{"id":"https://openalex.org/W2155777749","doi":"https://doi.org/10.5858/132.12.1907","title":"Immunohistochemical Evaluation of Androgen Receptor, HER-2/neu, and p53 in Benign Pleomorphic Adenomas","display_name":"Immunohistochemical Evaluation of Androgen Receptor, HER-2/neu, and p53 in Benign Pleomorphic Adenomas","publication_year":2008,"publication_date":"2008-12-01","ids":{"openalex":"https://openalex.org/W2155777749","doi":"https://doi.org/10.5858/132.12.1907","mag":"2155777749","pmid":"https://pubmed.ncbi.nlm.nih.gov/19061288"},"language":"en","primary_location":{"id":"doi:10.5858/132.12.1907","doi":"https://doi.org/10.5858/132.12.1907","is_oa":false,"landing_page_url":"https://doi.org/10.5858/132.12.1907","pdf_url":null,"source":{"id":"https://openalex.org/S139062638","display_name":"Archives of Pathology & Laboratory Medicine","issn_l":"0003-9985","issn":["0003-9985","1543-2165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pathology & Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044802708","display_name":"Tom C. DeRoche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom C. DeRoche","raw_affiliation_strings":["From the Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio","Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023587147","display_name":"Aaron P. Hoschar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron P. Hoschar","raw_affiliation_strings":["From the Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059315630","display_name":"Jennifer Leigh Hunt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Hunt","raw_affiliation_strings":["From the Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":null,"apc_paid":null,"fwci":3.7125,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.92826423,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"132","issue":"12","first_page":"1907","last_page":"1911"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11035","display_name":"Salivary Gland Tumors Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11035","display_name":"Salivary Gland Tumors Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11787","display_name":"Oral and Maxillofacial Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pleomorphic-adenoma","display_name":"pleomorphic adenoma","score":0.902999997138977},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8399999737739563},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":1.0},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.996999979019165},{"id":"https://openalex.org/keywords/salivary-gland-tumors","display_name":"salivary gland tumors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/carcinoma-ex-pleomorphic-adenoma","display_name":"carcinoma ex pleomorphic adenoma","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cytological-atypia","display_name":"cytologic atypia","score":0.8090000152587891},{"id":"https://openalex.org/keywords/carcinomatous-transformation","display_name":"carcinomatous transformation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.6970000267028809},{"id":"https://openalex.org/keywords/mitotic-rate","display_name":"mitotic activity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.8015016317367554},{"id":"https://openalex.org/C2781437628","wikidata":"https://www.wikidata.org/wiki/Q2064603","display_name":"Pleomorphic adenoma","level":3,"score":0.751248836517334},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.6828078031539917},{"id":"https://openalex.org/C2780885620","wikidata":"https://www.wikidata.org/wiki/Q5038165","display_name":"Carcinoma ex pleomorphic adenoma","level":4,"score":0.6528379917144775},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6400030851364136},{"id":"https://openalex.org/C2781283455","wikidata":"https://www.wikidata.org/wiki/Q1960558","display_name":"Atypia","level":2,"score":0.6380136609077454},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.5558901429176331},{"id":"https://openalex.org/C140884156","wikidata":"https://www.wikidata.org/wiki/Q1476681","display_name":"Myoepithelial cell","level":3,"score":0.5110889077186584},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.49177196621894836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4264475703239441},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.41400712728500366},{"id":"https://openalex.org/C2778937882","wikidata":"https://www.wikidata.org/wiki/Q134938","display_name":"Salivary gland","level":2,"score":0.37769466638565063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3196220099925995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1299954354763031},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11724826693534851},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.045142024755477905}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008949","descriptor_name":"Adenoma, Pleomorphic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008949","descriptor_name":"Adenoma, Pleomorphic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008949","descriptor_name":"Adenoma, Pleomorphic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010307","descriptor_name":"Parotid Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010307","descriptor_name":"Parotid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010307","descriptor_name":"Parotid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012468","descriptor_name":"Salivary Gland Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012468","descriptor_name":"Salivary Gland Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012468","descriptor_name":"Salivary Gland Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.5858/132.12.1907","doi":"https://doi.org/10.5858/132.12.1907","is_oa":false,"landing_page_url":"https://doi.org/10.5858/132.12.1907","pdf_url":null,"source":{"id":"https://openalex.org/S139062638","display_name":"Archives of Pathology & Laboratory Medicine","issn_l":"0003-9985","issn":["0003-9985","1543-2165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pathology & Laboratory Medicine","raw_type":"journal-article"},{"id":"pmid:19061288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19061288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of pathology & laboratory medicine","raw_type":"Journal Article"},{"id":"mag:2155777749","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/abstract/MED/19061288","pdf_url":null,"source":{"id":"https://openalex.org/S139062638","display_name":"Archives of Pathology & Laboratory Medicine","issn_l":"0003-9985","issn":["0003-9985","1543-2165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Archives of Pathology & Laboratory Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W56363140","https://openalex.org/W109449584","https://openalex.org/W167241193","https://openalex.org/W177788060","https://openalex.org/W1547474215","https://openalex.org/W1976010655","https://openalex.org/W1980268730","https://openalex.org/W1984632244","https://openalex.org/W1987176258","https://openalex.org/W1995492471","https://openalex.org/W1997359366","https://openalex.org/W2003460535","https://openalex.org/W2013809349","https://openalex.org/W2019111926","https://openalex.org/W2050141762","https://openalex.org/W2052286628","https://openalex.org/W2052309111","https://openalex.org/W2052987864","https://openalex.org/W2055622267","https://openalex.org/W2057572869","https://openalex.org/W2058191098","https://openalex.org/W2058769149","https://openalex.org/W2062485569","https://openalex.org/W2067299150","https://openalex.org/W2082497313","https://openalex.org/W2091026235","https://openalex.org/W2095093067","https://openalex.org/W2120136659","https://openalex.org/W2133155905","https://openalex.org/W2143077043","https://openalex.org/W2163947995","https://openalex.org/W6602305788","https://openalex.org/W6653910192"],"related_works":["https://openalex.org/W7167055385","https://openalex.org/W2095371304","https://openalex.org/W7120789124","https://openalex.org/W7097945671","https://openalex.org/W7056991488","https://openalex.org/W2161701075","https://openalex.org/W2033107011","https://openalex.org/W2319788945","https://openalex.org/W2976499416","https://openalex.org/W4299822427"],"abstract_inverted_index":{"CONTEXT:":[0],"Immunohistochemical":[1],"stains":[2],"for":[3,108,132,149],"androgen":[4],"receptor":[5],"(AR),":[6],"HER-2/neu,":[7,64,79,184],"and":[8,65,80,88,111,151,156,165,169,172,178,186,195],"p53":[9,66,81,133,187],"are":[10,48,188],"used":[11,204],"as":[12,45],"diagnostic":[13],"markers":[14,27,201],"associated":[15],"with":[16,35,105],"malignancy":[17],"in":[18,31,71,85,136,167,180,190,211],"several":[19],"histologic":[20],"types":[21],"of":[22,56,96,98,140,142,146,193],"salivary":[23],"gland":[24],"tumors.":[25],"These":[26,200],"may":[28],"be":[29,69,203],"useful":[30],"differentiating":[32],"pleomorphic":[33,42,74,91,100,198,212],"adenoma":[34,43],"cytologic":[36,129],"atypia":[37],"from":[38],"intracapsular":[39],"carcinoma":[40],"ex":[41],"(CXPA),":[44],"these":[46],"tumors":[47],"often":[49],"difficult":[50],"to":[51,119,205],"distinguish":[52],"on":[53],"the":[54,120,124,137],"basis":[55],"morphology":[57],"alone.":[58],"OBJECTIVE:":[59],"To":[60],"determine":[61],"whether":[62],"AR,":[63,185],"expression":[67],"can":[68],"seen":[70],"entirely":[72],"benign":[73,90,197],"adenomas.":[75,92,199],"DESIGN:":[76],"Androgen":[77],"receptor,":[78],"immunoreactivity":[82],"was":[83,116,134],"assessed":[84],"41":[86,99,143],"histologically":[87,194],"clinically":[89,196],"RESULTS:":[93],"A":[94],"total":[95],"3":[97],"adenomas":[101],"exhibited":[102],"multifocal":[103],"areas":[104],"moderate":[106],"staining":[107,115],"HER-2/":[109],"neu":[110],"AR.":[112,152],"The":[113],"positive":[114],"mainly":[117],"confined":[118],"epithelial":[121,138],"component,":[122],"where":[123],"ductal":[125],"epithelium":[126],"showed":[127],"no":[128],"atypia.":[130],"Immunoreactivity":[131],"observed":[135],"component":[139],"5":[141],"cases,":[144],"none":[145],"which":[147],"stained":[148],"HER-2/neu":[150],"Mean":[153],"mitotic":[154],"rate":[155],"Ki-67":[157],"index":[158],"were":[159],"1":[160,173],"per":[161,174],"10":[162,175],"high-powered":[163,176],"fields":[164,177],"2.7%":[166],"HER-2/neu-":[168],"AR-positive":[170],"cases":[171],"2.2%":[179],"p53-positive":[181],"cases.":[182],"CONCLUSIONS:":[183],"expressed":[189],"a":[191],"subset":[192],"cannot":[202],"reliably":[206],"predict":[207],"early":[208],"carcinomatous":[209],"transformation":[210],"adenoma.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}