{"id":"https://openalex.org/W2157200858","doi":"https://doi.org/10.1042/bj3280271","title":"The sphingomyelin\u2013ceramide pathway participates in cytokine regulation of C-reactive protein and serum amyloid A, but not \u03b1-fibrinogen","display_name":"The sphingomyelin\u2013ceramide pathway participates in cytokine regulation of C-reactive protein and serum amyloid A, but not \u03b1-fibrinogen","publication_year":1997,"publication_date":"1997-11-15","ids":{"openalex":"https://openalex.org/W2157200858","doi":"https://doi.org/10.1042/bj3280271","mag":"2157200858","pmid":"https://pubmed.ncbi.nlm.nih.gov/9359864","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1218917"},"language":"en","primary_location":{"id":"doi:10.1042/bj3280271","doi":"https://doi.org/10.1042/bj3280271","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3280271","pdf_url":"https://portlandpress.com/biochemj/article-pdf/328/1/271/628590/bj3280271.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/328/1/271/628590/bj3280271.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018821266","display_name":"Gerard Lozanski","orcid":"https://orcid.org/0000-0002-5095-0456","observed_orcids":["https://orcid.org/0000-0002-5095-0456"]},"institutions":[{"id":"https://openalex.org/I1299218025","display_name":"MetroHealth","ror":"https://ror.org/0377srw41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025"]},{"id":"https://openalex.org/I4210157264","display_name":"MetroHealth Medical Center","ror":"https://ror.org/05j4p5w63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025","https://openalex.org/I4210157264"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerard LOZANSKI","raw_affiliation_strings":["Case Western Reserve University at MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109-1998, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University at MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109-1998, U.S.A","institution_ids":["https://openalex.org/I1299218025","https://openalex.org/I4210157264","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024374015","display_name":"Franck Berthier","orcid":"https://orcid.org/0009-0004-0155-1901","observed_orcids":["https://orcid.org/0009-0004-0155-1901"]},"institutions":[{"id":"https://openalex.org/I1299218025","display_name":"MetroHealth","ror":"https://ror.org/0377srw41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025"]},{"id":"https://openalex.org/I4210157264","display_name":"MetroHealth Medical Center","ror":"https://ror.org/05j4p5w63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025","https://openalex.org/I4210157264"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franck BERTHIER","raw_affiliation_strings":["Case Western Reserve University at MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109-1998, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University at MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109-1998, U.S.A","institution_ids":["https://openalex.org/I1299218025","https://openalex.org/I4210157264","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077990157","display_name":"Irving Kushner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299218025","display_name":"MetroHealth","ror":"https://ror.org/0377srw41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025"]},{"id":"https://openalex.org/I4210157264","display_name":"MetroHealth Medical Center","ror":"https://ror.org/05j4p5w63","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025","https://openalex.org/I4210157264"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irving KUSHNER","raw_affiliation_strings":["Case Western Reserve University at MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109-1998, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University at MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109-1998, U.S.A","institution_ids":["https://openalex.org/I1299218025","https://openalex.org/I4210157264","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3969,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.51630659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"328","issue":"1","first_page":"271","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9670000076293945},{"id":"https://openalex.org/keywords/serum-amyloid-a","display_name":"serum amyloid A","score":1.0},{"id":"https://openalex.org/keywords/acute-phase-proteins","display_name":"acute phase proteins","score":0.7850000262260437},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9629999995231628},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ceramide-analogs","display_name":"ceramide analogues","score":0.7960000038146973},{"id":"https://openalex.org/keywords/acid-sphingomyelinase","display_name":"acid sphingomyelinase","score":0.906000018119812},{"id":"https://openalex.org/keywords/d609","display_name":"D609","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hep3b-cells","display_name":"Hep3B cells","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.8702188730239868},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.8609423637390137},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.7620989680290222},{"id":"https://openalex.org/C55359608","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum amyloid A","level":3,"score":0.6022815704345703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5530805587768555},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.508243978023529},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.49211758375167847},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4791692793369293},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4340957999229431},{"id":"https://openalex.org/C2910060150","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum Amyloid A Protein","level":4,"score":0.4244164228439331},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32156050205230713},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26019465923309326},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.25056594610214233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24048534035682678},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.14739832282066345},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12999305129051208},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000685","descriptor_name":"Serum Amyloid A Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000685","descriptor_name":"Serum Amyloid A Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000685","descriptor_name":"Serum Amyloid A Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001053","descriptor_name":"Apolipoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001053","descriptor_name":"Apolipoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001053","descriptor_name":"Apolipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001952","descriptor_name":"Bridged-Ring Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009636","descriptor_name":"Norbornanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013108","descriptor_name":"Sphingomyelin Phosphodiesterase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013108","descriptor_name":"Sphingomyelin Phosphodiesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013109","descriptor_name":"Sphingomyelins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013859","descriptor_name":"Thiocarbamates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013871","descriptor_name":"Thiones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj3280271","doi":"https://doi.org/10.1042/bj3280271","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3280271","pdf_url":"https://portlandpress.com/biochemj/article-pdf/328/1/271/628590/bj3280271.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:9359864","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9359864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1218917","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1218917/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1042/bj3280271","doi":"https://doi.org/10.1042/bj3280271","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3280271","pdf_url":"https://portlandpress.com/biochemj/article-pdf/328/1/271/628590/bj3280271.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2629322908","display_name":"INDUCTION OF ACUTE PHASE PROTEIN BIOSYNTHESIS","funder_award_id":"R01AG002467","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2157200858.pdf","grobid_xml":"https://content.openalex.org/works/W2157200858.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W91157394","https://openalex.org/W636776315","https://openalex.org/W1486630982","https://openalex.org/W1491611834","https://openalex.org/W1499006526","https://openalex.org/W1512960324","https://openalex.org/W1514081838","https://openalex.org/W1550942324","https://openalex.org/W1553492210","https://openalex.org/W1561919952","https://openalex.org/W1562457256","https://openalex.org/W1568339295","https://openalex.org/W1577946620","https://openalex.org/W1602943807","https://openalex.org/W1657392119","https://openalex.org/W1773327886","https://openalex.org/W1821840597","https://openalex.org/W1964788380","https://openalex.org/W1964815717","https://openalex.org/W1969158591","https://openalex.org/W1970161839","https://openalex.org/W1973780685","https://openalex.org/W1997261857","https://openalex.org/W2002776738","https://openalex.org/W2006923351","https://openalex.org/W2011495375","https://openalex.org/W2011583495","https://openalex.org/W2016013826","https://openalex.org/W2028652974","https://openalex.org/W2032971496","https://openalex.org/W2036452124","https://openalex.org/W2039435918","https://openalex.org/W2052960146","https://openalex.org/W2053204073","https://openalex.org/W2066299294","https://openalex.org/W2067855365","https://openalex.org/W2070005836","https://openalex.org/W2071842862","https://openalex.org/W2077156149","https://openalex.org/W2094336459","https://openalex.org/W2105866978","https://openalex.org/W2118114239","https://openalex.org/W2129198290","https://openalex.org/W2134812217","https://openalex.org/W2257159758","https://openalex.org/W2336544103","https://openalex.org/W2395274642","https://openalex.org/W2403517242","https://openalex.org/W2432986195","https://openalex.org/W6602355475","https://openalex.org/W6605852325","https://openalex.org/W6638852425","https://openalex.org/W6814902290","https://openalex.org/W6819633004"],"related_works":["https://openalex.org/W2120033507","https://openalex.org/W2006923351","https://openalex.org/W1561919952","https://openalex.org/W1634476623","https://openalex.org/W1968784427","https://openalex.org/W1970001205","https://openalex.org/W2052960146","https://openalex.org/W2071842862","https://openalex.org/W2054043005","https://openalex.org/W7096896602"],"abstract_inverted_index":{"Maximal":[0],"induction":[1,34,76,125,151,207,229],"of":[2,24,42,49,54,59,77,91,100,106,114,126,134,142,152,168,201,208,225],"the":[3,15,22,39,43,47,52,89,140,146,166,193,222],"acute-phase":[4],"proteins":[5],"C-reactive":[6],"protein":[7],"(CRP)":[8],"and":[9,27,62,71,80,128,136,154,171,185],"serum":[10],"amyloid":[11],"A":[12],"(SAA)":[13],"in":[14,46,57,108,150,179,220],"human":[16],"hepatoma":[17],"cell":[18],"line":[19],"Hep3B":[20,109],"requires":[21],"combination":[23,99],"interleukin":[25],"(IL)-6":[26],"IL-1.":[28],"In":[29,211],"contrast,":[30,212],"IL-1":[31],"inhibits":[32],"fibrinogen":[33,228],"by":[35,83,117,130,156,164,230],"IL-6.":[36,231],"To":[37],"explore":[38],"possible":[40],"participation":[41],"sphingomyelin-ceramide":[44,147,194],"pathway":[45,56,148,195,214],"transduction":[48],"cytokine":[50],"effects,":[51],"role":[53],"this":[55,213],"expression":[58],"CRP,":[60],"SAA":[61,81,129,155],"alpha-fibrinogen":[63,92],"was":[64],"investigated.":[65],"The":[66,98,132],"cell-permeable":[67],"ceramide":[68,115],"analogues":[69],"C2":[70,135,170],"C6":[72,137,172],"each":[73],"greatly":[74],"potentiated":[75],"both":[78],"CRP":[79,127,153,184],"mRNA":[82],"IL-6+IL-1beta":[84,101,157],"but":[85,119],"did":[86],"not":[87,120,216],"affect":[88],"responses":[90],"to":[93,96,103,138,175,218],"IL-6":[94,181],"or":[95],"IL-6+IL-1beta.":[97,131],"led":[102],"increased":[104],"turnover":[105],"sphingomyelin":[107],"cells.":[110],"D609,":[111],"an":[112],"inhibitor":[113],"production":[116],"acidic":[118],"neutral":[121],"sphingomyelinases,":[122],"substantially":[123],"inhibited":[124],"ability":[133],"potentiate":[139],"effects":[141,167,182,224],"cytokines":[143],"suggests":[144],"that":[145,192],"participates":[149],"under":[158],"these":[159],"experimental":[160],"conditions,":[161],"most":[162],"likely":[163],"transducing":[165],"IL-1beta.":[169],"were":[173],"unable":[174],"substitute":[176],"for":[177,206],"IL-1beta":[178,226],"enhancing":[180],"on":[183,227],"SAA,":[186],"consistent":[187],"with":[188],"other":[189],"reports":[190],"indicating":[191],"is":[196],"only":[197],"a":[198],"single":[199],"component":[200],"multiple":[202],"necessary":[203],"converging":[204],"pathways":[205],"many":[209],"genes.":[210],"does":[215],"appear":[217],"participate":[219],"mediating":[221],"inhibitory":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}