{"id":"https://openalex.org/W2156286204","doi":"https://doi.org/10.1586/14760584.5.3.395","title":"Achieving directed immunostimulating complexes incorporation","display_name":"Achieving directed immunostimulating complexes incorporation","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W2156286204","doi":"https://doi.org/10.1586/14760584.5.3.395","mag":"2156286204","pmid":"https://pubmed.ncbi.nlm.nih.gov/16827623"},"language":"en","primary_location":{"id":"doi:10.1586/14760584.5.3.395","doi":"https://doi.org/10.1586/14760584.5.3.395","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14760584.5.3.395","pdf_url":null,"source":{"id":"https://openalex.org/S163950488","display_name":"Expert Review of Vaccines","issn_l":"1476-0584","issn":["1476-0584","1744-8395"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Vaccines","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088236705","display_name":"Maria Wikman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135511","display_name":"AlbaNova","ror":"https://ror.org/044kkfr75","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4210135511"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Maria Wikman","raw_affiliation_strings":["AlbaNova University Center, Department of Biotechnology, Kungl Tekniska H\u00f6gskolan (KTH), SE-10691 Stockholm, Sweden. maria.wikman@biotech.kth.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AlbaNova University Center, Department of Biotechnology, Kungl Tekniska H\u00f6gskolan (KTH), SE-10691 Stockholm, Sweden. maria.wikman@biotech.kth.se","institution_ids":["https://openalex.org/I4210135511","https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059439911","display_name":"Mikaela Friedman","orcid":"https://orcid.org/0000-0002-5483-9771","observed_orcids":["https://orcid.org/0000-0002-5483-9771"]},"institutions":[{"id":"https://openalex.org/I4210135511","display_name":"AlbaNova","ror":"https://ror.org/044kkfr75","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4210135511"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mikaela Friedman","raw_affiliation_strings":["AlbaNova University Center, Department of Biotechnology, Kungl Tekniska H\u00f6gskolan (KTH), SE-10691 Stockholm, Sweden. mikaela.friedman@biotech.kth.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AlbaNova University Center, Department of Biotechnology, Kungl Tekniska H\u00f6gskolan (KTH), SE-10691 Stockholm, Sweden. mikaela.friedman@biotech.kth.se","institution_ids":["https://openalex.org/I4210135511","https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060927114","display_name":"Sunan Pinitkiatisakul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330204332","display_name":"Swedish Veterinary Agency","ror":"https://ror.org/00awbw743","country_code":"SE","type":"government","lineage":["https://openalex.org/I1330204332"]},{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sunan Pinitkiatisakul","raw_affiliation_strings":["National Veterinary Institute and Swedish University of Agricultural Sciences, Department of Parasitology (SWEPAR), SE-75189 Uppsala, Sweden. Sunan.Pinitkiatisakul@bvf.slu.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Veterinary Institute and Swedish University of Agricultural Sciences, Department of Parasitology (SWEPAR), SE-75189 Uppsala, Sweden. Sunan.Pinitkiatisakul@bvf.slu.se","institution_ids":["https://openalex.org/I1330204332","https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christin Andersson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135511","display_name":"AlbaNova","ror":"https://ror.org/044kkfr75","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4210135511"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christin Andersson","raw_affiliation_strings":["AlbaNova University Center, Department of Biotechnology, Kungl Tekniska H\u00f6gskolan (KTH), SE-10691 Stockholm, Sweden. Christin.V.Andersson@astrazeneca.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AlbaNova University Center, Department of Biotechnology, Kungl Tekniska H\u00f6gskolan (KTH), SE-10691 Stockholm, Sweden. Christin.V.Andersson@astrazeneca.com","institution_ids":["https://openalex.org/I4210135511","https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109334300","display_name":"Karin L\u00f6vgren\u2010Bengtsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karin L\u00f6vgren-Bengtsson","raw_affiliation_strings":["Isconova AB, Uppsala Science Park, SE-751 83 Uppsala, Sweden. karin.lovgren@isconova.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isconova AB, Uppsala Science Park, SE-751 83 Uppsala, Sweden. karin.lovgren@isconova.se","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024914104","display_name":"Anna Lund\u00e9n","orcid":"https://orcid.org/0000-0002-9614-9453","observed_orcids":["https://orcid.org/0000-0002-9614-9453"]},"institutions":[{"id":"https://openalex.org/I1330204332","display_name":"Swedish Veterinary Agency","ror":"https://ror.org/00awbw743","country_code":"SE","type":"government","lineage":["https://openalex.org/I1330204332"]},{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna Lund\u00e9n","raw_affiliation_strings":["National Veterinary Institute and Swedish University of Agricultural Sciences, Department of Parasitology (SWEPAR), SE-75189 Uppsala, Sweden. anna.lunden@bvf.slu.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Veterinary Institute and Swedish University of Agricultural Sciences, Department of Parasitology (SWEPAR), SE-75189 Uppsala, Sweden. anna.lunden@bvf.slu.se","institution_ids":["https://openalex.org/I1330204332","https://openalex.org/I298625061"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111541742","display_name":"Stefan St\u00e5hl","orcid":"https://orcid.org/0000-0002-9282-0174","observed_orcids":["https://orcid.org/0000-0002-9282-0174"]},"institutions":[{"id":"https://openalex.org/I4210135511","display_name":"AlbaNova","ror":"https://ror.org/044kkfr75","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4210135511"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Stefan St\u00e5hl","raw_affiliation_strings":["AlbaNova University Center, Department of Biotechnology, Kungl Tekniska H\u00f6gskolan (KTH), SE-10691 Stockholm, Sweden. stefan.stahl@biotech.kth.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AlbaNova University Center, Department of Biotechnology, Kungl Tekniska H\u00f6gskolan (KTH), SE-10691 Stockholm, Sweden. stefan.stahl@biotech.kth.se","institution_ids":["https://openalex.org/I4210135511","https://openalex.org/I86987016"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0536,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.04329609,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"3","first_page":"395","last_page":"403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iscoms","display_name":"ISCOMs","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gene-fusion","display_name":"gene fusion","score":0.753000020980835},{"id":"https://openalex.org/keywords/recombinant-antigen-expression","display_name":"recombinant antigen expression","score":0.7590000033378601},{"id":"https://openalex.org/keywords/vaccine-development","display_name":"vaccine development","score":0.824999988079071},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.6790000200271606},{"id":"https://openalex.org/keywords/antigen-standardization","display_name":"antigen standardization","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7089530229568481},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6504032611846924},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6298174858093262},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5611971616744995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5001263618469238},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4875194728374481},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4259435534477234},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4100988209247589},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36475545167922974},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24304822087287903},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016882","descriptor_name":"ISCOMs","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016882","descriptor_name":"ISCOMs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022223","descriptor_name":"Vaccines, Subunit","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1586/14760584.5.3.395","doi":"https://doi.org/10.1586/14760584.5.3.395","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14760584.5.3.395","pdf_url":null,"source":{"id":"https://openalex.org/S163950488","display_name":"Expert Review of Vaccines","issn_l":"1476-0584","issn":["1476-0584","1744-8395"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Vaccines","raw_type":"journal-article"},{"id":"pmid:16827623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16827623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of vaccines","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W50419558","https://openalex.org/W1537498478","https://openalex.org/W1591717496","https://openalex.org/W1930362282","https://openalex.org/W1968114019","https://openalex.org/W1969813979","https://openalex.org/W1972312879","https://openalex.org/W1977248454","https://openalex.org/W1977668505","https://openalex.org/W1981872132","https://openalex.org/W1990111799","https://openalex.org/W1991516961","https://openalex.org/W1993870692","https://openalex.org/W1993953211","https://openalex.org/W1997293169","https://openalex.org/W2003090737","https://openalex.org/W2003577609","https://openalex.org/W2004064112","https://openalex.org/W2010322886","https://openalex.org/W2012816847","https://openalex.org/W2015132931","https://openalex.org/W2015933644","https://openalex.org/W2028381188","https://openalex.org/W2031960693","https://openalex.org/W2032925654","https://openalex.org/W2043619106","https://openalex.org/W2057010810","https://openalex.org/W2060186677","https://openalex.org/W2065129970","https://openalex.org/W2065471902","https://openalex.org/W2072684118","https://openalex.org/W2076428152","https://openalex.org/W2089737238","https://openalex.org/W2107141790","https://openalex.org/W2137490166","https://openalex.org/W2139111319","https://openalex.org/W2314426169","https://openalex.org/W2471673629"],"related_works":["https://openalex.org/W159387192","https://openalex.org/W2386050173","https://openalex.org/W4251939963","https://openalex.org/W2075836516","https://openalex.org/W2048175618","https://openalex.org/W2032925654","https://openalex.org/W1992410431","https://openalex.org/W2184122757","https://openalex.org/W2114190520","https://openalex.org/W2018208145"],"abstract_inverted_index":{"In":[0,56],"recent":[1],"years,":[2],"several":[3],"studies":[4],"have":[5],"been":[6],"reported":[7],"with":[8,38],"the":[9,57,70,86],"common":[10,40],"aim":[11],"of":[12,23,35,42,49,60,72],"generating":[13],"general":[14],"expression":[15],"systems":[16,88],"for":[17,47],"straightforward":[18],"production":[19],"and":[20,82],"subsequent":[21],"coupling":[22],"expressed":[24],"antigens":[25,51],"to":[26,52,68,75],"an":[27,90],"adjuvant":[28],"system.":[29],"Here,":[30],"we":[31,83],"describe":[32],"a":[33,39],"series":[34],"such":[36],"efforts":[37],"theme":[41],"using":[43],"gene":[44],"fusion":[45],"technology":[46],"association":[48],"recombinant":[50],"immunostimulating":[53],"complexes":[54],"(iscoms).":[55],"early":[58],"stages":[59],"vaccine":[61],"development,":[62],"uniform":[63],"antigen":[64],"preparations":[65],"are":[66],"crucial":[67],"allow":[69],"comparison":[71],"immune":[73],"responses":[74],"different":[76],"antigens,":[77],"or":[78],"even":[79],"subdomains":[80],"thereof,":[81],"believe":[84],"that":[85],"described":[87],"constitute":[89],"important":[91],"development":[92],"in":[93],"this":[94],"context.":[95]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}