{"id":"https://openalex.org/W2155790664","doi":"https://doi.org/10.1073/pnas.96.25.14430","title":"Conserved characteristics of heterochromatin-forming DNA at the 15q11-q13 imprinting center","display_name":"Conserved characteristics of heterochromatin-forming DNA at the 15q11-q13 imprinting center","publication_year":1999,"publication_date":"1999-12-07","ids":{"openalex":"https://openalex.org/W2155790664","doi":"https://doi.org/10.1073/pnas.96.25.14430","mag":"2155790664","pmid":"https://pubmed.ncbi.nlm.nih.gov/10588722","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/24453"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.96.25.14430","doi":"https://doi.org/10.1073/pnas.96.25.14430","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.96.25.14430","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/24453","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048839844","display_name":"John M. Greally","orcid":"https://orcid.org/0000-0001-6069-7960","observed_orcids":["https://orcid.org/0000-0001-6069-7960"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Greally","raw_affiliation_strings":["Departments of Genetics and Pediatrics, Yale\r University School of Medicine, 333 Cedar Street, New Haven, CT 06520;\r and Department of Genetics, Case Western Reserve\r University School of Medicine and Center for Human Genetics, University\r Hospitals of Cleveland, Cleveland, OH 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Genetics and Pediatrics, Yale\r University School of Medicine, 333 Cedar Street, New Haven, CT 06520;\r and Department of Genetics, Case Western Reserve\r University School of Medicine and Center for Human Genetics, University\r Hospitals of Cleveland, Cleveland, OH 44106","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I32971472","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025350364","display_name":"Todd A. Gray","orcid":"https://orcid.org/0000-0003-0931-5503","observed_orcids":["https://orcid.org/0000-0003-0931-5503"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd A. Gray","raw_affiliation_strings":["Departments of Genetics and Pediatrics, Yale\r University School of Medicine, 333 Cedar Street, New Haven, CT 06520;\r and Department of Genetics, Case Western Reserve\r University School of Medicine and Center for Human Genetics, University\r Hospitals of Cleveland, Cleveland, OH 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Genetics and Pediatrics, Yale\r University School of Medicine, 333 Cedar Street, New Haven, CT 06520;\r and Department of Genetics, Case Western Reserve\r University School of Medicine and Center for Human Genetics, University\r Hospitals of Cleveland, Cleveland, OH 44106","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I32971472","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110836637","display_name":"James M. Gabriel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Gabriel","raw_affiliation_strings":["Departments of Genetics and Pediatrics, Yale\r University School of Medicine, 333 Cedar Street, New Haven, CT 06520;\r and Department of Genetics, Case Western Reserve\r University School of Medicine and Center for Human Genetics, University\r Hospitals of Cleveland, Cleveland, OH 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Genetics and Pediatrics, Yale\r University School of Medicine, 333 Cedar Street, New Haven, CT 06520;\r and Department of Genetics, Case Western Reserve\r University School of Medicine and Center for Human Genetics, University\r Hospitals of Cleveland, Cleveland, OH 44106","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I32971472","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014429738","display_name":"Li qun Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li qun Song","raw_affiliation_strings":["Departments of Genetics and Pediatrics, Yale\r University School of Medicine, 333 Cedar Street, New Haven, CT 06520;\r and Department of Genetics, Case Western Reserve\r University School of Medicine and Center for Human Genetics, University\r Hospitals of Cleveland, Cleveland, OH 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Genetics and Pediatrics, Yale\r University School of Medicine, 333 Cedar Street, New Haven, CT 06520;\r and Department of Genetics, Case Western Reserve\r University School of Medicine and Center for Human Genetics, University\r Hospitals of Cleveland, Cleveland, OH 44106","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I32971472","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018036870","display_name":"Sharon Zemel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Zemel","raw_affiliation_strings":["Departments of Genetics and Pediatrics, Yale\r University School of Medicine, 333 Cedar Street, New Haven, CT 06520;\r and Department of Genetics, Case Western Reserve\r University School of Medicine and Center for Human Genetics, University\r Hospitals of Cleveland, Cleveland, OH 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Genetics and Pediatrics, Yale\r University School of Medicine, 333 Cedar Street, New Haven, CT 06520;\r and Department of Genetics, Case Western Reserve\r University School of Medicine and Center for Human Genetics, University\r Hospitals of Cleveland, Cleveland, OH 44106","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I32971472","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058303676","display_name":"Robert D. Nicholls","orcid":"https://orcid.org/0000-0001-7863-786X","observed_orcids":["https://orcid.org/0000-0001-7863-786X"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Nicholls","raw_affiliation_strings":["Departments of Genetics and Pediatrics, Yale\r University School of Medicine, 333 Cedar Street, New Haven, CT 06520;\r and Department of Genetics, Case Western Reserve\r University School of Medicine and Center for Human Genetics, University\r Hospitals of Cleveland, Cleveland, OH 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Genetics and Pediatrics, Yale\r University School of Medicine, 333 Cedar Street, New Haven, CT 06520;\r and Department of Genetics, Case Western Reserve\r University School of Medicine and Center for Human Genetics, University\r Hospitals of Cleveland, Cleveland, OH 44106","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I32971472","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2889,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.88115616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"96","issue":"25","first_page":"14430","last_page":"14435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.05480000004172325,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genomic-imprinting","display_name":"genomic imprinting","score":0.9330000281333923},{"id":"https://openalex.org/keywords/matrix-attachment-regions","display_name":"matrix attachment regions","score":0.8270000219345093},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/oogenesis","display_name":"oogenesis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/position-effect","display_name":"position effect","score":0.5830000042915344},{"id":"https://openalex.org/keywords/replication-timing","display_name":"DNA replication timing","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.8203865885734558},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7429772019386292},{"id":"https://openalex.org/C201492766","wikidata":"https://www.wikidata.org/wiki/Q84087","display_name":"Genomic imprinting","level":5,"score":0.706671416759491},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6670004725456238},{"id":"https://openalex.org/C94715292","wikidata":"https://www.wikidata.org/wiki/Q624349","display_name":"Imprinting (psychology)","level":3,"score":0.435712993144989},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3588865399360657},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.3579104542732239},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.27461859583854675},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002884","descriptor_name":"Chromosomes, Human, Pair 15","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006570","descriptor_name":"Heterochromatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015530","descriptor_name":"Nuclear Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018392","descriptor_name":"Genomic Imprinting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.96.25.14430","doi":"https://doi.org/10.1073/pnas.96.25.14430","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.96.25.14430","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:24453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/24453","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:10588722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10588722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:24453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/24453","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1852504087","display_name":"MATRIX ATTACHMENT REGIONS IN AN IMPRINTED DOMAIN","funder_award_id":"7k08dk002467-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3653710649","display_name":null,"funder_award_id":"HD31491","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G399406910","display_name":null,"funder_award_id":"DK02467","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4019588085","display_name":"MOLECULAR STUDIES OF GENOMIC IMPRINTING IN HUMANS","funder_award_id":"R01HD031491","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5059454762","display_name":null,"funder_award_id":"HD36079","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5676750123","display_name":"FUNCTIONAL ANALYSIS OF IMPRINTING MUTATIONS","funder_award_id":"5r01hd036079-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G699076092","display_name":"Training in Genetics","funder_award_id":"T32GM008613","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8317631527","display_name":"MOLECULAR MECHANISMS OF IMPRINTING IN HUMAN DISEASE","funder_award_id":"F32GM018306","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W39451727","https://openalex.org/W190377005","https://openalex.org/W197832193","https://openalex.org/W1606632025","https://openalex.org/W1810665495","https://openalex.org/W1821582542","https://openalex.org/W1872127137","https://openalex.org/W1920582783","https://openalex.org/W1966104820","https://openalex.org/W1968567711","https://openalex.org/W1970139633","https://openalex.org/W1974257082","https://openalex.org/W1975989693","https://openalex.org/W1986586522","https://openalex.org/W1991935852","https://openalex.org/W1993821286","https://openalex.org/W2002202527","https://openalex.org/W2002828557","https://openalex.org/W2004215286","https://openalex.org/W2009369773","https://openalex.org/W2009475513","https://openalex.org/W2013785368","https://openalex.org/W2014314027","https://openalex.org/W2017183849","https://openalex.org/W2020858733","https://openalex.org/W2029761376","https://openalex.org/W2036390149","https://openalex.org/W2038283767","https://openalex.org/W2043734426","https://openalex.org/W2045857484","https://openalex.org/W2056793770","https://openalex.org/W2062927389","https://openalex.org/W2069065254","https://openalex.org/W2069169829","https://openalex.org/W2070766068","https://openalex.org/W2079688843","https://openalex.org/W2091969784","https://openalex.org/W2098187385","https://openalex.org/W2114768769","https://openalex.org/W2119712007","https://openalex.org/W2134548352","https://openalex.org/W2134588432","https://openalex.org/W2136392800","https://openalex.org/W2146105594","https://openalex.org/W2147714004","https://openalex.org/W2148641958","https://openalex.org/W2154213246","https://openalex.org/W2159348779","https://openalex.org/W2159615538","https://openalex.org/W2166703010","https://openalex.org/W2167289583","https://openalex.org/W2185090426","https://openalex.org/W2217532849","https://openalex.org/W2409302316","https://openalex.org/W2994096458"],"related_works":["https://openalex.org/W2105904675","https://openalex.org/W2009475513","https://openalex.org/W2168431888","https://openalex.org/W7097665772","https://openalex.org/W2047038877","https://openalex.org/W2126414759","https://openalex.org/W4283463131","https://openalex.org/W2002098647","https://openalex.org/W1602745749","https://openalex.org/W2090980177"],"abstract_inverted_index":{"Nuclear":[0],"matrix":[1,10,177],"binding":[2],"assays":[3],"(NMBAs)":[4],"define":[5],"certain":[6],"DNA":[7,86,242],"sequences":[8,147],"as":[9,153],"attachment":[11],"regions":[12],"(MARs),":[13],"which":[14],"often":[15],"have":[16],"cis-acting":[17],"epigenetic":[18],"regulatory":[19],"functions.":[20],"We":[21,33,141,224],"used":[22],"NMBAs":[23],"to":[24,51,59,121,128,171],"analyze":[25],"the":[26,36,52,70,75,78,104,108,125,138,144,149,180,184,192,204,210,213,227,232,239],"functionally":[27],"important":[28],"15q11-q13":[29,109,233],"imprinting":[30,205],"center":[31],"(IC).":[32],"find":[34,68],"that":[35,56,69,143,226],"IC":[37,150,186,211,234],"is":[38,74,116,187],"composed":[39],"of":[40,45,72,85,89,103,179,203],"an":[41,157],"unusually":[42],"high":[43],"density":[44],"MARs,":[46],"located":[47],"in":[48,63,168,222,244],"close":[49],"proximity":[50],"germ":[53,228],"line":[54,229],"elements":[55,230],"are":[57,92,151],"proposed":[58],"direct":[60],"imprint":[61],"switching":[62],"this":[64,90,164,245],"region.":[65],"Moreover,":[66],"we":[67],"organization":[71,158],"MARs":[73,88],"same":[76],"at":[77,148,209,231],"homologous":[79],"mouse":[80],"locus,":[81],"despite":[82],"extensive":[83,145],"divergence":[84],"sequence.":[87],"size":[91],"not":[93],"usually":[94],"associated":[95],"with":[96,100,163],"genes":[97,114],"but":[98],"rather":[99],"heterochromatin-forming":[101,241],"areas":[102],"genome.":[105],"In":[106],"contrast,":[107],"region":[110],"contains":[111],"multiple":[112],"transcribed":[113],"and":[115,134],"unusual":[117],"for":[118,201],"being":[119],"subject":[120],"genomic":[122],"imprinting,":[123],"causing":[124],"maternal":[126,181,214],"chromosome":[127,215],"be":[129],"more":[130,188],"transcriptionally":[131],"silent,":[132],"methylated,":[133],"late":[135],"replicating":[136],"than":[137],"paternal":[139,185],"chromosome.":[140],"suggest":[142],"MAR":[146],"organized":[152],"heterochromatin":[154,208],"during":[155,160],"oogenesis,":[156],"disrupted":[159],"spermatogenesis.":[161],"Consistent":[162],"model,":[165],"multicolor":[166],"fluorescence":[167],"situ":[169],"hybridization":[170],"halo":[172],"nuclei":[173],"demonstrates":[174],"a":[175,199,218],"strong":[176],"association":[178],"IC,":[182],"whereas":[183],"decondensed,":[189],"extending":[190],"into":[191],"nuclear":[193],"halo.":[194],"This":[195],"model":[196],"also":[197],"provides":[198],"mechanism":[200],"spreading":[202],"signal,":[206],"because":[207],"on":[212],"may":[216],"exert":[217],"suppressive":[219],"position":[220],"effect":[221],"cis.":[223],"propose":[225],"mediate":[235],"their":[236],"effects":[237],"through":[238],"candidate":[240],"identified":[243],"study.":[246]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}