{"id":"https://openalex.org/W2156854468","doi":null,"title":"Rotavirus NSP1 is an interferon system antagonist","display_name":"Rotavirus NSP1 is an interferon system antagonist","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2156854468","mag":"2156854468"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.montana.edu:1/1369","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.montana.edu/handle/1/1369","pdf_url":"https://scholarworks.montana.edu/xmlui/handle/1/1369","source":{"id":"https://openalex.org/S4306402563","display_name":"Montana State University ScholarWorks (Montana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23732399","host_organization_name":"Montana State University","host_organization_lineage":["https://openalex.org/I23732399"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarworks.montana.edu/xmlui/handle/1/1369","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071258763","display_name":"Joel W. Graff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joel W. Graff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5071258763"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.7329000234603882,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.7329000234603882,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.257099986076355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-antagonism","display_name":"interferon antagonism","score":0.8930000066757202},{"id":"https://openalex.org/keywords/irf3","display_name":"IRF3","score":0.8180000185966492},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/interferon-beta-induction","display_name":"interferon-beta induction","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nfkb-signaling","display_name":"NFKB signaling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/beta-trcp","display_name":"\u03b2-TrCP","score":0.9700000286102295},{"id":"https://openalex.org/keywords/zinc-binding-domain","display_name":"zinc-binding domain","score":0.7580000162124634},{"id":"https://openalex.org/keywords/bovine-rotavirus","display_name":"bovine rotavirus","score":0.8980000019073486},{"id":"https://openalex.org/keywords/porcine-rotavirus","display_name":"porcine rotavirus","score":0.8100000023841858},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2781367151","wikidata":"https://www.wikidata.org/wiki/Q164778","display_name":"Rotavirus","level":3,"score":0.7719628810882568},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5100120306015015},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5070352554321289},{"id":"https://openalex.org/C3020380090","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon \u03b3","level":4,"score":0.41740554571151733},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3566886782646179},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24112120270729065},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.11643612384796143},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.10656949877738953},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.09292662143707275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08543005585670471},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarworks.montana.edu:1/1369","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.montana.edu/handle/1/1369","pdf_url":"https://scholarworks.montana.edu/xmlui/handle/1/1369","source":{"id":"https://openalex.org/S4306402563","display_name":"Montana State University ScholarWorks (Montana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23732399","host_organization_name":"Montana State University","host_organization_lineage":["https://openalex.org/I23732399"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2156854468","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.montana.edu/xmlui/bitstream/1/1369/1/GraffJ0808.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarworks.montana.edu:1/1369","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.montana.edu/handle/1/1369","pdf_url":"https://scholarworks.montana.edu/xmlui/handle/1/1369","source":{"id":"https://openalex.org/S4306402563","display_name":"Montana State University ScholarWorks (Montana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23732399","host_organization_name":"Montana State University","host_organization_lineage":["https://openalex.org/I23732399"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2156854468.pdf","grobid_xml":"https://content.openalex.org/works/W2156854468.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1553110542","https://openalex.org/W1799809595","https://openalex.org/W1830966545","https://openalex.org/W1883394179","https://openalex.org/W1966256870","https://openalex.org/W1986384364","https://openalex.org/W1992744008","https://openalex.org/W1993554600","https://openalex.org/W2022489645","https://openalex.org/W2035209826","https://openalex.org/W2035524082","https://openalex.org/W2051026238","https://openalex.org/W2073658506","https://openalex.org/W2095194341","https://openalex.org/W2117817795","https://openalex.org/W2123122199","https://openalex.org/W2130576390","https://openalex.org/W2137303998","https://openalex.org/W2152424535","https://openalex.org/W2153987432"],"related_works":["https://openalex.org/W2145494049","https://openalex.org/W2129783463","https://openalex.org/W2102683798","https://openalex.org/W2157400667","https://openalex.org/W1984443288","https://openalex.org/W3145385269","https://openalex.org/W2152106572","https://openalex.org/W2165679960","https://openalex.org/W2058015620","https://openalex.org/W2164913825"],"abstract_inverted_index":{"Rotaviruses":[0],"cause":[1],"severe":[2],"gastroenteritis":[3],"in":[4,91,120,131,137,158,279,317],"mammals,":[5],"including":[6],"humans":[7],"and":[8,198,232,305],"livestock.":[9],"Most":[10],"rotavirus":[11,63,186,200,226,234,280,311,323],"proteins":[12,193,222],"have":[13,320],"known":[14,151],"functions,":[15],"either":[16],"as":[17,24,64,81,175,326,344],"a":[18,25,61,69,155,182,217,309],"mediator":[19],"of":[20,27,34,49,68,89,109,129,134,140,149,160,166,181,185,213,220,229,255,291,308,335],"virus":[21,30],"replication":[22],"or":[23],"component":[26],"the":[28,47,57,65,87,103,112,132,147,167,196,238,243,286,292,306,314,332],"infectious":[29],"particle.":[31],"The":[32,179,191],"function":[33,48],"nonstructural":[35],"protein":[36,67],"1":[37],"(NSP1)":[38],"was":[39,79,118,170,242,248,261,298],"unknown.":[40],"However,":[41],"it":[42],"has":[43],"been":[44],"suggested":[45],"that":[46,98,210,237,247,258,285,322],"NSP1":[50,58,99,124,130,152,173,180,192,221,304,307,324],"involved":[51],"interactions":[52],"with":[53,172,189],"cellular":[54],"proteins.":[55],"Using":[56],"encoded":[59,194],"by":[60,195,267,302,330,342],"bovine":[62,197,310],"bait":[66],"yeast-two":[70],"hybrid":[71],"interaction":[72],"trap,":[73],"interferon":[74,94,104,328],"regulatory":[75],"factor":[76],"3":[77],"(IRF3)":[78],"identified":[80],"an":[82,93,176,327,345],"NSP1-interacting":[83],"protein.":[84],"Due":[85],"to":[86,101,250,263],"importance":[88],"IRF3":[90,214,252,273],"initiating":[92],"response,":[95],"we":[96,283],"hypothesized":[97],"acts":[100],"antagonize":[102],"system.":[105],"A":[106,142],"comprehensive":[107],"set":[108],"experiments":[110],"yielded":[111],"following":[113],"observations.":[114],"Interferon-beta":[115],"(IFNbeta)":[116],"induction":[117,266,337],"blocked":[119],"wild-type,":[121],"but":[122],"not":[123],"null,":[125],"infected":[126,281],"cells.":[127],"Expression":[128],"absence":[133],"infection":[135],"resulted":[136],"proteasome-mediated":[138,333],"degradation":[139,212,301,334],"IRF3.":[141,190],"cysteine-rich":[143],"zinc-binding":[144,168],"region":[145],"near":[146],"amino-terminus":[148],"all":[150],"sequences":[153],"resembles":[154],"domain":[156,169],"found":[157,284],"hundreds":[159],"E3":[161,177,296,346],"ubiquitin":[162,347],"ligases.":[163],"Mutational":[164],"analysis":[165],"consistent":[171],"acting":[174,343],"enzyme.":[178],"murine":[183,199],"strain":[184,240,246,260],"also":[187],"interacted":[188],"strains":[201,235],"showed":[202,257],"low":[203],"sequence":[204],"homology":[205],"(37%":[206],"identity),":[207],"which":[208],"indicated":[209,236],"directing":[211,331],"may":[215],"be":[216],"common":[218],"property":[219],"from":[223],"many":[224],"different":[225],"strains.":[227],"Screening":[228],"simian,":[230],"bovine,":[231],"porcine":[233,239],"OSU":[241,256,303],"only":[244],"wild-type":[245],"unable":[249],"direct":[251],"degradation.":[253],"Characterization":[254],"this":[259,318],"able":[262],"block":[264],"IFNbeta":[265,336],"antagonizing":[268],"NFKB":[269,277],"signaling,":[270],"rather":[271],"than":[272],"signaling.":[274],"While":[275],"analyzing":[276],"signaling":[278,338],"cells,":[282],"F":[287],"box":[288,294],"protein,":[289],"betaTrCP,":[290],"Skp1/Cul1/F":[293],"multi-subunit":[295],"enzyme":[297],"targeted":[299],"for":[300],"strain.":[312],"Together,":[313],"results":[315],"presented":[316],"dissertation":[319],"determined":[321],"functions":[325],"antagonist":[329],"components,":[339],"most":[340],"likely":[341],"ligase.":[348]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}
