{"id":"https://openalex.org/W2157100731","doi":"https://doi.org/10.1158/1535-7163.mct-07-0164","title":"Synthesis and biological activity of stable branched neurotensin peptides for tumor targeting","display_name":"Synthesis and biological activity of stable branched neurotensin peptides for tumor targeting","publication_year":2007,"publication_date":"2007-09-01","ids":{"openalex":"https://openalex.org/W2157100731","doi":"https://doi.org/10.1158/1535-7163.mct-07-0164","mag":"2157100731","pmid":"https://pubmed.ncbi.nlm.nih.gov/17766836"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.mct-07-0164","doi":"https://doi.org/10.1158/1535-7163.mct-07-0164","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-07-0164","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084001430","display_name":"Chiara Falciani","orcid":"https://orcid.org/0000-0002-1027-8482","observed_orcids":["https://orcid.org/0000-0002-1027-8482"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Falciani","raw_affiliation_strings":["Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Monica Fabbrini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Fabbrini","raw_affiliation_strings":["Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026728075","display_name":"Alessandro Pini","orcid":"https://orcid.org/0000-0002-3832-8349","observed_orcids":["https://orcid.org/0000-0002-3832-8349"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Pini","raw_affiliation_strings":["Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056236901","display_name":"Luisa Lozzi","orcid":"https://orcid.org/0000-0002-1603-8770","observed_orcids":["https://orcid.org/0000-0002-1603-8770"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luisa Lozzi","raw_affiliation_strings":["Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074496775","display_name":"Barbara Lelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Lelli","raw_affiliation_strings":["Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035997491","display_name":"Silvia Pileri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Pileri","raw_affiliation_strings":["Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011378422","display_name":"Jlenia Brunetti","orcid":"https://orcid.org/0000-0001-8144-7186","observed_orcids":["https://orcid.org/0000-0001-8144-7186"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jlenia Brunetti","raw_affiliation_strings":["Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047741262","display_name":"Stefano Bindi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Bindi","raw_affiliation_strings":["Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002679823","display_name":"Silvia Scali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Scali","raw_affiliation_strings":["Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018992013","display_name":"Luisa Bracci","orcid":"https://orcid.org/0000-0002-0738-5746","observed_orcids":["https://orcid.org/0000-0002-0738-5746"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luisa Bracci","raw_affiliation_strings":["Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Laboratory of Molecular Biotechnology, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I102064193"],"apc_list":null,"apc_paid":null,"fwci":3.7241,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.92640401,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"9","first_page":"2441","last_page":"2448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurotensin","display_name":"neurotensin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dendrimers","display_name":"dendrimers","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.6629999876022339},{"id":"https://openalex.org/keywords/peptide-receptor-binding","display_name":"peptide-receptor binding","score":0.5440000295639038},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.6859999895095825},{"id":"https://openalex.org/keywords/chlorin-e6","display_name":"chlorin e6","score":0.8989999890327454},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9909999966621399},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.5350000262260437},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5910000205039978},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.6169999837875366},{"id":"https://openalex.org/keywords/fluorescence-imaging","display_name":"fluorescence imaging","score":0.414000004529953},{"id":"https://openalex.org/keywords/protease-resistance","display_name":"protease resistance","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2778976297","wikidata":"https://www.wikidata.org/wiki/Q419576","display_name":"Neurotensin","level":4,"score":0.9196339249610901},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.8042906522750854},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6418585181236267},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6327997446060181},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6015629172325134},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4998955726623535},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4836331605911255},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.459995836019516},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4169137179851532},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3740968704223633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35126739740371704},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.326815664768219},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.305359423160553},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009496","descriptor_name":"Neurotensin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009496","descriptor_name":"Neurotensin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009496","descriptor_name":"Neurotensin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018028","descriptor_name":"Receptors, Neurotensin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1535-7163.mct-07-0164","doi":"https://doi.org/10.1158/1535-7163.mct-07-0164","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-07-0164","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},{"id":"pmid:17766836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17766836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/66675","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/66675","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:usiena-air.unisi.it:11365/24941","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11365/24941","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W71275267","https://openalex.org/W1637697903","https://openalex.org/W1907629755","https://openalex.org/W1974617422","https://openalex.org/W1978039785","https://openalex.org/W1991703770","https://openalex.org/W1996092391","https://openalex.org/W1996231078","https://openalex.org/W2015415229","https://openalex.org/W2022200703","https://openalex.org/W2034646753","https://openalex.org/W2039376082","https://openalex.org/W2043635035","https://openalex.org/W2045681528","https://openalex.org/W2045742325","https://openalex.org/W2048922160","https://openalex.org/W2049094183","https://openalex.org/W2058130105","https://openalex.org/W2060809477","https://openalex.org/W2083105637","https://openalex.org/W2084058911","https://openalex.org/W2120127823","https://openalex.org/W2123926902","https://openalex.org/W2130787328","https://openalex.org/W2141104573","https://openalex.org/W2156777559","https://openalex.org/W2165034198","https://openalex.org/W2166132430","https://openalex.org/W2187650449","https://openalex.org/W2253379325","https://openalex.org/W2339176150","https://openalex.org/W2405234996","https://openalex.org/W4238511627"],"related_works":["https://openalex.org/W2954371482","https://openalex.org/W2152433320","https://openalex.org/W2317272412","https://openalex.org/W2766300496","https://openalex.org/W2332242737","https://openalex.org/W4238161939","https://openalex.org/W2029751363","https://openalex.org/W2944111742","https://openalex.org/W4237673835","https://openalex.org/W2045742325"],"abstract_inverted_index":{"Receptors":[0],"for":[1,19,72],"endogenous":[2,42],"regulatory":[3],"peptides,":[4,43],"like":[5,106],"the":[6,26,59,159],"neuropeptide":[7],"neurotensin,":[8],"are":[9],"overexpressed":[10],"in":[11,34,64,87,95,99,114,118,148],"several":[12],"human":[13,89,137],"cancers":[14],"and":[15,40,51,85,92,109],"can":[16],"be":[17],"targets":[18],"peptide-mediated":[20],"tumor-selective":[21],"therapy.":[22],"Peptides,":[23],"however,":[24],"have":[25],"main":[27],"drawback":[28],"of":[29,103,122],"an":[30],"extremely":[31],"short":[32],"half-life":[33],"vivo.":[35],"We":[36],"showed":[37],"that":[38],"neurotensin":[39,60],"other":[41],"when":[44],"synthesized":[45,58],"as":[46],"dendrimers,":[47],"retain":[48],"biological":[49],"activity":[50],"become":[52],"resistant":[53],"to":[54,69,81,111,155],"proteolysis.":[55],"Here,":[56],"we":[57],"functional":[61],"fragment":[62],"NT(8-13)":[63],"a":[65,115,145],"tetrabranched":[66],"form":[67],"linked":[68],"different":[70],"units":[71],"tumor":[73,97,138,149],"therapy":[74],"or":[75],"diagnosis.":[76],"Fluorescent":[77],"molecules":[78,105],"were":[79,140],"used":[80],"monitor":[82],"receptor":[83,93,131],"binding":[84,94],"internalization":[86],"HT29":[88,96],"adenocarcinoma":[90],"cells":[91,126],"xenografts":[98,139],"nude":[100,134],"mice.":[101],"Linking":[102],"chemotherapic":[104],"chlorin":[107],"e6":[108],"methotrexate":[110],"dendrimers":[112],"resulted":[113],"dramatic":[116],"increase":[117],"drug":[119],"selectivity,":[120],"uptake":[121],"which":[123],"by":[124],"target":[125],"became":[127],"dependent":[128],"on":[129],"peptide":[130],"binding.":[132],"When":[133],"mice":[135,156],"carrying":[136],"treated":[141,157],"with":[142,153,158],"branched":[143],"NT(8-13)-methotrexate,":[144],"60%":[146],"reduction":[147],"growth":[150],"was":[151],"observed":[152],"respect":[154],"free":[160],"drug.":[161]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
