{"id":"https://openalex.org/W2156255142","doi":"https://doi.org/10.1073/pnas.0601819103","title":"\u03bcO-conotoxin MrVIB selectively blocks Na v 1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits","display_name":"\u03bcO-conotoxin MrVIB selectively blocks Na v 1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits","publication_year":2006,"publication_date":"2006-11-02","ids":{"openalex":"https://openalex.org/W2156255142","doi":"https://doi.org/10.1073/pnas.0601819103","mag":"2156255142","pmid":"https://pubmed.ncbi.nlm.nih.gov/17077153","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1629086"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0601819103","doi":"https://doi.org/10.1073/pnas.0601819103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0601819103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1629086","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008299310","display_name":"Jenny A. K. Ekberg","orcid":"https://orcid.org/0000-0001-5151-4966","observed_orcids":["https://orcid.org/0000-0001-5151-4966","https://orcid.org/0000-0001-8129-3682"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J. Ekberg","raw_affiliation_strings":["*Institute for Molecular Bioscience and","School of Biomedical Sciences, University of Queensland, QLD 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Institute for Molecular Bioscience and","institution_ids":["https://openalex.org/I4405277047"]},{"raw_affiliation_string":"School of Biomedical Sciences, University of Queensland, QLD 4072, Australia;","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024208164","display_name":"Angelo Jayamanne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"A. Jayamanne","raw_affiliation_strings":["Pain Management Research Institute and Kolling Institute, Northern Clinical School, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain Management Research Institute and Kolling Institute, Northern Clinical School, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia; and","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078372566","display_name":"Christopher Walter Vaughan","orcid":"https://orcid.org/0000-0003-4314-7689","observed_orcids":["https://orcid.org/0000-0003-4314-7689"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"C. W. Vaughan","raw_affiliation_strings":["Pain Management Research Institute and Kolling Institute, Northern Clinical School, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain Management Research Institute and Kolling Institute, Northern Clinical School, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia; and","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012214287","display_name":"Sevda C. Aslan","orcid":"https://orcid.org/0000-0001-8129-2129","observed_orcids":["https://orcid.org/0000-0001-8129-2129"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"S. Aslan","raw_affiliation_strings":["Pain Management Research Institute and Kolling Institute, Northern Clinical School, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain Management Research Institute and Kolling Institute, Northern Clinical School, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia; and","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038205856","display_name":"Linda Thomas","orcid":"https://orcid.org/0000-0001-8989-8109","observed_orcids":["https://orcid.org/0000-0001-8989-8109"]},"institutions":[{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"L. Thomas","raw_affiliation_strings":["*Institute for Molecular Bioscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Institute for Molecular Bioscience and","institution_ids":["https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083342518","display_name":"Jorgen A. Mould","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J. Mould","raw_affiliation_strings":["*Institute for Molecular Bioscience and","School of Biomedical Sciences, University of Queensland, QLD 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Institute for Molecular Bioscience and","institution_ids":["https://openalex.org/I4405277047"]},{"raw_affiliation_string":"School of Biomedical Sciences, University of Queensland, QLD 4072, Australia;","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013170471","display_name":"Roger D. Drinkwater","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"R. Drinkwater","raw_affiliation_strings":["*Institute for Molecular Bioscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Institute for Molecular Bioscience and","institution_ids":["https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101864581","display_name":"Mark D. Baker","orcid":"https://orcid.org/0000-0003-1926-8763","observed_orcids":["https://orcid.org/0000-0003-1926-8763"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. D. Baker","raw_affiliation_strings":["Molecular Nociception Group, Department of Biology, University College of London, Gower Street, London WC1E 6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Nociception Group, Department of Biology, University College of London, Gower Street, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000783484","display_name":"Bjarke Abrahamsen","orcid":"https://orcid.org/0000-0002-6128-8269","observed_orcids":["https://orcid.org/0000-0002-6128-8269"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. Abrahamsen","raw_affiliation_strings":["Molecular Nociception Group, Department of Biology, University College of London, Gower Street, London WC1E 6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Nociception Group, Department of Biology, University College of London, Gower Street, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040885096","display_name":"John N. Wood","orcid":"https://orcid.org/0000-0002-9166-8158","observed_orcids":["https://orcid.org/0000-0002-9166-8158"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. N. Wood","raw_affiliation_strings":["Molecular Nociception Group, Department of Biology, University College of London, Gower Street, London WC1E 6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Nociception Group, Department of Biology, University College of London, Gower Street, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025386235","display_name":"David J. Adams","orcid":"https://orcid.org/0000-0002-7030-2288","observed_orcids":["https://orcid.org/0000-0002-7030-2288"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"D. J. Adams","raw_affiliation_strings":["School of Biomedical Sciences, University of Queensland, QLD 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences, University of Queensland, QLD 4072, Australia;","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032114486","display_name":"MacDonald J. Christie","orcid":"https://orcid.org/0000-0002-0622-609X","observed_orcids":["https://orcid.org/0000-0002-0622-609X"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"M. J. Christie","raw_affiliation_strings":["Pain Management Research Institute and Kolling Institute, Northern Clinical School, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain Management Research Institute and Kolling Institute, Northern Clinical School, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia; and","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025539645","display_name":"Richard James Lewis","orcid":"https://orcid.org/0000-0003-3470-923X","observed_orcids":["https://orcid.org/0000-0003-3470-923X","https://orcid.org/0000-0001-9404-8520"]},"institutions":[{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"R. J. Lewis","raw_affiliation_strings":["*Institute for Molecular Bioscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Institute for Molecular Bioscience and","institution_ids":["https://openalex.org/I4405277047"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5025539645","https://openalex.org/A5032114486"],"corresponding_institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252","https://openalex.org/I4405277047"],"apc_list":null,"apc_paid":null,"fwci":4.2667,"has_fulltext":false,"cited_by_count":197,"citation_normalized_percentile":{"value":0.9584902,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"103","issue":"45","first_page":"17030","last_page":"17035"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.3463999927043915,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conus-marmoreus","display_name":"Conus marmoreus","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nav1-8","display_name":"Nav1.8","score":0.7960000038146973},{"id":"https://openalex.org/keywords/tetrodotoxin-resistant-sodium-channels","display_name":"tetrodotoxin-resistant sodium channels","score":0.7360000014305115},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.6740000247955322},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9750000238418579},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.9760000109672546},{"id":"https://openalex.org/keywords/allodynia","display_name":"allodynia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sensory-neurons","display_name":"sensory neurons","score":0.7409999966621399},{"id":"https://openalex.org/keywords/intrathecal-administration","display_name":"intrathecal administration","score":0.7799999713897705},{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.9539999961853027},{"id":"https://openalex.org/keywords/motor-side-effects","display_name":"motor side effects","score":0.6499999761581421},{"id":"https://openalex.org/keywords/therapeutic-index","display_name":"therapeutic index","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.7853289842605591},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.7078446745872498},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.6779974699020386},{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.6311929821968079},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.5916718244552612},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5683819055557251},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.540332019329071},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49750855565071106},{"id":"https://openalex.org/C175234850","wikidata":"https://www.wikidata.org/wiki/Q417238","display_name":"Conotoxin","level":3,"score":0.4949139952659607},{"id":"https://openalex.org/C2776414672","wikidata":"https://www.wikidata.org/wiki/Q7553303","display_name":"Sodium channel blocker","level":4,"score":0.4941442310810089},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.44221892952919006},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.43953096866607666},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.4309561252593994},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4057563841342926},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.3978877067565918},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.38052287697792053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37928590178489685},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24257132411003113},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23157688975334167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14736002683639526},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12168198823928833},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020916","descriptor_name":"Conotoxins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020916","descriptor_name":"Conotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D026941","descriptor_name":"Sodium Channel Blockers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D026941","descriptor_name":"Sodium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062559","descriptor_name":"NAV1.8 Voltage-Gated Sodium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1073/pnas.0601819103","doi":"https://doi.org/10.1073/pnas.0601819103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0601819103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1465368","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1629086","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1629086","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1629086","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:17077153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17077153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:researchonline.jcu.edu.au:3498","doi":null,"is_oa":false,"landing_page_url":"https://researchonline.jcu.edu.au/3498/1/3498_Ekberg_2006.pdf","pdf_url":"https://researchonline.jcu.edu.au/3498/1/3498_Ekberg_2006.pdf","source":{"id":"https://openalex.org/S4377196350","display_name":"ResearchOnline - JCU (James Cook University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86467917","host_organization_name":"James Cook University","host_organization_lineage":["https://openalex.org/I86467917"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:researchbank.rmit.edu.au:rmit:4230","doi":null,"is_oa":false,"landing_page_url":"http://researchbank.rmit.edu.au/view/rmit:4230","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:ro.uow.edu.au:ihmri-1680","doi":null,"is_oa":false,"landing_page_url":"https://ro.uow.edu.au/ihmri/658","pdf_url":null,"source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Illawarra Health and Medical Research Institute","raw_type":"article"},{"id":"pmh:oai:alma61RMIT.INST:11247655180001341","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1073/pnas.0601819103","pdf_url":null,"source":{"id":"https://openalex.org/S4306402074","display_name":"RMIT Research Repository (RMIT University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I82951845","host_organization_name":"RMIT University","host_organization_lineage":["https://openalex.org/I82951845"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:100721","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/100721/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America , 7 (103) pp. 17030-17035. (2006)","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:113946","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/113946/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"P NATL ACAD SCI USA , 103 (45) 17030 - 17035. (2006)","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/27430128","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/_O-conotoxin_MrVIB_selectively_blocks_NaV1_8_sensory_neuron_specific_sodium_channels_and_chronic_pain_behaviour_without_motor_deficits/27430128","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:research-repository.griffith.edu.au:10072/28098","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10072/28098","pdf_url":null,"source":{"id":"https://openalex.org/S7407064376","display_name":"Griffith Research Online","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1465368","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1629086","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W40340874","https://openalex.org/W1549160512","https://openalex.org/W1879998039","https://openalex.org/W1959152155","https://openalex.org/W1967441802","https://openalex.org/W1975744071","https://openalex.org/W1975891442","https://openalex.org/W1979482847","https://openalex.org/W1985689777","https://openalex.org/W1998735385","https://openalex.org/W2008076148","https://openalex.org/W2008465842","https://openalex.org/W2017341638","https://openalex.org/W2021565244","https://openalex.org/W2042409384","https://openalex.org/W2051997075","https://openalex.org/W2062176870","https://openalex.org/W2064460771","https://openalex.org/W2066962218","https://openalex.org/W2067924690","https://openalex.org/W2068707948","https://openalex.org/W2071151959","https://openalex.org/W2076923772","https://openalex.org/W2091746433","https://openalex.org/W2092213559","https://openalex.org/W2093012301","https://openalex.org/W2097482307","https://openalex.org/W2099075885","https://openalex.org/W2104521984","https://openalex.org/W2108718363","https://openalex.org/W2130496291","https://openalex.org/W2137445147","https://openalex.org/W2172201406","https://openalex.org/W2339447116"],"related_works":["https://openalex.org/W1851624642","https://openalex.org/W2008076148","https://openalex.org/W2049710812","https://openalex.org/W2069176730","https://openalex.org/W7027104629","https://openalex.org/W1974320945","https://openalex.org/W1976352905","https://openalex.org/W2011139091","https://openalex.org/W2148719946","https://openalex.org/W4407130459"],"abstract_inverted_index":{"The":[0,136],"tetrodotoxin-resistant":[1,59],"voltage-gated":[2],"sodium":[3],"channel":[4],"(VGSC)":[5],"Na(v)1.8":[6,40,63,74,147],"is":[7,16],"expressed":[8,75],"predominantly":[9],"by":[10,101],"damage-sensing":[11],"primary":[12],"afferent":[13],"nerves":[14],"and":[15,21,41,90,96,130],"important":[17],"for":[18,39,128],"the":[19,120],"development":[20],"maintenance":[22],"of":[23,47,56,62,104,138],"persistent":[24,48],"pain":[25,43,93,151],"states.":[26],"Here":[27],"we":[28],"demonstrate":[29],"that":[30,141],"muO-conotoxin":[31],"MrVIB":[32,57,71,105,139],"from":[33],"Conus":[34],"marmoreus":[35],"displays":[36],"substantial":[37],"selectivity":[38,80,127,145],"inhibits":[42],"behavior":[44,152],"in":[45,76],"models":[46],"pain.":[49],"In":[50,88,118],"rat":[51],"sensory":[52],"neurons,":[53],"submicromolar":[54],"concentrations":[55],"blocked":[58,72],"current":[60],"characteristic":[61],"but":[64],"not":[65],"Na(v)1.9":[66],"or":[67],"tetrodotoxin-sensitive":[68],"VGSC":[69,122,142],"currents.":[70],"human":[73],"Xenopus":[77],"oocytes":[78],"with":[79,153],"at":[81,114],"least":[82],"10-fold":[83],"greater":[84,155],"than":[85,158],"other":[86],"VGSCs.":[87],"neuropathic":[89],"chronic":[91,150],"inflammatory":[92],"models,":[94],"allodynia":[95,129],"hyperalgesia":[97,131],"were":[98],"both":[99],"reduced":[100],"intrathecal":[102],"infusion":[103],"(0.03-3":[106],"nmol),":[107],"whereas":[108],"motor":[109,133],"side":[110,134],"effects":[111],"occurred":[112],"only":[113],"30-fold":[115],"higher":[116],"doses.":[117],"contrast,":[119],"nonselective":[121,159],"blocker":[123],"lignocaine":[124],"displayed":[125],"no":[126],"versus":[132],"effects.":[135],"actions":[137],"reveal":[140],"antagonists":[143],"displaying":[144],"toward":[146],"can":[148],"alleviate":[149],"a":[154],"therapeutic":[156],"index":[157],"antagonists.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}