{"id":"https://openalex.org/W2157157403","doi":"https://doi.org/10.1113/jphysiol.2014.286807","title":"Reply from Jonathan E. Elliott, Joseph W. Duke, Jerold A. Hawn, John R. Halliwill and Andrew T. Lovering","display_name":"Reply from Jonathan E. Elliott, Joseph W. Duke, Jerold A. Hawn, John R. Halliwill and Andrew T. Lovering","publication_year":2015,"publication_date":"2015-01-15","ids":{"openalex":"https://openalex.org/W2157157403","doi":"https://doi.org/10.1113/jphysiol.2014.286807","mag":"2157157403","pmid":"https://pubmed.ncbi.nlm.nih.gov/25630268","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4303393"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.2014.286807","doi":"https://doi.org/10.1113/jphysiol.2014.286807","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2014.286807","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4303393","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005863912","display_name":"Jonathan E. Elliott","orcid":"https://orcid.org/0000-0002-6992-6851","observed_orcids":["https://orcid.org/0000-0002-6992-6851"]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan E. Elliott","raw_affiliation_strings":["University of Oregon, Department of Human Physiology, Eugene, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oregon, Department of Human Physiology, Eugene, OR, USA","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088401451","display_name":"Joseph W. Duke","orcid":"https://orcid.org/0000-0001-5542-5581","observed_orcids":["https://orcid.org/0000-0001-5542-5581"]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph W. Duke","raw_affiliation_strings":["University of Oregon, Department of Human Physiology, Eugene, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oregon, Department of Human Physiology, Eugene, OR, USA","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012486621","display_name":"Jerold A. Hawn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jerold A. Hawn","raw_affiliation_strings":["Oregon Heart & Vascular Institute Cardiology  Springfield OR USA","Oregon Heart & Vascular Institute, Cardiology, Springfield, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Heart & Vascular Institute Cardiology  Springfield OR USA","institution_ids":[]},{"raw_affiliation_string":"Oregon Heart & Vascular Institute, Cardiology, Springfield, OR, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051890275","display_name":"John R. Halliwill","orcid":"https://orcid.org/0000-0003-3001-1715","observed_orcids":["https://orcid.org/0000-0003-3001-1715"]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Halliwill","raw_affiliation_strings":["University of Oregon, Department of Human Physiology, Eugene, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oregon, Department of Human Physiology, Eugene, OR, USA","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020536277","display_name":"Andrew Thomas Lovering","orcid":"https://orcid.org/0000-0001-7826-4290","observed_orcids":["https://orcid.org/0000-0001-7826-4290"]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew T. Lovering","raw_affiliation_strings":["University of Oregon, Department of Human Physiology, Eugene, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oregon, Department of Human Physiology, Eugene, OR, USA","institution_ids":["https://openalex.org/I181233156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020536277"],"corresponding_institution_ids":["https://openalex.org/I181233156"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"593","issue":"2","first_page":"483","last_page":"484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.510699987411499,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.510699987411499,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.10170000046491623,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.07050000131130219,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrapulmonary-shunt","display_name":"intrapulmonary shunt","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pulmonary-artery-systolic-pressure","display_name":"pulmonary artery systolic pressure","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.5339999794960022},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.5839999914169312},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.8309999704360962},{"id":"https://openalex.org/keywords/doppler-ultrasound","display_name":"Doppler ultrasound","score":0.47600001096725464},{"id":"https://openalex.org/keywords/modified-bernoulli-equation","display_name":"modified Bernoulli equation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/fluid-mechanics","display_name":"fluid mechanics","score":0.3540000021457672},{"id":"https://openalex.org/keywords/precapillary-sphincters","display_name":"precapillary sphincters","score":0.9319999814033508}],"concepts":[{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.6488842964172363},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5447458028793335},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5340142846107483},{"id":"https://openalex.org/C2780968331","wikidata":"https://www.wikidata.org/wiki/Q1890115","display_name":"Shunt (medical)","level":2,"score":0.5209335684776306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5170426964759827},{"id":"https://openalex.org/C169554166","wikidata":"https://www.wikidata.org/wiki/Q496359","display_name":"Systole","level":4,"score":0.5022063255310059},{"id":"https://openalex.org/C99398487","wikidata":"https://www.wikidata.org/wiki/Q257319","display_name":"Cardiac cycle","level":2,"score":0.4904436767101288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47203269600868225},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4493017792701721},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.4261711537837982},{"id":"https://openalex.org/C2779946567","wikidata":"https://www.wikidata.org/wiki/Q1344255","display_name":"Tricuspid valve","level":2,"score":0.41298162937164307},{"id":"https://openalex.org/C8443397","wikidata":"https://www.wikidata.org/wiki/Q15177","display_name":"Anastomosis","level":2,"score":0.41127943992614746},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.3062364161014557},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17710858583450317}],"mesh":[{"descriptor_ui":"D001163","descriptor_name":"Arteriovenous Anastomosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.2014.286807","doi":"https://doi.org/10.1113/jphysiol.2014.286807","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2014.286807","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4303393","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4303393","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:25630268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25630268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Letter"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4303393","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4303393","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6100000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1947218987","https://openalex.org/W1952756270","https://openalex.org/W2016659070","https://openalex.org/W2039523275"],"related_works":["https://openalex.org/W2039523275","https://openalex.org/W1947218987","https://openalex.org/W1553900252","https://openalex.org/W2181060862","https://openalex.org/W68023864","https://openalex.org/W2261966534","https://openalex.org/W2582633233","https://openalex.org/W2064918321","https://openalex.org/W2605991784","https://openalex.org/W200862793"],"abstract_inverted_index":{"In":[0,203,388,821],"their":[1,692,721],"letter":[2],"(Frise":[3],"&":[4],"Dorrington,":[5],"2015),":[6],"Drs":[7,178,442,645],"Frise":[8,179,443,646],"and":[9,39,53,90,120,180,249,303,322,345,353,405,444,480,489,647,669,768,795,804,827,828,851,859,873,879,907,920,936,947],"Dorrington":[10,181,445,648],"have":[11,48,342],"provided":[12,545],"a":[13,196,231,409,548,578,937],"number":[14],"of":[15,55,110,152,198,216,219,233,242,271,284,295,377,455,465,487,495,498,506,517,524,532,543,547,554,623,653,743,746,764,793,854,869,891,906,934,939,967],"critiques":[16],"on":[17,468,551,883,925,930,973],"our":[18,175,204,296,360,428,565,654,700,758,777,812,823],"recent":[19,957],"study,":[20,683,712],"entitled":[21],"\u2018Increased":[22],"cardiac":[23,154,364,469],"output,":[24],"not":[25,93,237,319,326,418,491,616,753,815],"pulmonary":[26,88,129,220,225,244,334,381,403,500,530,535,557,747,839,909,913],"artery":[27,74,130],"systolic":[28,75],"pressure,":[29,766],"increases":[30,391,401,438,510,884,893],"intrapulmonary":[31,159,189],"shunt":[32,435,610,630],"in":[33,78,127,174,293,333,392,402,408,420,427,433,439,511,520,564,581,609,629,680,709,769,776,783,789,838,846,885,894,944],"healthy":[34],"humans":[35],"breathing":[36],"room":[37],"air":[38],"40%":[40],"O2\u2019":[41],"(Elliott":[42],"et":[43,960,964],"al.":[44,961,965],"2014).":[45],"Specifically,":[46],"they":[47],"concerns,":[49],"\u2018that":[50],"the":[51,79,108,115,122,128,137,150,153,170,192,212,217,243,269,272,279,282,285,351,453,476,484,493,496,499,504,521,533,540,552,555,584,627,651,675,681,704,710,741,744,762,791,847,866,877,899,903,940,953,968],"title":[52,80],"content":[54],"[our]":[56],"manuscript":[57,824],"raise":[58],"two":[59],"fundamental":[60],"issues":[61],"related":[62],"to":[63,71,86,96,275,287,347,396,437,451,472,600,618,659,687,691,716,720,729,754,818,876,901,918,955,971],"fluid":[64],"mechanics.\u2019":[65],"First,":[66],"it":[67,657,684,713,888],"was":[68,84,318,330,577,649],"most":[69],"appropriate":[70],"specify":[72],"\u2018pulmonary":[73],"pressure\u2019":[76,146],"(PASP)":[77],"because":[81],"Doppler":[82],"ultrasound":[83],"used":[85,679,708],"determine":[87],"pressure":[89,125,267,280,404,582,794,911],"we":[91,99,324,337,340,562,573,739,773,921,951],"did":[92],"want":[94],"readers":[95],"think":[97],"that":[98,143,210,261,299,328,478,561,575,650,811,864],"had":[100,336],"measured":[101,825],"anything":[102],"but":[103,236],"PASP.":[104,895],"This":[105,806],"technique":[106],"measures":[107],"velocity":[109],"retrograde":[111],"blood":[112,124,163,199,221,226,290,382,412,731,748],"flow":[113,164,197,227,413,666,732,749,767,796],"across":[114,583],"tricuspid":[116],"valve":[117],"during":[118,131,370,587,725,857],"systole,":[119],"thus":[121],"peak":[123],"developed":[126],"systole":[132],"can":[133],"be":[134,252,276,348,394,514,787,816],"calculated":[135,852],"using":[136],"modified":[138],"Bernoulli":[139],"equation.":[140],"The":[141,696],"potential":[142,693,722,867],"\u2018systolic":[144],"[pulmonary]":[145],"per":[147],"se,":[148],"is":[149,166,194,207,228,375,475,614,631,634,685,714,833,948],"period":[151],"cycle":[155],"responsible":[156],"for":[157,356],"increasing":[158],"arteriovenous":[160],"anastomoses":[161],"(IPAVAs)":[162],"()":[165,366],"neither":[167,569],"implied":[168],"from":[169,611,644,699],"title,":[171],"nor":[172,571],"discussed":[173],"manuscript.":[176,566],"Second,":[177],"state:":[182,446],"\u2018cardiac":[183],"output":[184,365],"cannot":[185],"directly":[186,460],"increase":[187,332,432,608,628,730,845],"an":[188,208,331,431,466,836,844],"shunt,":[190,410],"since":[191],"latter":[193],"simply":[195],"down":[200],"some":[201],"tubes.\u2019":[202],"opinion,":[205],"this":[206,389,473,595,784,931,974],"oversimplification":[209],"ignores":[211],"many":[213],"physiological":[214,694,723,942],"intricacies":[215],"regulation":[218,745],"flow.":[222,291],"For":[223,502,927],"example,":[224,503],"dependent":[229],"upon":[230],"myriad":[232],"factors,":[234],"including,":[235],"limited":[238],"to,":[239],"gravity,":[240],"architecture":[241],"vascular":[245,485,522,914],"tree,":[246],"oxygen":[247],"tension,":[248],"may":[250,385,393],"even":[251],"determined":[253],"by":[254,350,597],"precapillary":[255],"sphincters":[256],"associated":[257,834],"with":[258,835,916],"supernumerary":[259],"vessels":[260],"are":[262,922],"still":[263],"poorly":[264],"understood.":[265],"Clearly":[266],"at":[268,281,308],"beginning":[270],"tube":[273,286],"needs":[274],"greater":[277],"than":[278],"end":[283],"facilitate":[288],"orthograde":[289],"However,":[292],"one":[294],"experimental":[297,677,706,799,862],"conditions,":[298],"combined":[300],"atropine":[301],"(ATR)":[302],"intravenous":[304],"(i.v.)":[305],"adrenaline":[306],"(ADR)":[307],"80":[309,315,590],"ng":[310],"kg\u22121":[311],"min\u22121":[312],"(ATR":[313],"+":[314,589],"ADR),":[316],"PASP":[317,512,826],"statistically":[320],"increased,":[321],"therefore":[323],"could":[325,513],"state":[327],"there":[329,374,576],"pressure;":[335],"done":[338],"so,":[339,355],"would":[341,448],"been":[343],"lying":[344],"likely":[346],"challenged":[349],"reviewers,":[352],"rightly":[354],"over-interpreting":[357],"or":[358,539,620,756,912],"misinterpreting":[359],"data.":[361,759],"Additionally,":[362],"when":[363,633],"increases,":[367],"as":[368,626,639,672,736,802,887],"occurs":[369],"low":[371],"intensity":[372],"exercise,":[373],"recruitment":[376],"under-":[378],"and/or":[379],"non-perfused":[380],"vessels,":[383],"which":[384,458,945],"include":[386],"IPAVAs.":[387],"way,":[390],"able":[395],"recruit":[397],"IPAVAs":[398,525],"without":[399,508],"significant":[400,509,892],"subsequently":[406],"result":[407],"if":[411,526],"through":[414,667,733],"these":[415,624,689,718],"pathways":[416],"does":[417],"participate":[419],"gas":[421,840],"exchange.":[422],"Several":[423],"other":[424,603,726,798,819],"studies,":[425],"referenced":[426],"manuscript,":[429],"demonstrate":[430],"right-to-left":[434],"secondary":[436],".":[440],"Third,":[441],"\u2018It":[447],"seem":[449],"desirable":[450],"avoid":[452],"use":[454],"vasoactive":[456],"drugs,":[457],"might":[459,814],"alter":[461,492],"IPAVA":[462],"tone":[463,486,494,523],"independent":[464,516,890],"effect":[467],"output.\u2019":[470],"Central":[471],"concern":[474],"assumption":[477],"ATR":[479,528,588],"ADR":[481,544],"specifically":[482,774],"affect":[483],"IPAVAs,":[488,734],"do":[490,572],"rest":[497,553],"vasculature.":[501],"observation":[505],"increased":[507,613,635],"explained":[515],"any":[518,661],"change":[519],"either":[527],"caused":[529],"vasodilatation":[531],"conventional":[534,556],"circulation":[536,558],"(not":[537],"IPAVAs),":[538],"lower":[541],"dose":[542],"less":[546],"vasoconstrictor":[549,619],"influence":[550],"\u2013":[559],"possibilities":[560],"detailed":[563],"Our":[567],"data":[568,897],"imply,":[570],"claim,":[574],"\u2018constant":[579],"drop":[580],"tubes":[585],"[IPAVAs]\u2019":[586],"ADR.":[591],"We":[592,760],"also":[593],"addressed":[594],"issue":[596],"providing":[598],"references":[599],"work":[601,701,782],"where":[602],"authors":[604],"concluded":[605],"that,":[606],"\u2018\u2026the":[607],"pharmacologically":[612],"probably":[615],"due":[617],"vasodilator":[621],"activity":[622],"drugs":[625],"observed":[632],"via":[636],"mechanical":[637],"means":[638],"well.\u2019":[640],"A":[641],"final":[642],"statement":[643,807],"complexity":[652],"study":[655],"\u2018\u2026makes":[656],"difficult":[658,686,715],"draw":[660],"conclusions":[662],"about":[663],"mechanisms":[664],"determining":[665],"IPAVA\u2026\u2019":[668],"quoted":[670],"us":[671],"follows:":[673],"\u2018considering":[674],"unique":[676,705,858],"conditions":[678,707,727,800,863,943],"present":[682,711],"extrapolate":[688,717],"findings":[690,719,813],"relevance.\u2019":[695],"entire":[697],"quote":[698],"was:":[702],"\u2018Considering":[703],"relevance":[724],"known":[728],"such":[735,801],"exercise.\u2019":[737,805],"Again,":[738],"acknowledged":[740],"complexities":[742,763],"while":[750],"being":[751],"careful":[752],"misinterpret":[755],"over-interpret":[757],"recognize":[761],"quantifying":[765],"humans.":[770],"As":[771],"such,":[772],"commented":[775],"paper":[778],"that:":[779,831],"\u2018Nevertheless,":[780],"future":[781],"area":[785,933],"will":[786],"helpful":[788],"clarifying":[790],"roles":[792],"under":[797],"hypoxia":[803],"very":[808,956],"clearly":[809],"acknowledges":[810],"applicable":[817],"conditions.":[820],"summary,":[822],"provides":[829],"evidence":[830],"(1)":[832],"impairment":[837],"exchange":[841],"efficiency,":[842],"i.e.":[843],"alveolar-to-arterial":[848],"difference":[849],"(A-aDO2),":[850],"volume":[853],"venous":[855],"admixture":[856],"tightly":[860],"controlled":[861],"reduce/eliminate":[865],"contribution":[868],"alveolar":[870],"ventilation-to-perfusion":[871],"inequality":[872],"diffusion":[874],"limitation":[875],"A-aDO2,":[878],"(2)":[880],"primarily":[881],"depends":[882],",":[886,919],"occurred":[889],"These":[896],"provide":[898],"impetus":[900],"investigate":[902],"relative":[904],"importance":[905],"mean":[908],"arterial":[910],"resistance":[915],"respect":[917],"actively":[923],"working":[924],"this.":[926],"more":[928],"information":[929],"exciting":[932],"physiology,":[935],"description":[938],"various":[941],"is,":[946],"not,":[949],"detected,":[950],"refer":[952],"reader":[954],"reviews":[958],"(Duke":[959],"2014;":[962],"Lovering":[963],"2015)":[966],"relevant":[969],"literature":[970],"date":[972],"topic.":[975],"None":[976],"declared.":[977]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}