{"id":"https://openalex.org/W2155668679","doi":"https://doi.org/10.1261/rna.2184703","title":"A twisted tRNA intermediate sets the threshold for decoding: FIGURE 1.","display_name":"A twisted tRNA intermediate sets the threshold for decoding: FIGURE 1.","publication_year":2003,"publication_date":"2003-03-20","ids":{"openalex":"https://openalex.org/W2155668679","doi":"https://doi.org/10.1261/rna.2184703","mag":"2155668679","pmid":"https://pubmed.ncbi.nlm.nih.gov/12649490","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1370405"},"language":"en","primary_location":{"id":"doi:10.1261/rna.2184703","doi":"https://doi.org/10.1261/rna.2184703","is_oa":true,"landing_page_url":"https://doi.org/10.1261/rna.2184703","pdf_url":"http://rnajournal.cshlp.org/content/9/4/384.full.pdf","source":{"id":"https://openalex.org/S187657468","display_name":"RNA","issn_l":"1355-8382","issn":["1355-8382","1469-9001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://rnajournal.cshlp.org/content/9/4/384.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086295306","display_name":"Michael Yarus","orcid":"https://orcid.org/0000-0003-0295-9795","observed_orcids":["https://orcid.org/0000-0003-0295-9795"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MICHAEL YARUS","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA. yarus@stripe.colorado.edu","Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA. yarus@stripe.colorado.edu","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021757579","display_name":"Mikel Valle","orcid":"https://orcid.org/0000-0001-8268-6912","observed_orcids":["https://orcid.org/0000-0001-8268-6912"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MIKEL VALLE","raw_affiliation_strings":["Department of Molecular, Cellular and Developmental Biology , University of Colorado , Boulder , CO 80309- 0347 , USA;","Howard Hughes Medical Institute, Health Research, Inc., Albany, New York 12201-0509, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular and Developmental Biology , University of Colorado , Boulder , CO 80309- 0347 , USA;","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Health Research, Inc., Albany, New York 12201-0509, USA","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042892654","display_name":"Joachim Frank","orcid":"https://orcid.org/0000-0001-5449-6943","observed_orcids":["https://orcid.org/0000-0001-5449-6943","https://orcid.org/0000-0002-2442-1112"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOACHIM FRANK","raw_affiliation_strings":["Department of Biomedical Sciences, State University of New York, Albany, Albany, New York 12201-0509, USA","Howard Hughes Medical Institute, Health Research, Inc., Albany, New York 12201-0509, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, State University of New York, Albany, Albany, New York 12201-0509, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I392282"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Health Research, Inc., Albany, New York 12201-0509, USA","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0344,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.73979282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"4","first_page":"384","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trna-decoding","display_name":"tRNA decoding","score":0.6899999976158142},{"id":"https://openalex.org/keywords/aminoacyl-trna","display_name":"aminoacyl-tRNA","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ribosome-a-site","display_name":"ribosomal A site","score":0.7990000247955322},{"id":"https://openalex.org/keywords/proofreading","display_name":"proofreading","score":0.8519999980926514},{"id":"https://openalex.org/keywords/trna-conformation","display_name":"tRNA conformation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/transient-kinetic-analysis","display_name":"transient kinetic analysis","score":0.671999990940094},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C170748874","wikidata":"https://www.wikidata.org/wiki/Q21117977","display_name":"Proofreading","level":4,"score":0.8714697360992432},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.8539085388183594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8314051032066345},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.5511083006858826},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.518425703048706},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5126113295555115},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41048139333724976},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.25661107897758484},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.16424161195755005},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11773726344108582},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1261/rna.2184703","doi":"https://doi.org/10.1261/rna.2184703","is_oa":true,"landing_page_url":"https://doi.org/10.1261/rna.2184703","pdf_url":"http://rnajournal.cshlp.org/content/9/4/384.full.pdf","source":{"id":"https://openalex.org/S187657468","display_name":"RNA","issn_l":"1355-8382","issn":["1355-8382","1469-9001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:118271","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1370405","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1370405","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1370405","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"Text"},{"id":"pmid:12649490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12649490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1261/rna.2184703","doi":"https://doi.org/10.1261/rna.2184703","is_oa":true,"landing_page_url":"https://doi.org/10.1261/rna.2184703","pdf_url":"http://rnajournal.cshlp.org/content/9/4/384.full.pdf","source":{"id":"https://openalex.org/S187657468","display_name":"RNA","issn_l":"1355-8382","issn":["1355-8382","1469-9001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2155668679.pdf","grobid_xml":"https://content.openalex.org/works/W2155668679.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W768743410","https://openalex.org/W1602898037","https://openalex.org/W1607797981","https://openalex.org/W2050329965","https://openalex.org/W2118391959","https://openalex.org/W2169284526"],"related_works":["https://openalex.org/W4231159793","https://openalex.org/W3039911054","https://openalex.org/W2137206793","https://openalex.org/W1969172282","https://openalex.org/W2050329965","https://openalex.org/W2007811417","https://openalex.org/W1587464192","https://openalex.org/W1983167449","https://openalex.org/W2616877598","https://openalex.org/W2156400868"],"abstract_inverted_index":{"Putting":[0],"together":[1],"consistent":[2],"cryo-EM":[3],"structure,":[4],"transient":[5],"kinetic":[6],"and":[7],"mutant":[8],"tRNA":[9],"suppressor":[10],"data,":[11],"it":[12],"appears":[13],"that":[14],"a":[15],"deformed":[16],"or":[17],"waggling":[18],"aminoacyl-tRNA":[19],"is":[20],"the":[21,27,32,45],"critical":[22],"transitional":[23],"structure":[24],"examined":[25],"by":[26],"ribosome":[28],"during":[29],"decoding":[30],"at":[31],"A":[33],"site.":[34],"The":[35],"unusual":[36],"conformation":[37],"may":[38],"be":[39],"required":[40],"for":[41],"effective":[42],"proofreading":[43],"of":[44],"codon-anticodon":[46],"complex.":[47]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}