{"id":"https://openalex.org/W2157000331","doi":null,"title":"Essential role for both CD80 and CD86 costimulation, but not CD40 interactions, in allergen-induced Th2 cytokine production from asthmatic bronchial tissue: role for alphabeta, but not gammadelta, T cells.","display_name":"Essential role for both CD80 and CD86 costimulation, but not CD40 interactions, in allergen-induced Th2 cytokine production from asthmatic bronchial tissue: role for alphabeta, but not gammadelta, T cells.","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W2157000331","mag":"2157000331","pmid":"https://pubmed.ncbi.nlm.nih.gov/10570322"},"language":"en","primary_location":{"id":"pmid:10570322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10570322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032464269","display_name":"Zeina H Jaffar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Z H Jaffar","raw_affiliation_strings":["University Medicine, Southampton General Hospital, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Medicine, Southampton General Hospital, Southampton, United Kingdom","institution_ids":["https://openalex.org/I2801388914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029256576","display_name":"Luminita Aurelia Stanciu","orcid":"https://orcid.org/0000-0001-6811-6972","observed_orcids":["https://orcid.org/0000-0001-6811-6972"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Stanciu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Pandit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Pandit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112898681","display_name":"James Laurence Lordan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Lordan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089020623","display_name":"Stephen T. Holgate","orcid":"https://orcid.org/0000-0003-2658-4617","observed_orcids":["https://orcid.org/0000-0003-2658-4617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S T Holgate","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111920444","display_name":"Kevan Roberts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Roberts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2099,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.9217517,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"163","issue":"11","first_page":"6283","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd80","display_name":"CD80","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-costimulation","display_name":"T cell costimulation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.8309999704360962},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.765999972820282},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.7850000262260437},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.925000011920929},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.7419999837875366},{"id":"https://openalex.org/keywords/bronchial-mucosa","display_name":"bronchial mucosa","score":0.824999988079071},{"id":"https://openalex.org/keywords/alpha-beta-t-cells","display_name":"alpha beta T cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7710000276565552},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.9440000057220459},{"id":"https://openalex.org/keywords/allergen-stimulation","display_name":"allergen stimulation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.7179999947547913},{"id":"https://openalex.org/keywords/asthma-treatment","display_name":"asthma treatment","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.7898536324501038},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.7235676050186157},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6509688496589661},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5439231395721436},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.47992759943008423},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.46154218912124634},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.46075186133384705},{"id":"https://openalex.org/C116484652","wikidata":"https://www.wikidata.org/wiki/Q3492926","display_name":"CCL5","level":5,"score":0.41596418619155884},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.39207881689071655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38564735651016235},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.3018445670604706},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19808432459831238},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.16179302334785461},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09783035516738892},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016692","descriptor_name":"Receptors, Antigen, T-Cell, gamma-delta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018122","descriptor_name":"B7-1 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10570322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10570322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"mag:2157000331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10570322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W38524656","https://openalex.org/W1485596855","https://openalex.org/W1497963394","https://openalex.org/W1513271561","https://openalex.org/W1517408232","https://openalex.org/W1537536448","https://openalex.org/W1538571668","https://openalex.org/W1560419085","https://openalex.org/W1564103635","https://openalex.org/W1661441964","https://openalex.org/W1943545698","https://openalex.org/W1955752095","https://openalex.org/W1971487921","https://openalex.org/W1976395570","https://openalex.org/W1978403614","https://openalex.org/W1981699748","https://openalex.org/W1983427343","https://openalex.org/W1988074496","https://openalex.org/W1990800747","https://openalex.org/W1991531286","https://openalex.org/W1993823557","https://openalex.org/W1998121841","https://openalex.org/W2003528700","https://openalex.org/W2017142317","https://openalex.org/W2038597389","https://openalex.org/W2040838085","https://openalex.org/W2041780752","https://openalex.org/W2042483530","https://openalex.org/W2048073154","https://openalex.org/W2053620210","https://openalex.org/W2058120223","https://openalex.org/W2062298433","https://openalex.org/W2069712305","https://openalex.org/W2071486288","https://openalex.org/W2073204838","https://openalex.org/W2078843264","https://openalex.org/W2081936911","https://openalex.org/W2087757222","https://openalex.org/W2087859003","https://openalex.org/W2092233067","https://openalex.org/W2094991897","https://openalex.org/W2102153142","https://openalex.org/W2111728003","https://openalex.org/W2115784025","https://openalex.org/W2121604038","https://openalex.org/W2126012855","https://openalex.org/W2128085654","https://openalex.org/W2134677648","https://openalex.org/W2140066663","https://openalex.org/W2140117437","https://openalex.org/W2147734974","https://openalex.org/W2154055388","https://openalex.org/W2154945180","https://openalex.org/W2160572043","https://openalex.org/W2160819439","https://openalex.org/W2163037816","https://openalex.org/W2315018741"],"related_works":["https://openalex.org/W4313343521","https://openalex.org/W1513271561","https://openalex.org/W1988074496","https://openalex.org/W1964684904","https://openalex.org/W2154294188","https://openalex.org/W2350191354","https://openalex.org/W7071161081","https://openalex.org/W2098465653","https://openalex.org/W2029950429","https://openalex.org/W2157821052"],"abstract_inverted_index":{"CD80":[0,194],"and":[1,6,40,72,82,121,188,195],"CD86":[2,196,205],"interact":[3],"with":[4,68],"CD28":[5,148],"deliver":[7],"costimulatory":[8,211,232],"signals":[9],"required":[10,213],"for":[11,199],"T":[12,143,180,222],"cell":[13,223],"activation.":[14],"We":[15],"demonstrate":[16,189],"that":[17,134,145,177,190],"ex":[18],"vivo":[19],"allergen":[20],"stimulation":[21,64],"of":[22,37,65,105,128,141,218,236],"bronchial":[23,137,186,227],"biopsy":[24],"tissue":[25,88,138,170,187],"from":[26,43],"mild":[27],"atopic":[28,32],"asthmatic,":[29],"but":[30,51,74,151],"not":[31,48,75,111],"nonasthmatic,":[33],"subjects":[34],"induced":[35,77],"production":[36,84,104],"IL-5,":[38],"IL-4,":[39],"IL-13.":[41],"Explants":[42],"both":[44,129,193],"study":[45],"groups":[46],"did":[47],"produce":[49],"IFN-gamma,":[50],"secreted":[52],"the":[53,86,103,126,164,209,226],"chemokine":[54],"RANTES":[55],"without":[56],"any":[57],"overt":[58],"stimulation.":[59],"In":[60,101,203],"addition":[61],"to":[62,70,94,115,157,207],"allergen,":[63],"asthmatic":[66,87,136,169,185],"explants":[67],"mAbs":[69,114,156],"CD3":[71],"TCR-alphabeta":[73],"TCR-gammadelta":[76],"IL-5":[78,81],"secretion.":[79],"Allergen-induced":[80],"IL-13":[83],"by":[85,91,98,108,113,119,168,192,229],"was":[89,110,117,122,139],"inhibited":[90,118],"anti-CD80":[92],"and,":[93],"a":[95],"lesser":[96],"extent,":[97],"anti-CD86":[99],"mAbs.":[100],"contrast,":[102,204],"these":[106,174,231],"cytokines":[107],"PBMCs":[109],"affected":[112],"CD80,":[116],"anti-CD86,":[120],"strongly":[123],"attenuated":[124],"in":[125,184,214,225,239],"presence":[127],"Abs.":[130],"FACS":[131],"analysis":[132],"revealed":[133],"stimulated":[135],"comprised":[140],"CD4+":[142],"cells":[144,181],"expressed":[146],"surface":[147],"(75.":[149],"3%)":[150],"little":[152],"CTLA-4":[153],"(4.0%).":[154],"Neutralizing":[155],"CD40":[158],"ligand":[159],"had":[160],"no":[161],"effect":[162],"on":[163],"cytokine":[165,201],"levels":[166],"produced":[167],"or":[171],"PBMCs.":[172],"Collectively,":[173],"findings":[175],"suggest":[176],"allergen-specific":[178],"alphabeta":[179,221],"are":[182],"resident":[183],"costimulation":[191],"is":[197],"essential":[198],"allergen-induced":[200],"production.":[202],"appears":[206],"be":[208,235],"principal":[210],"molecule":[212],"PBMC":[215],"responses.":[216],"Attenuation":[217],"type":[219],"2":[220],"responses":[224],"mucosa":[228],"blocking":[230],"molecules":[233],"may":[234],"therapeutic":[237],"potential":[238],"asthma.":[240]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
