{"id":"https://openalex.org/W2156100577","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a133687","title":"Interaction of Aminoacyl-tRNA with Bacterial Elongation Factor Tu : GTP Complex: Effects of the Amino Group of Amino Acid Esterified to tRNA, the Amino Acid Side Chain, and tRNA Structure","display_name":"Interaction of Aminoacyl-tRNA with Bacterial Elongation Factor Tu : GTP Complex: Effects of the Amino Group of Amino Acid Esterified to tRNA, the Amino Acid Side Chain, and tRNA Structure","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2156100577","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a133687","mag":"2156100577","pmid":"https://pubmed.ncbi.nlm.nih.gov/7040360"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.jbchem.a133687","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a133687","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a133687","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Shozo TANADA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shozo TANADA","raw_affiliation_strings":["Institute of Molecular Biology, Faculty of Science, Nagoya University Chikusa-ku, Nagoya, Aichi 464"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Faculty of Science, Nagoya University Chikusa-ku, Nagoya, Aichi 464","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084898660","display_name":"Makoto Kawakami","orcid":"https://orcid.org/0000-0003-0639-0882","observed_orcids":["https://orcid.org/0000-0003-0639-0882"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Makoto KAWAKAMI","raw_affiliation_strings":["Institute of Molecular Biology, Faculty of Science, Nagoya University Chikusa-ku, Nagoya, Aichi 464"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Faculty of Science, Nagoya University Chikusa-ku, Nagoya, Aichi 464","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048865728","display_name":"Koji Nishio","orcid":"https://orcid.org/0000-0001-6983-6509","observed_orcids":["https://orcid.org/0000-0001-6983-6509"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji NISHIO","raw_affiliation_strings":["Institute of Molecular Biology, Faculty of Science, Nagoya University Chikusa-ku, Nagoya, Aichi 464"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Faculty of Science, Nagoya University Chikusa-ku, Nagoya, Aichi 464","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108381760","display_name":"Shosuke Takemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shosuke TAKEMURA","raw_affiliation_strings":["Institute of Molecular Biology, Faculty of Science, Nagoya University Chikusa-ku, Nagoya, Aichi 464"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Faculty of Science, Nagoya University Chikusa-ku, Nagoya, Aichi 464","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084898660"],"corresponding_institution_ids":["https://openalex.org/I60134161"],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":0.9938,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.70009855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"91","issue":"1","first_page":"291","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoacyl-trna","display_name":"aminoacyl-tRNA","score":0.996999979019165},{"id":"https://openalex.org/keywords/elongation-factor-tu","display_name":"elongation factor Tu","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ternary-complex","display_name":"ternary complex","score":0.8199999928474426},{"id":"https://openalex.org/keywords/aminoacyl-trna-binding","display_name":"aminoacyl-tRNA binding","score":0.6480000019073486},{"id":"https://openalex.org/keywords/alpha-amino-group","display_name":"alpha-amino group","score":0.8899999856948853},{"id":"https://openalex.org/keywords/amino-acid-side-chains","display_name":"amino acid side chains","score":0.953000009059906},{"id":"https://openalex.org/keywords/trna-structure","display_name":"tRNA structure","score":0.9610000252723694},{"id":"https://openalex.org/keywords/dissociation-constant","display_name":"dissociation constant","score":0.9150000214576721},{"id":"https://openalex.org/keywords/rnase-resistance","display_name":"RNase resistance","score":0.6380000114440918},{"id":"https://openalex.org/keywords/bacterial-protein-synthesis","display_name":"bacterial protein synthesis","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.8508214354515076},{"id":"https://openalex.org/C2780658535","wikidata":"https://www.wikidata.org/wiki/Q209022","display_name":"Aminoacyl-tRNA","level":5,"score":0.7426134943962097},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6656379103660583},{"id":"https://openalex.org/C139124968","wikidata":"https://www.wikidata.org/wiki/Q126252","display_name":"Elongation factor","level":5,"score":0.6424431800842285},{"id":"https://openalex.org/C75442077","wikidata":"https://www.wikidata.org/wiki/Q24726678","display_name":"EF-Tu","level":5,"score":0.6092519760131836},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.539700448513031},{"id":"https://openalex.org/C33947775","wikidata":"https://www.wikidata.org/wiki/Q271439","display_name":"Elongation","level":3,"score":0.52321457862854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5065187215805054},{"id":"https://openalex.org/C2779315393","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Aminoacyl tRNA synthetase","level":5,"score":0.48569759726524353},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47457149624824524},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.4505864977836609},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.346101313829422},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2846313416957855},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12012860178947449},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09721916913986206},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.09194770455360413},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05825001001358032},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004951","descriptor_name":"Esterification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005575","descriptor_name":"Formyltetrahydrofolates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010444","descriptor_name":"Peptide Elongation Factor Tu","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010445","descriptor_name":"Peptide Elongation Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012346","descriptor_name":"RNA, Transfer, Amino Acyl","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012358","descriptor_name":"RNA, Transfer, Met","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/oxfordjournals.jbchem.a133687","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a133687","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a133687","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:7040360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7040360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2032576005","https://openalex.org/W835855066","https://openalex.org/W1548506268","https://openalex.org/W2043783701","https://openalex.org/W1799607092","https://openalex.org/W2151147824","https://openalex.org/W1576415461","https://openalex.org/W2063593756","https://openalex.org/W271668805","https://openalex.org/W2016684208"],"abstract_inverted_index":{"The":[0,72],"present":[1],"investigation":[2],"was":[3],"undertaken":[4],"to":[5,7],"see":[6],"what":[8],"extent":[9],"the":[10,14,17,21,27,34,54,58,69,76,81,98],"alpha-amino":[11],"group":[12,79],"of":[13,20,24,36,57,61,80,101],"amino":[15,22,82],"acid,":[16],"side":[18],"chain":[19],"acid":[23],"aminoacyl-tRNA,":[25],"and":[26,48,53],"tRNA":[28],"structure":[29],"are":[30],"involved":[31],"in":[32,84],"determining":[33],"affinity":[35],"aminoacyl-tRNA":[37,62,85],"for":[38,89,103],"bacterial":[39],"elongation":[40],"factor":[41],"Tu-GTP":[42],"complex.":[43],"Various":[44],"aminoacyl-tRNAs,":[45],"mis-aminoacylated":[46],"tRNAs,":[47],"formylated":[49],"aminoacyl-tRNAs":[50],"were":[51,66],"prepared,":[52],"dissociation":[55],"constants":[56],"ternary":[59],"complexes":[60],"with":[63,91],"ET-Tu:":[64],"GTP":[65],"determined":[67],"by":[68],"RNase-resistance":[70],"assay.":[71],"results":[73],"indicated":[74],"that":[75],"free":[77],"amino-acid":[78],"acids":[83],"is":[86,106],"strongly":[87],"required":[88],"binding":[90],"EF-Tu":[92],":":[93],"GTP.":[94],"In":[95],"this":[96],"concentration,":[97],"biological":[99],"significance":[100],"formylation":[102],"Met-tRNAMetf":[104],"species":[105],"discussed.":[107]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}