{"id":"https://openalex.org/W2156335124","doi":"https://doi.org/10.1371/journal.pone.0084384","title":"Structural Determinants of the 5\u2032-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase","display_name":"Structural Determinants of the 5\u2032-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase","publication_year":2014,"publication_date":"2014-01-08","ids":{"openalex":"https://openalex.org/W2156335124","doi":"https://doi.org/10.1371/journal.pone.0084384","mag":"2156335124","pmid":"https://pubmed.ncbi.nlm.nih.gov/24416224","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3885546"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0084384","doi":"https://doi.org/10.1371/journal.pone.0084384","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0084384","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0084384&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0084384&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057615865","display_name":"Teraya M. Donaldson","orcid":"https://orcid.org/0000-0002-1635-8854","observed_orcids":["https://orcid.org/0000-0002-1635-8854"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teraya M. Donaldson","raw_affiliation_strings":["Departments of Medicine, Pathology, and of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Pathology, and of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111567245","display_name":"Li-Min Ting","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li-Min Ting","raw_affiliation_strings":["Departments of Medicine, Pathology, and of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Pathology, and of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113179363","display_name":"Chenyang Zhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenyang Zhan","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084179015","display_name":"Wuxian Shi","orcid":"https://orcid.org/0000-0003-4771-4601","observed_orcids":["https://orcid.org/0000-0003-4771-4601"]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wuxian Shi","raw_affiliation_strings":["National Synchrotron Light Source, Brookhaven National Laboratory, Brookhaven, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Synchrotron Light Source, Brookhaven National Laboratory, Brookhaven, New York, United States of America","institution_ids":["https://openalex.org/I200870766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103396577","display_name":"Renjian Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renjian Zheng","raw_affiliation_strings":["Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006013523","display_name":"Steven C. Almo","orcid":"https://orcid.org/0000-0003-2591-5234","observed_orcids":["https://orcid.org/0000-0003-2591-5234"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C. Almo","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042341113","display_name":"Kami Kim","orcid":"https://orcid.org/0000-0003-3384-152X","observed_orcids":["https://orcid.org/0000-0003-3384-152X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kami Kim","raw_affiliation_strings":["Departments of Medicine, Pathology, and of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Pathology, and of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042341113"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.2517,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.53460666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"1","first_page":"e84384","last_page":"e84384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.8659999966621399},{"id":"https://openalex.org/keywords/purine-nucleoside-phosphorylase","display_name":"purine nucleoside phosphorylase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dual-substrate-specificity","display_name":"dual substrate specificity","score":0.640999972820282},{"id":"https://openalex.org/keywords/purine-salvage-pathway","display_name":"purine salvage pathway","score":0.9580000042915344},{"id":"https://openalex.org/keywords/catalytic-residues","display_name":"catalytic residues","score":0.7509999871253967},{"id":"https://openalex.org/keywords/hydrophobic-pocket","display_name":"hydrophobic pocket","score":0.8659999966621399},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7260000109672546},{"id":"https://openalex.org/keywords/antimalarial-drug-targets","display_name":"antimalarial drug targets","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C71615608","wikidata":"https://www.wikidata.org/wiki/Q24720082","display_name":"Purine nucleoside phosphorylase","level":4,"score":0.8594895005226135},{"id":"https://openalex.org/C2777610669","wikidata":"https://www.wikidata.org/wiki/Q422564","display_name":"Inosine","level":3,"score":0.8436291813850403},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.6130121350288391},{"id":"https://openalex.org/C194101687","wikidata":"https://www.wikidata.org/wiki/Q583813","display_name":"Nucleotide salvage","level":4,"score":0.5513361692428589},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5325255393981934},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5125396251678467},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.4878823757171631},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.4687025249004364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45254796743392944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45169445872306824},{"id":"https://openalex.org/C169586020","wikidata":"https://www.wikidata.org/wiki/Q3780159","display_name":"Purine metabolism","level":3,"score":0.43273138999938965},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.398972749710083},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.3753146529197693},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2509665787220001},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008778","descriptor_name":"Methylthioinosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008778","descriptor_name":"Methylthioinosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0084384","doi":"https://doi.org/10.1371/journal.pone.0084384","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0084384","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0084384&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2874082","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3885546","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3885546","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3885546","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24416224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24416224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b66ba5175d9247838475e6a384e369a5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b66ba5175d9247838475e6a384e369a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 1, p e84384 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/896823","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Structural_Determinants_of_the_5_Methylthioinosine_Specificity_of_Plasmodium_Purine_Nucleoside_Phosphorylase/896823","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0084384","doi":"https://doi.org/10.1371/journal.pone.0084384","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0084384","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0084384&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3834503677","display_name":null,"funder_award_id":"RR 15301","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5929214267","display_name":"An Undulator Resource for Structural Biology","funder_award_id":"P41RR015301","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7431513933","display_name":null,"funder_award_id":"RR-15301","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G8211212867","display_name":null,"funder_award_id":"RR-15301","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G9000221485","display_name":null,"funder_award_id":"RR15301","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320310446","display_name":"Callaghan Innovation","ror":"https://ror.org/02n25sf77"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2156335124.pdf","grobid_xml":"https://content.openalex.org/works/W2156335124.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1539796472","https://openalex.org/W1964072874","https://openalex.org/W1964803671","https://openalex.org/W1968560682","https://openalex.org/W1970327093","https://openalex.org/W1982351108","https://openalex.org/W1982524397","https://openalex.org/W2011564054","https://openalex.org/W2014305334","https://openalex.org/W2016765195","https://openalex.org/W2018554028","https://openalex.org/W2020313346","https://openalex.org/W2022889821","https://openalex.org/W2025572792","https://openalex.org/W2030067084","https://openalex.org/W2034698551","https://openalex.org/W2038840577","https://openalex.org/W2040317364","https://openalex.org/W2042666860","https://openalex.org/W2043052053","https://openalex.org/W2044389899","https://openalex.org/W2061774324","https://openalex.org/W2064589373","https://openalex.org/W2065283382","https://openalex.org/W2079378100","https://openalex.org/W2083367125","https://openalex.org/W2084213291","https://openalex.org/W2090814002","https://openalex.org/W2097147953","https://openalex.org/W2104941500","https://openalex.org/W2105164270","https://openalex.org/W2110397834","https://openalex.org/W2114520383","https://openalex.org/W2129901166","https://openalex.org/W2136383137","https://openalex.org/W2137015675","https://openalex.org/W2145962807","https://openalex.org/W2788073857"],"related_works":["https://openalex.org/W2014305334","https://openalex.org/W2112205055","https://openalex.org/W2060182916","https://openalex.org/W2098928132","https://openalex.org/W2007724956","https://openalex.org/W2011678278","https://openalex.org/W2092148101","https://openalex.org/W2146087470","https://openalex.org/W2067930499","https://openalex.org/W1982351108"],"abstract_inverted_index":{"Plasmodium":[0,8,17,41],"parasites":[1],"rely":[2],"upon":[3],"purine":[4,9,18,43],"salvage":[5,19],"for":[6,60,72,86,109,156],"survival.":[7],"nucleoside":[10,44],"phosphorylase":[11,45],"is":[12],"part":[13],"of":[14,26,32,50,88,102,123,128,133],"the":[15,24,89,103,134,145,157,160],"streamlined":[16],"pathway":[20],"that":[21,47,56,96,115],"leads":[22],"to":[23,68],"phosphorylysis":[25],"both":[27],"purines":[28],"and":[29],"5'-methylthiopurines,":[30],"byproducts":[31],"polyamine":[33],"synthesis.":[34],"We":[35,63],"have":[36],"explored":[37],"structural":[38],"features":[39],"in":[40,142,159],"falciparum":[42],"(PfPNP)":[46],"affect":[48],"efficiency":[49],"catalysis":[51],"as":[52,54,76,78],"well":[53,77],"those":[55],"make":[57],"it":[58],"suitable":[59],"dual":[61],"specificity.":[62],"used":[64],"site":[65],"directed":[66],"mutagenesis":[67],"identify":[69],"residues":[70,80],"critical":[71,79],"PfPNP":[73,113,137],"catalytic":[74],"activity":[75,108,125],"within":[81],"a":[82],"hydrophobic":[83,161],"pocket":[84],"required":[85],"accommodation":[87],"5'-methylthio":[90,104,124],"group.":[91],"Kinetic":[92],"analysis":[93],"data":[94],"shows":[95],"several":[97],"mutants":[98],"had":[99,120],"disrupted":[100],"binding":[101],"group":[105],"while":[106],"retaining":[107],"inosine.":[110],"A":[111],"triple":[112,135],"mutant":[114,136],"mimics":[116],"Toxoplasma":[117],"gondii":[118],"PNP":[119],"significant":[121],"loss":[122],"with":[126,138,144],"retention":[127],"inosine":[129],"activity.":[130],"Crystallographic":[131],"investigation":[132],"Tyr160Phe,":[139],"Val66Ile,":[140],"andVal73Ile":[141],"complex":[143],"transition":[146],"state":[147],"inhibitor":[148,158],"immucillin":[149],"H":[150],"reveals":[151],"fewer":[152],"hydrogen":[153],"bond":[154],"interactions":[155],"pocket.":[162]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
