{"id":"https://openalex.org/W2156984718","doi":"https://doi.org/10.1073/pnas.95.22.12956","title":"Inhibiting transthyretin conformational changes that lead to amyloid fibril formation","display_name":"Inhibiting transthyretin conformational changes that lead to amyloid fibril formation","publication_year":1998,"publication_date":"1998-10-27","ids":{"openalex":"https://openalex.org/W2156984718","doi":"https://doi.org/10.1073/pnas.95.22.12956","mag":"2156984718","pmid":"https://pubmed.ncbi.nlm.nih.gov/9789022","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/23669"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.95.22.12956","doi":"https://doi.org/10.1073/pnas.95.22.12956","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.95.22.12956","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/23669","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110059625","display_name":"Scott Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A. Peterson","raw_affiliation_strings":["Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037; and Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037; and Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057888842","display_name":"Thomas Klabunde","orcid":"https://orcid.org/0000-0002-0745-4940","observed_orcids":["https://orcid.org/0000-0002-0745-4940"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Klabunde","raw_affiliation_strings":["Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037; and Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037; and Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086170675","display_name":"Hilal Ahmed Lashuel","orcid":"https://orcid.org/0000-0001-7682-8320","observed_orcids":["https://orcid.org/0000-0001-7682-8320","https://orcid.org/0000-0002-3737-1054"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hilal A. Lashuel","raw_affiliation_strings":["Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037; and Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843","Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037; and Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018363968","display_name":"Hans E. Purkey","orcid":"https://orcid.org/0000-0002-8570-364X","observed_orcids":["https://orcid.org/0000-0002-8570-364X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans Purkey","raw_affiliation_strings":["Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037; and Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037; and Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103456216","display_name":"James C. Sacchettini","orcid":"https://orcid.org/0000-0001-5767-2367","observed_orcids":["https://orcid.org/0000-0001-5767-2367"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C. Sacchettini","raw_affiliation_strings":["Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037; and Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037; and Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081499831","display_name":"Jeffery W. Kelly","orcid":"https://orcid.org/0000-0001-8943-3395","observed_orcids":["https://orcid.org/0000-0001-8943-3395","https://orcid.org/0000-0003-4921-1135"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey W. Kelly","raw_affiliation_strings":["Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037; and Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Skaggs Institute of Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road MB 12, La Jolla, CA 92037; and Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3044,"has_fulltext":false,"cited_by_count":208,"citation_normalized_percentile":{"value":0.93309386,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"95","issue":"22","first_page":"12956","last_page":"12960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prealbumin","display_name":"prealbumin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/flufenamic-acid","display_name":"flufenamic acid","score":0.9639999866485596},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.7360000014305115},{"id":"https://openalex.org/keywords/protein-conformational-stability","display_name":"protein conformational stability","score":0.7549999952316284},{"id":"https://openalex.org/keywords/familial-amyloid-polyneuropathy","display_name":"hereditary transthyretin amyloidosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/senile-systemic-amyloidosis","display_name":"senile systemic amyloidosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8500000238418579},{"id":"https://openalex.org/keywords/amyloid-hypothesis","display_name":"amyloid hypothesis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C121157162","wikidata":"https://www.wikidata.org/wiki/Q419999","display_name":"Transthyretin","level":2,"score":0.8678325414657593},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.7297464609146118},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.7296691536903381},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.6951165795326233},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6868541240692139},{"id":"https://openalex.org/C2909607560","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid disease","level":5,"score":0.6113561391830444},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5237248539924622},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.4818202555179596},{"id":"https://openalex.org/C2779155187","wikidata":"https://www.wikidata.org/wiki/Q114391","display_name":"Congo red","level":3,"score":0.4599032402038574},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44022905826568604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4375409185886383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1658751666545868},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14278358221054077},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.14158648252487183},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10030704736709595},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0877470076084137},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0793800950050354},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005439","descriptor_name":"Flufenamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011228","descriptor_name":"Prealbumin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011228","descriptor_name":"Prealbumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011228","descriptor_name":"Prealbumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.95.22.12956","doi":"https://doi.org/10.1073/pnas.95.22.12956","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.95.22.12956","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:23669","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/23669","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9789022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9789022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:infoscience.epfl.ch:142143","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/142143","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:142143","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/142143","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"},{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/181628","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1969.1/181628","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:23669","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/23669","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000003207","display_name":null,"funder_award_id":"DK 46335","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000862409","display_name":"Probing the biochemical mechanism of amyloid disease","funder_award_id":"R01DK046335","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320310358","display_name":"Achievement Rewards for College Scientists Foundation","ror":"https://ror.org/054awkm93"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1560285331","https://openalex.org/W1568589356","https://openalex.org/W1645430207","https://openalex.org/W1821221039","https://openalex.org/W1967144890","https://openalex.org/W1968925833","https://openalex.org/W1971840315","https://openalex.org/W1975914851","https://openalex.org/W1976632394","https://openalex.org/W1980125299","https://openalex.org/W1998592142","https://openalex.org/W2002746220","https://openalex.org/W2005974273","https://openalex.org/W2011606718","https://openalex.org/W2013083986","https://openalex.org/W2024615249","https://openalex.org/W2042975557","https://openalex.org/W2049521571","https://openalex.org/W2055258921","https://openalex.org/W2067823521","https://openalex.org/W2068477037","https://openalex.org/W2079250951","https://openalex.org/W2081954759","https://openalex.org/W2083419051","https://openalex.org/W2089250146","https://openalex.org/W2090797167","https://openalex.org/W2105848312","https://openalex.org/W2151796887","https://openalex.org/W2314304229","https://openalex.org/W4211192758","https://openalex.org/W4253098746","https://openalex.org/W4319704052"],"related_works":["https://openalex.org/W2002746220","https://openalex.org/W2024615249","https://openalex.org/W2144688054","https://openalex.org/W1969321117","https://openalex.org/W1999510416","https://openalex.org/W1505079219","https://openalex.org/W2169280166","https://openalex.org/W2333890911","https://openalex.org/W1991250544","https://openalex.org/W2184843071"],"abstract_inverted_index":{"Insoluble":[0],"protein":[1,112],"fibrils":[2,144],"resulting":[3],"from":[4],"the":[5,14,49,55,65,96,107,129,134,138],"self-assembly":[6],"of":[7,54,68,78,100,110,142],"a":[8,111,116],"conformational":[9,66],"intermediate":[10],"are":[11,37],"implicated":[12],"as":[13,115,125],"causative":[15,140],"agent":[16],"in":[17,48,145],"several":[18],"severe":[19],"human":[20],"amyloid":[21,27,42,72,121,135,143,146],"diseases,":[22],"including":[23],"Alzheimer's":[24],"disease,":[25],"familial":[26],"polyneuropathy,":[28],"and":[29,90],"senile":[30],"systemic":[31],"amyloidosis.":[32],"The":[33,75],"latter":[34],"two":[35],"diseases":[36],"associated":[38,70],"with":[39,71,81],"transthyretin":[40],"(TTR)":[41],"fibrils,":[43],"which":[44],"appear":[45],"to":[46,119,131],"form":[47],"acidic":[50],"partial":[51],"denaturing":[52],"environment":[53],"lysosome.":[56],"Here":[57],"we":[58],"demonstrate":[59],"that":[60,84,94,105],"flufenamic":[61],"acid":[62],"(Flu)":[63],"inhibits":[64],"changes":[67],"TTR":[69,79],"fibril":[73],"formation.":[74],"crystal":[76],"structure":[77],"complexed":[80],"Flu":[82,85,126],"demonstrates":[83],"mediates":[86],"intersubunit":[87,91],"hydrophobic":[88],"interactions":[89],"hydrogen":[92],"bonds":[93],"stabilize":[95],"normal":[97,108],"tetrameric":[98],"fold":[99],"TTR.":[101],"A":[102],"small-molecule":[103],"inhibitor":[104],"stabilizes":[106],"conformation":[109],"is":[113],"desirable":[114],"possible":[117],"approach":[118],"treat":[120],"diseases.":[122],"Molecules":[123],"such":[124],"also":[127],"provide":[128],"means":[130],"rigorously":[132],"test":[133],"hypothesis,":[136],"i.e.,":[137],"apparent":[139],"role":[141],"disease.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
