{"id":"https://openalex.org/W2156196408","doi":"https://doi.org/10.1111/j.1600-0676.1985.tb00228.x","title":"Immune mechanisms for hepatic fibrogenesis. T\u2010lymphocyte\u2010mediated stimulation of fibroblast collagen production in chronic active hepatitis","display_name":"Immune mechanisms for hepatic fibrogenesis. T\u2010lymphocyte\u2010mediated stimulation of fibroblast collagen production in chronic active hepatitis","publication_year":1985,"publication_date":"1985-06-01","ids":{"openalex":"https://openalex.org/W2156196408","doi":"https://doi.org/10.1111/j.1600-0676.1985.tb00228.x","mag":"2156196408","pmid":"https://pubmed.ncbi.nlm.nih.gov/3876501"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0676.1985.tb00228.x","doi":"https://doi.org/10.1111/j.1600-0676.1985.tb00228.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0676.1985.tb00228.x","pdf_url":null,"source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000353884","display_name":"Alessandro Casini","orcid":"https://orcid.org/0000-0001-7910-933X","observed_orcids":["https://orcid.org/0000-0001-7910-933X"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Casini","raw_affiliation_strings":["Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universita\u0300 di Firenze, Florence, Italy","Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universit\u00e0 di Firenze, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universita\u0300 di Firenze, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universit\u00e0 di Firenze, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071329164","display_name":"Oriano Elvio Ricci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Oriano Elvio Ricci","raw_affiliation_strings":["Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universita\u0300 di Firenze, Florence, Italy","Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universit\u00e0 di Firenze, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universita\u0300 di Firenze, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universit\u00e0 di Firenze, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109376918","display_name":"Francesco Paoletti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Paoletti","raw_affiliation_strings":["Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universita\u0300 di Firenze, Florence, Italy","Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universit\u00e0 di Firenze, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universita\u0300 di Firenze, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universit\u00e0 di Firenze, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110056863","display_name":"C. Surrenti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Calogero Surrenti","raw_affiliation_strings":["Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universita\u0300 di Firenze, Florence, Italy","Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universit\u00e0 di Firenze, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universita\u0300 di Firenze, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Cattedra di Gastroenterologia and Istituto di Patologia Generale, Universit\u00e0 di Firenze, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110056863"],"corresponding_institution_ids":["https://openalex.org/I45084792"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.17347814,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"3","first_page":"134","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-fibrogenesis","display_name":"hepatic fibrogenesis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/chronic-active-hepatitis","display_name":"chronic active hepatitis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9449999928474426},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.5799999833106995},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lymphokines","display_name":"lymphokines","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.777999997138977},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.6430000066757202},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.5989999771118164},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.7179999947547913},{"id":"https://openalex.org/keywords/immune-mechanisms","display_name":"immune mechanisms","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.8112965822219849},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.7168583869934082},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6686789393424988},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5891950130462646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5773687362670898},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5600303411483765},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.4841807186603546},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.44685134291648865},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.42429155111312866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38800573348999023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3823956847190857},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.37549489736557007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1354030966758728},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.07722485065460205},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006521","descriptor_name":"Hepatitis, Chronic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1600-0676.1985.tb00228.x","doi":"https://doi.org/10.1111/j.1600-0676.1985.tb00228.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0676.1985.tb00228.x","pdf_url":null,"source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver","raw_type":"journal-article"},{"id":"pmid:3876501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3876501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver","raw_type":"Comparative Study"},{"id":"pmh:oai:flore.unifi.it:2158/307715","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/307715","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1510157117","https://openalex.org/W1535620800","https://openalex.org/W1540339285","https://openalex.org/W1568336135","https://openalex.org/W1676695400","https://openalex.org/W1997732764","https://openalex.org/W2008880584","https://openalex.org/W2032017768","https://openalex.org/W2033554515","https://openalex.org/W2064948718","https://openalex.org/W2101579547","https://openalex.org/W2121844839","https://openalex.org/W2395856778","https://openalex.org/W2401801026","https://openalex.org/W2407051909","https://openalex.org/W2440116834","https://openalex.org/W2468119228","https://openalex.org/W4253686387","https://openalex.org/W4299544258"],"related_works":["https://openalex.org/W31039239","https://openalex.org/W3199418691","https://openalex.org/W4244428360","https://openalex.org/W4234285373","https://openalex.org/W2308997148","https://openalex.org/W6886218654","https://openalex.org/W4244041053","https://openalex.org/W1544353554","https://openalex.org/W2022002431","https://openalex.org/W2032017768"],"abstract_inverted_index":{"Lymphocytes":[0],"can":[1],"produce":[2],"soluble":[3],"factors":[4],"capable":[5],"of":[6,67,73,81,106,113,129,134,158,194,200],"enhancing":[7],"fibroblast":[8,51,74,178],"proliferation":[9],"and":[10,16,29,39,165],"collagen":[11,46,82,107,179],"synthesis.":[12],"T-lymphocytes,":[13],"adherent":[14,90],"cells":[15,21],"undifferentiated":[17],"peripheral":[18],"blood":[19],"mononuclear":[20,63],"from":[22,30,89,171],"patients":[23],"with":[24,36],"HBsAg-positive":[25],"chronic":[26,201],"active":[27],"hepatitis":[28],"HBsAg":[31,38,54,172],"healthy":[32,173],"carriers":[33,174],"were":[34],"triggered":[35],"purified":[37],"tested":[40],"for":[41],"their":[42],"ability":[43],"to":[44,71],"enhance":[45],"production":[47,108],"by":[48,116,126,145],"human":[49],"dermal":[50],"cultures.":[52,65],"Purified":[53],"did":[55,93,175],"not":[56,94,142,176],"induce":[57],"any":[58,96],"proliferative":[59],"response":[60],"in":[61,77,132,152,191],"the":[62,85,103,111,130,184,192,197],"cell":[64,91,169],"Addition":[66],"patient":[68],"T-lymphocyte":[69],"supernates":[70,87,170],"monolayers":[72],"consistently":[75],"resulted":[76],"a":[78,153,159],"significant":[79],"enhancement":[80,105],"production.":[83],"On":[84],"contrary,":[86],"harvested":[88],"cultures":[92],"demonstrate":[95],"stimulatory":[97],"activity.":[98],"We":[99],"therefore":[100],"assumed":[101],"that":[102,187],"observed":[104],"was":[109],"probably":[110],"result":[112],"lymphokine(s)":[114],"produced":[115],"T-lymphocytes.":[117],"This":[118],"fibrogenic":[119],"factor":[120],"(or":[121],"factors),":[122],"which":[123,155],"is":[124,136,150],"released":[125],"T-cells":[127],"independently":[128],"presence":[131],"vitro":[133],"HBsAg,":[135],"stable":[137],"at":[138],"-80":[139],"degrees":[140],"C,":[141],"dialyzable":[143],"and,":[144],"Sephadex":[146],"G-100":[147],"gel":[148],"filtration,":[149],"present":[151],"fraction":[154],"collects":[156],"substances":[157],"molecular":[160],"weight":[161],"between":[162],"50":[163],"000":[164],"100":[166],"000.":[167],"Mononuclear":[168],"influence":[177],"accumulation.":[180],"These":[181],"data":[182],"emphasize":[183],"possible":[185],"role":[186],"lymphokines":[188],"may":[189],"play":[190],"pathogenesis":[193],"fibrosis":[195],"during":[196],"natural":[198],"history":[199],"liver":[202],"disease.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
