{"id":"https://openalex.org/W2156426014","doi":"https://doi.org/10.1073/pnas.1303916110","title":"Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration","display_name":"Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration","publication_year":2013,"publication_date":"2013-05-06","ids":{"openalex":"https://openalex.org/W2156426014","doi":"https://doi.org/10.1073/pnas.1303916110","mag":"2156426014","pmid":"https://pubmed.ncbi.nlm.nih.gov/23650370","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3666708"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1303916110","doi":"https://doi.org/10.1073/pnas.1303916110","is_oa":false,"landing_page_url":"https://www.pnas.org/content/pnas/110/21/E1923.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3666708","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037537612","display_name":"Hea-Jin Jung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hea-Jin Jung","raw_affiliation_strings":["Molecular Biology Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008166631","display_name":"Chika Nobumori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chika Nobumori","raw_affiliation_strings":["Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040915172","display_name":"Chris N. Goulbourne","orcid":"https://orcid.org/0000-0003-1185-2682","observed_orcids":["https://orcid.org/0000-0003-1185-2682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris N. Goulbourne","raw_affiliation_strings":["Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017708813","display_name":"Yiping Tu","orcid":"https://orcid.org/0000-0002-4630-9113","observed_orcids":["https://orcid.org/0000-0002-4630-9113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiping Tu","raw_affiliation_strings":["Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000331309","display_name":"John Michael Lee","orcid":"https://orcid.org/0000-0001-8473-4674","observed_orcids":["https://orcid.org/0000-0001-8473-4674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Lee","raw_affiliation_strings":["Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055875192","display_name":"Angelica Tatar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angelica Tatar","raw_affiliation_strings":["Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034606058","display_name":"Daniel Y. Wu","orcid":"https://orcid.org/0000-0002-3242-5172","observed_orcids":["https://orcid.org/0000-0002-3242-5172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Wu","raw_affiliation_strings":["Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057960297","display_name":"Yuko Yoshinaga","orcid":"https://orcid.org/0000-0002-4978-9394","observed_orcids":["https://orcid.org/0000-0002-4978-9394"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuko Yoshinaga","raw_affiliation_strings":["Children\u2019s Hospital Oakland Research Institute, Oakland, CA 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Oakland Research Institute, Oakland, CA 94609","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101563372","display_name":"Pieter J. de Jong","orcid":"https://orcid.org/0000-0002-7972-5260","observed_orcids":["https://orcid.org/0000-0002-7972-5260"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pieter J. de Jong","raw_affiliation_strings":["Children\u2019s Hospital Oakland Research Institute, Oakland, CA 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Oakland Research Institute, Oakland, CA 94609","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039907737","display_name":"Catherine Coffinier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Coffinier","raw_affiliation_strings":["Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068606823","display_name":"Loren G. Fong","orcid":"https://orcid.org/0000-0002-4465-5290","observed_orcids":["https://orcid.org/0000-0002-4465-5290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Loren G. Fong","raw_affiliation_strings":["Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085755071","display_name":"Stephen G. Young","orcid":"https://orcid.org/0000-0001-7270-3176","observed_orcids":["https://orcid.org/0000-0001-7270-3176"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen G. Young","raw_affiliation_strings":["Department of Human Genetics, University of California, Los Angeles, CA 90095; and","Department of Medicine, and","Molecular Biology Institute,","Department of Human Genetics, University of California, Los Angeles, CA 90095; and; Department of Medicine, and; Molecular Biology Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of California, Los Angeles, CA 90095; and","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Medicine, and","institution_ids":[]},{"raw_affiliation_string":"Molecular Biology Institute,","institution_ids":[]},{"raw_affiliation_string":"Department of Human Genetics, University of California, Los Angeles, CA 90095; and; Department of Medicine, and; Molecular Biology Institute,","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5971,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.94774523,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"110","issue":"21","first_page":"E1923","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lamin-b1","display_name":"lamin B1","score":0.9459999799728394},{"id":"https://openalex.org/keywords/lamin-b2","display_name":"lamin B2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/protein-farnesylation","display_name":"farnesylation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nuclear-lamina","display_name":"nuclear lamina","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neuronal-migration","display_name":"neuronal migration","score":0.7490000128746033},{"id":"https://openalex.org/keywords/neurodevelopmental-defects","display_name":"neurodevelopmental defects","score":0.8069999814033508},{"id":"https://openalex.org/keywords/knock-in-mice","display_name":"knock-in mice","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hutchinson-gilford-progeria-syndrome","display_name":"Hutchinson-Gilford progeria syndrome","score":0.6790000200271606},{"id":"https://openalex.org/keywords/nuclear-abnormalities","display_name":"nuclear abnormalities","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C179093185","wikidata":"https://www.wikidata.org/wiki/Q424506","display_name":"Lamin","level":3,"score":0.9886577129364014},{"id":"https://openalex.org/C94912109","wikidata":"https://www.wikidata.org/wiki/Q687194","display_name":"Nuclear lamina","level":5,"score":0.945467472076416},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8410376310348511},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6180974245071411},{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.6085193157196045},{"id":"https://openalex.org/C160704184","wikidata":"https://www.wikidata.org/wiki/Q18031028","display_name":"Ran","level":2,"score":0.5333437919616699},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.4942322075366974},{"id":"https://openalex.org/C65871279","wikidata":"https://www.wikidata.org/wiki/Q42884945","display_name":"Inner membrane","level":3,"score":0.49258309602737427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46928322315216064},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3305942416191101},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.2730412185192108},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21928706765174866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.157247394323349},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12657827138900757},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.05964580178260803},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017368","descriptor_name":"Protein Prenylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D034881","descriptor_name":"Nuclear Lamina","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034881","descriptor_name":"Nuclear Lamina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034921","descriptor_name":"Lamin Type B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034921","descriptor_name":"Lamin Type B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1303916110","doi":"https://doi.org/10.1073/pnas.1303916110","is_oa":false,"landing_page_url":"https://www.pnas.org/content/pnas/110/21/E1923.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2819172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3666708","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3666708","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3666708","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:23650370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23650370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2819172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3666708","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G178143519","display_name":"New Therapeutic Approaches for Hutchinson-Gilford Progeria Syndrome","funder_award_id":"R01HL086683","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4522303692","display_name":"CaaX Protein Processing and Human Disease","funder_award_id":"R01AG035626","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8940860874","display_name":"Protein Prenylation and Progeria","funder_award_id":"R01HL089781","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W254147912","https://openalex.org/W1001811995","https://openalex.org/W1564406238","https://openalex.org/W1964551999","https://openalex.org/W1970771850","https://openalex.org/W1975227291","https://openalex.org/W1978257498","https://openalex.org/W1978390749","https://openalex.org/W1980314357","https://openalex.org/W1991120047","https://openalex.org/W1996899853","https://openalex.org/W1998666034","https://openalex.org/W2003250511","https://openalex.org/W2003267467","https://openalex.org/W2009306385","https://openalex.org/W2016268789","https://openalex.org/W2017985097","https://openalex.org/W2019042255","https://openalex.org/W2035838778","https://openalex.org/W2036973053","https://openalex.org/W2042168939","https://openalex.org/W2044865509","https://openalex.org/W2054771288","https://openalex.org/W2056074681","https://openalex.org/W2058162240","https://openalex.org/W2064005074","https://openalex.org/W2065240476","https://openalex.org/W2088969742","https://openalex.org/W2094303671","https://openalex.org/W2095202174","https://openalex.org/W2096131870","https://openalex.org/W2097325653","https://openalex.org/W2106817434","https://openalex.org/W2108298524","https://openalex.org/W2111175126","https://openalex.org/W2113027309","https://openalex.org/W2116234410","https://openalex.org/W2118036121","https://openalex.org/W2119932131","https://openalex.org/W2120207407","https://openalex.org/W2123704670","https://openalex.org/W2127804300","https://openalex.org/W2139797302","https://openalex.org/W2140358769","https://openalex.org/W2142269770","https://openalex.org/W2143963878","https://openalex.org/W2151214732","https://openalex.org/W2151331444","https://openalex.org/W2154950275","https://openalex.org/W2172254982","https://openalex.org/W2176744910"],"related_works":["https://openalex.org/W1978390749","https://openalex.org/W1978257498","https://openalex.org/W1991120047","https://openalex.org/W2090787210","https://openalex.org/W2042168939","https://openalex.org/W2042979866","https://openalex.org/W2018275041","https://openalex.org/W2070067710","https://openalex.org/W2514118534","https://openalex.org/W1974662012"],"abstract_inverted_index":{"The":[0,125],"role":[1],"of":[2,12,23,53,63,73,86,102,151,168],"protein":[3,74],"farnesylation":[4,24,75,150],"in":[5,17,44,60,123,128],"lamin":[6,29,32,87,90,95,109,152,155],"A":[7],"biogenesis":[8],"and":[9,31,40,55,89,99,119,161],"the":[10,21,26,50,66,71,135,139,146,166,169],"pathogenesis":[11],"progeria":[13],"has":[14,34],"been":[15,58],"studied":[16],"considerable":[18],"detail,":[19],"but":[20],"importance":[22,72],"for":[25,76,158,162],"B-type":[27,77],"lamins,":[28,78],"B1":[30,39,88,110],"B2,":[33],"received":[35],"little":[36],"attention.":[37],"Lamins":[38],"B2":[41,96],"are":[42],"expressed":[43],"nearly":[45],"every":[46],"cell":[47,67],"type":[48],"from":[49,134,145],"earliest":[51],"stages":[52],"development,":[54],"they":[56],"have":[57],"implicated":[59],"a":[61],"variety":[62],"functions":[64],"within":[65,165],"nucleus.":[68],"To":[69],"assess":[70],"we":[79],"created":[80],"knock-in":[81],"mice":[82,106],"expressing":[83,93,107],"nonfarnesylated":[84,94,108],"versions":[85],"B2.":[91],"Mice":[92],"developed":[97],"normally":[98],"were":[100],"free":[101],"disease.":[103],"In":[104],"contrast,":[105],"died":[111],"soon":[112],"after":[113],"birth,":[114],"with":[115],"severe":[116],"neurodevelopmental":[117],"defects":[118],"striking":[120],"nuclear":[121,126,147,170],"abnormalities":[122],"neurons.":[124],"lamina":[127,171],"migrating":[129],"neurons":[130],"was":[131,141],"pulled":[132],"away":[133],"chromatin":[136,140,164],"so":[137],"that":[138],"left":[142],"\"naked\"":[143],"(free":[144],"lamina).":[148],"Thus,":[149],"B1--but":[153],"not":[154],"B2--is":[156],"crucial":[157],"brain":[159],"development":[160],"retaining":[163],"bounds":[167],"during":[172],"neuronal":[173],"migration.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}