{"id":"https://openalex.org/W2157122000","doi":"https://doi.org/10.2174/092986710790149738","title":"Curcumin as an Anti-Cancer Agent: Review of the Gap Between Basic and Clinical Applications","display_name":"Curcumin as an Anti-Cancer Agent: Review of the Gap Between Basic and Clinical Applications","publication_year":2009,"publication_date":"2009-12-21","ids":{"openalex":"https://openalex.org/W2157122000","doi":"https://doi.org/10.2174/092986710790149738","mag":"2157122000","pmid":"https://pubmed.ncbi.nlm.nih.gov/20214562"},"language":"en","primary_location":{"id":"doi:10.2174/092986710790149738","doi":"https://doi.org/10.2174/092986710790149738","is_oa":false,"landing_page_url":"https://doi.org/10.2174/092986710790149738","pdf_url":null,"source":{"id":"https://openalex.org/S33159018","display_name":"Current Medicinal Chemistry","issn_l":"0929-8673","issn":["0929-8673","1875-533X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medicinal Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2157122000"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070627238","display_name":"Gil Bar\u2010Sela","orcid":"https://orcid.org/0000-0001-6579-1841","observed_orcids":["https://orcid.org/0000-0001-6579-1841","https://orcid.org/0000-0001-5788-4167"]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"G. Bar-Sela","raw_affiliation_strings":["Department of Oncology and Radiation Therapy, Rambam Health Care Campus, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Radiation Therapy, Rambam Health Care Campus, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077990416","display_name":"Ron Epelbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"R. Epelbaum","raw_affiliation_strings":["Department of Oncology and Radiation Therapy, Rambam Health Care Campus, Haifa, Israel.,Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Radiation Therapy, Rambam Health Care Campus, Haifa, Israel.,Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018919328","display_name":"Moshe Schaffer","orcid":"https://orcid.org/0000-0003-1294-4116","observed_orcids":["https://orcid.org/0000-0003-1294-4116"]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"M. Schaffer","raw_affiliation_strings":["Department of Oncology and Radiation Therapy, Rambam Health Care Campus, Haifa, Israel.,Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Radiation Therapy, Rambam Health Care Campus, Haifa, Israel.,Israel","institution_ids":["https://openalex.org/I2801301638"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018919328","https://openalex.org/A5077990416"],"corresponding_institution_ids":["https://openalex.org/I2801301638"],"apc_list":null,"apc_paid":null,"fwci":9.1825,"has_fulltext":false,"cited_by_count":488,"citation_normalized_percentile":{"value":0.99006623,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"17","issue":"3","first_page":"190","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/turmeric","display_name":"turmeric","score":0.9359999895095825},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7179999947547913},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7009999752044678},{"id":"https://openalex.org/keywords/gemcitabine-combination-therapy","display_name":"gemcitabine combination therapy","score":0.7689999938011169},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7929999828338623},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.8539999723434448},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7609999775886536},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.796999990940094},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7620000243186951},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.7889999747276306},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.6990000009536743},{"id":"https://openalex.org/keywords/uterine-cervical-neoplasms","display_name":"cervical neoplasia","score":0.9459999799728394},{"id":"https://openalex.org/keywords/barrett-s-metaplasia","display_name":"Barrett's metaplasia","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.8641868233680725},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6022290587425232},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4449217915534973},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31649264693260193},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1885666847229004}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/092986710790149738","doi":"https://doi.org/10.2174/092986710790149738","is_oa":false,"landing_page_url":"https://doi.org/10.2174/092986710790149738","pdf_url":null,"source":{"id":"https://openalex.org/S33159018","display_name":"Current Medicinal Chemistry","issn_l":"0929-8673","issn":["0929-8673","1875-533X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:20214562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20214562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W74993898","https://openalex.org/W82083248","https://openalex.org/W152873362","https://openalex.org/W1939049205","https://openalex.org/W1969815998","https://openalex.org/W1971566724","https://openalex.org/W1974901513","https://openalex.org/W1975770667","https://openalex.org/W1991327193","https://openalex.org/W1997149430","https://openalex.org/W2001295014","https://openalex.org/W2005875057","https://openalex.org/W2012901780","https://openalex.org/W2016634986","https://openalex.org/W2021711019","https://openalex.org/W2022043280","https://openalex.org/W2022175849","https://openalex.org/W2029966164","https://openalex.org/W2031634983","https://openalex.org/W2033431239","https://openalex.org/W2037222034","https://openalex.org/W2038077024","https://openalex.org/W2056468898","https://openalex.org/W2068004114","https://openalex.org/W2073699206","https://openalex.org/W2085080174","https://openalex.org/W2090615462","https://openalex.org/W2090630841","https://openalex.org/W2094992173","https://openalex.org/W2110111555","https://openalex.org/W2122627366","https://openalex.org/W2122908813","https://openalex.org/W2124199787","https://openalex.org/W2129397604","https://openalex.org/W2131357228","https://openalex.org/W2131813131","https://openalex.org/W2133346842","https://openalex.org/W2138508372","https://openalex.org/W2139981029","https://openalex.org/W2139993130","https://openalex.org/W2141116781","https://openalex.org/W2146897015","https://openalex.org/W2154748960","https://openalex.org/W2156211060","https://openalex.org/W2159179419","https://openalex.org/W2167639932","https://openalex.org/W2171352831","https://openalex.org/W2271685849","https://openalex.org/W2318388129","https://openalex.org/W2340248789","https://openalex.org/W2607876420"],"related_works":["https://openalex.org/W2264151067","https://openalex.org/W2033431239","https://openalex.org/W2565605993","https://openalex.org/W2897637303","https://openalex.org/W2025924937","https://openalex.org/W2374739184","https://openalex.org/W2015833166","https://openalex.org/W296450459","https://openalex.org/W2111114352"],"abstract_inverted_index":{"Curcumin,":[0],"commonly":[1],"called":[2],"diferuloyl":[3],"methane,":[4],"is":[5],"a":[6,63,76,82,103,149,202,221],"hydrophobic":[7],"polyphenol":[8],"derived":[9],"from":[10],"rhizome":[11],"(turmeric)":[12],"of":[13,29,49,65,106,113,132,146,157,178,198],"the":[14,21,50,111,126,130,155,175,195,212,227],"herb":[15],"Curcuma":[16],"longa.":[17],"Extensive":[18],"research":[19,36],"over":[20],"last":[22],"half":[23],"century":[24],"has":[25,37,57,72],"revealed":[26,102],"important":[27],"functions":[28],"curcumin.":[30],"In":[31],"vitro":[32,229],"and":[33,53,67,88,93,223,226],"in":[34,75,86,129,142,228],"vivo":[35],"shown":[38,60],"various":[39],"activities,":[40],"such":[41],"as":[42,81,116,201,220],"anti-inflammatory,":[43],"cytokines":[44],"release,":[45],"antioxidant,":[46],"immunomodulatory,":[47],"enhancing":[48],"apoptotic":[51],"process,":[52],"anti-angiogenic":[54],"properties.":[55],"Curcumin":[56],"also":[58],"been":[59,73],"to":[61,184],"be":[62],"mediator":[64],"chemo-resistance":[66],"radio-resistance.":[68],"The":[69,180],"anti-cancer":[70],"effect":[71,151,177],"seen":[74],"few":[77],"clinical":[78,97,120,189,213],"trials,":[79],"mainly":[80],"native":[83],"chemoprevention":[84],"agent":[85,225],"colon":[87],"pancreatic":[89,136],"cancer,":[90],"cervical":[91],"neoplasia":[92],"Barrets":[94],"metaplasia.":[95],"Some":[96],"studies":[98,190],"with":[99,122,125,134,148,167,218],"healthy":[100],"volunteers":[101],"low":[104],"bioavailability":[105],"curcumin,":[107,123],"casting":[108],"doubt":[109],"on":[110,152,211],"use":[112],"curcumin":[114,219],"only":[115],"food":[117],"additive.":[118],"Our":[119],"experience":[121,217],"along":[124],"anti-metabolite":[127],"gemcitabine":[128],"treatment":[131,200],"patients":[133],"advanced":[135],"carcinoma,":[137],"produced":[138],"an":[139],"objective":[140],"response":[141],"less":[143],"than":[144],"10%":[145],"patients,":[147],"minor":[150],"survival.":[153],"However,":[154],"safety":[156],"this":[158,199],"combination":[159],"was":[160],"proved.":[161],"Curcumin's":[162],"potent":[163],"anti-proliferative":[164],"activity":[165],"interacting":[166],"several":[168],"intracellular":[169],"signal":[170],"transduction":[171],"pathways":[172],"may":[173],"potentiate":[174],"anti-tumor":[176],"gemcitabine.":[179],"preclinical":[181],"data":[182],"lead":[183],"various,":[185],"but":[186],"still":[187],"scarce,":[188],"(some":[191],"on-going)":[192],"that":[193],"demonstrated":[194],"possible":[196],"efficacy":[197],"chemopreventive":[203,222],"or":[204],"chemotherapeutic":[205],"agent.":[206],"This":[207],"review":[208],"will":[209],"focus":[210],"evidence,":[214],"including":[215],"our":[216],"therapeutic":[224],"background":[230],"results.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":42},{"year":2019,"cited_by_count":41},{"year":2018,"cited_by_count":35},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":37},{"year":2015,"cited_by_count":35},{"year":2014,"cited_by_count":34},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}
