{"id":"https://openalex.org/W2155808369","doi":"https://doi.org/10.1146/annurev-cellbio-101011-155822","title":"LINE-1 Retrotransposition in the Nervous System","display_name":"LINE-1 Retrotransposition in the Nervous System","publication_year":2012,"publication_date":"2012-10-11","ids":{"openalex":"https://openalex.org/W2155808369","doi":"https://doi.org/10.1146/annurev-cellbio-101011-155822","mag":"2155808369","pmid":"https://pubmed.ncbi.nlm.nih.gov/23057747"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-cellbio-101011-155822","doi":"https://doi.org/10.1146/annurev-cellbio-101011-155822","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-cellbio-101011-155822","pdf_url":null,"source":{"id":"https://openalex.org/S93285647","display_name":"Annual Review of Cell and Developmental Biology","issn_l":"1081-0706","issn":["1081-0706","1530-8995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109861002","display_name":"Charles A. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Thomas","raw_affiliation_strings":["Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California 92093; email: muotri@ucsd.edu","Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California 92093;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California 92093; email: muotri@ucsd.edu","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210087384"]},{"raw_affiliation_string":"Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California 92093;","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210087384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012040139","display_name":"Apu\u00e3 C.M. Paquola","orcid":"https://orcid.org/0000-0002-1329-6870","observed_orcids":["https://orcid.org/0000-0002-1329-6870"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Apu\u00e3 C.M. Paquola","raw_affiliation_strings":["Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California 92093; email: muotri@ucsd.edu","Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California 92093;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California 92093; email: muotri@ucsd.edu","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210087384"]},{"raw_affiliation_string":"Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California 92093;","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210087384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048323500","display_name":"Alysson Renato Muotri","orcid":"https://orcid.org/0000-0003-0867-2875","observed_orcids":["https://orcid.org/0000-0003-0867-2875"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alysson R. Muotri","raw_affiliation_strings":["Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California 92093; email: muotri@ucsd.edu","Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California 92093;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California 92093; email: muotri@ucsd.edu","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210087384"]},{"raw_affiliation_string":"Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California 92093;","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210087384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8164,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.59242144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"28","issue":"1","first_page":"555","last_page":"573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/line-1-retrotransposons","display_name":"LINE-1 retrotransposons","score":0.906000018119812},{"id":"https://openalex.org/keywords/retrotransposition","display_name":"retrotransposition","score":0.9539999961853027},{"id":"https://openalex.org/keywords/nervous-system","display_name":"nervous system","score":0.6710000038146973},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.5740000009536743},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.8320000171661377},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.5529999732971191},{"id":"https://openalex.org/keywords/somatic-mutagenesis","display_name":"somatic mutagenesis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/rett-syndrome","display_name":"Rett syndrome","score":0.8429999947547913},{"id":"https://openalex.org/keywords/ataxia-telangiectasia","display_name":"ataxia telangiectasia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.9100000262260437},{"id":"https://openalex.org/keywords/genome-evolution","display_name":"genome evolution","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C7029365","wikidata":"https://www.wikidata.org/wiki/Q413988","display_name":"Retrotransposon","level":5,"score":0.8901764154434204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8875079154968262},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5978717803955078},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5661537051200867},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5487896800041199},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5463287830352783},{"id":"https://openalex.org/C2777543196","wikidata":"https://www.wikidata.org/wiki/Q917357","display_name":"Rett syndrome","level":3,"score":0.5388363003730774},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5067952275276184},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.5045064687728882},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40339356660842896},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.24566775560379028},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2455340027809143},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16056889295578003},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.1385379433631897}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001260","descriptor_name":"Ataxia Telangiectasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001260","descriptor_name":"Ataxia Telangiectasia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001260","descriptor_name":"Ataxia Telangiectasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015186","descriptor_name":"Hominidae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015518","descriptor_name":"Rett Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015518","descriptor_name":"Rett Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015518","descriptor_name":"Rett Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020084","descriptor_name":"Long Interspersed Nucleotide Elements","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020084","descriptor_name":"Long Interspersed Nucleotide Elements","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev-cellbio-101011-155822","doi":"https://doi.org/10.1146/annurev-cellbio-101011-155822","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-cellbio-101011-155822","pdf_url":null,"source":{"id":"https://openalex.org/S93285647","display_name":"Annual Review of Cell and Developmental Biology","issn_l":"1081-0706","issn":["1081-0706","1530-8995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmid:23057747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23057747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of cell and developmental biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4025999903678894,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.49000000953674316,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3332460751","display_name":null,"funder_award_id":"1F31NS076198-01A1","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4567852460","display_name":"Modeling autism with human pluripotent cells","funder_award_id":"1dp2od006495-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G635908542","display_name":"MeCP2 regulation on LINE-1 retrotransposition in neurons","funder_award_id":"1f31ns076198-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7289770416","display_name":"The Impact of L1retrotransposition in the nervous system","funder_award_id":"R01MH094753","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W180449918","https://openalex.org/W614939294","https://openalex.org/W1509378838","https://openalex.org/W1559742681","https://openalex.org/W1629059403","https://openalex.org/W1645540159","https://openalex.org/W1866458240","https://openalex.org/W1964770396","https://openalex.org/W1965141089","https://openalex.org/W1974669442","https://openalex.org/W1978596306","https://openalex.org/W1981495424","https://openalex.org/W1982763490","https://openalex.org/W1984971821","https://openalex.org/W1985714764","https://openalex.org/W1986319478","https://openalex.org/W1986876163","https://openalex.org/W1986929596","https://openalex.org/W1987332588","https://openalex.org/W1988036066","https://openalex.org/W1989814892","https://openalex.org/W1990808653","https://openalex.org/W1991333931","https://openalex.org/W1991335876","https://openalex.org/W1999775510","https://openalex.org/W2001936578","https://openalex.org/W2002190096","https://openalex.org/W2007589425","https://openalex.org/W2007793712","https://openalex.org/W2010939701","https://openalex.org/W2012537642","https://openalex.org/W2013624745","https://openalex.org/W2015734897","https://openalex.org/W2017916825","https://openalex.org/W2024364777","https://openalex.org/W2026519705","https://openalex.org/W2031683488","https://openalex.org/W2032679533","https://openalex.org/W2033994550","https://openalex.org/W2035222904","https://openalex.org/W2036994672","https://openalex.org/W2037454793","https://openalex.org/W2038439057","https://openalex.org/W2041534255","https://openalex.org/W2046415390","https://openalex.org/W2051541780","https://openalex.org/W2052036700","https://openalex.org/W2052332313","https://openalex.org/W2053736750","https://openalex.org/W2055873867","https://openalex.org/W2058993504","https://openalex.org/W2062098224","https://openalex.org/W2062238129","https://openalex.org/W2064629259","https://openalex.org/W2066394211","https://openalex.org/W2070807615","https://openalex.org/W2071660897","https://openalex.org/W2075224242","https://openalex.org/W2075700771","https://openalex.org/W2077599130","https://openalex.org/W2087459771","https://openalex.org/W2096192426","https://openalex.org/W2097592047","https://openalex.org/W2098041458","https://openalex.org/W2104400024","https://openalex.org/W2106551806","https://openalex.org/W2113324240","https://openalex.org/W2113973815","https://openalex.org/W2114766453","https://openalex.org/W2114924552","https://openalex.org/W2115759508","https://openalex.org/W2119742125","https://openalex.org/W2120473562","https://openalex.org/W2122826014","https://openalex.org/W2125512488","https://openalex.org/W2125548284","https://openalex.org/W2127714237","https://openalex.org/W2129396106","https://openalex.org/W2131226790","https://openalex.org/W2131345268","https://openalex.org/W2133330202","https://openalex.org/W2139421798","https://openalex.org/W2145598239","https://openalex.org/W2146806115","https://openalex.org/W2152668149","https://openalex.org/W2154352037","https://openalex.org/W2154444538","https://openalex.org/W2156847772","https://openalex.org/W2158882685","https://openalex.org/W2159168998","https://openalex.org/W2161548300","https://openalex.org/W2168909179","https://openalex.org/W2315255667","https://openalex.org/W2402407270","https://openalex.org/W3103598586"],"related_works":["https://openalex.org/W2848963100","https://openalex.org/W2570453477","https://openalex.org/W347040816","https://openalex.org/W2465097595","https://openalex.org/W7097618158","https://openalex.org/W4318823497","https://openalex.org/W2097289125","https://openalex.org/W2276713634","https://openalex.org/W2755387354","https://openalex.org/W2119742125"],"abstract_inverted_index":{"Long":[0],"interspersed":[1],"element-1":[2],"(LINE-1":[3],"or":[4],"L1)":[5],"is":[6,24,100],"a":[7,15],"repetitive":[8],"DNA":[9],"retrotransposon":[10],"capable":[11],"of":[12,62,71,77,92],"duplication":[13],"by":[14,66],"copy-and-paste":[16],"genetic":[17],"mechanism.":[18],"Scattered":[19],"throughout":[20],"mammalian":[21],"genomes,":[22],"L1":[23,36,45,78,115],"typically":[25],"quiescent":[26],"in":[27,81],"most":[28],"somatic":[29,82],"cell":[30],"types.":[31],"In":[32,124],"developing":[33],"neurons,":[34],"however,":[35],"can":[37,47,58],"express":[38],"and":[39,111,135,143],"retrotranspose":[40],"at":[41],"high":[42,90],"frequency.":[43],"The":[44,75],"element":[46],"insert":[48],"into":[49],"various":[50],"genomic":[51,79],"locations":[52],"including":[53],"intragenic":[54],"regions.":[55],"These":[56],"insertions":[57],"alter":[59],"the":[60,63,68,89,129],"dynamic":[61],"neuronal":[64,140],"transcriptome":[65],"changing":[67],"expression":[69],"pattern":[70],"several":[72],"nearby":[73],"genes.":[74],"consequences":[76],"alterations":[80],"cells":[83],"are":[84],"still":[85],"under":[86],"investigation,":[87],"but":[88],"level":[91],"mutagenesis":[93],"within":[94],"neurons":[95],"suggests":[96],"that":[97],"each":[98],"neuron":[99],"genetically":[101],"unique.":[102],"Furthermore,":[103],"some":[104,121],"neurological":[105,144],"diseases,":[106],"such":[107],"as":[108],"Rett":[109],"syndrome":[110],"ataxia":[112],"telangiectasia,":[113],"misregulate":[114],"retrotransposition,":[116],"which":[117],"could":[118],"contribute":[119],"to":[120,132,139],"pathological":[122],"aspects.":[123],"this":[125],"review,":[126],"we":[127],"survey":[128],"literature":[130],"related":[131],"neurodevelopmental":[133],"retrotransposition":[134],"discuss":[136],"possible":[137],"relevance":[138],"function,":[141],"evolution,":[142],"disease.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}