{"id":"https://openalex.org/W2156908646","doi":"https://doi.org/10.1073/pnas.112040099","title":"An Arabidopsis mutation in translation elongation factor 2 causes superinduction of CBF/DREB1 transcription factor genes but blocks the induction of their downstream targets under low temperatures","display_name":"An Arabidopsis mutation in translation elongation factor 2 causes superinduction of CBF/DREB1 transcription factor genes but blocks the induction of their downstream targets under low temperatures","publication_year":2002,"publication_date":"2002-05-14","ids":{"openalex":"https://openalex.org/W2156908646","doi":"https://doi.org/10.1073/pnas.112040099","mag":"2156908646","pmid":"https://pubmed.ncbi.nlm.nih.gov/12032361","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/124352"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.112040099","doi":"https://doi.org/10.1073/pnas.112040099","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.112040099","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/124352","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041543923","display_name":"Yan Guo","orcid":"https://orcid.org/0000-0002-6955-8008","observed_orcids":["https://orcid.org/0000-0002-6955-8008"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Guo","raw_affiliation_strings":["Department of Plant Sciences, University of Arizona, Tucson, AZ 85721"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Sciences, University of Arizona, Tucson, AZ 85721","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034403471","display_name":"Liming Xiong","orcid":"https://orcid.org/0000-0001-8099-0806","observed_orcids":["https://orcid.org/0000-0001-8099-0806"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liming Xiong","raw_affiliation_strings":["Department of Plant Sciences, University of Arizona, Tucson, AZ 85721"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Sciences, University of Arizona, Tucson, AZ 85721","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045705453","display_name":"Manabu Ishitani","orcid":"https://orcid.org/0000-0002-6950-4018","observed_orcids":["https://orcid.org/0000-0002-6950-4018"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manabu Ishitani","raw_affiliation_strings":["Department of Plant Sciences, University of Arizona, Tucson, AZ 85721"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Sciences, University of Arizona, Tucson, AZ 85721","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049293054","display_name":"Jian\u2010Kang Zhu","orcid":"https://orcid.org/0000-0001-5134-731X","observed_orcids":["https://orcid.org/0000-0001-5134-731X"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian-Kang Zhu","raw_affiliation_strings":["Department of Plant Sciences, University of Arizona, Tucson, AZ 85721"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Sciences, University of Arizona, Tucson, AZ 85721","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":null,"apc_paid":null,"fwci":8.3901,"has_fulltext":false,"cited_by_count":160,"citation_normalized_percentile":{"value":0.97546263,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"99","issue":"11","first_page":"7786","last_page":"7791"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cold-stress-response","display_name":"cold stress response","score":0.4690000116825104},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cold-responsive-gene-expression","display_name":"cold-responsive gene expression","score":0.6179999709129333},{"id":"https://openalex.org/keywords/freeze-tolerance","display_name":"freezing tolerance","score":0.8709999918937683},{"id":"https://openalex.org/keywords/vernalization","display_name":"vernalization","score":0.8970000147819519},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.6420000195503235},{"id":"https://openalex.org/keywords/feedback-inhibition","display_name":"product inhibition","score":0.6200000047683716},{"id":"https://openalex.org/keywords/transcriptional-activator","display_name":"transcriptional activator","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7190475463867188},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6926395297050476},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6543856859207153},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6343037486076355},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.5533414483070374},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5144565105438232},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48020920157432556},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4714782238006592},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.468985378742218},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4680919945240021},{"id":"https://openalex.org/C139124968","wikidata":"https://www.wikidata.org/wiki/Q126252","display_name":"Elongation factor","level":5,"score":0.4567611515522003},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43135586380958557},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.12336108088493347},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.08246639370918274},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018749","descriptor_name":"RNA, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020652","descriptor_name":"Peptide Elongation Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020652","descriptor_name":"Peptide Elongation Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.112040099","doi":"https://doi.org/10.1073/pnas.112040099","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.112040099","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:176683","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/124352","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:12032361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12032361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:124352","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC124352/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:176683","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/124352","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.40450000762939453,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W195195871","https://openalex.org/W644508853","https://openalex.org/W1844993037","https://openalex.org/W1848060965","https://openalex.org/W1970487075","https://openalex.org/W1978661900","https://openalex.org/W1978751527","https://openalex.org/W2021681068","https://openalex.org/W2049841550","https://openalex.org/W2052062475","https://openalex.org/W2058326123","https://openalex.org/W2061063334","https://openalex.org/W2067660931","https://openalex.org/W2075362706","https://openalex.org/W2076966763","https://openalex.org/W2079153043","https://openalex.org/W2083152136","https://openalex.org/W2083722533","https://openalex.org/W2090936658","https://openalex.org/W2094119933","https://openalex.org/W2106870370","https://openalex.org/W2111023901","https://openalex.org/W2125528087","https://openalex.org/W2137981728","https://openalex.org/W2146341411","https://openalex.org/W2147166558","https://openalex.org/W2168532265","https://openalex.org/W2171012097","https://openalex.org/W4236463097","https://openalex.org/W4243742482","https://openalex.org/W6730410353"],"related_works":["https://openalex.org/W1933383348","https://openalex.org/W2011100661","https://openalex.org/W2163193359","https://openalex.org/W3129354583","https://openalex.org/W7100593607","https://openalex.org/W2125528087","https://openalex.org/W2111646009","https://openalex.org/W2135212876","https://openalex.org/W2153409704","https://openalex.org/W2348048631"],"abstract_inverted_index":{"Low":[0],"temperature":[1,23,37,168],"regulates":[2],"gene":[3,126,184],"expression":[4,71],"in":[5,13,29,35,45,119,144,149,162],"bacteria,":[6],"yeast,":[7],"and":[8],"animals":[9],"as":[10,12],"well":[11,27],"plants.":[14],"However,":[15],"the":[16,21,73,87,95,107,150,163],"signal":[17],"transduction":[18,165],"cascades":[19],"mediating":[20],"low":[22,36,54,63,167],"responses":[24],"are":[25,49],"not":[26,105],"understood":[28],"any":[30],"organism.":[31],"To":[32],"identify":[33],"components":[34],"signaling":[38],"genetically,":[39],"we":[40],"isolated":[41],"Arabidopsis":[42],"thaliana":[43],"mutants":[44],"which":[46],"cold-responsive":[47,67],"genes":[48],"no":[50],"longer":[51],"induced":[52],"by":[53,86,182,187],"temperatures.":[55],"One":[56],"of":[57,66,72,97,158,166,177,189],"these":[58],"mutations,":[59],"los1-1,":[60],"specifically":[61,148],"blocks":[62],"temperature-induced":[64],"transcription":[65,176],"genes.":[68,193],"Surprisingly,":[69],"cold-induced":[70,175],"early":[74],"response":[75],"transcriptional":[76],"activators,":[77],"C-repeat/dehydration":[78],"responsive":[79],"element":[80],"binding":[81],"factors":[82],"(CBF/DREB1s),":[83],"is":[84,115,142,179],"enhanced":[85],"los1-1":[88,91,114,145],"mutation.":[89],"The":[90,124],"mutation":[92,118],"also":[93,172],"reduces":[94],"capacity":[96],"plants":[98,147],"to":[99],"develop":[100],"freezing":[101],"tolerance":[102],"but":[103],"does":[104],"impair":[106],"vernalization":[108],"response.":[109],"Genetic":[110],"analysis":[111],"indicated":[112],"that":[113,138,174],"a":[116,120,128,155],"recessive":[117],"single":[121],"nuclear":[122],"gene.":[123],"LOS1":[125],"encodes":[127],"translation":[129],"elongation":[130],"factor":[131],"2-like":[132],"protein.":[133],"Protein":[134],"labeling":[135],"studies":[136],"show":[137],"new":[139,159],"protein":[140,160],"synthesis":[141,161],"blocked":[143],"mutant":[146],"cold.":[151],"These":[152],"results":[153,171],"reveal":[154],"critical":[156],"role":[157],"proper":[164],"signals.":[169],"Our":[170],"suggest":[173],"CBF/DREB1s":[178],"feedback":[180],"inhibited":[181],"their":[183,190],"products":[185,188],"or":[186],"downstream":[191],"target":[192]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}