{"id":"https://openalex.org/W2156758587","doi":"https://doi.org/10.1152/ajpgi.00525.2002","title":"Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis","display_name":"Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2156758587","doi":"https://doi.org/10.1152/ajpgi.00525.2002","mag":"2156758587","pmid":"https://pubmed.ncbi.nlm.nih.gov/12637254"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00525.2002","doi":"https://doi.org/10.1152/ajpgi.00525.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00525.2002","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066579546","display_name":"Marcellus Henrique Loiola Ponte de Souza","orcid":"https://orcid.org/0000-0003-2376-3433","observed_orcids":["https://orcid.org/0000-0003-2376-3433"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marcellus H. L. P. Souza","raw_affiliation_strings":["Dept. of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089709190","display_name":"Oct\u00e1vio Menezes de Lima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Octavio Menezes de Lima","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069820863","display_name":"Stella Regina Zamun\u00e9r","orcid":"https://orcid.org/0000-0002-4694-7617","observed_orcids":["https://orcid.org/0000-0002-4694-7617"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stella R. Zamuner","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057720130","display_name":"Stefano Fiorucci","orcid":"https://orcid.org/0000-0003-3816-4222","observed_orcids":["https://orcid.org/0000-0003-3816-4222"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefano Fiorucci","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027937626","display_name":"John Lawrence Wallace","orcid":"https://orcid.org/0000-0002-4853-1682","observed_orcids":["https://orcid.org/0000-0002-4853-1682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John L. Wallace","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8584,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.93194799,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"285","issue":"1","first_page":"G54","last_page":"G61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastritis","display_name":"gastritis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/aspirin-induced-gastric-injury","display_name":"aspirin-induced gastric injury","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.878000020980835},{"id":"https://openalex.org/keywords/lipoxin-a4","display_name":"lipoxin A4","score":0.875},{"id":"https://openalex.org/keywords/rofecoxib","display_name":"rofecoxib","score":0.796999990940094},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8550000190734863},{"id":"https://openalex.org/keywords/gastric-mucosal-defense","display_name":"gastric mucosal defense","score":0.8069999814033508},{"id":"https://openalex.org/keywords/leukocyte-adhesion","display_name":"leukocyte adhesion","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C2780415110","wikidata":"https://www.wikidata.org/wiki/Q4329","display_name":"Lipoxin","level":3,"score":0.8819562196731567},{"id":"https://openalex.org/C2778582115","wikidata":"https://www.wikidata.org/wiki/Q411412","display_name":"Rofecoxib","level":4,"score":0.8629584312438965},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.8378251791000366},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5982567071914673},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.5976271629333496},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.581756591796875},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.5638644099235535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5186887979507446},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.451097697019577},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42336955666542053},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.41594868898391724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3419766426086426},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32572245597839355},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17619699239730835},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005756","descriptor_name":"Gastritis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005756","descriptor_name":"Gastritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044045","descriptor_name":"Lipoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpgi.00525.2002","doi":"https://doi.org/10.1152/ajpgi.00525.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00525.2002","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:12637254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12637254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.597.8450","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.597.8450","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://farncombe.mcmaster.ca/documents/Souzaetal.AmJPhysiolGastrointestLiverPhysiol2003285154-61.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W320653501","https://openalex.org/W1523941392","https://openalex.org/W1847001776","https://openalex.org/W1891720417","https://openalex.org/W1952008641","https://openalex.org/W1971568959","https://openalex.org/W1973123971","https://openalex.org/W1982283061","https://openalex.org/W1985458126","https://openalex.org/W1986569854","https://openalex.org/W1988476789","https://openalex.org/W2007344220","https://openalex.org/W2008574207","https://openalex.org/W2019954713","https://openalex.org/W2022612847","https://openalex.org/W2023887529","https://openalex.org/W2024065712","https://openalex.org/W2040732382","https://openalex.org/W2048087356","https://openalex.org/W2048565177","https://openalex.org/W2063397701","https://openalex.org/W2067429421","https://openalex.org/W2071201771","https://openalex.org/W2073059894","https://openalex.org/W2074917122","https://openalex.org/W2083303422","https://openalex.org/W2154368914","https://openalex.org/W2162382352","https://openalex.org/W2163756514","https://openalex.org/W2178892173","https://openalex.org/W2314346356"],"related_works":["https://openalex.org/W2019954713","https://openalex.org/W2115735203","https://openalex.org/W1971236330","https://openalex.org/W2083990812","https://openalex.org/W2076559527","https://openalex.org/W2110315281","https://openalex.org/W2048995724","https://openalex.org/W2151270620","https://openalex.org/W1791264693","https://openalex.org/W3151746197"],"abstract_inverted_index":{"Products":[0],"of":[1,9,21,77,96,105,113],"cyclooxygenase":[2],"(COX)-2":[3],"contribute":[4],"to":[5,16,43,62,175,208],"mucosal":[6,44,209],"defense.":[7,45],"Acetylation":[8],"COX-2":[10,101,203],"by":[11,53,128,186,189],"aspirin":[12,114,169],"has":[13],"been":[14],"shown":[15],"result":[17],"in":[18,28,50,136,140,178,211],"the":[19,29,51,55,63,75,116,137,141,190,196,213],"generation":[20],"15(R)-epi-lipoxin":[22,87],"A4,":[23],"which":[24],"exerts":[25],"protective":[26],"effects":[27,95],"stomach.":[30,217],"In":[31,165],"gastritis,":[32,168],"it":[33],"is":[34],"possible":[35],"that":[36,198],"lipoxin":[37,107,134,152,159,191,200],"A4":[38,88],"makes":[39,204],"a":[40,99,106],"greater":[41,133],"contribution":[42,207],"We":[46],"tested":[47],"this":[48,182],"hypothesis":[49],"rat,":[52],"using":[54],"iodoacetamide-induced":[56],"gastritis":[57],"model.":[58],"Iodoacetamide":[59],"was":[60,80,146,184],"added":[61],"drinking":[64],"water":[65],"for":[66],"5":[67],"days.":[68],"Rats":[69],"were":[70,92,110,126],"then":[71],"given":[72],"aspirin,":[73],"and":[74,89,104,115,144,154,181,215],"extent":[76],"gastric":[78,148],"damage":[79],"blindly":[81],"assessed":[82,127],"3":[83],"h":[84],"later.":[85],"Gastric":[86],"PGE2":[90],"levels":[91],"determined.":[93],"The":[94,158],"pretreatment":[97],"with":[98,167],"selective":[100],"inhibitor,":[102],"rofecoxib,":[103],"receptor":[108],"antagonist":[109,160],"assessed.":[111],"Effects":[112],"other":[117],"test":[118],"drugs":[119],"on":[120],"leukocyte":[121,171],"adherence":[122,172],"within":[123],"mesenteric":[124],"venules":[125],"intravital":[129],"microscopy.":[130],"Aspirin":[131],"elicited":[132],"synthesis":[135,153,201],"inflamed":[138,216],"than":[139],"normal":[142,179,214],"stomach,":[143],"there":[145],"reduced":[147,170],"damage.":[149,157,164],"Rofecoxib":[150],"inhibited":[151],"exacerbated":[155,162],"aspirin-induced":[156,163],"also":[161],"rats":[166],"(in":[173],"contrast":[174],"an":[176,205],"increase":[177],"rats),":[180],"effect":[183],"reversed":[185],"rofecoxib":[187],"or":[188],"antagonist.":[192],"These":[193],"results":[194],"support":[195],"notion":[197],"aspirin-triggered":[199],"via":[202],"important":[206],"defense":[210],"both":[212]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}