{"id":"https://openalex.org/W2155644455","doi":"https://doi.org/10.1002/anie.200701520","title":"Total Synthesis of (+)\u2010Azaspiracid\u20101. Part II: Synthesis of the EFGHI Sulfone and Completion of the Synthesis","display_name":"Total Synthesis of (+)\u2010Azaspiracid\u20101. Part II: Synthesis of the EFGHI Sulfone and Completion of the Synthesis","publication_year":2007,"publication_date":"2007-06-01","ids":{"openalex":"https://openalex.org/W2155644455","doi":"https://doi.org/10.1002/anie.200701520","mag":"2155644455","pmid":"https://pubmed.ncbi.nlm.nih.gov/17546578"},"language":"en","primary_location":{"id":"doi:10.1002/anie.200701520","doi":"https://doi.org/10.1002/anie.200701520","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.200701520","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035782410","display_name":"David Albert Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David\u2005A. Evans","raw_affiliation_strings":["Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA. evans@chemistry.harvard.edu","Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA. evans@chemistry.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026691845","display_name":"Travis B. Dunn","orcid":"https://orcid.org/0000-0003-1538-4513","observed_orcids":["https://orcid.org/0000-0003-1538-4513"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis\u2005B. Dunn","raw_affiliation_strings":["Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045967117","display_name":"Lisbet Kv\u00e6rn\u00f8","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisbet Kv\u00e6rn\u00f8","raw_affiliation_strings":["Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060317614","display_name":"Andr\u00e9 M. Beauchemin","orcid":"https://orcid.org/0000-0003-0667-6215","observed_orcids":["https://orcid.org/0000-0003-0667-6215"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Beauchemin","raw_affiliation_strings":["Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034603441","display_name":"Brian K. Raymer","orcid":"https://orcid.org/0000-0003-3913-5327","observed_orcids":["https://orcid.org/0000-0003-3913-5327"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Raymer","raw_affiliation_strings":["Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049740405","display_name":"Edward J. Olhava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward\u2005J. Olhava","raw_affiliation_strings":["Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008023047","display_name":"Jason A. Mulder","orcid":"https://orcid.org/0000-0001-6475-3253","observed_orcids":["https://orcid.org/0000-0001-6475-3253"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason\u2005A. Mulder","raw_affiliation_strings":["Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065558779","display_name":"Martin Juhl","orcid":"https://orcid.org/0000-0001-5395-9627","observed_orcids":["https://orcid.org/0000-0001-5395-9627"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Juhl","raw_affiliation_strings":["Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001616688","display_name":"Katsuji Kagechika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katsuji Kagechika","raw_affiliation_strings":["Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040344271","display_name":"David A. Favor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David\u2005A. Favor","raw_affiliation_strings":["Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA,","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035782410"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":3.4187,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.92867483,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"46","issue":"25","first_page":"4698","last_page":"4703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.5785999894142151,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.5785999894142151,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.2687999904155731,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13971","display_name":"Isoquinoline Alkaloid Synthesis","score":0.07429999858140945,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azaspiracid-1","display_name":"azaspiracid-1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/marine-toxins","display_name":"marine toxins","score":0.5350000262260437},{"id":"https://openalex.org/keywords/polyether-synthesis","display_name":"polyether synthesis","score":0.3720000088214874},{"id":"https://openalex.org/keywords/natural-product-synthesis","display_name":"natural product synthesis","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C2778806918","wikidata":"https://www.wikidata.org/wiki/Q411193","display_name":"Sulfone","level":2,"score":0.8032472133636475},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49283695220947266},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.4326649308204651},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35057532787323},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.33861151337623596},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.179584801197052}],"mesh":[{"descriptor_ui":"D000095702","descriptor_name":"Polyether Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008387","descriptor_name":"Marine Toxins","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D008387","descriptor_name":"Marine Toxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013141","descriptor_name":"Spiro Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D013141","descriptor_name":"Spiro Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049872","descriptor_name":"Bivalvia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/anie.200701520","doi":"https://doi.org/10.1002/anie.200701520","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.200701520","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"pmid:17546578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17546578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1200204894","display_name":null,"funder_award_id":"GM 33328-20","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1964230126","https://openalex.org/W1967360804","https://openalex.org/W1970741028","https://openalex.org/W1976898246","https://openalex.org/W1978756917","https://openalex.org/W1979640190","https://openalex.org/W1979799949","https://openalex.org/W1982526793","https://openalex.org/W1988157406","https://openalex.org/W1988354257","https://openalex.org/W1994763564","https://openalex.org/W1999894195","https://openalex.org/W2001157489","https://openalex.org/W2002068050","https://openalex.org/W2002114059","https://openalex.org/W2004373069","https://openalex.org/W2013316633","https://openalex.org/W2021328852","https://openalex.org/W2025783995","https://openalex.org/W2027592245","https://openalex.org/W2028883877","https://openalex.org/W2029598167","https://openalex.org/W2030103668","https://openalex.org/W2035715046","https://openalex.org/W2036545996","https://openalex.org/W2038919022","https://openalex.org/W2042975218","https://openalex.org/W2051462270","https://openalex.org/W2054878658","https://openalex.org/W2058623521","https://openalex.org/W2063929710","https://openalex.org/W2064805680","https://openalex.org/W2066820742","https://openalex.org/W2092709106","https://openalex.org/W2094121970","https://openalex.org/W2099168233","https://openalex.org/W2100055517","https://openalex.org/W2115082288","https://openalex.org/W2126503330","https://openalex.org/W2135031689","https://openalex.org/W2155620963","https://openalex.org/W2160555659","https://openalex.org/W2164305778","https://openalex.org/W2168272760","https://openalex.org/W2345729300","https://openalex.org/W2949576985","https://openalex.org/W2949845568","https://openalex.org/W2950131693","https://openalex.org/W2950215543","https://openalex.org/W2950716655","https://openalex.org/W2951110882","https://openalex.org/W3005275105","https://openalex.org/W3025154132","https://openalex.org/W4231644331","https://openalex.org/W4243495665","https://openalex.org/W4243515842","https://openalex.org/W4244464785","https://openalex.org/W4246016775","https://openalex.org/W4249605462"],"related_works":["https://openalex.org/W2952390823","https://openalex.org/W2135031689","https://openalex.org/W2952791096","https://openalex.org/W208208647","https://openalex.org/W576610594","https://openalex.org/W2949235250","https://openalex.org/W2911504747","https://openalex.org/W2951312981","https://openalex.org/W2131189856","https://openalex.org/W2949892396"],"abstract_inverted_index":{"Supporting":[0],"information":[1,31],"for":[2,23,49],"this":[3],"article":[4],"is":[5,20],"available":[6],"on":[7],"the":[8,14,24,34,46,50],"WWW":[9],"under":[10],"http://www.wiley-vch.de/contents/jc_2002/2007/z701520_s.pdf":[11],"or":[12,26],"from":[13],"author.":[15],"Please":[16],"note:":[17],"The":[18],"publisher":[19],"not":[21],"responsible":[22],"content":[25],"functionality":[27],"of":[28],"any":[29],"supporting":[30],"supplied":[32],"by":[33],"authors.":[35],"Any":[36],"queries":[37],"(other":[38],"than":[39],"missing":[40],"content)":[41],"should":[42],"be":[43],"directed":[44],"to":[45],"corresponding":[47],"author":[48],"article.":[51]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}