{"id":"https://openalex.org/W2157038882","doi":"https://doi.org/10.1186/1471-2350-8-s1-s14","title":"Genome-wide association with bone mass and geometry in the Framingham Heart Study","display_name":"Genome-wide association with bone mass and geometry in the Framingham Heart Study","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2157038882","doi":"https://doi.org/10.1186/1471-2350-8-s1-s14","mag":"2157038882","pmid":"https://pubmed.ncbi.nlm.nih.gov/17903296","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1995606"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2350-8-s1-s14","doi":"https://doi.org/10.1186/1471-2350-8-s1-s14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2350-8-s1-s14","pdf_url":"https://bmcmedgenet.biomedcentral.com/counter/pdf/10.1186/1471-2350-8-S1-S14","source":{"id":"https://openalex.org/S143585532","display_name":"BMC Medical Genetics","issn_l":"1471-2350","issn":["1471-2350"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genetics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedgenet.biomedcentral.com/counter/pdf/10.1186/1471-2350-8-S1-S14","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011048149","display_name":"Douglas P. Kiel","orcid":"https://orcid.org/0000-0001-8474-0310","observed_orcids":["https://orcid.org/0000-0001-8474-0310"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas P Kiel","raw_affiliation_strings":["Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA. kiel@hrca.harvard.edu","Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA. kiel@hrca.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210123879"]},{"raw_affiliation_string":"Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210123879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067354038","display_name":"Serkalem Demissie","orcid":"https://orcid.org/0000-0002-8009-0987","observed_orcids":["https://orcid.org/0000-0002-8009-0987"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serkalem Demissie","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053091216","display_name":"Jos\u00e9e Dupuis","orcid":"https://orcid.org/0000-0003-2871-3603","observed_orcids":["https://orcid.org/0000-0003-2871-3603"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jos\u00e9e Dupuis","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086558373","display_name":"Kathryn L. Lunetta","orcid":"https://orcid.org/0000-0002-9268-810X","observed_orcids":["https://orcid.org/0000-0002-9268-810X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn L Lunetta","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038663858","display_name":"Joanne M. Murabito","orcid":"https://orcid.org/0000-0002-0192-7516","observed_orcids":["https://orcid.org/0000-0002-0192-7516"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne M Murabito","raw_affiliation_strings":["Section of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA","The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA","institution_ids":["https://openalex.org/I4210123017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074078604","display_name":"David Karasik","orcid":"https://orcid.org/0000-0002-8826-0530","observed_orcids":["https://orcid.org/0000-0002-8826-0530"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Karasik","raw_affiliation_strings":["Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210123879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011048149"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210123879"],"apc_list":{"value":2380,"currency":"USD","value_usd":2380},"apc_paid":{"value":2380,"currency":"USD","value_usd":2380},"fwci":null,"has_fulltext":true,"cited_by_count":266,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"Suppl 1","first_page":"S14","last_page":"S14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.18070000410079956,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.890999972820282},{"id":"https://openalex.org/keywords/bone-geometry","display_name":"bone geometry","score":0.8289999961853027},{"id":"https://openalex.org/keywords/femoral-neck","display_name":"femoral neck","score":0.41100001335144043},{"id":"https://openalex.org/keywords/calcaneal-quantitative-ultrasound","display_name":"calcaneal ultrasound","score":0.7929999828338623},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.7720000147819519},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6669999957084656},{"id":"https://openalex.org/keywords/linkage-analysis","display_name":"linkage analysis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/chromosome-15","display_name":"chromosome 15","score":0.7990000247955322},{"id":"https://openalex.org/keywords/chromosome-22","display_name":"chromosome 22","score":0.996999979019165},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.7059999704360962},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.503000020980835},{"id":"https://openalex.org/keywords/framingham-heart-study","display_name":"Framingham Heart Study","score":0.7400000095367432},{"id":"https://openalex.org/keywords/family-based-association-test","display_name":"family-based association test","score":0.5509999990463257},{"id":"https://openalex.org/keywords/generalized-estimating-equations","display_name":"generalized estimating equations","score":0.7960000038146973},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C27403532","wikidata":"https://www.wikidata.org/wiki/Q5532474","display_name":"Generalized estimating equation","level":2,"score":0.6420761942863464},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.6146910786628723},{"id":"https://openalex.org/C111815664","wikidata":"https://www.wikidata.org/wiki/Q1440693","display_name":"Framingham Heart Study","level":4,"score":0.6046326160430908},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5587302446365356},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5442848205566406},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.483893483877182},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.4815366864204407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4519670605659485},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.42714187502861023},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4123242497444153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38744473457336426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3826766014099121},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.3083122968673706},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.29472917318344116},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.16424086689949036},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09558436274528503},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08722031116485596},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07423821091651917}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015502","descriptor_name":"Absorptiometry, Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1186/1471-2350-8-s1-s14","doi":"https://doi.org/10.1186/1471-2350-8-s1-s14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2350-8-s1-s14","pdf_url":"https://bmcmedgenet.biomedcentral.com/counter/pdf/10.1186/1471-2350-8-S1-S14","source":{"id":"https://openalex.org/S143585532","display_name":"BMC Medical Genetics","issn_l":"1471-2350","issn":["1471-2350"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1995606","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1995606","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med Genet","raw_type":"Text"},{"id":"pmid:17903296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17903296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical genetics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.278.9632","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.278.9632","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d3/6a/BMC_Med_Genet_2007_Sep_19_8(Suppl_1)_S14.tar.gz","raw_type":"text"},{"id":"pmh:oai:dash.harvard.edu:1/4728490","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:4728490","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d05ea15519094653845aad92c1806f37","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d05ea15519094653845aad92c1806f37","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Genetics, Vol 8, Iss Suppl 1, p S14 (2007)","raw_type":"article"},{"id":"pmh:oai:null:2144/1195","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2144/1195","pdf_url":null,"source":{"id":"https://openalex.org/S4306402384","display_name":"OpenBU (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:open.bu.edu:2144/1195","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2144/1195","pdf_url":null,"source":{"id":"https://openalex.org/S4306402384","display_name":"OpenBU (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:open.bu.edu:2144/2503","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2144/2503","pdf_url":null,"source":{"id":"https://openalex.org/S4306402384","display_name":"OpenBU (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1471-2350-8-s1-s14","doi":"https://doi.org/10.1186/1471-2350-8-s1-s14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2350-8-s1-s14","pdf_url":"https://bmcmedgenet.biomedcentral.com/counter/pdf/10.1186/1471-2350-8-S1-S14","source":{"id":"https://openalex.org/S143585532","display_name":"BMC Medical Genetics","issn_l":"1471-2350","issn":["1471-2350"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1037486044","display_name":"GENETIC OF BONE STRUCTURAL GEOMETRY: FRAMINGHAM COHORTS","funder_award_id":"R01AR050066","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G1344639305","display_name":null,"funder_award_id":"R01 AR/AG 41398","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G250621538","display_name":null,"funder_award_id":"N01\u2010HC25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2681271563","display_name":null,"funder_award_id":"R01AR/AG 41398","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3205625555","display_name":null,"funder_award_id":"N01-HC-25195","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G513442103","display_name":null,"funder_award_id":"1S10 RR163736-01A1","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G641917991","display_name":"The Framingham Heart Study","funder_award_id":"n01hc25195-41-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G80149192","display_name":null,"funder_award_id":"N01-HC25195","funder_id":"https://openalex.org/F4320309647","funder_display_name":"School of Medicine, Boston University"},{"id":"https://openalex.org/G9000124674","display_name":null,"funder_award_id":"N01-HC 25195","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000880538","display_name":"Novel Molecular Biomarkers of Bone Microarchitecture","funder_award_id":"R01AR041398","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320309647","display_name":"School of Medicine, Boston University","ror":"https://ror.org/05qwgg493"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2157038882.pdf","grobid_xml":"https://content.openalex.org/works/W2157038882.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W175660244","https://openalex.org/W1970837101","https://openalex.org/W1973141736","https://openalex.org/W1974956023","https://openalex.org/W1975162165","https://openalex.org/W1980507908","https://openalex.org/W1984045048","https://openalex.org/W1988034790","https://openalex.org/W1993155215","https://openalex.org/W1996163526","https://openalex.org/W2006055339","https://openalex.org/W2008838318","https://openalex.org/W2013201273","https://openalex.org/W2017756590","https://openalex.org/W2020392126","https://openalex.org/W2021924608","https://openalex.org/W2022189136","https://openalex.org/W2022293718","https://openalex.org/W2027148835","https://openalex.org/W2027594619","https://openalex.org/W2030331000","https://openalex.org/W2035153654","https://openalex.org/W2035559267","https://openalex.org/W2036125852","https://openalex.org/W2038494934","https://openalex.org/W2042588640","https://openalex.org/W2044908713","https://openalex.org/W2047885845","https://openalex.org/W2052930003","https://openalex.org/W2057478159","https://openalex.org/W2064967270","https://openalex.org/W2066742442","https://openalex.org/W2069967113","https://openalex.org/W2078870313","https://openalex.org/W2080714701","https://openalex.org/W2082090546","https://openalex.org/W2095483721","https://openalex.org/W2105118448","https://openalex.org/W2105950104","https://openalex.org/W2108063837","https://openalex.org/W2108262726","https://openalex.org/W2113715175","https://openalex.org/W2115335486","https://openalex.org/W2118767531","https://openalex.org/W2121598492","https://openalex.org/W2133389919","https://openalex.org/W2146114310","https://openalex.org/W2147162951","https://openalex.org/W2152304413","https://openalex.org/W2156923127","https://openalex.org/W2163012157"],"related_works":["https://openalex.org/W7098572172","https://openalex.org/W2072906400","https://openalex.org/W2153261224","https://openalex.org/W2082910152","https://openalex.org/W803810465","https://openalex.org/W1974165481","https://openalex.org/W2154287502","https://openalex.org/W1970837101","https://openalex.org/W2132623630","https://openalex.org/W2707682706"],"abstract_inverted_index":{"BACKGROUND:":[0],"Osteoporosis":[1],"is":[2],"characterized":[3],"by":[4],"low":[5],"bone":[6,10,60,153,274],"mass":[7],"and":[8,25,66,87,119,132,173,199,216,225,248,273,304,318,329,331,334,339,368],"compromised":[9],"structure,":[11],"heritable":[12],"traits":[13,30,243,276],"that":[14,260],"contribute":[15],"to":[16,51,126,253,363,369],"fracture":[17],"risk.":[18],"There":[19],"have":[20,261],"been":[21,264],"no":[22],"genome-wide":[23,361],"association":[24,89,281],"linkage":[26,141,340],"studies":[27],"for":[28,151,177,214,266,280,290,296,375],"these":[29],"using":[31,145],"high-density":[32],"genotyping":[33],"platforms.":[34],"METHODS:":[35],"We":[36,101],"used":[37,81],"the":[38,46,70,231,236],"Affymetrix":[39],"100K":[40,190,355],"SNP":[41,356],"GeneChip":[42],"marker":[43],"set":[44],"in":[45,124,192,202,256,293,301,306,309,312,315,320,326],"Framingham":[47],"Heart":[48],"Study":[49],"(FHS)":[50],"examine":[52],"genetic":[53],"associations":[54,74,188,201,270],"with":[55,75,106,189,235],"ten":[56,183],"primary":[57,184],"quantitative":[58],"traits:":[59],"mineral":[61],"density":[62],"(BMD),":[63],"calcaneal":[64],"ultrasound,":[65],"geometric":[67,275],"indices":[68],"of":[69,239],"hip.":[71],"To":[72],"test":[73],"multivariable-adjusted":[76],"residual":[77],"trait":[78],"values,":[79],"we":[80],"additive":[82],"generalized":[83],"estimating":[84],"equation":[85],"(GEE)":[86],"family-based":[88],"tests":[90],"(FBAT)":[91],"models":[92,194,204],"within":[93],"each":[94],"sex":[95],"as":[96,98,299,322,324,344],"well":[97,323],"sexes":[99],"combined.":[100],"evaluated":[102],"70,987":[103],"autosomal":[104],"SNPs":[105,191,234,292,325],"genotypic":[107],"call":[108],"rates":[109],">":[110,115,121,159],"or":[111,116,122,160,257,283],"=80%,":[112],"HWE":[113],"p":[114,196,206,285],"=":[117],"0.001,":[118],"MAF":[120],"=10%":[123],"up":[125],"1141":[127],"phenotyped":[128],"individuals":[129],"(495":[130],"men":[131],"646":[133],"women,":[134],"mean":[135],"age":[136],"62.5":[137],"yrs).":[138],"Variance":[139],"component":[140],"analysis":[142],"was":[143,288],"performed":[144],"11,200":[146],"markers.":[147],"RESULTS:":[148],"Heritability":[149],"estimates":[150],"all":[152,219],"phenotypes":[154,185],"were":[155,162,218,255,277],"30-66%.":[156],"LOD":[157,168],"scores":[158],"=3.0":[161],"found":[163],"on":[164],"chromosomes":[165],"15":[166],"(1.5":[167],"confidence":[169],"interval:":[170],"51,336,679-58,934,236":[171],"bp)":[172,176],"22":[174],"(35,890,398-48,603,847":[175],"femoral":[178,245],"shaft":[179],"section":[180],"modulus.":[181],"The":[182,209,353],"had":[186],"12":[187],"GEE":[193,215,284],"at":[195,205,349],"<":[197,207,286],"0.000001":[198],"2":[200],"FBAT":[203,217,338],"0.000001.":[208],"25":[210],"most":[211],"significant":[212],"p-values":[213],"less":[220],"than":[221],"3.5":[222],"x":[223,227],"10(-6)":[224],"2.5":[226],"10(-5),":[228],"respectively.":[229],"Of":[230],"40":[232],"top":[233],"greatest":[237],"numbers":[238],"significantly":[240],"associated":[241],"BMD":[242,272],"(including":[244],"neck,":[246],"trochanter,":[247],"lumbar":[249],"spine),":[250],"one":[251],"half":[252],"two-thirds":[254],"near":[258],"genes":[259,295,374],"not":[262],"previously":[263,371],"studied":[265],"osteoporosis.":[267,376],"Notably,":[268],"pleiotropic":[269],"between":[271],"uncommon.":[278],"Evidence":[279],"(FBAT":[282],"0.05)":[287],"observed":[289],"several":[291],"candidate":[294,366,373],"osteoporosis,":[297],"such":[298],"rs1801133":[300],"MTHFR;":[302],"rs1884052":[303],"rs3778099":[305],"ESR1;":[307],"rs4988300":[308],"LRP5;":[310],"rs2189480":[311],"VDR;":[313],"rs2075555":[314],"COLIA1;":[316],"rs10519297":[317],"rs2008691":[319],"CYP19,":[321],"PPARG":[327],"(rs10510418":[328],"rs2938392)":[330],"ANKH":[332],"(rs2454873":[333],"rs379016).":[335],"All":[336],"GEE,":[337],"results":[341,347],"are":[342],"provided":[343],"an":[345,359],"open-access":[346],"resource":[348],"http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007":[350],"webcite.":[351],"CONCLUSION:":[352],"FHS":[354],"project":[357],"offers":[358],"unbiased":[360],"strategy":[362],"identify":[364],"new":[365],"loci":[367],"replicate":[370],"suggested":[372]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":24}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
