{"id":"https://openalex.org/W2157166246","doi":"https://doi.org/10.1016/0168-3659(92)90088-9","title":"Preclinical evaluation of polymer-bound doxorubicin","display_name":"Preclinical evaluation of polymer-bound doxorubicin","publication_year":1992,"publication_date":"1992-03-01","ids":{"openalex":"https://openalex.org/W2157166246","doi":"https://doi.org/10.1016/0168-3659(92)90088-9","mag":"2157166246"},"language":"en","primary_location":{"id":"doi:10.1016/0168-3659(92)90088-9","doi":"https://doi.org/10.1016/0168-3659(92)90088-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0168-3659(92)90088-9","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111989755","display_name":"Ruth Duncan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56007636","display_name":"Keele University","ror":"https://ror.org/00340yn33","country_code":"GB","type":"education","lineage":["https://openalex.org/I56007636"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"R. Duncan","raw_affiliation_strings":["CRC Polymer-Controlled Drug Delivery Group, University of Keele, Keele, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRC Polymer-Controlled Drug Delivery Group, University of Keele, Keele, UK","institution_ids":["https://openalex.org/I56007636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032131181","display_name":"Leonard William Seymour","orcid":"https://orcid.org/0000-0003-3825-0841","observed_orcids":["https://orcid.org/0000-0003-3825-0841"]},"institutions":[{"id":"https://openalex.org/I56007636","display_name":"Keele University","ror":"https://ror.org/00340yn33","country_code":"GB","type":"education","lineage":["https://openalex.org/I56007636"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L.W. Seymour","raw_affiliation_strings":["CRC Polymer-Controlled Drug Delivery Group, University of Keele, Keele, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRC Polymer-Controlled Drug Delivery Group, University of Keele, Keele, UK","institution_ids":["https://openalex.org/I56007636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085709557","display_name":"K.B. O'Hare","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56007636","display_name":"Keele University","ror":"https://ror.org/00340yn33","country_code":"GB","type":"education","lineage":["https://openalex.org/I56007636"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K.B. O'Hare","raw_affiliation_strings":["CRC Polymer-Controlled Drug Delivery Group, University of Keele, Keele, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRC Polymer-Controlled Drug Delivery Group, University of Keele, Keele, UK","institution_ids":["https://openalex.org/I56007636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036457658","display_name":"Pauline A. Flanagan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56007636","display_name":"Keele University","ror":"https://ror.org/00340yn33","country_code":"GB","type":"education","lineage":["https://openalex.org/I56007636"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P.A. Flanagan","raw_affiliation_strings":["CRC Polymer-Controlled Drug Delivery Group, University of Keele, Keele, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRC Polymer-Controlled Drug Delivery Group, University of Keele, Keele, UK","institution_ids":["https://openalex.org/I56007636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058765817","display_name":"Stephen R. Wedge","orcid":"https://orcid.org/0000-0002-3644-6157","observed_orcids":["https://orcid.org/0000-0002-3644-6157"]},"institutions":[{"id":"https://openalex.org/I56007636","display_name":"Keele University","ror":"https://ror.org/00340yn33","country_code":"GB","type":"education","lineage":["https://openalex.org/I56007636"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Wedge","raw_affiliation_strings":["CRC Polymer-Controlled Drug Delivery Group, University of Keele, Keele, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRC Polymer-Controlled Drug Delivery Group, University of Keele, Keele, UK","institution_ids":["https://openalex.org/I56007636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108478033","display_name":"Isabella C. Hume","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56007636","display_name":"Keele University","ror":"https://ror.org/00340yn33","country_code":"GB","type":"education","lineage":["https://openalex.org/I56007636"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I.C. Hume","raw_affiliation_strings":["CRC Polymer-Controlled Drug Delivery Group, University of Keele, Keele, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRC Polymer-Controlled Drug Delivery Group, University of Keele, Keele, UK","institution_ids":["https://openalex.org/I56007636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040270800","display_name":"Karel Ulbrich","orcid":"https://orcid.org/0000-0003-2174-9654","observed_orcids":["https://orcid.org/0000-0003-2174-9654"]},"institutions":[{"id":"https://openalex.org/I4210101964","display_name":"Czech Academy of Sciences, Institute of Macromolecular Chemistry","ror":"https://ror.org/0143w7709","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"K. Ulbrich","raw_affiliation_strings":["Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia","institution_ids":["https://openalex.org/I4210101964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111815289","display_name":"Ji\u0159\u00ed Strohalm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101964","display_name":"Czech Academy of Sciences, Institute of Macromolecular Chemistry","ror":"https://ror.org/0143w7709","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"J. Strohalm","raw_affiliation_strings":["Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia","institution_ids":["https://openalex.org/I4210101964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061590219","display_name":"Vladim\u00edr \u0160ubr","orcid":"https://orcid.org/0000-0002-1614-6595","observed_orcids":["https://orcid.org/0000-0002-1614-6595"]},"institutions":[{"id":"https://openalex.org/I4210101964","display_name":"Czech Academy of Sciences, Institute of Macromolecular Chemistry","ror":"https://ror.org/0143w7709","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"V. Subr","raw_affiliation_strings":["Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia","institution_ids":["https://openalex.org/I4210101964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111765313","display_name":"F. Spreafico","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Spreafico","raw_affiliation_strings":["Farmitalia Carlo Erba, Centro Richerche, Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Farmitalia Carlo Erba, Centro Richerche, Nerviano, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045153764","display_name":"Maria Grandi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Grandi","raw_affiliation_strings":["Farmitalia Carlo Erba, Centro Richerche, Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Farmitalia Carlo Erba, Centro Richerche, Nerviano, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022895523","display_name":"Marina Ripamonti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Ripamonti","raw_affiliation_strings":["Farmitalia Carlo Erba, Centro Richerche, Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Farmitalia Carlo Erba, Centro Richerche, Nerviano, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090067835","display_name":"Mariella Farao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Farao","raw_affiliation_strings":["Farmitalia Carlo Erba, Centro Richerche, Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Farmitalia Carlo Erba, Centro Richerche, Nerviano, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057090090","display_name":"Antonino Suarato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Suarato","raw_affiliation_strings":["Farmitalia Carlo Erba, Centro Richerche, Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Farmitalia Carlo Erba, Centro Richerche, Nerviano, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111989755"],"corresponding_institution_ids":["https://openalex.org/I56007636"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":5.4569,"has_fulltext":false,"cited_by_count":187,"citation_normalized_percentile":{"value":0.97202797,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"19","issue":"1-3","first_page":"331","last_page":"346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hpma-copolymer","display_name":"HPMA copolymer","score":0.972000002861023},{"id":"https://openalex.org/keywords/polymer-drug-conjugates","display_name":"polymer-drug conjugates","score":0.8600000143051147},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.703000009059906},{"id":"https://openalex.org/keywords/liver-targeting","display_name":"liver targeting","score":0.7250000238418579},{"id":"https://openalex.org/keywords/galactosamine","display_name":"galactosamine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/antitumour-activity","display_name":"antitumour activity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/l1210-leukaemia","display_name":"L1210 leukaemia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7709959745407104},{"id":"https://openalex.org/C2775961978","wikidata":"https://www.wikidata.org/wiki/Q1549805","display_name":"Methacrylamide","level":5,"score":0.6602438688278198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6221123337745667},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5132761001586914},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.49012455344200134},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4353301525115967},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.428059458732605},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.41022366285324097},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3837288022041321},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.3298066556453705},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32388073205947876},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30456075072288513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2814848721027374},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.15918853878974915},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.15862378478050232},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14094015955924988},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.10510885715484619},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10244065523147583},{"id":"https://openalex.org/C2779402116","wikidata":"https://www.wikidata.org/wiki/Q342939","display_name":"Acrylamide","level":4,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/0168-3659(92)90088-9","doi":"https://doi.org/10.1016/0168-3659(92)90088-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0168-3659(92)90088-9","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W19332757","https://openalex.org/W48912195","https://openalex.org/W389377414","https://openalex.org/W584609198","https://openalex.org/W1507726888","https://openalex.org/W1574338658","https://openalex.org/W1819818791","https://openalex.org/W1830217992","https://openalex.org/W1938889768","https://openalex.org/W1967816890","https://openalex.org/W1977983687","https://openalex.org/W1979851400","https://openalex.org/W1986821485","https://openalex.org/W1986844753","https://openalex.org/W1987016173","https://openalex.org/W1996701312","https://openalex.org/W2002461252","https://openalex.org/W2003763258","https://openalex.org/W2018840529","https://openalex.org/W2019704184","https://openalex.org/W2030686317","https://openalex.org/W2031644592","https://openalex.org/W2045460706","https://openalex.org/W2052901854","https://openalex.org/W2068708514","https://openalex.org/W2071008344","https://openalex.org/W2073020333","https://openalex.org/W2077367574","https://openalex.org/W2079859890","https://openalex.org/W2084226590","https://openalex.org/W2088501009","https://openalex.org/W2112824007","https://openalex.org/W2209147002","https://openalex.org/W2211924732","https://openalex.org/W2271359589","https://openalex.org/W2317660904","https://openalex.org/W2325935072","https://openalex.org/W2401304387","https://openalex.org/W2986439886","https://openalex.org/W6770157738","https://openalex.org/W6844065420"],"related_works":["https://openalex.org/W2163757114","https://openalex.org/W7097390590","https://openalex.org/W2069262864","https://openalex.org/W1970499331","https://openalex.org/W2068175198","https://openalex.org/W1990859382","https://openalex.org/W1986960592","https://openalex.org/W2415479794","https://openalex.org/W2164998070","https://openalex.org/W2207302007"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
