{"id":"https://openalex.org/W2156719014","doi":"https://doi.org/10.1128/jvi.72.3.2062-2071.1998","title":"Efficient Gap Repair Catalyzed In Vitro by an Intrinsic DNA Polymerase Activity of Human Immunodeficiency Virus Type 1 Integrase","display_name":"Efficient Gap Repair Catalyzed In Vitro by an Intrinsic DNA Polymerase Activity of Human Immunodeficiency Virus Type 1 Integrase","publication_year":1998,"publication_date":"1998-03-01","ids":{"openalex":"https://openalex.org/W2156719014","doi":"https://doi.org/10.1128/jvi.72.3.2062-2071.1998","mag":"2156719014","pmid":"https://pubmed.ncbi.nlm.nih.gov/9499061","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/109500"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.72.3.2062-2071.1998","doi":"https://doi.org/10.1128/jvi.72.3.2062-2071.1998","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.72.3.2062-2071.1998","pdf_url":"https://jvi.asm.org/content/jvi/72/3/2062.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/72/3/2062.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014151199","display_name":"Andrea Acel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrea Acel","raw_affiliation_strings":["<!--label omitted: 1-->Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]},{"raw_affiliation_string":"Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046189378","display_name":"Brian E. Udashkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brian E. Udashkin","raw_affiliation_strings":["<!--label omitted: 1-->Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]},{"raw_affiliation_string":"Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029881635","display_name":"Mark A. Wainberg","orcid":"https://orcid.org/0000-0002-0272-1317","observed_orcids":["https://orcid.org/0000-0002-0272-1317"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mark A. Wainberg","raw_affiliation_strings":["<!--label omitted: 1-->Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","<!--label omitted: 2-->Microbiology,2 McGill University, Montreal, Quebec, Canada H3T 1E2","Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","Microbiology,2 McGill University, Montreal, Quebec, Canada H3T 1E2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]},{"raw_affiliation_string":"<!--label omitted: 2-->Microbiology,2 McGill University, Montreal, Quebec, Canada H3T 1E2","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]},{"raw_affiliation_string":"Microbiology,2 McGill University, Montreal, Quebec, Canada H3T 1E2","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039897986","display_name":"Emmanuel A. Faust","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Emmanuel A. Faust","raw_affiliation_strings":["<!--label omitted: 1-->Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","<!--label omitted: 3-->Departments of Medicine3 and","Departments of Medicine3 and","Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]},{"raw_affiliation_string":"<!--label omitted: 3-->Departments of Medicine3 and","institution_ids":[]},{"raw_affiliation_string":"Departments of Medicine3 and","institution_ids":[]},{"raw_affiliation_string":"Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital and McGill AIDS Center,1 and","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8038,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.69525351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"72","issue":"3","first_page":"2062","last_page":"2071"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.1185000017285347,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-integrase","display_name":"HIV-1 integrase","score":0.996999979019165},{"id":"https://openalex.org/keywords/gap-repair","display_name":"gap repair","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hiv-1-integration","display_name":"HIV-1 integration","score":0.7580000162124634},{"id":"https://openalex.org/keywords/proviral-dna","display_name":"proviral DNA","score":0.5410000085830688},{"id":"https://openalex.org/keywords/c-terminal-deletion","display_name":"C-terminal deletion","score":0.39500001072883606},{"id":"https://openalex.org/keywords/monoclonal-antibody-inhibition","display_name":"monoclonal antibody inhibition","score":0.7689999938011169},{"id":"https://openalex.org/keywords/n-ethylmaleimide-inhibition","display_name":"N-ethylmaleimide inhibition","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.8378641605377197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7383732795715332},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.7322103381156921},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.6861807107925415},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6284412741661072},{"id":"https://openalex.org/C88354546","wikidata":"https://www.wikidata.org/wiki/Q3502973","display_name":"DNA polymerase II","level":5,"score":0.6008461117744446},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.5979112386703491},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5375736355781555},{"id":"https://openalex.org/C164965036","wikidata":"https://www.wikidata.org/wiki/Q2529148","display_name":"DNA polymerase I","level":5,"score":0.5003814697265625},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.4714661240577698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4429927468299866},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.43135374784469604},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.3355643153190613},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.15431734919548035},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13936984539031982},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09679010510444641},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013698","descriptor_name":"Templates, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013942","descriptor_name":"Thymine Nucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054306","descriptor_name":"Dideoxynucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.72.3.2062-2071.1998","doi":"https://doi.org/10.1128/jvi.72.3.2062-2071.1998","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.72.3.2062-2071.1998","pdf_url":"https://jvi.asm.org/content/jvi/72/3/2062.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:109500","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/109500","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC109500/pdf/jv002062.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:166089","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC109500","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:9499061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9499061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jvi.72.3.2062-2071.1998","doi":"https://doi.org/10.1128/jvi.72.3.2062-2071.1998","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.72.3.2062-2071.1998","pdf_url":"https://jvi.asm.org/content/jvi/72/3/2062.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2156719014.pdf","grobid_xml":"https://content.openalex.org/works/W2156719014.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1480613123","https://openalex.org/W1488279264","https://openalex.org/W1489055488","https://openalex.org/W1495877624","https://openalex.org/W1497955091","https://openalex.org/W1502533342","https://openalex.org/W1510806403","https://openalex.org/W1525365796","https://openalex.org/W1528370780","https://openalex.org/W1532556961","https://openalex.org/W1532856669","https://openalex.org/W1535843470","https://openalex.org/W1536398886","https://openalex.org/W1602825981","https://openalex.org/W1619075339","https://openalex.org/W1621406154","https://openalex.org/W1685289055","https://openalex.org/W1712929562","https://openalex.org/W1738249403","https://openalex.org/W1846959000","https://openalex.org/W1885422414","https://openalex.org/W1934282415","https://openalex.org/W1936017520","https://openalex.org/W1960707077","https://openalex.org/W1965883561","https://openalex.org/W1974841940","https://openalex.org/W1982707123","https://openalex.org/W1988766714","https://openalex.org/W1989054182","https://openalex.org/W1991149253","https://openalex.org/W1994611827","https://openalex.org/W1995455922","https://openalex.org/W1998628246","https://openalex.org/W2004163470","https://openalex.org/W2006572311","https://openalex.org/W2008921565","https://openalex.org/W2014265802","https://openalex.org/W2015481117","https://openalex.org/W2025107875","https://openalex.org/W2026184248","https://openalex.org/W2032891258","https://openalex.org/W2038820646","https://openalex.org/W2055112989","https://openalex.org/W2057611551","https://openalex.org/W2059201099","https://openalex.org/W2062458249","https://openalex.org/W2089882643","https://openalex.org/W2117759649","https://openalex.org/W2127381528","https://openalex.org/W2166420278","https://openalex.org/W2171044922","https://openalex.org/W2343451506","https://openalex.org/W2442403341"],"related_works":["https://openalex.org/W2062774485","https://openalex.org/W2029218512","https://openalex.org/W2024664208","https://openalex.org/W2007984616","https://openalex.org/W2892148890","https://openalex.org/W2987184845","https://openalex.org/W1804821915","https://openalex.org/W7099091699","https://openalex.org/W4281382580","https://openalex.org/W1614466918"],"abstract_inverted_index":{"Cleavage":[0],"and":[1,91,97,122,252,328,405,410],"DNA":[2,24,34,48,60,76,121,154,177,190,196,205,227,319,357,364,368,378,451,465],"joining":[3],"reactions,":[4],"carried":[5],"out":[6],"by":[7,83,93,186,243,253],"human":[8],"immunodeficiency":[9],"virus":[10,471],"type":[11],"1":[12],"(HIV-1)":[13],"integrase,":[14],"are":[15,63,441],"necessary":[16],"to":[17,39,89,134,142,199,223,324,371,409,423],"effect":[18],"the":[19,26,30,36,45,145,153,164,171,176,180,210,259,267,270,285,289,293,317,341,351,355,366,373,377,388,401,416,429,435,458],"covalent":[20],"insertion":[21],"of":[22,32,138,148,159,167,175,182,209,221,235,269,280,331,354,432,454,460],"HIV-1":[23,33,69,149,455],"into":[25,35],"host":[27,58],"genome.":[28],"For":[29],"integration":[31,466],"cellular":[37],"genome":[38],"be":[40,50],"completed,":[41],"short":[42,461],"gaps":[43,225,326,462],"flanking":[44,463],"integrated":[46],"proviral":[47,464],"must":[49],"repaired.":[51],"It":[52],"has":[53],"been":[54,297],"widely":[55],"assumed":[56],"that":[57,68,316,468],"cell":[59],"repair":[61,224,325,372,383,437,459],"enzymes":[62],"involved.":[64],"Here":[65],"we":[66],"report":[67],"integrase":[70,150,168,222,318,367,433,456],"multimers":[71],"possess":[72],"an":[73,135],"intrinsic":[74],"DNA-dependent":[75],"polymerase":[77,155,191,320,369,452],"activity.":[78,156],"The":[79,100,189,219,313,439],"activity":[80,116,124,183],"was":[81,184,228,359,394],"characterized":[82],"its":[84],"dependence":[85],"on":[86,202,249,258,266,387,415],"Mg2+,":[87],"resistance":[88],"N-ethylmaleimide,":[90],"inhibition":[92],"3'-azido-2',3'-dideoxythymidine-5'-triphosphate,":[94],"coumermycin":[95],"A1,":[96],"pyridoxal":[98],"5'-phosphate.":[99],"enzyme":[101],"efficiently":[102,192,327],"utilized":[103],"poly(dA)-oligo(dT)":[104],"or":[105,127,215,275,282,303,336,345],"self-annealing":[106],"oligonucleotides":[107],"as":[108,310,340],"a":[109,194,203,233,239,244,254,300,362,425,444,448],"template":[110,379],"primer":[111,197],"but":[112],"displayed":[113],"relatively":[114],"low":[115],"with":[117,125,299,443],"gapped":[118,236,356],"calf":[119],"thymus":[120],"no":[123],"poly(dA)":[126],"poly(rA)-oligo(dT).":[128],"A":[129,157,381],"monoclonal":[130],"antibody":[131],"binding":[132],"specifically":[133,322],"epitope":[136],"comprised":[137],"amino":[139,161],"acids":[140,162],"264":[141],"273":[143],"near":[144],"C":[146,165,430],"terminus":[147,166,431],"severely":[151],"inhibited":[152],"deletion":[158],"50":[160],"at":[163,217],"drastically":[169],"altered":[170],"gel":[172],"filtration":[173],"properties":[174],"polymerase,":[178],"although":[179,207],"level":[181],"unaffected":[185],"this":[187],"mutation.":[188],"extended":[193],"hairpin":[195],"up":[198],"19":[200],"nucleotides":[201,399],"T20":[204],"template,":[206],"addition":[208],"last":[211,374],"nucleotide":[212,375],"occurred":[213],"infrequently":[214],"not":[216],"all.":[218],"ability":[220],"in":[226,284,292,376,434,457],"also":[229,421],"investigated.":[230],"We":[231,419],"designed":[232,323],"series":[234],"molecules":[237],"containing":[238],"single-stranded":[240,286],"region":[241],"flanked":[242],"duplex":[245,255],"U5":[246,352],"viral":[247,294],"arm":[248,257,295,353],"one":[250],"side":[251],"nonviral":[256,301],"other":[260],"side.":[261],"Molecules":[262],"varied":[263],"structurally":[264],"depending":[265],"size":[268],"gap":[271,332,402],"(one,":[272],"two,":[273],"five,":[274],"seven":[276],"nucleotides),":[277],"their":[278,413],"content":[279],"T's":[281],"C's":[283],"region,":[287],"whether":[288,304],"CA":[290,343,389,417],"dinucleotide":[291,344],"had":[296],"replaced":[298],"sequence,":[302],"they":[305],"contained":[306],"5'":[307],"AC":[308,348],"dinucleotides":[309],"unpaired":[311,346],"tails.":[312],"results":[314,440],"indicated":[315],"is":[321],"completely,":[329],"regardless":[330],"size,":[333],"base":[334],"composition,":[335],"structural":[337],"features":[338],"such":[339],"internal":[342],"5'-terminal":[347],"dinucleotides.":[349],"When":[350],"substrate":[358],"removed,":[360],"leaving":[361],"nongapped":[363],"template-primer,":[365],"failed":[370],"effectively.":[380],"post-gap":[382,436],"reaction":[384,393],"did":[385],"depend":[386],"dinucleotide.":[390,418],"This":[391],"secondary":[392],"highly":[395],"regulated.":[396],"Only":[397],"two":[398],"beyond":[400],"were":[403,407,420],"synthesized,":[404],"these":[406],"complementary":[408],"dependent":[411],"for":[412,428,447],"synthesis":[414],"able":[422],"identify":[424],"specific":[426],"requirement":[427],"reaction.":[438],"consistent":[442],"direct":[445],"role":[446],"heretofore":[449],"unsuspected":[450],"function":[453],"intermediates":[467],"arise":[469],"during":[470],"infection.":[472]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}