{"id":"https://openalex.org/W2155666236","doi":"https://doi.org/10.1093/bioinformatics/bts263","title":"SEQCHIP: a powerful method to integrate sequence and genotype data for the detection of rare variant associations","display_name":"SEQCHIP: a powerful method to integrate sequence and genotype data for the detection of rare variant associations","publication_year":2012,"publication_date":"2012-05-03","ids":{"openalex":"https://openalex.org/W2155666236","doi":"https://doi.org/10.1093/bioinformatics/bts263","mag":"2155666236","pmid":"https://pubmed.ncbi.nlm.nih.gov/22556370","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3381973"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bts263","doi":"https://doi.org/10.1093/bioinformatics/bts263","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts263","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/13/1745/48869080/bioinformatics_28_13_1745.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","ccf-a","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/28/13/1745/48869080/bioinformatics_28_13_1745.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044571272","display_name":"Dajiang J. Liu","orcid":"https://orcid.org/0000-0001-6553-858X","observed_orcids":["https://orcid.org/0000-0001-6553-858X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dajiang J. Liu","raw_affiliation_strings":["1 Department of Biostatistics, Center of Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109 and 2Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics, Center of Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109 and 2Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085826245","display_name":"Suzanne M. Leal","orcid":"https://orcid.org/0000-0003-1231-8174","observed_orcids":["https://orcid.org/0000-0003-1231-8174"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Suzanne M. Leal","raw_affiliation_strings":["1 Department of Biostatistics, Center of Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109 and 2Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics, Center of Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109 and 2Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044571272","https://openalex.org/A5085826245"],"corresponding_institution_ids":["https://openalex.org/I181547552","https://openalex.org/I27837315"],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":null,"fwci":1.1505,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.78820327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"28","issue":"13","first_page":"1745","last_page":"1751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rare-variant-association","display_name":"rare variant association","score":0.8880000114440918},{"id":"https://openalex.org/keywords/type-i-error-control","display_name":"type I error control","score":0.652999997138977},{"id":"https://openalex.org/keywords/complex-trait-genetics","display_name":"complex trait genetics","score":0.5799999833106995},{"id":"https://openalex.org/keywords/statistical-power","display_name":"statistical power","score":0.640999972820282},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.6484254598617554},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5976166129112244},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5210753679275513},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5044878721237183},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.47577348351478577},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.47521406412124634},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.4736553430557251},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.4731106758117676},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.45709505677223206},{"id":"https://openalex.org/C40696583","wikidata":"https://www.wikidata.org/wiki/Q989120","display_name":"Type I and type II errors","level":2,"score":0.4526410698890686},{"id":"https://openalex.org/C2994538360","wikidata":"https://www.wikidata.org/wiki/Q774081","display_name":"Association test","level":5,"score":0.41855743527412415},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.408636212348938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37977883219718933},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3673458695411682},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2197139859199524},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.143029123544693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1221616268157959},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.08483931422233582},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/bts263","doi":"https://doi.org/10.1093/bioinformatics/bts263","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts263","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/13/1745/48869080/bioinformatics_28_13_1745.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","ccf-a","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2690382","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3381973","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3381973","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3381973","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmid:22556370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22556370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.874.1415","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.874.1415","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bioinformatics.oxfordjournals.org/content/early/2012/05/02/bioinformatics.bts263.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bts263","doi":"https://doi.org/10.1093/bioinformatics/bts263","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts263","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/13/1745/48869080/bioinformatics_28_13_1745.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","ccf-a","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1068064772","display_name":null,"funder_award_id":"HG006493","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G2277543773","display_name":"Northwest Genomics Center","funder_award_id":"RC2HL102926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2550646349","display_name":null,"funder_award_id":"MH084676","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3729132659","display_name":"Minority Health-GRID Network:  A Genomics Resource for Health Disparity Research","funder_award_id":"RC4MD005964","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G4848365225","display_name":"UW Center for Mendelian Genomics","funder_award_id":"U54HG006493","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G6965363806","display_name":"Northwest Genomics Center","funder_award_id":"UC2HL102926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7983693291","display_name":"Statistical Methods for the Design and Interpretation of Deep Resequencing Studie","funder_award_id":"R01MH084676","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8286803078","display_name":"UW Center for Mendelian Genomics","funder_award_id":"UM1HG006493","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G843766559","display_name":null,"funder_award_id":"HL-102926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G856161852","display_name":null,"funder_award_id":"MD005964","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G9000345790","display_name":null,"funder_award_id":"HG006493","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2155666236.pdf","grobid_xml":"https://content.openalex.org/works/W2155666236.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1515251601","https://openalex.org/W1965442268","https://openalex.org/W1967296216","https://openalex.org/W1973082823","https://openalex.org/W1991176673","https://openalex.org/W2015849111","https://openalex.org/W2019483502","https://openalex.org/W2027266229","https://openalex.org/W2029387902","https://openalex.org/W2038015622","https://openalex.org/W2051778804","https://openalex.org/W2052992240","https://openalex.org/W2057933447","https://openalex.org/W2070984858","https://openalex.org/W2073674093","https://openalex.org/W2078663610","https://openalex.org/W2081221567","https://openalex.org/W2091597180","https://openalex.org/W2097013149","https://openalex.org/W2097804771","https://openalex.org/W2103631750","https://openalex.org/W2108409892","https://openalex.org/W2113892998","https://openalex.org/W2114444269","https://openalex.org/W2121662608","https://openalex.org/W2124768193","https://openalex.org/W2132530359","https://openalex.org/W2138494572","https://openalex.org/W2139327524","https://openalex.org/W2143962878","https://openalex.org/W2143992683","https://openalex.org/W2146750742","https://openalex.org/W2152234131","https://openalex.org/W2153899794","https://openalex.org/W2156613316","https://openalex.org/W2159998163","https://openalex.org/W2161935988","https://openalex.org/W2163953557","https://openalex.org/W2166501262","https://openalex.org/W2171060123"],"related_works":["https://openalex.org/W2140375311","https://openalex.org/W2001545837","https://openalex.org/W2537153370","https://openalex.org/W2346287086","https://openalex.org/W2144111629","https://openalex.org/W2168210396","https://openalex.org/W2095661813","https://openalex.org/W2059744149","https://openalex.org/W2280781077","https://openalex.org/W2060723637"],"abstract_inverted_index":{"MOTIVATION:":[0],"Next-generation":[1],"sequencing":[2],"greatly":[3],"increases":[4],"the":[5,46,53,57,90,131],"capacity":[6],"to":[7,17,41,48,73,87,105],"detect":[8],"rare-variant":[9,78,118],"complex-trait":[10],"associations.":[11],"However,":[12],"it":[13],"is":[14,40,122,139,151,157],"still":[15],"expensive":[16],"sequence":[18,42,67,109],"a":[19,34,43,101],"large":[20],"number":[21],"of":[22,45],"samples":[23],"and":[24,51,68,108,127,138,156],"therefore":[25],"often":[26],"small":[27],"datasets":[28,129],"are":[29,63,93],"used.":[30],"Given":[31],"cost":[32],"constraints,":[33],"potentially":[35],"more":[36,141],"powerful":[37,142],"two-step":[38],"strategy":[39],"subset":[44],"sample":[47],"discover":[49],"variants,":[50],"genotype":[52,69,107],"identified":[54],"variants":[55],"in":[56,77,153],"remaining":[58],"sample.":[59],"If":[60],"only":[61],"cases":[62],"sequenced,":[64],"directly":[65],"combining":[66],"data":[70],"will":[71],"lead":[72],"inflated":[74],"type-I":[75,136],"errors":[76],"association":[79],"analysis.":[80],"Although":[81],"several":[82],"methods":[83],"have":[84],"been":[85],"developed":[86],"correct":[88],"for":[89],"bias,":[91],"they":[92],"either":[94],"underpowered":[95],"or":[96],"theoretically":[97],"invalid.":[98],"We":[99],"proposed":[100],"new":[102],"method":[103,133],"SEQCHIP":[104,132,150],"integrate":[106],"data,":[110],"which":[111],"can":[112],"be":[113],"used":[114],"with":[115],"most":[116],"existing":[117],"tests.":[119],"RESULTS:":[120],"It":[121],"demonstrated":[123],"using":[124],"both":[125],"simulated":[126],"real":[128],"that":[130],"has":[134],"controlled":[135],"errors,":[137],"substantially":[140],"than":[143],"all":[144],"other":[145],"currently":[146],"available":[147,158],"methods.":[148],"AVAILABILITY:":[149],"implemented":[152],"an":[154],"R-Package":[155],"at":[159],"http://linkage.rockefeller.edu/suzanne/seqchip/Seqchip.html.":[160]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}