{"id":"https://openalex.org/W2155807344","doi":"https://doi.org/10.1073/pnas.81.5.1529","title":"kappa gene diversity among the clonal progeny of pre-B lymphocytes.","display_name":"kappa gene diversity among the clonal progeny of pre-B lymphocytes.","publication_year":1984,"publication_date":"1984-03-01","ids":{"openalex":"https://openalex.org/W2155807344","doi":"https://doi.org/10.1073/pnas.81.5.1529","mag":"2155807344","pmid":"https://pubmed.ncbi.nlm.nih.gov/6324199","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/344870"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.81.5.1529","doi":"https://doi.org/10.1073/pnas.81.5.1529","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.81.5.1529","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC344870","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050390918","display_name":"Steven F. Ziegler","orcid":"https://orcid.org/0000-0003-0657-5529","observed_orcids":["https://orcid.org/0000-0003-0657-5529","https://orcid.org/0000-0002-9043-9273"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S F Ziegler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069311789","display_name":"Lucy J. Treiman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L J Treiman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087708211","display_name":"Owen N. Witte","orcid":"https://orcid.org/0000-0003-4461-4533","observed_orcids":["https://orcid.org/0000-0003-4461-4533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O N Witte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6923,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.85334531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"81","issue":"5","first_page":"1529","last_page":"1533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kappa-light-chain-genes","display_name":"kappa light chain genes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pre-b-cell-development","display_name":"pre-B cell development","score":0.5450000166893005},{"id":"https://openalex.org/keywords/gene-rearrangement","display_name":"gene rearrangement","score":0.6389999985694885},{"id":"https://openalex.org/keywords/abelson-murine-leukemia-virus","display_name":"Abelson murine leukemia virus","score":0.753000020980835},{"id":"https://openalex.org/keywords/restriction-site-polymorphism","display_name":"restriction site polymorphism","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2778724333","wikidata":"https://www.wikidata.org/wiki/Q14401","display_name":"Kappa","level":2,"score":0.8253612518310547},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.8100652694702148},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6872988343238831},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6414092183113098},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6195449829101562},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5830551981925964},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5693541765213013},{"id":"https://openalex.org/C2992511266","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"Gene rearrangement","level":3,"score":0.42365899682044983},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3379947543144226},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000011","descriptor_name":"Abelson murine leukemia virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004262","descriptor_name":"DNA Restriction Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007145","descriptor_name":"Immunoglobulin kappa-Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.81.5.1529","doi":"https://doi.org/10.1073/pnas.81.5.1529","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.81.5.1529","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:57247","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC344870","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:344870","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/344870","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:6324199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6324199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:57247","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC344870","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1588885776","https://openalex.org/W1737898466","https://openalex.org/W1742358547","https://openalex.org/W1968617992","https://openalex.org/W1973099218","https://openalex.org/W1974596630","https://openalex.org/W1981042444","https://openalex.org/W1984387553","https://openalex.org/W1991172691","https://openalex.org/W1992967316","https://openalex.org/W2000971934","https://openalex.org/W2004707654","https://openalex.org/W2007255991","https://openalex.org/W2007643304","https://openalex.org/W2014395675","https://openalex.org/W2016225921","https://openalex.org/W2017044557","https://openalex.org/W2021118214","https://openalex.org/W2027839043","https://openalex.org/W2043606127","https://openalex.org/W2063450941","https://openalex.org/W2065596486","https://openalex.org/W2066663570","https://openalex.org/W2067538215","https://openalex.org/W2068378281","https://openalex.org/W2069386554","https://openalex.org/W2069490422","https://openalex.org/W2077077811","https://openalex.org/W2081477822","https://openalex.org/W2082205791","https://openalex.org/W2116392882","https://openalex.org/W2395958375"],"related_works":["https://openalex.org/W2062028511","https://openalex.org/W1593785927","https://openalex.org/W2024112963","https://openalex.org/W2165809537","https://openalex.org/W2130719741","https://openalex.org/W2116608920","https://openalex.org/W2035826293","https://openalex.org/W1553590598","https://openalex.org/W2068758690","https://openalex.org/W1502342204"],"abstract_inverted_index":{"Some":[0],"clonal":[1],"pre-B":[2,38],"cell":[3,39],"lines,":[4],"when":[5],"transformed":[6],"by":[7,137],"Abelson":[8],"murine":[9],"leukemia":[10],"virus,":[11],"are":[12],"able":[13],"to":[14,123,188],"rearrange":[15],"and":[16,54,165,167],"express":[17],"kappa":[18,51,69,71,88,98,115,145,162,180],"light":[19,26,72,117,181],"chain":[20,118],"genes.":[21],"We":[22],"have":[23,151],"analyzed":[24],"the":[25,50,77,80,110,119,130,142,159,171,186],"chains":[27,182],"expressed":[28,66,86,113,131,160,172],"in":[29,129,141,153,158,170],"sets":[30,83],"of":[31,61,64,76,79,84,109,179,192],"early":[32,189],"B-cell":[33,190],"subclones":[34,65,85],"derived":[35],"from":[36,101],"two":[37,82],"clones.":[40],"Each":[41],"subclone":[42,108],"makes":[43],"an":[44],"indistinguishable":[45],"mu":[46],"heavy":[47],"chain,":[48],"while":[49],"gene":[52,164],"rearrangements":[53],"proteins":[55,132],"synthesized":[56],"were":[57],"distinct.":[58],"All":[59],"members":[60,78],"one":[62,75,104],"set":[63,111],"a":[67,91,97,154],"V":[68,87,114,144,161],"21":[70,116,146,163],"chain.":[73],"Only":[74],"other":[81],"21.":[89],"Thus,":[90],"single":[92],"pre-B-cell":[93],"clone":[94],"can":[95,133,183],"select":[96],"variable":[99],"region":[100],"more":[102],"than":[103],"family.":[105],"In":[106],"each":[107],"that":[112,177],"same":[120],"member":[121],"appears":[122],"be":[124,135],"used.":[125],"The":[126],"differences":[127,169],"detected":[128],"best":[134],"explained":[136],"primary":[138],"sequence":[139,149],"alterations":[140,150],"rearranged":[143],"segment.":[147],"These":[148,174],"resulted":[152],"restriction":[155],"site":[156],"polymorphism":[157],"charge":[166],"size":[168],"proteins.":[173],"data":[175],"suggest":[176],"diversification":[178],"occur":[184],"at":[185],"pre-B-":[187],"stage":[191],"development.":[193]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
