{"id":"https://openalex.org/W2157059938","doi":"https://doi.org/10.1093/ndt/gfq619","title":"Role of Sema4C in TGF- 1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells","display_name":"Role of Sema4C in TGF- 1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells","publication_year":2010,"publication_date":"2010-10-19","ids":{"openalex":"https://openalex.org/W2157059938","doi":"https://doi.org/10.1093/ndt/gfq619","mag":"2157059938","pmid":"https://pubmed.ncbi.nlm.nih.gov/20959347","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3070071"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfq619","doi":"https://doi.org/10.1093/ndt/gfq619","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfq619","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/ndt/gfq619","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064719218","display_name":"Rui Zeng","orcid":"https://orcid.org/0000-0003-1808-9755","observed_orcids":["https://orcid.org/0000-0003-1808-9755"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"R. Zeng","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China","Division of Nephrology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]},{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046191605","display_name":"Min Ho Han","orcid":"https://orcid.org/0000-0002-4293-7630","observed_orcids":["https://orcid.org/0000-0002-4293-7630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Han","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044210913","display_name":"Y. Luo","orcid":"https://orcid.org/0000-0001-8245-6279","observed_orcids":["https://orcid.org/0000-0001-8245-6279"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Luo","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Li","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"G. Pei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Pei","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101829784","display_name":"Wenhui Liao","orcid":"https://orcid.org/0000-0001-8015-6918","observed_orcids":["https://orcid.org/0000-0001-8015-6918"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W. Liao","raw_affiliation_strings":["Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046352994","display_name":"Shoujun Bai","orcid":"https://orcid.org/0000-0002-3717-5053","observed_orcids":["https://orcid.org/0000-0002-3717-5053"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Bai","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110445096","display_name":"Ge Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Ge","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"X. Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X. Liu","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101928938","display_name":"Gang Xu","orcid":"https://orcid.org/0000-0002-8136-9277","observed_orcids":["https://orcid.org/0000-0002-8136-9277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Xu","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064719218"],"corresponding_institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":{"value":3474,"currency":"EUR","value_usd":3926},"fwci":0.971,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.7285099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"4","first_page":"1149","last_page":"1156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sema4c","display_name":"Sema4C","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8690000176429749},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9150000214576721},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9940000176429749},{"id":"https://openalex.org/keywords/renal-tubular-epithelial-cells","display_name":"renal tubular epithelial cells","score":0.9150000214576721},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.921999990940094},{"id":"https://openalex.org/keywords/semaphorins","display_name":"semaphorins","score":0.7239999771118164},{"id":"https://openalex.org/keywords/proximal-tubular-epithelium","display_name":"proximal tubular epithelium","score":0.8029999732971191},{"id":"https://openalex.org/keywords/5-6-nephrectomy","display_name":"5/6 nephrectomy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8529999852180481},{"id":"https://openalex.org/keywords/sb203580","display_name":"SB203580","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6124647259712219},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5546481013298035},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5201264023780823},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4853033423423767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4767813980579376},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4449024796485901},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4219551086425781},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.42099684476852417},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41068127751350403},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.319507360458374},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20812517404556274},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07864481210708618}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005923","descriptor_name":"Glomerulosclerosis, Focal Segmental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005923","descriptor_name":"Glomerulosclerosis, Focal Segmental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009392","descriptor_name":"Nephrectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039961","descriptor_name":"Semaphorins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D039961","descriptor_name":"Semaphorins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039961","descriptor_name":"Semaphorins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/ndt/gfq619","doi":"https://doi.org/10.1093/ndt/gfq619","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfq619","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3070071","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3070071","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrol Dial Transplant","raw_type":"Text"},{"id":"pmid:20959347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20959347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.849.4649","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.849.4649","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ndt.oxfordjournals.org/content/26/4/1149.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/ndt/gfq619","doi":"https://doi.org/10.1093/ndt/gfq619","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfq619","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W208000445","https://openalex.org/W1930083400","https://openalex.org/W1982670131","https://openalex.org/W1985439299","https://openalex.org/W2000762378","https://openalex.org/W2012070523","https://openalex.org/W2023121345","https://openalex.org/W2025995069","https://openalex.org/W2027374185","https://openalex.org/W2050068296","https://openalex.org/W2053428121","https://openalex.org/W2055510343","https://openalex.org/W2057539625","https://openalex.org/W2086692663","https://openalex.org/W2101466169","https://openalex.org/W2102298863","https://openalex.org/W2113638068","https://openalex.org/W2130525687","https://openalex.org/W2140551998","https://openalex.org/W2148184356","https://openalex.org/W2149398393","https://openalex.org/W2154568166","https://openalex.org/W2158556013","https://openalex.org/W2317298663"],"related_works":["https://openalex.org/W7096615261","https://openalex.org/W3026195626","https://openalex.org/W2402244609","https://openalex.org/W2005166345","https://openalex.org/W2170345729","https://openalex.org/W1912639232","https://openalex.org/W2030279034","https://openalex.org/W7006388214","https://openalex.org/W1930083400","https://openalex.org/W2138713501"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,88,101,126,165],"p38":[2,37,90,99,109,146,159,201,227],"mitogen-activated":[3],"protein":[4],"kinase":[5],"(p38":[6],"MAPK)":[7],"is":[8,48],"an":[9,218],"important":[10,219],"intracellular":[11],"signal":[12],"transduction":[13],"pathway":[14],"involved":[15],"in":[16,44,66,131,184,221,229],"TGF-\u03b21-induced":[17,46,150,222],"epithelial-mesenchymal":[18],"transition":[19],"(EMT).":[20],"Sema4C,":[21,104],"a":[22,174],"member":[23],"of":[24,36,42,103,107,128,140,145,153,167,181,188,199,226],"the":[25,34,40,98,105,179,185],"semaphorin":[26],"family,":[27],"was":[28,53,64,78,83,94,204],"found":[29],"to":[30,96],"be":[31],"essential":[32],"for":[33],"activation":[35,225],"MAPK.":[38],"However,":[39],"role":[41,220],"Sema4C":[43,63,86,129,141,154,156,168,182,203,216],"promoting":[45],"EMT":[47,170,223],"unclear.":[49],"METHODS:":[50],"Renal":[51],"fibrosis":[52],"induced":[54,65],"by":[55,73,80,85,116,173,206],"5/6":[56],"subtotal":[57],"nephrectomy":[58],"rat":[59],"model.":[60],"In":[61,177],"vitro,":[62],"human":[67,192],"proximal":[68,230],"tubular":[69,186,231],"epithelial":[70,232],"cells":[71,133],"(HKC)":[72],"treatment":[74],"with":[75,137],"TGF-\u03b21,":[76],"or":[77,82,121],"inhibited":[79,143],"siRNA":[81],"over-expressed":[84],"transfection.":[87],"selective":[89],"MAPK":[91,147,160,228],"inhibitor,":[92],"SB203580,":[93],"administered":[95],"inhibit":[97],"pathway.":[100],"expression":[102,127,180],"markers":[106],"EMT,":[108],"phosphorylation":[110,144,161],"and":[111,148,162,191,196,202],"fibronectin":[112],"secretion":[113],"were":[114,135,171],"measured":[115],"western":[117],"blotting,":[118],"immunohistochemistry,":[119],"immunocytochemistry":[120],"enzyme-linked":[122],"immunosorbent":[123],"assay.":[124],"RESULTS:":[125],"increased":[130,183],"HKC":[132],"that":[134,215],"treated":[136],"TGF-\u03b21.":[138],"Knockdown":[139],"potently":[142],"reversed":[149],"EMT.":[151,164],"Over-expression":[152],"via":[155],"transfection":[157],"elicited":[158],"promoted":[163],"effects":[166],"during":[169],"blocked":[172],"p38-specific":[175],"inhibitor.":[176],"vivo,":[178],"epithelia":[187],"5/6-nephrectomized":[189],"rats":[190],"fibrotic":[193],"renal":[194],"tissue,":[195],"similar":[197],"localization":[198],"phosphorylated":[200],"demonstrated":[205],"immunohistochemistry":[207],"on":[208],"serial":[209],"sections.":[210],"CONCLUSIONS:":[211],"Our":[212],"findings":[213],"suggest":[214],"plays":[217],"through":[224],"cells.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
