{"id":"https://openalex.org/W2156140253","doi":"https://doi.org/10.1186/1471-2415-10-19","title":"Intraocular pressure and aqueous humor flow during a euglycemic-hyperinsulinemic clamp in patients with type 1 diabetes and microvascular complications","display_name":"Intraocular pressure and aqueous humor flow during a euglycemic-hyperinsulinemic clamp in patients with type 1 diabetes and microvascular complications","publication_year":2010,"publication_date":"2010-06-23","ids":{"openalex":"https://openalex.org/W2156140253","doi":"https://doi.org/10.1186/1471-2415-10-19","mag":"2156140253","pmid":"https://pubmed.ncbi.nlm.nih.gov/20573241","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2908568"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2415-10-19","doi":"https://doi.org/10.1186/1471-2415-10-19","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2415-10-19","pdf_url":"https://bmcophthalmol.biomedcentral.com/counter/pdf/10.1186/1471-2415-10-19","source":{"id":"https://openalex.org/S49440999","display_name":"BMC Ophthalmology","issn_l":"1471-2415","issn":["1471-2415"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcophthalmol.biomedcentral.com/counter/pdf/10.1186/1471-2415-10-19","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030005728","display_name":"James T. Lane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James T Lane","raw_affiliation_strings":["Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5840, USA. jtlane1@unmc.edu","Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5840, USA. jtlane1@unmc.edu","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005377185","display_name":"LuAnn Larson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LuAnn Larson","raw_affiliation_strings":["Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003576484","display_name":"Shan Fan","orcid":"https://orcid.org/0000-0002-7865-2805","observed_orcids":["https://orcid.org/0000-0002-7865-2805"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shan Fan","raw_affiliation_strings":["Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE, 68198-5840, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE, 68198-5840, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111461266","display_name":"Julie Ann Stoner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A Stoner","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111747729","display_name":"Eyal Margalit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eyal Margalit","raw_affiliation_strings":["Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE, 68198-5840, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE, 68198-5840, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091104086","display_name":"Carol B. Toris","orcid":"https://orcid.org/0000-0003-3794-6142","observed_orcids":["https://orcid.org/0000-0003-3794-6142"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol B Toris","raw_affiliation_strings":["Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE, 68198-5840, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE, 68198-5840, USA","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030005728"],"corresponding_institution_ids":["https://openalex.org/I59130452"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.0,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.31254843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"1","first_page":"19","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.8769999742507935},{"id":"https://openalex.org/keywords/aqueous-humor-flow","display_name":"aqueous humor flow","score":0.9169999957084656},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/diabetic-microvascular-complications","display_name":"diabetic microvascular complications","score":0.921999990940094},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/microalbuminuria","display_name":"microalbuminuria","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hyperinsulinemic-euglycemic-clamp","display_name":"hyperinsulinemic-euglycemic clamp","score":0.9160000085830688},{"id":"https://openalex.org/keywords/ocular-pulse-amplitude","display_name":"ocular pulse amplitude","score":0.718999981880188},{"id":"https://openalex.org/keywords/outflow-facility","display_name":"outflow facility","score":0.8849999904632568},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9064680933952332},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.695012092590332},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.6879940629005432},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.5773029327392578},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.5105632543563843},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.49360740184783936},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4805077314376831},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.46924710273742676},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.4308880865573883},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4160045385360718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3942906856536865},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3526310324668884},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3420500159263611},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2760506272315979}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001082","descriptor_name":"Aqueous Humor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006946","descriptor_name":"Hyperinsulinism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011674","descriptor_name":"Pulse","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015309","descriptor_name":"Glucose Clamp Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2415-10-19","doi":"https://doi.org/10.1186/1471-2415-10-19","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2415-10-19","pdf_url":"https://bmcophthalmol.biomedcentral.com/counter/pdf/10.1186/1471-2415-10-19","source":{"id":"https://openalex.org/S49440999","display_name":"BMC Ophthalmology","issn_l":"1471-2415","issn":["1471-2415"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2908568","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2908568","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Ophthalmol","raw_type":"Text"},{"id":"pmid:20573241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20573241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC ophthalmology","raw_type":"Comparative Study"},{"id":"pmh:oai:doaj.org/article:650d5715df234d2c8ecd12bf07f61b84","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/650d5715df234d2c8ecd12bf07f61b84","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Ophthalmology, Vol 10, Iss 1, p 19 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2415-10-19","doi":"https://doi.org/10.1186/1471-2415-10-19","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2415-10-19","pdf_url":"https://bmcophthalmol.biomedcentral.com/counter/pdf/10.1186/1471-2415-10-19","source":{"id":"https://openalex.org/S49440999","display_name":"BMC Ophthalmology","issn_l":"1471-2415","issn":["1471-2415"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7699999809265137}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320309137","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2156140253.pdf","grobid_xml":"https://content.openalex.org/works/W2156140253.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W9822936","https://openalex.org/W93259927","https://openalex.org/W144789232","https://openalex.org/W293477272","https://openalex.org/W596578524","https://openalex.org/W1524098896","https://openalex.org/W1596865488","https://openalex.org/W1889456496","https://openalex.org/W1973235785","https://openalex.org/W1976330342","https://openalex.org/W1983918303","https://openalex.org/W1990427151","https://openalex.org/W1993562164","https://openalex.org/W2007098380","https://openalex.org/W2021939694","https://openalex.org/W2027290406","https://openalex.org/W2028079387","https://openalex.org/W2030011072","https://openalex.org/W2030258782","https://openalex.org/W2031744172","https://openalex.org/W2032099355","https://openalex.org/W2037037676","https://openalex.org/W2037366980","https://openalex.org/W2038552648","https://openalex.org/W2043028650","https://openalex.org/W2046433337","https://openalex.org/W2046673177","https://openalex.org/W2048236176","https://openalex.org/W2049047511","https://openalex.org/W2052103334","https://openalex.org/W2057062366","https://openalex.org/W2057735163","https://openalex.org/W2077514842","https://openalex.org/W2082533150","https://openalex.org/W2082793745","https://openalex.org/W2089954390","https://openalex.org/W2091248462","https://openalex.org/W2092328292","https://openalex.org/W2096078834","https://openalex.org/W2100591986","https://openalex.org/W2105912552","https://openalex.org/W2119074953","https://openalex.org/W2119514827","https://openalex.org/W2127154777","https://openalex.org/W2128540764","https://openalex.org/W2143434427","https://openalex.org/W2146420176","https://openalex.org/W2153692026","https://openalex.org/W2155009865","https://openalex.org/W2160292547","https://openalex.org/W2345903479","https://openalex.org/W2500153525","https://openalex.org/W2587587505","https://openalex.org/W2769264260","https://openalex.org/W4233562854","https://openalex.org/W4244248663","https://openalex.org/W4302620707"],"related_works":["https://openalex.org/W7099034509","https://openalex.org/W2089954390","https://openalex.org/W2049047511","https://openalex.org/W2150180275","https://openalex.org/W2082793745","https://openalex.org/W2025868889","https://openalex.org/W2160329850","https://openalex.org/W2397108846","https://openalex.org/W2565084059","https://openalex.org/W2069185160"],"abstract_inverted_index":{"BACKGROUND:":[0],"Microvascular":[1],"complications,":[2],"including":[3],"retinopathy":[4,261],"and":[5,55,64,68,95,104,120,194,218,238,260],"nephropathy":[6],"are":[7,266],"seen":[8],"with":[9,30,48,60,254],"type":[10,61,255],"1":[11,62,256],"diabetes.":[12],"It":[13],"is":[14],"unknown":[15],"whether":[16],"functional":[17],"changes":[18],"in":[19,28,51,131,165,175,204,232,275],"aqueous":[20,52,124,276],"humor":[21,53],"flow":[22,54,74,125,277],"or":[23],"intraocular":[24],"pressure":[25,87,228],"(IOP)":[26],"develop":[27],"parallel":[29],"these":[31],"complications.":[32],"This":[33],"study":[34],"was":[35,75,88,107,126,156,163,202,229,278],"designed":[36],"to":[37,136,208,250],"test":[38],"the":[39,49,99,102,132,160,166,176,192,196,199,205,209,212,233,271],"hypothesis":[40],"that":[41,248,265],"clinical":[42],"markers":[43],"of":[44,101,117,198,211],"microvascular":[45],"complications":[46],"coexist":[47],"alteration":[50],"IOP.":[56],"METHODS:":[57],"Ten":[58],"patients":[59,253],"diabetes":[63,133,167,206,234,257],"ten":[65],"healthy":[66,251],"age-":[67],"weight-matched":[69],"controls":[70,137],"were":[71,221,242],"studied.":[72],"Aqueous":[73],"measured":[76,89,108],"by":[77,90,109,128,268],"fluorophotometry":[78],"during":[79],"a":[80,273],"hyperinsulinemic-euglycemic":[81],"clamp":[82],"(insulin":[83],"2":[84],"mU/kg/min).":[85],"Intraocular":[86],"tonometry":[91],"at":[92,111,188],"-10,":[93],"90":[94,189],"240":[96,112],"minutes":[97,190],"from":[98],"start":[100],"clamp,":[103,161,193,272],"outflow":[105,219],"facility":[106,220],"tonography":[110],"minutes.":[113],"RESULTS:":[114],"During":[115,270],"conditions":[116],"identical":[118],"glucose":[119],"insulin":[121],"concentrations,":[122],"mean":[123,147,239],"lower":[127],"0.58":[129],"microl/min":[130],"group":[134,168,178,207],"compared":[135,249],"(2.58":[138],"+/-":[139,143,148,170,180],"0.65":[140],"versus":[141],"3.16":[142],"0.66":[144],"microl/min,":[145],"respectively,":[146],"SD,":[149],"p":[150,184],"=":[151,185],"0.07)":[152],"but":[153,187,236],"statistical":[154],"significance":[155],"not":[157,222,243,279],"reached.":[158],"Before":[159],"IOP":[162,201],"higher":[164,231,263],"(22.6":[169],"3.0":[171],"mm":[172,182],"Hg)":[173],"than":[174],"control":[177,213],"(19.3":[179],"1.8":[181],"Hg,":[183],"0.01)":[186],"into":[191],"for":[195],"remainder":[197],"study,":[200],"reduced":[203],"level":[210],"group.":[214],"Ocular":[215],"pulse":[216],"amplitude":[217],"different":[223],"between":[224],"groups.":[225],"Systolic":[226],"blood":[227],"significantly":[230],"group,":[235],"diastolic":[237],"arterial":[240],"pressures":[241],"different.":[244],"CONCLUSIONS:":[245],"We":[246],"conclude":[247],"participants,":[252],"having":[258],"microalbuminuria":[259],"have":[262],"IOPs":[264],"normalized":[267],"hyperinsulinemia.":[269],"reduction":[274],"statistically":[280],"significant.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}