{"id":"https://openalex.org/W2156007965","doi":"https://doi.org/10.1542/peds.2014-3770","title":"Early Cardiac Iron Overload in a Child on Treatment of Acute Lymphoblastic Leukemia","display_name":"Early Cardiac Iron Overload in a Child on Treatment of Acute Lymphoblastic Leukemia","publication_year":2015,"publication_date":"2015-08-18","ids":{"openalex":"https://openalex.org/W2156007965","doi":"https://doi.org/10.1542/peds.2014-3770","mag":"2156007965","pmid":"https://pubmed.ncbi.nlm.nih.gov/26283784","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7514881"},"language":"en","primary_location":{"id":"doi:10.1542/peds.2014-3770","doi":"https://doi.org/10.1542/peds.2014-3770","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.2014-3770","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7514881","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011482544","display_name":"Aaron J. Reitman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron J. Reitman","raw_affiliation_strings":["Children\u2019s Center for Cancer and Blood Diseases, Children\u2019s Hospital Los Angeles, Los Angeles, California; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Center for Cancer and Blood Diseases, Children\u2019s Hospital Los Angeles, Los Angeles, California; and","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077729374","display_name":"Thomas D. Coates","orcid":"https://orcid.org/0000-0001-9878-6029","observed_orcids":["https://orcid.org/0000-0001-9878-6029"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas D. Coates","raw_affiliation_strings":["Children\u2019s Center for Cancer and Blood Diseases, Children\u2019s Hospital Los Angeles, Los Angeles, California; and","Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Center for Cancer and Blood Diseases, Children\u2019s Hospital Los Angeles, Los Angeles, California; and","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087224572","display_name":"David R. Freyer","orcid":"https://orcid.org/0000-0001-5280-990X","observed_orcids":["https://orcid.org/0000-0001-5280-990X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Freyer","raw_affiliation_strings":["Children\u2019s Center for Cancer and Blood Diseases, Children\u2019s Hospital Los Angeles, Los Angeles, California; and","Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Center for Cancer and Blood Diseases, Children\u2019s Hospital Los Angeles, Los Angeles, California; and","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077729374"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"],"apc_list":null,"apc_paid":null,"fwci":0.2619,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.62854162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"136","issue":"3","first_page":"e697","last_page":"e700"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-iron-overload","display_name":"cardiac iron overload","score":0.9879999756813049},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9210000038146973},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9380000233650208},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pancreatic-iron-overload","display_name":"pancreatic iron overload","score":0.7149999737739563},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9579880237579346},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6344701051712036},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.6324262619018555},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.6234292387962341},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.46410736441612244},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.42718201875686646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4061245918273926},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.39595937728881836},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.26537129282951355},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.08245494961738586}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D065227","descriptor_name":"Transfusion Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1542/peds.2014-3770","doi":"https://doi.org/10.1542/peds.2014-3770","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.2014-3770","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7514881","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7514881","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Text"},{"id":"pmid:26283784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26283784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Case Reports"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7514881","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7514881","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G9000910363","display_name":"University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA014089","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W8599571","https://openalex.org/W1558712851","https://openalex.org/W1968151924","https://openalex.org/W1990355537","https://openalex.org/W1995852376","https://openalex.org/W2003632997","https://openalex.org/W2014696661","https://openalex.org/W2018938097","https://openalex.org/W2019133295","https://openalex.org/W2023570397","https://openalex.org/W2025780824","https://openalex.org/W2031242160","https://openalex.org/W2033034640","https://openalex.org/W2038697609","https://openalex.org/W2052952037","https://openalex.org/W2058298928","https://openalex.org/W2078982459","https://openalex.org/W2082049631","https://openalex.org/W2083522890","https://openalex.org/W2094765038","https://openalex.org/W2097394922","https://openalex.org/W2129961000","https://openalex.org/W2148209445","https://openalex.org/W2160848017"],"related_works":["https://openalex.org/W1995852376","https://openalex.org/W4392947370","https://openalex.org/W2076994280","https://openalex.org/W2083522890","https://openalex.org/W4379339295","https://openalex.org/W2055462489","https://openalex.org/W3200162766","https://openalex.org/W7100593594","https://openalex.org/W4403548798","https://openalex.org/W2094877469"],"abstract_inverted_index":{"An":[0],"11-year-old":[1],"boy":[2],"with":[3,45,88],"Down":[4],"syndrome":[5],"and":[6,28,40,50,101,107],"acute":[7],"lymphoblastic":[8],"leukemia":[9],"developed":[10],"hepatic":[11],"dysfunction":[12],"after":[13],"only":[14],"10":[15],"months":[16],"of":[17,98,104],"treatment.":[18],"MRI":[19],"revealed":[20],"severe":[21],"iron":[22,42,64,100],"deposition":[23],"in":[24,37,51,57,66,71,81,86],"the":[25,105],"liver,":[26],"pancreas,":[27],"heart.":[29],"In":[30],"stark":[31],"contrast":[32],"to":[33,95],"what":[34],"is":[35,75],"seen":[36],"hemoglobinopathies,":[38],"pancreatic":[39],"cardiac":[41],"overload":[43,65],"occurred":[44],"relatively":[46],"low":[47],"transfusion":[48],"exposure":[49],"a":[52],"very":[53],"short":[54],"time":[55],"period":[56],"this":[58],"patient.":[59],"Although":[60],"extensive":[61],"experience":[62],"managing":[63],"hemoglobinopathies":[67,82],"informs":[68],"our":[69],"approach":[70],"other":[72],"diseases,":[73],"it":[74],"clear":[76],"that":[77,93],"factors":[78],"not":[79],"present":[80],"may":[83],"be":[84],"operative":[85],"patients":[87],"malignancy":[89],"undergoing":[90],"intense":[91],"chemotherapy":[92],"lead":[94],"high":[96],"levels":[97],"free":[99],"rapid":[102],"loading":[103],"heart":[106],"endocrine":[108],"organs.":[109]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}