{"id":"https://openalex.org/W2155777450","doi":"https://doi.org/10.1158/1055-9965.epi-08-1078","title":"Associations between Polymorphisms in DNA Repair Genes and Glioblastoma","display_name":"Associations between Polymorphisms in DNA Repair Genes and Glioblastoma","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W2155777450","doi":"https://doi.org/10.1158/1055-9965.epi-08-1078","mag":"2155777450","pmid":"https://pubmed.ncbi.nlm.nih.gov/19318434","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2667563"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.epi-08-1078","doi":"https://doi.org/10.1158/1055-9965.epi-08-1078","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-08-1078","pdf_url":"https://aacrjournals.org/cebp/article-pdf/18/4/1118/2268885/1118.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cebp/article-pdf/18/4/1118/2268885/1118.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084583154","display_name":"Roberta McKean\u2010Cowdin","orcid":"https://orcid.org/0000-0002-6121-688X","observed_orcids":["https://orcid.org/0000-0002-6121-688X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberta McKean-Cowdin","raw_affiliation_strings":["1Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California;","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051948022","display_name":"Jill S. Barnholtz\u2010Sloan","orcid":"https://orcid.org/0000-0001-6190-9304","observed_orcids":["https://orcid.org/0000-0001-6190-9304"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill Barnholtz-Sloan","raw_affiliation_strings":["2Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio;","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044807350","display_name":"Peter D. Inskip","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter D. Inskip","raw_affiliation_strings":["3Division of Cancer Epidemiology and Genetics, National Cancer Institute Bethesda, Maryland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Division of Cancer Epidemiology and Genetics, National Cancer Institute Bethesda, Maryland;","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108565161","display_name":"Avima M. Ruder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avima M. Ruder","raw_affiliation_strings":["4National Institute for Occupational Safety and Health, Cincinnati, Ohio;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4National Institute for Occupational Safety and Health, Cincinnati, Ohio;","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110164266","display_name":"M. A. Butler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MaryAnn Butler","raw_affiliation_strings":["4National Institute for Occupational Safety and Health, Cincinnati, Ohio;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4National Institute for Occupational Safety and Health, Cincinnati, Ohio;","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002103948","display_name":"Preetha Rajaraman","orcid":"https://orcid.org/0000-0001-6649-999X","observed_orcids":["https://orcid.org/0000-0001-6649-999X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Preetha Rajaraman","raw_affiliation_strings":["3Division of Cancer Epidemiology and Genetics, National Cancer Institute Bethesda, Maryland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Division of Cancer Epidemiology and Genetics, National Cancer Institute Bethesda, Maryland;","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029733167","display_name":"Pedram Razavi","orcid":"https://orcid.org/0000-0003-4236-0576","observed_orcids":["https://orcid.org/0000-0003-4236-0576"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedram Razavi","raw_affiliation_strings":["1Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California;","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039670777","display_name":"Joe Patoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe Patoka","raw_affiliation_strings":["5Department of Neurological Surgery, University of California at San Francisco, San Francisco, California; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Neurological Surgery, University of California at San Francisco, San Francisco, California; and","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023943352","display_name":"John K. Wiencke","orcid":"https://orcid.org/0000-0001-7101-6489","observed_orcids":["https://orcid.org/0000-0001-7101-6489"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John K. Wiencke","raw_affiliation_strings":["5Department of Neurological Surgery, University of California at San Francisco, San Francisco, California; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Neurological Surgery, University of California at San Francisco, San Francisco, California; and","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012085802","display_name":"Melissa L. Bondy","orcid":"https://orcid.org/0000-0002-0278-414X","observed_orcids":["https://orcid.org/0000-0002-0278-414X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa L. Bondy","raw_affiliation_strings":["6University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069788891","display_name":"Margaret Wrensch","orcid":"https://orcid.org/0000-0002-3070-7600","observed_orcids":["https://orcid.org/0000-0002-3070-7600"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Wrensch","raw_affiliation_strings":["5Department of Neurological Surgery, University of California at San Francisco, San Francisco, California; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Neurological Surgery, University of California at San Francisco, San Francisco, California; and","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1312,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.91528239,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"18","issue":"4","first_page":"1118","last_page":"1126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dna-repair-genes","display_name":"DNA repair genes","score":0.996999979019165},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9909999966621399},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8899999856948853},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/prkdc","display_name":"PRKDC","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ercc2","display_name":"XPD","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ercc1","display_name":"ERCC1","score":1.0},{"id":"https://openalex.org/keywords/haplotype-association","display_name":"haplotype association","score":0.8130000233650208},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.6730619668960571},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6297630071640015},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.543325662612915},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5251531004905701},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49683836102485657},{"id":"https://openalex.org/C2778883343","wikidata":"https://www.wikidata.org/wiki/Q426168","display_name":"ERCC2","level":5,"score":0.47243911027908325},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46590620279312134},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.44937825202941895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4465649425983429},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.41444632411003113},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.41233256459236145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38083788752555847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37639570236206055},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30118316411972046},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.23924380540847778},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1589343249797821}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1158/1055-9965.epi-08-1078","doi":"https://doi.org/10.1158/1055-9965.epi-08-1078","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-08-1078","pdf_url":"https://aacrjournals.org/cebp/article-pdf/18/4/1118/2268885/1118.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},{"id":"pmid:19318434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19318434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2667563","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2667563","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Epidemiol Biomarkers Prev","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.epi-08-1078","doi":"https://doi.org/10.1158/1055-9965.epi-08-1078","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-08-1078","pdf_url":"https://aacrjournals.org/cebp/article-pdf/18/4/1118/2268885/1118.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6062090933","display_name":"MOLECULAR EPIDEMIOLOGY OF GLIOMAS","funder_award_id":"R01CA070917","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6257973320","display_name":null,"funder_award_id":"R01CA52689","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8649277707","display_name":"Genetic and molecular epidemiology of adult glioma","funder_award_id":"R01CA052689","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000917356","display_name":"Brain Tumor SPORE Grant","funder_award_id":"P50CA097257","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2155777450.pdf","grobid_xml":"https://content.openalex.org/works/W2155777450.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W164445532","https://openalex.org/W1560079560","https://openalex.org/W1598300615","https://openalex.org/W1891283710","https://openalex.org/W1908561757","https://openalex.org/W1965531809","https://openalex.org/W1968466970","https://openalex.org/W1971517620","https://openalex.org/W2007979640","https://openalex.org/W2011701470","https://openalex.org/W2011955349","https://openalex.org/W2012071848","https://openalex.org/W2017541181","https://openalex.org/W2021010615","https://openalex.org/W2021169782","https://openalex.org/W2022586826","https://openalex.org/W2023582269","https://openalex.org/W2027380102","https://openalex.org/W2029048792","https://openalex.org/W2036355280","https://openalex.org/W2042270470","https://openalex.org/W2046332627","https://openalex.org/W2050178809","https://openalex.org/W2054745580","https://openalex.org/W2054883878","https://openalex.org/W2059299769","https://openalex.org/W2064187211","https://openalex.org/W2064235474","https://openalex.org/W2077712995","https://openalex.org/W2088868608","https://openalex.org/W2089822522","https://openalex.org/W2090863751","https://openalex.org/W2098181955","https://openalex.org/W2103501038","https://openalex.org/W2105100844","https://openalex.org/W2106634946","https://openalex.org/W2111229057","https://openalex.org/W2116832637","https://openalex.org/W2126817546","https://openalex.org/W2131430885","https://openalex.org/W2133366214","https://openalex.org/W2137364966","https://openalex.org/W2142506362","https://openalex.org/W2148259474","https://openalex.org/W2149615023","https://openalex.org/W2158685889","https://openalex.org/W2161356863","https://openalex.org/W2161858905","https://openalex.org/W2166182249","https://openalex.org/W2313535070","https://openalex.org/W2397563285","https://openalex.org/W3144645696","https://openalex.org/W6681291512"],"related_works":["https://openalex.org/W1983058880","https://openalex.org/W2109054687","https://openalex.org/W2330912043","https://openalex.org/W3034581394","https://openalex.org/W2268986409","https://openalex.org/W2130188373","https://openalex.org/W2042455296","https://openalex.org/W2027380102","https://openalex.org/W2069065892","https://openalex.org/W2107991575"],"abstract_inverted_index":{"A":[0,130,174],"pooled":[1],"analysis":[2],"was":[3,110,138,160,178,208],"conducted":[4,51],"to":[5],"examine":[6],"the":[7,19,46,59,63,71,81,98,106,144,148,230],"association":[8],"between":[9,232],"select":[10],"variants":[11,233],"in":[12,45,97,116,133,214,234,257],"DNA":[13,89,235,258],"repair":[14,90,236,259],"genes":[15,237,260],"and":[16,22,37,69,80,188,238,241],"glioblastoma":[17,34,56,119,136,249,267],"multiforme,":[18,57],"most":[20,204],"common":[21,205,255],"deadliest":[23],"form":[24],"of":[25,73,83,105,147,171],"adult":[26,55],"brain":[27,239],"tumors.":[28],"Genetic":[29],"data":[30],"for":[31,66,95,118,135,140,143,266],"approximately":[32],"1,000":[33],"multiforme":[35,120,137],"cases":[36],"2,000":[38],"controls":[39],"were":[40,93,198],"combined":[41],"from":[42],"four":[43],"centers":[44],"United":[47],"States":[48],"that":[49,254],"have":[50,227,244],"case-control":[52],"studies":[53,226],"on":[54,195,229,248],"including":[58],"National":[60,64],"Cancer":[61,78],"Institute,":[62],"Institute":[65],"Occupational":[67],"Safety":[68],"Health,":[70],"University":[72,82],"Texas":[74],"M.":[75],"D.":[76],"Anderson":[77],"Center,":[79],"California":[84],"at":[85],"San":[86],"Francisco.":[87],"Twelve":[88],"single-nucleotide":[91,182],"polymorphisms":[92,183],"selected":[94],"investigation":[96],"pilot":[99],"collaborative":[100],"project.":[101],"The":[102,203],"C":[103],"allele":[104,146],"PARP1":[107],"rs1136410":[108],"variant":[109,151],"associated":[111,209,263],"with":[112,168,210,220,264],"a":[113,161,201,211],"20%":[114],"reduction":[115,213],"risk":[117,134,215,265],"(odds":[121,152],"ratio(CT":[122],"or":[123],"CC),":[124],"0.80;":[125],"95%":[126,155],"confidence":[127,156],"interval,":[128,157],"0.67-0.95).":[129],"44%":[131],"increase":[132],"found":[139,179],"individuals":[141],"homozygous":[142],"G":[145,172],"PRKDC":[149],"rs7003908":[150],"ratio(GG),":[153],"1.44;":[154],"1.13-1.84);":[158],"there":[159],"statistically":[162],"significant":[163],"trend":[164],"(P":[165,216],"=":[166,217],"0.009)":[167],"increasing":[169],"number":[170],"alleles.":[173],"significant,":[175],"protective":[176],"effect":[177],"when":[180],"three":[181],"(ERCC2":[184],"rs13181,":[185],"ERCC1":[186],"rs3212986,":[187],"GLTSCR1":[189],"rs1035938)":[190],"located":[191],"near":[192],"each":[193],"other":[194,222],"chromosome":[196],"19":[197],"modeled":[199],"as":[200],"haplotype.":[202],"haplotype":[206],"(AGC)":[207],"23%":[212],"0.03)":[218],"compared":[219],"all":[221],"haplotypes":[223],"combined.":[224],"Few":[225],"reported":[228],"associations":[231],"tumors,":[240],"few":[242],"specifically":[243],"examined":[245],"their":[246],"impact":[247],"multiforme.":[250,268],"Our":[251],"results":[252],"suggest":[253],"variation":[256],"may":[261],"be":[262]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}