{"id":"https://openalex.org/W2156387753","doi":null,"title":"Comparative analysis of local anesthesia with 2 different concentrations of adrenaline: a randomized and single blind study.","display_name":"Comparative analysis of local anesthesia with 2 different concentrations of adrenaline: a randomized and single blind study.","publication_year":2015,"publication_date":"2015-03-01","ids":{"openalex":"https://openalex.org/W2156387753","mag":"2156387753","pmid":"https://pubmed.ncbi.nlm.nih.gov/25878474","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4385721"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4385721","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4385721/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4385721/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Int Oral Health","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4385721/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071398321","display_name":"Anil Maruti Managutti","orcid":"https://orcid.org/0000-0003-4958-8346","observed_orcids":["https://orcid.org/0000-0003-4958-8346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anil Managutti","raw_affiliation_strings":["Professor and Head, Vice Principal, Department of Oral & Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor and Head, Vice Principal, Department of Oral & Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044183355","display_name":"Michael Prakasam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Prakasam","raw_affiliation_strings":["Reader, Department of Oral & Maxillofacial Surgery, Modern Dental College and Hospital, Indore, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reader, Department of Oral & Maxillofacial Surgery, Modern Dental College and Hospital, Indore, Madhya Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062523352","display_name":"Nagraj Puthanakar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nagraj Puthanakar","raw_affiliation_strings":["Reader, Department of Prosthodontics, Annasaheb Chudaman Patil Memorial Dental College, Dhule, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reader, Department of Prosthodontics, Annasaheb Chudaman Patil Memorial Dental College, Dhule, Maharashtra, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044467756","display_name":"Shailesh Menat","orcid":"https://orcid.org/0000-0002-0752-2907","observed_orcids":["https://orcid.org/0000-0002-0752-2907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shailesh Menat","raw_affiliation_strings":["Reader, Department of Oral and Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reader, Department of Oral and Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Disha Shah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Disha Shah","raw_affiliation_strings":["Postgraduate Student, Department of Oral and Maxillofacial surgery, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postgraduate Student, Department of Oral and Maxillofacial surgery, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058668868","display_name":"Harsh D. Patel","orcid":"https://orcid.org/0000-0002-4828-0035","observed_orcids":["https://orcid.org/0000-0002-4828-0035"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harsh Patel","raw_affiliation_strings":["Postgraduate Student, Department of Oral and Maxillofacial surgery, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postgraduate Student, Department of Oral and Maxillofacial surgery, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1486,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.73701343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"7","issue":"3","first_page":"24","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12145","display_name":"Dental Anxiety and Anesthesia Techniques","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12145","display_name":"Dental Anxiety and Anesthesia Techniques","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/local-anesthesia","display_name":"local anesthesia","score":0.9150000214576721},{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.8180000185966492},{"id":"https://openalex.org/keywords/vasoconstrictors","display_name":"vasoconstrictors","score":0.777999997138977},{"id":"https://openalex.org/keywords/cardiovascular-effects","display_name":"cardiovascular effects","score":0.8730000257492065},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.9860000014305115},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.9869999885559082},{"id":"https://openalex.org/keywords/anesthesia-duration","display_name":"anesthesia duration","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cardiac-patients","display_name":"cardiac patients","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8822638988494873},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.7233659625053406},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7015931010246277},{"id":"https://openalex.org/C2778994108","wikidata":"https://www.wikidata.org/wiki/Q1868462","display_name":"Local anesthetic","level":2,"score":0.6456847190856934},{"id":"https://openalex.org/C2776742690","wikidata":"https://www.wikidata.org/wiki/Q1455662","display_name":"Local anesthesia","level":2,"score":0.5807856321334839},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.5205113291740417},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5012381076812744},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4998805522918701},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.49650341272354126},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2999081611633301},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18683865666389465}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4385721","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4385721/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4385721/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Int Oral Health","raw_type":"Text"},{"id":"pmid:25878474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25878474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of international oral health : JIOH","raw_type":"Journal Article"},{"id":"mag:2156387753","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25878474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4385721","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4385721/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4385721/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Int Oral Health","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2156387753.pdf","grobid_xml":"https://content.openalex.org/works/W2156387753.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W9508912","https://openalex.org/W1966858773","https://openalex.org/W1978309427","https://openalex.org/W2011664378","https://openalex.org/W2015329095","https://openalex.org/W2039987447","https://openalex.org/W2041537878","https://openalex.org/W2041691059","https://openalex.org/W2072849079","https://openalex.org/W2076723480","https://openalex.org/W2133934838","https://openalex.org/W2150777208"],"related_works":["https://openalex.org/W2936182868","https://openalex.org/W4401276197","https://openalex.org/W2886590561","https://openalex.org/W4413357357","https://openalex.org/W3116754909","https://openalex.org/W7215109496","https://openalex.org/W2076723480","https://openalex.org/W2941901655","https://openalex.org/W3162823343","https://openalex.org/W2434935243"],"abstract_inverted_index":{"BACKGROUND:":[0],"Local":[1],"anesthetic":[2,26],"agents":[3,27,35],"are":[4,23,70],"more":[5],"commonly":[6,48],"used":[7,53,185],"in":[8,17,54,80,141,186],"dentistry":[9],"to":[10,202],"have":[11],"painless":[12],"procedure":[13],"during":[14],"surgical":[15],"intervention":[16],"bone":[18],"and":[19,41,95,130,144,166],"soft":[20],"tissue.":[21],"There":[22,136],"many":[24],"local":[25,45],"available":[28],"with":[29,50,98,104,122,128,133,146,150,156,172,175,181,206],"the":[30,38,42,93,99,131,142,147,163,173,195],"wide":[31],"selection":[32],"of":[33,44,65,101,115],"vaso-constrictive":[34],"that":[36],"improve":[37],"clinical":[39],"efficacy":[40,94,143],"duration":[43,145],"anesthesia.":[46],"Most":[47],"lignocaine":[49,103,121,149,155,174,180,205],"adrenaline":[51,58,158,189],"is":[52,183,200],"various":[55],"concentrations.":[56,107,153],"Systemically":[57],"like":[59],"drugs":[60],"can":[61],"cause":[62],"a":[63],"number":[64],"cardiovascular":[66,96,196],"disturbances":[67],"while":[68],"most":[69],"short":[71],"lived,":[72],"permanent":[73],"injury":[74],"or":[75,87],"even":[76],"death":[77],"may":[78],"follow":[79],"drug":[81],"induced":[82],"ventricular":[83],"fibrillation,":[84],"myocardial":[85],"infarction":[86],"cerebro-vascular":[88],"accidents.":[89],"This":[90],"study":[91],"compared":[92,171],"effects":[97],"use":[100,203],"2%":[102,120,148,154,179,204],"two":[105,123],"different":[106,124,152],"MATERIALS":[108],"AND":[109],"METHODS:":[110],"Forty":[111],"patients":[112],"underwent":[113],"extractions":[114],"mandibular":[116],"bilateral":[117],"teeth":[118],"using":[119],"concentrations":[125,190],"-":[126],"one":[127],"1:80000":[129,157,182],"other":[132],"1:200000.":[134,176],"RESULTS:":[135],"was":[137],"no":[138],"significant":[139],"difference":[140],"2":[151],"concentration":[159],"has":[160],"significantly":[161],"increased":[162],"heart":[164],"rate":[165],"blood":[167],"pressure":[168],"especially":[169],"systolic":[170],"CONCLUSION:":[177],"Though":[178],"widely":[184],"India,":[187],"1:200000":[188,207],"do":[191],"not":[192],"much":[193],"affect":[194],"parameters.":[197],"So":[198],"it":[199],"recommended":[201],"for":[208],"cardiac":[209],"patients.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}