{"id":"https://openalex.org/W2156790419","doi":null,"title":"Apolipoprotein E gene and age-related macular degeneration in a Chinese population.","display_name":"Apolipoprotein E gene and age-related macular degeneration in a Chinese population.","publication_year":2011,"publication_date":"2011-04-20","ids":{"openalex":"https://openalex.org/W2156790419","mag":"2156790419","pmid":"https://pubmed.ncbi.nlm.nih.gov/21541275","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3084239"},"language":"en","primary_location":{"id":"pmid:21541275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21541275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3084239/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073820197","display_name":"Erdan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Erdan Sun","raw_affiliation_strings":["Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022406947","display_name":"Apiradee Lim","orcid":"https://orcid.org/0000-0002-7137-4101","observed_orcids":["https://orcid.org/0000-0002-7137-4101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Apiradee Lim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081621960","display_name":"Xipu Liu","orcid":"https://orcid.org/0009-0001-5603-9970","observed_orcids":["https://orcid.org/0009-0001-5603-9970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xipu Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071293220","display_name":"Torkel Snellingen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Torkel Snellingen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360133","display_name":"Ningli Wang","orcid":"https://orcid.org/0000-0002-8933-4482","observed_orcids":["https://orcid.org/0000-0002-8933-4482","https://orcid.org/0000-0002-8686-0954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ningli Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047119761","display_name":"Ningpu Liu","orcid":"https://orcid.org/0000-0002-8319-1425","observed_orcids":["https://orcid.org/0000-0002-8319-1425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ningpu Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3183,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.85933618,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":null,"first_page":"997","last_page":"1002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.996999979019165},{"id":"https://openalex.org/keywords/apoe-polymorphism","display_name":"APOE polymorphism","score":0.921999990940094},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.8500000238418579},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9279999732971191},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.7540000081062317},{"id":"https://openalex.org/keywords/apoe-epsilon2-allele","display_name":"APOE \u03b52 allele","score":0.9750000238418579},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.8565670251846313},{"id":"https://openalex.org/C2779093074","wikidata":"https://www.wikidata.org/wiki/Q1140528","display_name":"Drusen","level":3,"score":0.6661854982376099},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6587888598442078},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.6417236924171448},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5595382452011108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5109402537345886},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4995884895324707},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.43349170684814453},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32405886054039},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3211709260940552},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25383445620536804},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2530662715435028},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.21532511711120605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21367105841636658},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.07959377765655518},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053329","descriptor_name":"Apolipoprotein E2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:21541275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21541275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3084239","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3084239/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.785.7875","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.785.7875","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/29/7b/mv-v17-997.PMC3084239.pdf","raw_type":"text"},{"id":"mag:2156790419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21541275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3084239","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3084239/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1492973782","https://openalex.org/W1500295102","https://openalex.org/W1511664208","https://openalex.org/W1563115321","https://openalex.org/W1776177507","https://openalex.org/W1942904161","https://openalex.org/W1963021413","https://openalex.org/W1963996422","https://openalex.org/W1967749499","https://openalex.org/W1968012352","https://openalex.org/W1977141171","https://openalex.org/W2007691367","https://openalex.org/W2024729125","https://openalex.org/W2031522013","https://openalex.org/W2031535355","https://openalex.org/W2034968148","https://openalex.org/W2035883738","https://openalex.org/W2036865813","https://openalex.org/W2037239961","https://openalex.org/W2039730121","https://openalex.org/W2041625092","https://openalex.org/W2054899217","https://openalex.org/W2063763497","https://openalex.org/W2067808411","https://openalex.org/W2077219082","https://openalex.org/W2077953785","https://openalex.org/W2082887801","https://openalex.org/W2086327418","https://openalex.org/W2089639488","https://openalex.org/W2091485657","https://openalex.org/W2094082523","https://openalex.org/W2121433602","https://openalex.org/W2122414444","https://openalex.org/W2136525843","https://openalex.org/W2137792435","https://openalex.org/W2159197516","https://openalex.org/W2398107675","https://openalex.org/W2411273799"],"related_works":["https://openalex.org/W2404209422","https://openalex.org/W2063763497","https://openalex.org/W2414441486","https://openalex.org/W2806037657","https://openalex.org/W4411108588","https://openalex.org/W2094082523","https://openalex.org/W1968012352","https://openalex.org/W7155749911","https://openalex.org/W2136525843","https://openalex.org/W7047355610"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"examine":[2],"the":[3,68,90,108,152,177,228],"association":[4,205],"between":[5],"apolipoprotein":[6],"E":[7],"(APOE)":[8],"polymorphisms":[9,208],"and":[10,34,55,61,83,101,119,131,143,165,188],"age-related":[11],"macular":[12],"degeneration":[13],"(AMD)":[14],"in":[15,77,80,85,95,98,103,113,116,121,128,227],"a":[16,73,222],"Chinese":[17,229],"population.":[18,230],"METHODS:":[19],"The":[20],"study":[21],"consisted":[22],"of":[23,51,75,89,107,206],"712":[24],"subjects,":[25],"including":[26],"201":[27],"controls,":[28,78,96,114,138],"363":[29],"cases":[30,36,139,144],"with":[31,37,72,140,145,209],"early":[32,81,99,117,141,163,186,210],"AMD,":[33,82,100,118,142,213],"148":[35],"exudative":[38,86,104,122,146,171,194,212],"AMD.":[39,87,105,123,147,172,195],"Genomic":[40],"DNA":[41],"was":[42,67,93,111,135,155,180],"extracted":[43],"from":[44],"venous":[45],"blood":[46],"leukocytes.":[47],"Common":[48],"allelic":[49],"variants":[50],"APOE":[52,65,129,207,216],"(\u03b52,":[53],"\u03b53,":[54],"\u03b54)":[56],"were":[57],"analyzed":[58],"by":[59],"PCR":[60],"direct":[62],"sequencing.":[63],"RESULTS:":[64],"\u03b53\u03b53":[66],"most":[69],"frequent":[70],"genotype,":[71],"frequency":[74,133],"72.6%":[76],"72.5%":[79],"70.3%":[84],"Frequency":[88,106],"\u03b52":[91,149],"allele":[92,110,132,150,175],"6.7%":[94],"7.4%":[97],"8.8%":[102],"\u03b54":[109,174],"8.7%":[112],"7.7%":[115],"7.8%":[120],"No":[124],"statistically":[125],"significant":[126],"difference":[127],"genotype":[130],"distribution":[134],"observed":[136],"among":[137],"For":[148,173],"carriers,":[151,176],"odds":[153,178],"ratio":[154,179],"1.12":[156],"(95%":[157,167,182,190],"confidence":[158],"interval":[159],"[CI],":[160],"0.65-1.93)":[161],"for":[162,170,185,193],"AMD":[164,187,224],"1.06":[166],"CI,":[168,183,191],"0.53-2.10)":[169],"1.04":[181],"0.61-1.75)":[184],"0.83":[189],"0.42-1.62)":[192],"CONCLUSIONS:":[196],"Our":[197],"data":[198],"provide":[199],"no":[200],"evidence":[201],"to":[202,220],"support":[203],"an":[204],"or":[211],"suggesting":[214],"that":[215],"is":[217],"less":[218],"likely":[219],"be":[221],"major":[223],"susceptibility":[225],"gene":[226]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
