{"id":"https://openalex.org/W2156309972","doi":"https://doi.org/10.1074/jbc.274.20.14464","title":"A Novel and Highly Divergent Homolog of Human Eosinophil Granule Major Basic Protein","display_name":"A Novel and Highly Divergent Homolog of Human Eosinophil Granule Major Basic Protein","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W2156309972","doi":"https://doi.org/10.1074/jbc.274.20.14464","mag":"2156309972","pmid":"https://pubmed.ncbi.nlm.nih.gov/10318872"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.274.20.14464","doi":"https://doi.org/10.1074/jbc.274.20.14464","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.20.14464","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.274.20.14464","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078086876","display_name":"Douglas A. Plager","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas A. Plager","raw_affiliation_strings":["Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA. plager.douglas@mayo.edu","Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA. plager.douglas@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109985048","display_name":"David A. Loegering","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Loegering","raw_affiliation_strings":["Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046445522","display_name":"Deborah A. Weiler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah A. Weiler","raw_affiliation_strings":["Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077407559","display_name":"James L. Checkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James L. Checkel","raw_affiliation_strings":["Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111587135","display_name":"Jill M. Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill M. Wagner","raw_affiliation_strings":["Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104180175","display_name":"Nigel J. Clarke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nigel J. Clarke","raw_affiliation_strings":["Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063582082","display_name":"Stephen Naylor","orcid":"https://orcid.org/0000-0001-7619-6044","observed_orcids":["https://orcid.org/0000-0001-7619-6044"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Naylor","raw_affiliation_strings":["Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000574521","display_name":"Scott M. Page","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott M. Page","raw_affiliation_strings":["Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612-3864"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612-3864","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112004537","display_name":"Larry L. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry L. Thomas","raw_affiliation_strings":["Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612-3864"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612-3864","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058123303","display_name":"Ingrid E. Akerblom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ingrid Akerblom","raw_affiliation_strings":["Incyte Pharmaceuticals, Palo Alto, California 94304"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Incyte Pharmaceuticals, Palo Alto, California 94304","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ben Cocks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben Cocks","raw_affiliation_strings":["Incyte Pharmaceuticals, Palo Alto, California 94304"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Incyte Pharmaceuticals, Palo Alto, California 94304","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065268767","display_name":"Susan G. Stuart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Stuart","raw_affiliation_strings":["Incyte Pharmaceuticals, Palo Alto, California 94304"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Incyte Pharmaceuticals, Palo Alto, California 94304","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089757484","display_name":"Gerald J. Gleich","orcid":"https://orcid.org/0000-0002-6317-0811","observed_orcids":["https://orcid.org/0000-0002-6317-0811"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald J. Gleich","raw_affiliation_strings":["Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Immunology, Internal Medicine, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078086876"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.0211,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.91414997,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"274","issue":"20","first_page":"14464","last_page":"14473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eosinophil-major-basic-protein","display_name":"eosinophil major basic protein","score":0.8579999804496765},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.9089999794960022},{"id":"https://openalex.org/keywords/eosinophil-granule-proteins","display_name":"eosinophil granule proteins","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.5609999895095825},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.878000020980835},{"id":"https://openalex.org/keywords/basophil-histamine-release","display_name":"basophil histamine release","score":0.7760000228881836},{"id":"https://openalex.org/keywords/helminth-infection","display_name":"helminthiasis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/allergic-diseases","display_name":"allergic diseases","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.7327941060066223},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.7125752568244934},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6528725624084473},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5760532021522522},{"id":"https://openalex.org/C60483475","wikidata":"https://www.wikidata.org/wiki/Q1886099","display_name":"Major basic protein","level":4,"score":0.5138099789619446},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5136660933494568},{"id":"https://openalex.org/C2777456892","wikidata":"https://www.wikidata.org/wiki/Q107988","display_name":"Basophil","level":4,"score":0.4637809991836548},{"id":"https://openalex.org/C181901479","wikidata":"https://www.wikidata.org/wiki/Q14877650","display_name":"Interleukin 5","level":4,"score":0.4358818233013153},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34439459443092346},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.2970890402793884},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26262998580932617},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22589805722236633},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.20534709095954895},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.15977931022644043},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.10315245389938354},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015848","descriptor_name":"Interleukin-5","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047091","descriptor_name":"Eosinophil Granule Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.274.20.14464","doi":"https://doi.org/10.1074/jbc.274.20.14464","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.20.14464","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10318872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10318872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.274.20.14464","doi":"https://doi.org/10.1074/jbc.274.20.14464","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.20.14464","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1189270403","display_name":null,"funder_award_id":"AI 34577","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G378755198","display_name":null,"funder_award_id":"AI 32041","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4981684286","display_name":null,"funder_award_id":"AI 09728","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6821224193","display_name":"EOSINOPHIL MAJOR PROTEIN AS INFLAMMATORY MEDIATOR","funder_award_id":"5r01ai032041-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W71969623","https://openalex.org/W91361999","https://openalex.org/W120439566","https://openalex.org/W1014366764","https://openalex.org/W1491148615","https://openalex.org/W1508470956","https://openalex.org/W1541382453","https://openalex.org/W1546923829","https://openalex.org/W1547396258","https://openalex.org/W1551341341","https://openalex.org/W1558693276","https://openalex.org/W1594700207","https://openalex.org/W1677715709","https://openalex.org/W1785252001","https://openalex.org/W1840906208","https://openalex.org/W1849498460","https://openalex.org/W1879658727","https://openalex.org/W1912839853","https://openalex.org/W1964102602","https://openalex.org/W1966745870","https://openalex.org/W1970156673","https://openalex.org/W1971256855","https://openalex.org/W1975404555","https://openalex.org/W1976445645","https://openalex.org/W1978103390","https://openalex.org/W1978368163","https://openalex.org/W1978895831","https://openalex.org/W1984324451","https://openalex.org/W1986763896","https://openalex.org/W1989496118","https://openalex.org/W1991046721","https://openalex.org/W1991469497","https://openalex.org/W1998251495","https://openalex.org/W1999800943","https://openalex.org/W2010888033","https://openalex.org/W2012617920","https://openalex.org/W2013025204","https://openalex.org/W2024908512","https://openalex.org/W2044761411","https://openalex.org/W2046537804","https://openalex.org/W2084195264","https://openalex.org/W2087306389","https://openalex.org/W2088723838","https://openalex.org/W2093548393","https://openalex.org/W2106068114","https://openalex.org/W2110311040","https://openalex.org/W2118577784","https://openalex.org/W2120726212","https://openalex.org/W2130671398","https://openalex.org/W2151238743","https://openalex.org/W2151894170","https://openalex.org/W2155494562","https://openalex.org/W2162284659","https://openalex.org/W2162807358","https://openalex.org/W2185476483","https://openalex.org/W2187357944","https://openalex.org/W2247230024","https://openalex.org/W2338549889","https://openalex.org/W2405609661","https://openalex.org/W2411410378","https://openalex.org/W2417122831","https://openalex.org/W2462932523","https://openalex.org/W4213387068","https://openalex.org/W4249877820"],"related_works":["https://openalex.org/W2011479229","https://openalex.org/W7098992248","https://openalex.org/W2045489340","https://openalex.org/W1840906208","https://openalex.org/W1677715709","https://openalex.org/W2093165986","https://openalex.org/W1551341341","https://openalex.org/W1849498460","https://openalex.org/W2185476483","https://openalex.org/W2108958562"],"abstract_inverted_index":{"Eosinophils":[0],"are":[1],"important":[2,215],"effector":[3],"cells":[4,32],"in":[5,11,47,103,120,173],"defense":[6],"against":[7],"helminth":[8],"infection":[9],"and":[10,35,76,86,99,124,147,156,176,181,184,187],"allergic":[12],"diseases.":[13],"To":[14],"identify":[15],"novel":[16,200],"eosinophil":[17,104,144],"proteins,":[18],"large":[19,133],"scale":[20],"sequencing":[21,155],"of":[22,50,84,118,131,161,212],"a":[23,51,132],"cDNA":[24,52,63,134],"library":[25],"prepared":[26],"from":[27,142],"interleukin-5-stimulated":[28],"umbilical":[29],"cord":[30],"precursor":[31],"was":[33,64,127,140,150],"performed,":[34],"the":[36,48,70,94,110,162,207],"major":[37],"genes":[38],"expressed":[39],"by":[40,79,129,152,157],"maturing":[41],"eosinophils":[42],"were":[43],"determined.":[44],"This":[45,62],"resulted":[46],"identification":[49],"with":[53,81,195],"64%":[54],"identity":[55,149],"to":[56,171],"human":[57,143],"prepro-major":[58],"basic":[59],"protein":[60],"(hprepro-MBP).":[61],"designated":[65],"hprepro-MBP":[66],"homolog":[67,95],"(hprepro-MBPH).":[68],"Interestingly,":[69],"calculated":[71],"pI":[72,82],"values":[73,83],"for":[74,219],"hMBPH":[75,139,167],"hMBP":[77,172,213],"differed":[78],">100-fold,":[80],"8.7":[85],"11.4,":[87],"respectively.":[88],"Given":[89],"this":[90,125,199],"pronounced":[91],"basicity":[92],"difference,":[93],"transcript's":[96],"abundance":[97],"(1.1%),":[98],"MBP's":[100],"critical":[101],"role":[102],"biological":[105,163,220],"activity,":[106],"we":[107],"further":[108],"characterized":[109],"homolog.":[111],"Reverse":[112],"transcription-polymerase":[113],"chain":[114],"reaction":[115],"detected":[116],"transcription":[117],"hprepro-MBPH":[119],"bone":[121],"marrow":[122],"only,":[123],"result":[126],"confirmed":[128],"analysis":[130],"data":[135],"base":[136],"(electronic":[137],"Northern).":[138],"isolated":[141],"granule":[145],"lysates,":[146],"its":[148],"verified":[151],"amino":[153],"acid":[154],"mass":[158],"spectrometry.":[159],"Analyses":[160],"activities":[164],"showed":[165],"that":[166,206],"had":[168],"effects":[169],"similar":[170],"cell":[174],"killing":[175],"neutrophil":[177],"(superoxide":[178],"anion":[179],"production":[180],"interleukin-8":[182],"release)":[183,190],"basophil":[185],"(histamine":[186],"leukotriene":[188],"C4":[189],"stimulation":[191],"assays,":[192],"but":[193,216],"usually":[194],"reduced":[196],"potency.":[197],"Overall,":[198],"homolog's":[201],"unique":[202],"physical":[203],"properties":[204],"indicated":[205],"high":[208],"net":[209],"positive":[210],"charge":[211],"is":[214],"not":[217],"essential":[218],"activity.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
