{"id":"https://openalex.org/W2156454419","doi":"https://doi.org/10.1002/prot.22743","title":"Differential effects of phe19 and phe20 on fibril formation by amyloidogenic peptide A\u03b216\u201322 (Ac\u2010KLVFFAE\u2010NH2)","display_name":"Differential effects of phe19 and phe20 on fibril formation by amyloidogenic peptide A\u03b216\u201322 (Ac\u2010KLVFFAE\u2010NH2)","publication_year":2010,"publication_date":"2010-04-12","ids":{"openalex":"https://openalex.org/W2156454419","doi":"https://doi.org/10.1002/prot.22743","mag":"2156454419","pmid":"https://pubmed.ncbi.nlm.nih.gov/20544966"},"language":"en","primary_location":{"id":"doi:10.1002/prot.22743","doi":"https://doi.org/10.1002/prot.22743","is_oa":false,"landing_page_url":"https://doi.org/10.1002/prot.22743","pdf_url":null,"source":{"id":"https://openalex.org/S121161810","display_name":"Proteins Structure Function and Bioinformatics","issn_l":"0887-3585","issn":["0887-3585","1097-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteins: Structure, Function, and Bioinformatics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031751687","display_name":"Hideyo Inouye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]},{"id":"https://openalex.org/I4210114347","display_name":"Rigaku (Japan)","ror":"https://ror.org/01z4jpw82","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210114347"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hideyo Inouye","raw_affiliation_strings":["Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA","Current address: X-ray Analysis Division, Rigaku Corporation, 3-9-12, Matsubara-cho Akishima-shi, Tokyo 196-8666, Japan","Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA","institution_ids":["https://openalex.org/I103531236"]},{"raw_affiliation_string":"Current address: X-ray Analysis Division, Rigaku Corporation, 3-9-12, Matsubara-cho Akishima-shi, Tokyo 196-8666, Japan","institution_ids":["https://openalex.org/I4210114347"]},{"raw_affiliation_string":"Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029406319","display_name":"Katherine A. Gleason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine A. Gleason","raw_affiliation_strings":["Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467","institution_ids":["https://openalex.org/I103531236"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150693791","display_name":"Mount Holyoke College","ror":"https://ror.org/031z8pr38","country_code":"US","type":"education","lineage":["https://openalex.org/I150693791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Zhang","raw_affiliation_strings":["Department of Chemistry, Mount Holyoke College, South Hadley, Massachusetts 01075"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Mount Holyoke College, South Hadley, Massachusetts 01075","institution_ids":["https://openalex.org/I150693791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111686065","display_name":"Sean M. Decatur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150693791","display_name":"Mount Holyoke College","ror":"https://ror.org/031z8pr38","country_code":"US","type":"education","lineage":["https://openalex.org/I150693791"]},{"id":"https://openalex.org/I70571728","display_name":"Oberlin College","ror":"https://ror.org/05ac26z88","country_code":"US","type":"education","lineage":["https://openalex.org/I70571728"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean M. Decatur","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Oberlin College, Oberlin, OH 44074, USA","Department of Chemistry, Mount Holyoke College, South Hadley, Massachusetts 01075"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Oberlin College, Oberlin, OH 44074, USA","institution_ids":["https://openalex.org/I70571728"]},{"raw_affiliation_string":"Department of Chemistry, Mount Holyoke College, South Hadley, Massachusetts 01075","institution_ids":["https://openalex.org/I150693791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039151870","display_name":"Daniel A. Kirschner","orcid":"https://orcid.org/0000-0003-3498-1452","observed_orcids":["https://orcid.org/0000-0003-3498-1452"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel A. Kirschner","raw_affiliation_strings":["Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467","institution_ids":["https://openalex.org/I103531236"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5039151870"],"corresponding_institution_ids":["https://openalex.org/I103531236"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":2.4539,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.88857595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"78","issue":"10","first_page":"2306","last_page":"2321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta-16-22","display_name":"amyloid-beta 16-22","score":0.8320000171661377},{"id":"https://openalex.org/keywords/fibril-formation","display_name":"fibril formation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6230000257492065},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.6859999895095825},{"id":"https://openalex.org/keywords/peptide-self-assembly","display_name":"peptide self-assembly","score":0.6060000061988831},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.593999981880188},{"id":"https://openalex.org/keywords/x-ray-fiber-diffraction","display_name":"X-ray fiber diffraction","score":0.7289999723434448},{"id":"https://openalex.org/keywords/infrared-spectroscopy","display_name":"infrared spectroscopy","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.6694475412368774},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6106384992599487},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.4992702007293701},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4831782877445221},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.43540680408477783},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.39300230145454407},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37283697724342346},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.33676886558532715},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2122921347618103},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.1690053939819336},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15743198990821838},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10712602734565735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.077800452709198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06737461686134338},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.06427478790283203},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005612","descriptor_name":"Freeze Drying","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013055","descriptor_name":"Spectrophotometry, Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033362","descriptor_name":"Powder Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/prot.22743","doi":"https://doi.org/10.1002/prot.22743","is_oa":false,"landing_page_url":"https://doi.org/10.1002/prot.22743","pdf_url":null,"source":{"id":"https://openalex.org/S121161810","display_name":"Proteins Structure Function and Bioinformatics","issn_l":"0887-3585","issn":["0887-3585","1097-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteins: Structure, Function, and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20544966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20544966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteins","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W19362288","https://openalex.org/W1503605661","https://openalex.org/W1574786843","https://openalex.org/W1603204990","https://openalex.org/W1965153954","https://openalex.org/W1971452956","https://openalex.org/W1972847254","https://openalex.org/W1975383146","https://openalex.org/W1976210162","https://openalex.org/W1977646659","https://openalex.org/W1977687419","https://openalex.org/W1980706539","https://openalex.org/W1980709154","https://openalex.org/W1982695192","https://openalex.org/W1985178780","https://openalex.org/W1990592765","https://openalex.org/W1992257884","https://openalex.org/W1992556206","https://openalex.org/W1993262901","https://openalex.org/W1994448876","https://openalex.org/W1996667889","https://openalex.org/W1998454170","https://openalex.org/W2000523989","https://openalex.org/W2000659036","https://openalex.org/W2000683826","https://openalex.org/W2001204474","https://openalex.org/W2004098528","https://openalex.org/W2004286543","https://openalex.org/W2006817353","https://openalex.org/W2008307658","https://openalex.org/W2008524154","https://openalex.org/W2008966525","https://openalex.org/W2011056613","https://openalex.org/W2014451295","https://openalex.org/W2019369720","https://openalex.org/W2021895448","https://openalex.org/W2022323132","https://openalex.org/W2025209357","https://openalex.org/W2029554137","https://openalex.org/W2030749300","https://openalex.org/W2032419204","https://openalex.org/W2054534026","https://openalex.org/W2058515217","https://openalex.org/W2065979278","https://openalex.org/W2067214887","https://openalex.org/W2072327749","https://openalex.org/W2076403207","https://openalex.org/W2076461761","https://openalex.org/W2079990598","https://openalex.org/W2081657801","https://openalex.org/W2084324333","https://openalex.org/W2086024092","https://openalex.org/W2092806451","https://openalex.org/W2092809867","https://openalex.org/W2092887599","https://openalex.org/W2102589172","https://openalex.org/W2103298870","https://openalex.org/W2108595869","https://openalex.org/W2114648545","https://openalex.org/W2117959132","https://openalex.org/W2118280241","https://openalex.org/W2122294662","https://openalex.org/W2130104108","https://openalex.org/W2139157463","https://openalex.org/W2142692094","https://openalex.org/W2147443012","https://openalex.org/W2162741488","https://openalex.org/W2168780779","https://openalex.org/W2327480334","https://openalex.org/W2334646058","https://openalex.org/W2749203687","https://openalex.org/W4250104128"],"related_works":["https://openalex.org/W2005791922","https://openalex.org/W2079720739","https://openalex.org/W2072327749","https://openalex.org/W2110153587","https://openalex.org/W2108880064","https://openalex.org/W2029665220","https://openalex.org/W1992556206","https://openalex.org/W2079757770","https://openalex.org/W1897961240","https://openalex.org/W7096663245"],"abstract_inverted_index":{"The":[0,110,139],"sequence":[1],"KLVFFAE":[2],"(A":[3],"beta":[4,60,76,173],"16-22)":[5],"in":[6,35,167,188,217,226,240,243],"Alzheimer's":[7],"beta-amyloid":[8],"is":[9,179,186,208],"thought":[10],"to":[11,56,105],"be":[12],"a":[13,20,230],"core":[14],"beta-structure":[15],"that":[16,97,166],"could":[17],"act":[18],"as":[19],"template":[21],"for":[22,152,158,211,222,236],"folding":[23,44],"other":[24],"parts":[25],"of":[26,41,123,170,233],"the":[27,39,42,79,102,106,121,124,127,132,144,168,175,182,195,199,205,212,223,237],"polypeptide":[28,107],"or":[29,86],"molecules":[30],"into":[31],"fibrillar":[32],"assemblies":[33,114,134],"rich":[34],"beta-sheet.":[36],"To":[37],"elucidate":[38],"mechanism":[40],"initial":[43],"process,":[45],"we":[46],"undertook":[47],"combined":[48],"X-ray":[49,161],"fiber/powder":[50],"diffraction":[51],"and":[52,62,78,112,154,163,185],"infrared":[53],"(IR)":[54],"spectroscopy":[55],"analyze":[57],"lyophilized":[58],"A":[59,75,172],"16-22":[61,77,174],"solubilized/dried":[63],"peptide":[64,80,128,145],"containing":[65,81],"nitrile":[66,238],"probes":[67],"at":[68,83,87],"F19":[69,84,176],"and/or":[70],"F20.":[71],"Solubilized/dried":[72],"wild-type":[73],"(WT)":[74],"cyanophenylalanine":[82],"(19CN)":[85],"F20":[88,200],"(20CN)":[89],"gave":[90],"fiber":[91],"patterns":[92],"consistent":[93],"with":[94,191],"slab-like":[95],"beta-crystallites":[96],"were":[98],"cylindrically":[99],"averaged":[100],"around":[101],"axis":[103],"parallel":[104],"chain":[108,129,146,178,202],"direction.":[109],"WT":[111,153,171],"19CN":[113],"showed":[115,229],"30-A":[116],"period":[117],"arrays":[118],"arising":[119],"from":[120],"stacking":[122],"slabs":[125],"along":[126,143],"direction,":[130],"whereas":[131,198],"20CN":[133,241],"lacked":[135],"any":[136],"such":[137],"stacking.":[138,219],"electron":[140],"density":[141],"projection":[142],"direction":[147],"indicated":[148],"similar":[149],"side-chain":[150],"dispositions":[151],"20CN,":[155],"but":[156,215],"not":[157],"19CN.":[159],"These":[160],"results":[162],"modeling":[164],"imply":[165],"assembly":[169],"side":[177,201],"localized":[180,203],"within":[181],"intersheet":[183,196,213],"space":[184],"involved":[187,216],"hydrophobic":[189],"contact":[190],"amino":[192],"acids":[193],"across":[194],"space,":[197],"near":[204],"slab":[206,218],"surface":[207],"less":[209],"important":[210],"interaction,":[214],"IR":[220],"observations":[221],"same":[224],"peptides":[225],"dilute":[227],"solution":[228],"greater":[231],"degree":[232],"hydrogen":[234],"bonding":[235],"groups":[239],"than":[242],"19CN,":[244],"supporting":[245],"this":[246],"interpretation.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}