{"id":"https://openalex.org/W2156641905","doi":"https://doi.org/10.1677/joe.0.1780533","title":"GH and ghrelin increase with fasting in a naturally adapted species, the northern elephant seal (Mirounga angustirostris)","display_name":"GH and ghrelin increase with fasting in a naturally adapted species, the northern elephant seal (Mirounga angustirostris)","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W2156641905","doi":"https://doi.org/10.1677/joe.0.1780533","mag":"2156641905","pmid":"https://pubmed.ncbi.nlm.nih.gov/12967344"},"language":"en","primary_location":{"id":"doi:10.1677/joe.0.1780533","doi":"https://doi.org/10.1677/joe.0.1780533","is_oa":true,"landing_page_url":"https://doi.org/10.1677/joe.0.1780533","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/178/3/533.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/178/3/533.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102160971","display_name":"RM Ortiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"RM Ortiz","raw_affiliation_strings":["Department of Biology, University of California, Santa Cruz, California 95064, USA. rortiz1@tulane.edu","Department of Biology, University of California, Santa Cruz, California 95064, USA","Department of Physiology SL-39, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, Louisiana 70112, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of California, Santa Cruz, California 95064, USA. rortiz1@tulane.edu","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Department of Biology, University of California, Santa Cruz, California 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Department of Physiology SL-39, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, Louisiana 70112, USA;","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015582157","display_name":"Dawn P. Noren","orcid":"https://orcid.org/0000-0002-9544-4530","observed_orcids":["https://orcid.org/0000-0002-9544-4530"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DP Noren","raw_affiliation_strings":["Department of Biology, University of California, Santa Cruz, California 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of California, Santa Cruz, California 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103573625","display_name":"CL Ortiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CL Ortiz","raw_affiliation_strings":["Department of Biology, University of California, Santa Cruz, California 95064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of California, Santa Cruz, California 95064, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033066814","display_name":"Frank J. Talamantes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Talamantes","raw_affiliation_strings":["Department of Biology, University of California, Santa Cruz, California 95064, USA","Department of Physiology SL-39 , Tulane University Health Sciences Center , 1430 Tulane Ave , New Orleans , Louisiana 70112 , USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of California, Santa Cruz, California 95064, USA","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Department of Physiology SL-39 , Tulane University Health Sciences Center , 1430 Tulane Ave , New Orleans , Louisiana 70112 , USA;","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102160971"],"corresponding_institution_ids":["https://openalex.org/I114832834","https://openalex.org/I185103710"],"apc_list":null,"apc_paid":null,"fwci":1.0173,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.79312321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"178","issue":"3","first_page":"533","last_page":"539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.6967999935150146,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.6967999935150146,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.26339998841285706,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/northern-elephant-seal","display_name":"northern elephant seal","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fasting","display_name":"fasting","score":0.7400000095367432},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":1.0},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9440000057220459},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.9869999885559082},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9509999752044678},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.9490000009536743},{"id":"https://openalex.org/keywords/blood-urea-nitrogen","display_name":"blood urea nitrogen","score":0.9580000042915344},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/protein-sparing","display_name":"protein sparing","score":0.9210000038146973},{"id":"https://openalex.org/keywords/fat-oxidation","display_name":"fat oxidation","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9190924763679504},{"id":"https://openalex.org/C2779772378","wikidata":"https://www.wikidata.org/wiki/Q6953452","display_name":"NEFA","level":3,"score":0.9114020466804504},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.9034634828567505},{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.7030507326126099},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.6170216798782349},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6049038767814636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5560688376426697},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.474107563495636},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.4189299941062927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18384292721748352},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.1632334291934967}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014886","descriptor_name":"Weaning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046048","descriptor_name":"Seals, Earless","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1677/joe.0.1780533","doi":"https://doi.org/10.1677/joe.0.1780533","is_oa":true,"landing_page_url":"https://doi.org/10.1677/joe.0.1780533","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/178/3/533.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:12967344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12967344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1677/joe.0.1780533","doi":"https://doi.org/10.1677/joe.0.1780533","is_oa":true,"landing_page_url":"https://doi.org/10.1677/joe.0.1780533","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/178/3/533.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1119485945","display_name":"University of California, Santa Cruz IMSD Program","funder_award_id":"5r25gm058903-20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3252883980","display_name":null,"funder_award_id":"GM 58903-01","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333677","display_name":"Office of the President, University of California","ror":"https://ror.org/00dmfq477"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337772","display_name":"National Marine Fisheries Service","ror":"https://ror.org/033mqx355"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2156641905.pdf","grobid_xml":"https://content.openalex.org/works/W2156641905.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W11515472","https://openalex.org/W1616806865","https://openalex.org/W1637971961","https://openalex.org/W1841690979","https://openalex.org/W1908337624","https://openalex.org/W1964652533","https://openalex.org/W1964848585","https://openalex.org/W1990602060","https://openalex.org/W2004598521","https://openalex.org/W2010255616","https://openalex.org/W2012710632","https://openalex.org/W2017053735","https://openalex.org/W2021725988","https://openalex.org/W2031664768","https://openalex.org/W2033468788","https://openalex.org/W2038164529","https://openalex.org/W2049284415","https://openalex.org/W2049585279","https://openalex.org/W2062175236","https://openalex.org/W2063962883","https://openalex.org/W2090389952","https://openalex.org/W2095415951","https://openalex.org/W2097497540","https://openalex.org/W2105573142","https://openalex.org/W2111536564","https://openalex.org/W2113628166","https://openalex.org/W2124735849","https://openalex.org/W2141610601","https://openalex.org/W2158711945","https://openalex.org/W2161559015","https://openalex.org/W2163865122","https://openalex.org/W2170967182","https://openalex.org/W2275751129","https://openalex.org/W2303539230","https://openalex.org/W2331609610","https://openalex.org/W2970853907","https://openalex.org/W4241398143","https://openalex.org/W4251040403"],"related_works":["https://openalex.org/W2097497540","https://openalex.org/W2095415951","https://openalex.org/W2417877125","https://openalex.org/W2065074701","https://openalex.org/W2058873776","https://openalex.org/W2169337619","https://openalex.org/W1985464247","https://openalex.org/W3175026045","https://openalex.org/W2008434697","https://openalex.org/W2070600895"],"abstract_inverted_index":{"After":[0],"nursing,":[1],"pups":[2,49,98,249],"of":[3,22,43,225,247],"the":[4,20,32,56,111,165,173,187,223,245],"northern":[5],"elephant":[6],"seal":[7,248],"(Mirounga":[8],"angustirostris)":[9],"are":[10],"approximately":[11],"46%":[12,148],"body":[13],"fat":[14,25],"and":[15,85,95,105,117,123,127,133,137,145,149,155,160,179,190,194,199,234],"rely":[16],"almost":[17],"entirely":[18],"on":[19],"oxidation":[21],"their":[23,29,44],"large":[24],"stores":[26],"to":[27,54,183],"sustain":[28],"metabolism":[30,246],"for":[31,218],"ensuing":[33],"8-12":[34],"week":[35,103],"postweaning":[36],"fast,":[37],"which":[38],"is":[39],"a":[40,65,170],"natural":[41],"component":[42],"life":[45],"history.":[46],"Thus,":[47],"fasting":[48,201],"provide":[50],"an":[51],"ideal":[52],"opportunity":[53],"examine":[55],"hormonal":[57],"alterations":[58],"associated":[59],"with":[60,158],"prolonged":[61,251],"food":[62],"deprivation":[63],"in":[64,92,213,222,230,243],"naturally":[66],"adapted":[67],"model.":[68],"Cortisol,":[69],"ghrelin,":[70,115,232],"glucagon,":[71,220,233],"growth":[72,76],"hormone":[73],"(GH),":[74],"insulin-like":[75],"factor-I":[77],"(IGF-I),":[78],"insulin,":[79],"blood":[80,99],"urea":[81],"nitrogen":[82],"(BUN),":[83],"glucose":[84,146,214],"non-esterified":[86],"fatty":[87],"acids":[88],"(NEFA)":[89],"were":[90,192],"examined":[91,168],"20":[93,96],"male":[94],"female":[97],"sampled":[100],"early":[101,126,198],"(<1":[102],"postweaning)":[104,109],"late":[106,128,200],"(6-8":[107],"weeks":[108],"during":[110,186,250],"fast.":[112,188],"Mean":[113],"cortisol,":[114,231],"GH,":[116],"glucagon":[118],"increased":[119,141],"1.8-,":[120,121],"1.4-,":[122],"2.3-fold":[124],"between":[125,197],"periods,":[129],"while":[130,143],"mean":[131],"IGF-I":[132],"insulin":[134],"decreased":[135,147],"97%":[136],"38%,":[138],"respectively.":[139,151],"NEFA":[140,152],"2.3-fold,":[142],"BUN":[144,191],"11%,":[150],"was":[153,167],"significantly":[154,195],"positively":[156],"correlated":[157,196],"cortisol":[159,178],"GH;":[161],"individually;":[162],"however,":[163],"when":[164],"relationship":[166],"as":[169,209],"multiple":[171],"regression":[172],"correlation":[174],"improved":[175],"suggesting":[176,202],"that":[177,203,237],"GH":[180,189,204,235],"act":[181],"synergistically":[182],"promote":[184,206],"lipolysis":[185],"negatively":[193],"may":[205,215,240],"protein":[207],"sparing":[208],"well.":[210],"The":[211,228],"decrease":[212],"be":[216,241],"responsible":[217],"stimulating":[219],"resulting":[221],"maintenance":[224],"relative":[226],"hyperglycemia.":[227],"increases":[229],"suggest":[236],"these":[238],"hormones":[239],"integral":[242],"mediating":[244],"fasting.":[252]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
