score":0.7760000228881836},{"id":"https://openalex.org/keywords/ultrafine-particles","display_name":"ultrafine particles","score":0.8629999756813049},{"id":"https://openalex.org/keywords/neutrophil-influx","display_name":"neutrophil influx","score":0.8320000171661377},{"id":"https://openalex.org/keywords/quartz","display_name":"quartz","score":0.5260000228881836},{"id":"https://openalex.org/keywords/dust-toxicity","display_name":"dust toxicity","score":0.5199999809265137},{"id":"https://openalex.org/keywords/nuisance-dust","display_name":"nuisance dust","score":0.5889999866485596},{"id":"https://openalex.org/keywords/carbon-black","display_name":"carbon black","score":0.5440000295639038},{"id":"https://openalex.org/keywords/titanium-dioxide","display_name":"titanium dioxide","score":0.9789999723434448},{"id":"https://openalex.org/keywords/latex-particles","display_name":"latex particles","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7203915119171143},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5401735305786133},{"id":"https://openalex.org/C150032891","wikidata":"https://www.wikidata.org/wiki/Q7880535","display_name":"Ultrafine particle","level":2,"score":0.521273136138916},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4438899755477905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3566206097602844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32341456413269043},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3172306418418884},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.30025285482406616},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.22828704118728638},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15052983164787292}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/annhyg/46.suppl_1.242","doi":"https://doi.org/10.1093/annhyg/46.suppl_1.242","is_oa":false,"landing_page_url":"https://doi.org/10.1093/annhyg/46.suppl_1.242","pdf_url":null,"source":{"id":"https://openalex.org/S206992039","display_name":"The Annals of Occupational Hygiene","issn_l":"0003-4878","issn":["0003-4878","1475-3162"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of Occupational Hygiene","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1982504819","https://openalex.org/W2026644554","https://openalex.org/W2110824853","https://openalex.org/W2159364645","https://openalex.org/W2162621124","https://openalex.org/W2163615601","https://openalex.org/W2178588887"],"related_works":["https://openalex.org/W7099660553","https://openalex.org/W2140036981","https://openalex.org/W2024481637","https://openalex.org/W7095526750","https://openalex.org/W2103449823","https://openalex.org/W2028440527","https://openalex.org/W2283760820","https://openalex.org/W7095746569","https://openalex.org/W2026372164","https://openalex.org/W2112375980"],"abstract_inverted_index":{"A":[0],"range":[1],"of":[2,21,36,62,76,83,91,94,110,119,131,146,176,199,228,236,248],"different":[3],"particle":[4,96],"types":[5,20],"cause":[6],"excessive":[7],"lung":[8,38,104],"inflammation":[9,111],"that":[10,48,143,202],"is":[11,140],"thought":[12],"to":[13,68,115,159,172,225],"play":[14],"a":[15,89,117,128,249],"role":[16],"in":[17,157],"the":[18,34,49,54,77,81,103,120,174,194,212,226,234,245],"various":[19,95],"pathology":[22],"they":[23,135],"produce.":[24],"Recently":[25],"attention":[26],"has":[27,64,72,112],"been":[28,66,73,113],"focused":[29],"on":[30,224,244],"ultrafine":[31,125,144],"particles":[32,63,126,145],"and":[33,42,80,98],"phenomenon":[35],"rat":[37],"overload.":[39,85],"The":[40,108],"authors":[41],"their":[43,160],"collaborators":[44],"have":[45,87,153],"shown":[46,114],"previously":[47],"surface":[50,121,133,162,197,252],"area":[51,122,253],"metric":[52],"drives":[53],"overload":[55],"response.":[56],"Acute":[57],"inflammatory":[58,246],"response":[59,247],"following":[60],"instillation":[61],"also":[65],"used":[67],"evaluate":[69],"hazard":[70],"but":[71],"criticized":[74],"because":[75],"non-physiological":[78],"delivery":[79],"problems":[82],"local":[84],"We":[86,164],"instilled":[88,182,251],"number":[90],"low-toxicity":[92,216],"dusts":[93,242],"sizes":[97],"assessed":[99],"neutrophil":[100],"influx":[101],"into":[102],"at":[105],"18\u201324":[106],"h.":[107],"extent":[109],"be":[116],"function":[118],"instilled.":[123],"Since":[124],"present":[127],"\u2018special\u2019":[129],"case":[130],"high":[132,195],"area,":[134],"are":[136],"relatively":[137],"inflammogenic.":[138],"There":[139],"no":[141],"evidence":[142],"carbon":[147],"black,":[148],"titanium":[149],"dioxide":[150],"or":[151,187],"latex":[152],"any":[154],"special":[155],"reactivity":[156,175],"addition":[158],"large":[161],"area.":[163],"tested":[165],"whether":[166],"we":[167],"could":[168],"use":[169],"this":[170],"approach":[171,232],"model":[173],"highly":[177],"toxic":[178],"dusts.":[179,217,230],"Rats":[180],"were":[181],"with":[183],"either":[184],"DQ12":[185,190,200,222],"quartz":[186],"aluminium":[188,220],"lactate-treated":[189,221],"and,":[191],"as":[192],"anticipated,":[193],"specific":[196],"toxicity":[198,239],"meant":[201],"it":[203],"was":[204,209],"much":[205],"more":[206],"inflammogenic":[207],"than":[208],"predicted":[210],"using":[211],"relationship":[213],"described":[214],"for":[215,240],"By":[218],"contrast,":[219],"fell":[223],"line":[227],"\u2018low-toxicity\u2019":[229],"This":[231],"presents":[233],"possibility":[235],"modelling":[237],"potential":[238],"nuisance":[241],"based":[243],"given":[250],"dose.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}