{"id":"https://openalex.org/W2155909189","doi":null,"title":"Effects of acute intra-hippocompal injection of bupropion on active avoidance learning in rats","display_name":"Effects of acute intra-hippocompal injection of bupropion on active avoidance learning in rats","publication_year":2010,"publication_date":"2010-10-10","ids":{"openalex":"https://openalex.org/W2155909189","mag":"2155909189"},"language":"en","primary_location":{"id":"mag:2155909189","doi":null,"is_oa":false,"landing_page_url":"http://phypha.ir/ppj/article-1-614-en.html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Physiology and Pharmacology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069739692","display_name":"saber ghaedrpour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38476204","display_name":"Urmia University","ror":"https://ror.org/032fk0x53","country_code":"IR","type":"education","lineage":["https://openalex.org/I38476204"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"saber ghaedrpour","raw_affiliation_strings":["Department of Biology, Faculty of Science, Urmia University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Urmia University,","institution_ids":["https://openalex.org/I38476204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101986078","display_name":"Samad Zare","orcid":"https://orcid.org/0000-0003-1462-6306","observed_orcids":["https://orcid.org/0000-0003-1462-6306"]},"institutions":[{"id":"https://openalex.org/I38476204","display_name":"Urmia University","ror":"https://ror.org/032fk0x53","country_code":"IR","type":"education","lineage":["https://openalex.org/I38476204"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Samad Zare","raw_affiliation_strings":["Department of Biology, Faculty of Science, Urmia University,"],"raw_orcid":"https://orcid.org/0000-0003-1462-6306","affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Urmia University,","institution_ids":["https://openalex.org/I38476204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039264288","display_name":"Firouz Ghaderi Pakdel","orcid":"https://orcid.org/0000-0002-7630-2676","observed_orcids":["https://orcid.org/0000-0002-7630-2676"]},"institutions":[{"id":"https://openalex.org/I38476204","display_name":"Urmia University","ror":"https://ror.org/032fk0x53","country_code":"IR","type":"education","lineage":["https://openalex.org/I38476204"]},{"id":"https://openalex.org/I4391767979","display_name":"Urmia University of Medical Sciences","ror":"https://ror.org/03jbsdf87","country_code":"IR","type":"education","lineage":["https://openalex.org/I4391767979"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Firouz Ghaderi Pakdel","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, Urmia University of Medical Science"],"raw_orcid":"https://orcid.org/0000-0002-7630-2676","affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, Urmia University of Medical Science","institution_ids":["https://openalex.org/I38476204","https://openalex.org/I4391767979"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.33650399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"3","first_page":"293","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bupropion","display_name":"bupropion","score":1.0},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7889999747276306},{"id":"https://openalex.org/keywords/active-avoidance","display_name":"active avoidance","score":0.9620000123977661},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.7760000228881836},{"id":"https://openalex.org/keywords/stereotactic-injection","display_name":"stereotactic injection","score":0.6620000004768372},{"id":"https://openalex.org/keywords/dopamine-reuptake-inhibition","display_name":"dopamine uptake inhibition","score":0.746999979019165},{"id":"https://openalex.org/keywords/acetylcholine-receptor","display_name":"acetylcholine receptor","score":0.8920000195503235},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2779908668","wikidata":"https://www.wikidata.org/wiki/Q834280","display_name":"Bupropion","level":3,"score":0.9451055526733398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.623672604560852},{"id":"https://openalex.org/C146926590","wikidata":"https://www.wikidata.org/wiki/Q4829142","display_name":"Avoidance response","level":2,"score":0.5835081338882446},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5818231701850891},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.4965408444404602},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4631722569465637},{"id":"https://openalex.org/C2993535909","wikidata":"https://www.wikidata.org/wiki/Q69887268","display_name":"Avoidance learning","level":2,"score":0.4501327872276306},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.2647209167480469},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1949884593486786},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.12706297636032104},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2155909189","doi":null,"is_oa":false,"landing_page_url":"http://phypha.ir/ppj/article-1-614-en.html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Physiology and Pharmacology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1680855902","https://openalex.org/W1963799398","https://openalex.org/W1964467966","https://openalex.org/W1970953263","https://openalex.org/W1979990523","https://openalex.org/W1987540037","https://openalex.org/W1990606428","https://openalex.org/W1991204199","https://openalex.org/W2000349913","https://openalex.org/W2020392840","https://openalex.org/W2020805907","https://openalex.org/W2022582927","https://openalex.org/W2046020459","https://openalex.org/W2046809238","https://openalex.org/W2050340461","https://openalex.org/W2056579603","https://openalex.org/W2057325807","https://openalex.org/W2062767067","https://openalex.org/W2074385293","https://openalex.org/W2092165199","https://openalex.org/W2092950487","https://openalex.org/W2100296366","https://openalex.org/W2108009185","https://openalex.org/W2111216523","https://openalex.org/W2115288063","https://openalex.org/W2122522992","https://openalex.org/W2133516314","https://openalex.org/W2137744200","https://openalex.org/W2163815564","https://openalex.org/W2256174545","https://openalex.org/W2281459549","https://openalex.org/W2314590238","https://openalex.org/W2482405395"],"related_works":["https://openalex.org/W2190569732","https://openalex.org/W2017370097","https://openalex.org/W3217721499","https://openalex.org/W2059879877","https://openalex.org/W2271280669","https://openalex.org/W2948728462","https://openalex.org/W4244752716","https://openalex.org/W1160253399","https://openalex.org/W2414327352","https://openalex.org/W1995470885"],"abstract_inverted_index":{"Introduction:":[0],"Learning":[1],"and":[2,16,20,31,87,104,112,159,187,219,233,260,265],"memory":[3,32,266],"deficits":[4],"in":[5,51,72,141,201,207],"some":[6],"diseases":[7],"are":[8],"new":[9],"subjects":[10],"of":[11,42,62,95,156,162,195,204,211,213,230],"research.":[12],"Bupropion,":[13],"as":[14,257],"dopamine":[15,242],"noradrenaline":[17],"reuptake":[18,243],"inhibitor":[19],"an":[21,160],"antidepressant":[22],"agent,":[23],"has":[24],"been":[25],"previously":[26],"shown":[27],"to":[28,38,253],"affect":[29],"learning":[30,49,70,189,215,264],"processes.":[33,267],"This":[34],"study":[35],"was":[36,117,165,191],"designed":[37],"test":[39,186],"the":[40,129,153,157,167,188,196,202,208,214,228,235,263],"effect":[41],"intra-hippocompal":[43],"bupropion":[44,97,179,220,239,250],"injection":[45],"on":[46,173],"active":[47,75,144],"avoidance":[48,76,145,205,231],"task":[50,146],"rats.":[52],"Methods:":[53],"Adult":[54],"male":[55],"Wistar":[56],"rats":[57,132],"(obtained":[58],"from":[59],"Pasteur":[60],"Institute":[61],"Iran,":[63],"weighing":[64],"200-250":[65],"g)":[66],"were":[67,80,133,150,171],"tested":[68],"for":[69],"behavior":[71],"a":[73,120,142,241],"two-way":[74],"shuttle-box.":[77],"The":[78],"animals":[79,222],"divided":[81],"into":[82],"control,":[83],"sham":[84],"operated,":[85],"vehicle":[86,181,218],"3":[88],"treatment":[89],"groups":[90],"treated":[91,221],"with":[92,262],"different":[93],"doses":[94],"intra-hippocampal":[96],"(0.25":[98],"mg/1":[99],"\u00b5L,":[100,107],"1.25":[101],"mg/5":[102],"\u00b5L":[103],"2.5":[105],"mg/10":[106],"injected":[108,118],"during":[109],"1-2,":[110],"5":[111,163,174],"10":[113,126],"min,":[114],"respectively).":[115],"Drug":[116],"by":[119],"stereotaxic":[121,130],"implanted":[122],"guide":[123],"cannulae.":[124],"Briefly,":[125],"days":[127],"after":[128],"surgery,":[131],"trained":[134],"(20":[135],"trails,":[136],"2":[137,168],"times":[138],"each":[139,185],"day)":[140],"twoway":[143],"shuttle":[147],"box.":[148],"Sessions":[149],"started":[151],"at":[152],"same":[154],"time":[155],"day":[158],"interval":[161],"hours":[164],"between":[166,217],"sessions.":[169],"Tests":[170],"repeated":[172],"consecutive":[175],"days.":[176],"Rats":[177],"received":[178],"or":[180],"30":[182],"min":[183],"before":[184],"process":[190],"assessed.":[192],"Results:":[193],"Analysis":[194],"data":[197],"showed":[198],"significant":[199],"differences":[200],"number":[203,229],"reactions":[206,232],"early":[209],"sessions":[210],"trials":[212],"tasks":[216],"(p<0.05).":[223],"Conclusion:":[224],"Bupropion":[225],"can":[226,251],"decrease":[227],"increase":[234],"reaction":[236],"latency.":[237],"Although":[238],"is":[240,247],"blocker,":[244],"but":[245],"it":[246],"concluded":[248],"that":[249],"bind":[252],"other":[254],"receptors":[255,259],"such":[256],"acetylcholine":[258],"interfere":[261]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}