{"id":"https://openalex.org/W2156016604","doi":"https://doi.org/10.1016/0041-008x(88)90275-x","title":"Cellular Ca2+ homeostasis and Ca2+-mediated cell processes as critical targets for toxicant action: Conceptual and methodological pitfalls","display_name":"Cellular Ca2+ homeostasis and Ca2+-mediated cell processes as critical targets for toxicant action: Conceptual and methodological pitfalls","publication_year":1988,"publication_date":"1988-07-01","ids":{"openalex":"https://openalex.org/W2156016604","doi":"https://doi.org/10.1016/0041-008x(88)90275-x","mag":"2156016604","pmid":"https://pubmed.ncbi.nlm.nih.gov/3041648"},"language":"en","primary_location":{"id":"doi:10.1016/0041-008x(88)90275-x","doi":"https://doi.org/10.1016/0041-008x(88)90275-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0041-008x(88)90275-x","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038563335","display_name":"Joel G. Pounds","orcid":"https://orcid.org/0000-0002-6616-1566","observed_orcids":["https://orcid.org/0000-0002-6616-1566"]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel G. Pounds","raw_affiliation_strings":["Department of Applied Science, Brookhaven National Laboratory, Upton, New York 11973","Division of Atomic and Applied Physics, Department of Applied Science, Brookhaven National Laboratory, Upton, New York 11973 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Science, Brookhaven National Laboratory, Upton, New York 11973","institution_ids":["https://openalex.org/I200870766"]},{"raw_affiliation_string":"Division of Atomic and Applied Physics, Department of Applied Science, Brookhaven National Laboratory, Upton, New York 11973 USA","institution_ids":["https://openalex.org/I200870766"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109973578","display_name":"John F. Rosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F. Rosen","raw_affiliation_strings":["Department of Pediatrics, Albert Einstein College of Medicine, Montefiore Hospital and Medical Center, Bronx, New York 10467 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Albert Einstein College of Medicine, Montefiore Hospital and Medical Center, Bronx, New York 10467 USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":4.0203,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.95192878,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"94","issue":"3","first_page":"331","last_page":"341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.21559999883174896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.05979999899864197,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.953000009059906},{"id":"https://openalex.org/keywords/methodological-pitfalls","display_name":"methodological pitfalls","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2780473477","wikidata":"https://www.wikidata.org/wiki/Q3072135","display_name":"Toxicant","level":3,"score":0.8484565615653992},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.7109384536743164},{"id":"https://openalex.org/C2994604686","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell function","level":3,"score":0.7022985816001892},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6158938407897949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.520754337310791},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.4932679533958435},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4294127821922302},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3780370056629181},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3546510934829712},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32571911811828613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2795979678630829},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14543339610099792},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.12432125210762024},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014116","descriptor_name":"Toxicology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0041-008x(88)90275-x","doi":"https://doi.org/10.1016/0041-008x(88)90275-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0041-008x(88)90275-x","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:3041648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3041648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G120304544","display_name":null,"funder_award_id":"ES04039","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G3634820669","display_name":null,"funder_award_id":"ES04040","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G871231655","display_name":null,"funder_award_id":"ES01060","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W47349699","https://openalex.org/W151643130","https://openalex.org/W172520768","https://openalex.org/W629099406","https://openalex.org/W1508175871","https://openalex.org/W1551428274","https://openalex.org/W1603146813","https://openalex.org/W1627867690","https://openalex.org/W1931703918","https://openalex.org/W1964562899","https://openalex.org/W1970488589","https://openalex.org/W1981784783","https://openalex.org/W1985402028","https://openalex.org/W1995275517","https://openalex.org/W2028719352","https://openalex.org/W2031961758","https://openalex.org/W2040571145","https://openalex.org/W2060501080","https://openalex.org/W2063871606","https://openalex.org/W2064333892","https://openalex.org/W2066060501","https://openalex.org/W2067814812","https://openalex.org/W2069423266","https://openalex.org/W2076985244","https://openalex.org/W2111691978","https://openalex.org/W2141260882","https://openalex.org/W2168979459","https://openalex.org/W2186047541","https://openalex.org/W2341915415","https://openalex.org/W2349715690","https://openalex.org/W2405014992","https://openalex.org/W2419398617","https://openalex.org/W2421191313","https://openalex.org/W2474656707","https://openalex.org/W2598528694","https://openalex.org/W4247501421","https://openalex.org/W6649168771","https://openalex.org/W6670151456"],"related_works":["https://openalex.org/W2077374324","https://openalex.org/W2021039464","https://openalex.org/W270682686","https://openalex.org/W2410878685","https://openalex.org/W4231245247","https://openalex.org/W7096364841","https://openalex.org/W2049732856","https://openalex.org/W2417769415","https://openalex.org/W2620256364","https://openalex.org/W2261663282"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}