{"id":"https://openalex.org/W2156700619","doi":"https://doi.org/10.1200/jco.2007.13.1193","title":"EPIC: Phase III Trial of Cetuximab Plus Irinotecan After Fluoropyrimidine and Oxaliplatin Failure in Patients With Metastatic Colorectal Cancer","display_name":"EPIC: Phase III Trial of Cetuximab Plus Irinotecan After Fluoropyrimidine and Oxaliplatin Failure in Patients With Metastatic Colorectal Cancer","publication_year":2008,"publication_date":"2008-04-08","ids":{"openalex":"https://openalex.org/W2156700619","doi":"https://doi.org/10.1200/jco.2007.13.1193","mag":"2156700619","pmid":"https://pubmed.ncbi.nlm.nih.gov/18390971"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.13.1193","doi":"https://doi.org/10.1200/jco.2007.13.1193","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2007.13.1193","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2007.13.1193?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2007.13.1193?role=tab","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011308487","display_name":"Alberto Felice Sobrero","orcid":"https://orcid.org/0000-0001-7764-673X","observed_orcids":["https://orcid.org/0000-0001-7764-673X"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Alberto F. Sobrero","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028687949","display_name":"Joan Maurel","orcid":"https://orcid.org/0000-0002-9413-5592","observed_orcids":["https://orcid.org/0000-0002-9413-5592"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Joan Maurel","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074479466","display_name":"Louis Fehrenbacher","orcid":"https://orcid.org/0000-0002-1300-1905","observed_orcids":["https://orcid.org/0000-0002-1300-1905"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Louis Fehrenbacher","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108460887","display_name":"Werner Scheithauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Werner Scheithauer","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111549659","display_name":"Yousif A. Abubakr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Yousif A. Abubakr","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066686378","display_name":"Manfred Paul Lutz","orcid":"https://orcid.org/0000-0003-1989-4553","observed_orcids":["https://orcid.org/0000-0003-1989-4553"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Manfred P. Lutz","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109157282","display_name":"M. E. Vega-Villegas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"M. Eugenia Vega-Villegas","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009132832","display_name":"Cathy Eng","orcid":"https://orcid.org/0000-0003-2335-0612","observed_orcids":["https://orcid.org/0000-0003-2335-0612"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Cathy Eng","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110261596","display_name":"Ernst U. Steinhauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Ernst U. Steinhauer","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020077097","display_name":"Jana Prausov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Jana Prausova","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045441776","display_name":"Heinz\u2010Josef Lenz","orcid":"https://orcid.org/0000-0003-2178-9568","observed_orcids":["https://orcid.org/0000-0003-2178-9568"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Heinz-Josef Lenz","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022288769","display_name":"Christophe Borg","orcid":"https://orcid.org/0000-0002-2167-1458","observed_orcids":["https://orcid.org/0000-0002-2167-1458","https://orcid.org/0000-0001-6161-0169"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Christophe Borg","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037541807","display_name":"Gary Middleton","orcid":"https://orcid.org/0000-0001-5695-3474","observed_orcids":["https://orcid.org/0000-0001-5695-3474"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Gary Middleton","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110057516","display_name":"Hendrik Kr\u00f6ning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Hendrik Kr\u00f6ning","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076874377","display_name":"Gabriele Luppi","orcid":"https://orcid.org/0000-0001-8520-1351","observed_orcids":["https://orcid.org/0000-0001-8520-1351"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Gabriele Luppi","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025870969","display_name":"Oliver Kisker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Oliver Kisker","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015424908","display_name":"Angela Zubel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Angela Zubel","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083779552","display_name":"Christiane Langer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Christiane Langer","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034809035","display_name":"Justin Kopit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Justin Kopit","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072308451","display_name":"Howard A. Burris","orcid":"https://orcid.org/0000-0002-1501-2931","observed_orcids":["https://orcid.org/0000-0002-1501-2931"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]},{"id":"https://openalex.org/I4210109058","display_name":"Azienda Ospedaliero-Universitaria di Modena","ror":"https://ror.org/01hmmsr16","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109058"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE","ES","IT"],"is_corresponding":false,"raw_author_name":"Howard A. Burris","raw_affiliation_strings":["From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology, Ospedale San Martino, Genoa; Department of Oncology and Hematology, Policlinico, Modena, Italy; Department of Medical Oncology, Hospital Cl\u00ednic Barcelona, CIBERehd, Barcelona; Hospital Universitario Marques de Valdecilla, Santander, Spain; Clinical Division of Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Austria; Caritasklinik St. Theresia, Saarbr\u00fccken; Department of Hematology/Oncology, Klinikum Kassel, Kassel; Oncological","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I4210099858","https://openalex.org/I4210109058","https://openalex.org/I4210115097","https://openalex.org/I4210146472","https://openalex.org/I4210150299","https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":41.9089,"has_fulltext":true,"cited_by_count":946,"citation_normalized_percentile":{"value":0.99918535,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"26","issue":"14","first_page":"2311","last_page":"2319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":1.0},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.8600000143051147},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.7139999866485596},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.875},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hypomagnesemia","display_name":"hypomagnesemia","score":0.8119999766349792},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5820000171661377},{"id":"https://openalex.org/keywords/anti-egfr-therapy","display_name":"anti-EGFR therapy","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.9337249398231506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.92063307762146},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.9032630920410156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.757723331451416},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6524127125740051},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.6174225211143494},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5422218441963196},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5305956602096558},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5059689879417419},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.4110979437828064},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37981635332107544},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30590102076530457},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2730720639228821},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.23040664196014404},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.17765921354293823}],"mesh":[{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1200/jco.2007.13.1193","doi":"https://doi.org/10.1200/jco.2007.13.1193","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2007.13.1193","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2007.13.1193?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:18390971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18390971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:HAL:inserm-00484211v1","doi":null,"is_oa":false,"landing_page_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2007.13.1193","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Oncology, 2008, 26 (14), pp.2311-9. &#x27E8;10.1200/JCO.2007.13.1193&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/b27be7cb-1d78-41c2-ad5e-77d703aff26d","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/b27be7cb-1d78-41c2-ad5e-77d703aff26d","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:zenodo.org:205324","doi":null,"is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/205324","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5281/zenodo.205324","doi":"https://doi.org/10.5281/zenodo.205324","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.205324","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Image"}],"best_oa_location":{"id":"doi:10.1200/jco.2007.13.1193","doi":"https://doi.org/10.1200/jco.2007.13.1193","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2007.13.1193","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2007.13.1193?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308982","display_name":"American Society of Clinical Oncology","ror":"https://ror.org/04fy6j421"},{"id":"https://openalex.org/F4320311647","display_name":"Merck KGaA","ror":"https://ror.org/04b2dty93"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2156700619.pdf","grobid_xml":"https://content.openalex.org/works/W2156700619.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1847661643","https://openalex.org/W1952393227","https://openalex.org/W2003680979","https://openalex.org/W2006824814","https://openalex.org/W2053230335","https://openalex.org/W2096122707","https://openalex.org/W2097121246","https://openalex.org/W2098737602","https://openalex.org/W2101020979","https://openalex.org/W2104389711","https://openalex.org/W2112727687","https://openalex.org/W2114682727","https://openalex.org/W2115790682","https://openalex.org/W2121368761","https://openalex.org/W2124560610","https://openalex.org/W2128403792","https://openalex.org/W2128447158","https://openalex.org/W2133399075","https://openalex.org/W2142564546","https://openalex.org/W2146100972","https://openalex.org/W2157416388","https://openalex.org/W2157769714","https://openalex.org/W2164837623","https://openalex.org/W2167571044","https://openalex.org/W2168213749","https://openalex.org/W2168377135","https://openalex.org/W2227477053","https://openalex.org/W2314927739","https://openalex.org/W2318605753","https://openalex.org/W2409420104","https://openalex.org/W2418338096","https://openalex.org/W2619195059","https://openalex.org/W3149591292"],"related_works":["https://openalex.org/W2091789348","https://openalex.org/W2153166088","https://openalex.org/W2068448950","https://openalex.org/W2142100270","https://openalex.org/W2518044072","https://openalex.org/W2006216255","https://openalex.org/W2072499010","https://openalex.org/W2380609539","https://openalex.org/W1982756255","https://openalex.org/W2187791819"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"whether":[3],"adding":[4],"cetuximab":[5,52,152,270],"to":[6,51,106,116,128,141,148,164,179],"irinotecan":[7,63,70,119,149,165,237,248,266,272],"prolongs":[8],"survival":[9,77,84],"in":[10,194,198,244,264],"patients":[11,35,146,263],"with":[12,19,36,108,118,160],"metastatic":[13],"colorectal":[14],"cancer":[15],"(mCRC)":[16],"previously":[17],"treated":[18],"fluoropyrimidine":[20,46],"and":[21,47,89,110,184,192,220,236,240,242,271],"oxaliplatin.":[22],"PATIENTS":[23],"AND":[24],"METHODS:":[25],"This":[26,133],"multicenter,":[27],"open-label,":[28],"phase":[29],"III":[30],"study":[31,254],"randomly":[32],"assigned":[33,147],"1,298":[34],"epidermal":[37],"growth":[38],"factor":[39],"receptor-expressing":[40],"mCRC":[41],"who":[42,156,268],"had":[43],"experienced":[44],"first-line":[45],"oxaliplatin":[48],"treatment":[49,232],"failure":[50],"(400":[53],"mg/m(2)":[54,60,65],"day":[55],"1":[56],"followed":[57],"by":[58,258],"250":[59],"weekly)":[61],"plus":[62],"(350":[64],"every":[66],"3":[67],"weeks)":[68],"or":[69],"alone.":[71,249],"Primary":[72],"end":[73,80],"point":[74],"was":[75,97,225,251],"overall":[76],"(OS);":[78],"secondary":[79],"points":[81],"included":[82],"progression-free":[83],"(PFS),":[85],"response":[86],"rate":[87],"(RR),":[88],"quality":[90],"of":[91,135,145,154,202,262],"life":[92],"(QOL).":[93],"RESULTS:":[94],"Median":[95],"OS":[96,250],"comparable":[98],"between":[99,253],"treatments:":[100],"10.7":[101],"months":[102,112],"(95%":[103,113],"CI,":[104,114,126,177],"9.6":[105],"11.3)":[107,117],"cetuximab/irinotecan":[109],"10.0":[111],"9.1":[115],"alone":[120],"(hazard":[121],"ratio":[122],"[HR],":[123],"0.975;":[124],"95%":[125,176],"0.854":[127],"1.114;":[129],"P":[130,181,189],"=":[131,207],".71).":[132],"lack":[134],"difference":[136],"may":[137],"have":[138],"been":[139],"due":[140],"post-trial":[142],"therapy:":[143],"46.9%":[144],"eventually":[150],"received":[151,158,269],"(87.2%":[153],"those":[155],"did,":[157],"it":[159],"irinotecan).":[161],"Cetuximab":[162,209,235],"added":[163],"significantly":[166,195],"improved":[167,238],"PFS":[168,239],"(median,":[169],"4.0":[170],"v":[171,187],"2.6":[172],"months;":[173],"HR,":[174],"0.692;":[175],"0.617":[178],"0.776;":[180],"<or=":[182],".0001)":[183],"RR":[185],"(16.4%":[186],"4.2%;":[188],"<":[190],".0001),":[191],"resulted":[193,243],"better":[196,245],"scores":[197],"the":[199,226,259,265],"QOL":[200,246],"analysis":[201],"global":[203],"health":[204],"status":[205],"(P":[206],".047).":[208],"did":[210],"not":[211],"exacerbate":[212],"toxicity,":[213],"except":[214],"for":[215],"acneform":[216],"rash,":[217],"diarrhea,":[218],"hypomagnesemia,":[219],"associated":[221],"electrolyte":[222],"imbalances.":[223],"Neutropenia":[224],"most":[227],"common":[228],"severe":[229],"toxicity":[230],"across":[231],"arms.":[233],"CONCLUSION:":[234],"RR,":[241],"versus":[247],"similar":[252],"groups,":[255],"possibly":[256],"influenced":[257],"large":[260],"number":[261],"arm":[267],"poststudy.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":29},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":45},{"year":2019,"cited_by_count":36},{"year":2018,"cited_by_count":38},{"year":2017,"cited_by_count":47},{"year":2016,"cited_by_count":55},{"year":2015,"cited_by_count":69},{"year":2014,"cited_by_count":86},{"year":2013,"cited_by_count":96},{"year":2012,"cited_by_count":72}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}