{"id":"https://openalex.org/W2156285456","doi":"https://doi.org/10.1093/toxsci/kfp096","title":"Population-Based Discovery of Toxicogenomics Biomarkers for Hepatotoxicity Using a Laboratory Strain Diversity Panel","display_name":"Population-Based Discovery of Toxicogenomics Biomarkers for Hepatotoxicity Using a Laboratory Strain Diversity Panel","publication_year":2009,"publication_date":"2009-05-06","ids":{"openalex":"https://openalex.org/W2156285456","doi":"https://doi.org/10.1093/toxsci/kfp096","mag":"2156285456","pmid":"https://pubmed.ncbi.nlm.nih.gov/19420014","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2696330"},"language":"en","primary_location":{"id":"doi:10.1093/toxsci/kfp096","doi":"https://doi.org/10.1093/toxsci/kfp096","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfp096","pdf_url":"https://academic.oup.com/toxsci/article-pdf/110/1/235/10990710/kfp096.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/toxsci/article-pdf/110/1/235/10990710/kfp096.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074665137","display_name":"Alison H. Harrill","orcid":"https://orcid.org/0000-0001-5544-1338","observed_orcids":["https://orcid.org/0000-0001-5544-1338","https://orcid.org/0000-0001-9429-1897","https://orcid.org/0009-0007-5393-5677"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison H. Harrill","raw_affiliation_strings":["Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA","Curriculum in Toxicology","Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Curriculum in Toxicology","institution_ids":[]},{"raw_affiliation_string":"Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054514306","display_name":"Pamela K. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela K. Ross","raw_affiliation_strings":["\u2020 Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030457099","display_name":"Daniel M. Gatti","orcid":"https://orcid.org/0000-0003-0667-9926","observed_orcids":["https://orcid.org/0000-0003-0667-9926"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel M. Gatti","raw_affiliation_strings":["\u2020 Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025298255","display_name":"David W. Threadgill","orcid":"https://orcid.org/0000-0003-3538-1635","observed_orcids":["https://orcid.org/0000-0003-3538-1635"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Threadgill","raw_affiliation_strings":["Curriculum in Toxicology","\u2021 Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Curriculum in Toxicology","institution_ids":[]},{"raw_affiliation_string":"\u2021 Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019868317","display_name":"Ivan Rusyn","orcid":"https://orcid.org/0000-0001-9340-7384","observed_orcids":["https://orcid.org/0000-0001-9340-7384","https://orcid.org/0000-0002-4865-9491"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ivan Rusyn","raw_affiliation_strings":["Curriculum in Toxicology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Curriculum in Toxicology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019868317"],"corresponding_institution_ids":[],"apc_list":{"value":4671,"currency":"USD","value_usd":4671},"apc_paid":null,"fwci":5.7766,"has_fulltext":true,"cited_by_count":103,"citation_normalized_percentile":{"value":0.97463905,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"110","issue":"1","first_page":"235","last_page":"243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxicogenomics","display_name":"toxicogenomics","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8309999704360962},{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.8889999985694885},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.6610000133514404},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.8309999704360962},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/hepatocellular-necrosis","display_name":"liver necrosis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9010000228881836},{"id":"https://openalex.org/keywords/osmr","display_name":"OSMR","score":0.9909999966621399},{"id":"https://openalex.org/keywords/chemical-risk-assessment","display_name":"chemical risk assessment","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C93231420","wikidata":"https://www.wikidata.org/wiki/Q841450","display_name":"Toxicogenomics","level":4,"score":0.8972471952438354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7249919772148132},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5887420177459717},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.5430163741111755},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4593863785266876},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4400302767753601},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41115429997444153},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3872634470462799},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3115139901638031},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2725249230861664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16274237632751465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09559175372123718},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011153","descriptor_name":"Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043922","descriptor_name":"Toxicogenetics","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1093/toxsci/kfp096","doi":"https://doi.org/10.1093/toxsci/kfp096","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfp096","pdf_url":"https://academic.oup.com/toxsci/article-pdf/110/1/235/10990710/kfp096.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2696330","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2696330","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicol Sci","raw_type":"Text"},{"id":"pmid:19420014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19420014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological sciences : an official journal of the Society of Toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.710.6373","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.710.6373","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rusynlab.org/publications/2009/Harrill%20et%20al%202009%20ToxSci.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.873.8613","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.873.8613","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://toxsci.oxfordjournals.org/content/110/1/235.full.pdf","raw_type":"text"},{"id":"pmh:cdr.lib.unc.edu:2b88qm73j","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/tgqr-5t60","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxicological Sciences, 110(1)","raw_type":"Article"},{"id":"doi:10.17615/tgqr-5t60","doi":"https://doi.org/10.17615/tgqr-5t60","is_oa":true,"landing_page_url":"https://doi.org/10.17615/tgqr-5t60","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1093/toxsci/kfp096","doi":"https://doi.org/10.1093/toxsci/kfp096","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfp096","pdf_url":"https://academic.oup.com/toxsci/article-pdf/110/1/235/10990710/kfp096.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2792619824","display_name":"Profiles of Sucsceptibility to Toxicant Stress","funder_award_id":"U19ES011391","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000883576","display_name":"UNC Center for Environmental Health and Susceptibility","funder_award_id":"P30ES010126","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000906690","display_name":"Pre- and Postdoctoral Training in Toxicology","funder_award_id":"T32ES007126","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320306107","display_name":"U.S. Environmental Protection Agency","ror":"https://ror.org/03tns0030"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2156285456.pdf","grobid_xml":"https://content.openalex.org/works/W2156285456.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1516383449","https://openalex.org/W1516719898","https://openalex.org/W1602971398","https://openalex.org/W1964000992","https://openalex.org/W1968593126","https://openalex.org/W1973025942","https://openalex.org/W1976634335","https://openalex.org/W1982584241","https://openalex.org/W1986765826","https://openalex.org/W1989534065","https://openalex.org/W1997542915","https://openalex.org/W2002239837","https://openalex.org/W2011305327","https://openalex.org/W2017783406","https://openalex.org/W2019464839","https://openalex.org/W2029226467","https://openalex.org/W2035057558","https://openalex.org/W2042645188","https://openalex.org/W2047154332","https://openalex.org/W2050492959","https://openalex.org/W2055082479","https://openalex.org/W2061826575","https://openalex.org/W2091196175","https://openalex.org/W2094500750","https://openalex.org/W2096037842","https://openalex.org/W2098303558","https://openalex.org/W2098577464","https://openalex.org/W2103802172","https://openalex.org/W2104822265","https://openalex.org/W2118308505","https://openalex.org/W2118353044","https://openalex.org/W2127553886","https://openalex.org/W2145246101","https://openalex.org/W2147507929","https://openalex.org/W2151791643","https://openalex.org/W2154711012","https://openalex.org/W2154972152","https://openalex.org/W2158418435","https://openalex.org/W2162555240","https://openalex.org/W2169958072","https://openalex.org/W2170370399","https://openalex.org/W2415940705","https://openalex.org/W2486409930","https://openalex.org/W4245271255"],"related_works":["https://openalex.org/W7099927340","https://openalex.org/W2231559868","https://openalex.org/W2104726887","https://openalex.org/W7099435229","https://openalex.org/W2132976060","https://openalex.org/W2343229618","https://openalex.org/W2170370399","https://openalex.org/W2082843554","https://openalex.org/W1979574159","https://openalex.org/W2968813555"],"abstract_inverted_index":{"Toxicogenomic":[0],"studies":[1],"are":[2,174],"increasingly":[3],"used":[4,85],"to":[5,18,27,31,50,76,143],"uncover":[6],"potential":[7],"biomarkers":[8,52,79,140],"of":[9,24,45,59,73,141,170,176,242,245],"adverse":[10],"health":[11],"events,":[12],"enrich":[13],"chemical":[14],"risk":[15],"assessment,":[16],"and":[17,22,106,157,184,199,205,218,239],"facilitate":[19,240],"proper":[20],"identification":[21,241],"treatment":[23,156],"persons":[25],"susceptible":[26],"toxicity.":[28],"Current":[29],"approaches":[30],"biomarker":[32,172],"discovery":[33],"through":[34],"gene":[35,151],"expression":[36,123,152],"profiling":[37,124],"usually":[38],"utilize":[39],"a":[40,86,114,228],"single":[41],"or":[42],"few":[43],"strains":[44,97],"rodents,":[46],"limiting":[47],"the":[48,56,71,148,177],"ability":[49],"detect":[51,77],"that":[53,227],"may":[54,231],"represent":[55],"wide":[57],"range":[58],"toxicity":[60,237],"responses":[61,238],"typically":[62],"observed":[63],"in":[64,146,150,181],"genetically":[65,81],"heterogeneous":[66],"human":[67],"populations.":[68],"To":[69],"enhance":[70],"utility":[72,233],"animal":[74],"models":[75],"response":[78,142],"for":[80,164,234],"diverse":[82],"populations,":[83],"we":[84],"laboratory":[87],"mouse":[88,166],"strain":[89],"diversity":[90],"panel.":[91],"Specifically,":[92],"mice":[93],"from":[94,99],"36":[95],"inbred":[96],"derived":[98],"Mus":[100,103,107],"mus":[101,104,108],"musculus,":[102],"castaneous,":[105],"domesticus":[109],"origins":[110],"were":[111,153],"treated":[112],"with":[113,189,210],"model":[115],"hepatotoxic":[116],"agent,":[117],"acetaminophen":[118,144],"(300":[119],"mg/kg,":[120],"ig).":[121],"Gene":[122],"was":[125],"performed":[126],"on":[127],"liver":[128,158],"tissue":[129],"collected":[130],"at":[131],"24":[132],"h":[133],"after":[134],"dosing.":[135],"We":[136],"identified":[137],"26":[138],"population-wide":[139],"hepatotoxicity":[145],"which":[147],"changes":[149],"significant":[154,163],"across":[155],"necrosis":[159],"score":[160],"but":[161],"not":[162,207],"individual":[165],"strains.":[167],"Importantly,":[168],"most":[169],"these":[171],"genes":[173,186,206],"part":[175],"intracellular":[178],"signaling":[179],"involved":[180],"hepatocyte":[182],"death":[183],"include":[185],"previously":[187,208],"associated":[188,209],"acetaminophen-induced":[190],"hepatotoxicity,":[191],"such":[192,212],"as":[193,213],"cyclin-dependent":[194],"kinase":[195],"inhibitor":[196],"1A":[197],"(p21)":[198],"interleukin":[200],"6":[201],"signal":[202],"transducer":[203],"(Il6st),":[204],"acetaminophen,":[211],"oncostatin":[214],"M":[215],"receptor":[216],"(Osmr)":[217],"MLX":[219],"interacting":[220],"protein":[221],"like":[222],"(Mlxipl).":[223],"Our":[224],"data":[225],"demonstrate":[226],"multistrain":[229],"approach":[230],"provide":[232],"understanding":[235],"genotype-independent":[236],"novel":[243],"targets":[244],"therapeutic":[246],"intervention.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
