{"id":"https://openalex.org/W2155634992","doi":null,"title":"Gene expression analysis of esophageal squamous cell carcinoma reveals consistent molecular profiles related to a family history of upper gastrointestinal cancer.","display_name":"Gene expression analysis of esophageal squamous cell carcinoma reveals consistent molecular profiles related to a family history of upper gastrointestinal cancer.","publication_year":2003,"publication_date":"2003-07-15","ids":{"openalex":"https://openalex.org/W2155634992","mag":"2155634992","pmid":"https://pubmed.ncbi.nlm.nih.gov/12873975"},"language":"en","primary_location":{"id":"pmid:12873975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12873975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hua Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Su","raw_affiliation_strings":["Cancer Prevention Studies Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Prevention Studies Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101603422","display_name":"Nan Hu","orcid":"https://orcid.org/0009-0009-0845-6532","observed_orcids":["https://orcid.org/0009-0009-0845-6532","https://orcid.org/0000-0001-8356-8571","https://orcid.org/0000-0002-0516-0738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nan Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054197287","display_name":"Joanna H. Shih","orcid":"https://orcid.org/0000-0001-9815-3651","observed_orcids":["https://orcid.org/0000-0001-9815-3651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna Shih","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101932705","display_name":"Ying Chuan Hu","orcid":"https://orcid.org/0000-0003-2763-580X","observed_orcids":["https://orcid.org/0000-0003-2763-580X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061867313","display_name":"Quanhong Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Quan-Hong Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062893898","display_name":"Eric Yao-Yu Chuang","orcid":"https://orcid.org/0000-0003-2530-0096","observed_orcids":["https://orcid.org/0000-0003-2530-0096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Y Chuang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103395989","display_name":"Mark J. Roth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark J Roth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100765527","display_name":"Chaoyu Wang","orcid":"https://orcid.org/0000-0002-5849-8943","observed_orcids":["https://orcid.org/0000-0002-5849-8943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chaoyu Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063007431","display_name":"Alisa M. Goldstein","orcid":"https://orcid.org/0000-0002-7538-3582","observed_orcids":["https://orcid.org/0000-0002-7538-3582"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alisa M Goldstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014333073","display_name":"Ti Ding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ti Ding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072634086","display_name":"Sanford M. Dawsey","orcid":"https://orcid.org/0000-0003-2185-0533","observed_orcids":["https://orcid.org/0000-0003-2185-0533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanford M Dawsey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037413259","display_name":"Carol A. Giffen","orcid":"https://orcid.org/0000-0001-5302-6771","observed_orcids":["https://orcid.org/0000-0001-5302-6771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carol Giffen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111388717","display_name":"Michael R. Emmert\u2010Buck","orcid":"https://orcid.org/0009-0009-8623-9605","observed_orcids":["https://orcid.org/0009-0009-8623-9605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael R Emmert-Buck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080559639","display_name":"Philip R. Taylor","orcid":"https://orcid.org/0000-0003-0163-1421","observed_orcids":["https://orcid.org/0000-0003-0163-1421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip R Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0359,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.96515864,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"63","issue":"14","first_page":"3872","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.906000018119812},{"id":"https://openalex.org/keywords/family-history-of-cancer","display_name":"family history of cancer","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hereditary-cancer-syndromes","display_name":"hereditary cancer","score":0.6690000295639038},{"id":"https://openalex.org/keywords/upper-gastrointestinal-cancer","display_name":"upper gastrointestinal cancer","score":0.7279999852180481},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8420000076293945},{"id":"https://openalex.org/keywords/molecular-profiles","display_name":"molecular profiles","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.6644184589385986},{"id":"https://openalex.org/C2994415158","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal squamous cell carcinoma","level":3,"score":0.6342347264289856},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.572869062423706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5211165547370911},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.4957214593887329},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48229411244392395},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.47921520471572876},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4708420932292938},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39632439613342285},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3724813461303711},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3620528280735016},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35909348726272583},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33137601613998413},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26664066314697266}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005192","descriptor_name":"Family Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12873975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12873975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2155634992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12873975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W643143593","https://openalex.org/W1483828791","https://openalex.org/W1495406308","https://openalex.org/W1549647993","https://openalex.org/W1934524148","https://openalex.org/W1980648321","https://openalex.org/W2003631245","https://openalex.org/W2017609866","https://openalex.org/W2050847440","https://openalex.org/W2060844333","https://openalex.org/W2071650644","https://openalex.org/W2079778406","https://openalex.org/W2081808575","https://openalex.org/W2100519188","https://openalex.org/W2107820833","https://openalex.org/W2108561222","https://openalex.org/W2108942254","https://openalex.org/W2118934761","https://openalex.org/W2119505427","https://openalex.org/W2137724755","https://openalex.org/W2150641058","https://openalex.org/W2150926065","https://openalex.org/W2232080125","https://openalex.org/W2269840113","https://openalex.org/W2442211081","https://openalex.org/W3144719512","https://openalex.org/W4251638073"],"related_works":["https://openalex.org/W7100167449","https://openalex.org/W2152289186","https://openalex.org/W1749265708","https://openalex.org/W3082364455","https://openalex.org/W2155468833","https://openalex.org/W1963851160","https://openalex.org/W2365186205","https://openalex.org/W2139362027","https://openalex.org/W3110514504","https://openalex.org/W2079387205"],"abstract_inverted_index":{"Tumor":[0],"and":[1,38,44,98,119],"matched":[2,39],"normal":[3,40],"tissue":[4],"from":[5,12,89,127],"19":[6],"esophageal":[7,112],"squamous":[8,113],"cell":[9,114],"carcinoma":[10,115],"patients":[11],"a":[13,70],"high-risk":[14],"area":[15],"of":[16,82],"China":[17],"were":[18,27],"analyzed":[19],"with":[20],"7680":[21],"gene":[22],"cDNA":[23],"microarrays.":[24],"Forty-one":[25],"genes":[26,81],"differentially":[28],"expressed":[29],"(P":[30,74],"<":[31,103],"0.001;":[32],">/==\"":[33],"BORDER=\"0\">2-fold":[34],"change)":[35],"between":[36],"tumor":[37],"samples":[41],"(13":[42],"overexpressed":[43,97],"28":[45],"underexpressed).":[46],"Hierarchical":[47],"clustering":[48],"showed":[49],"consistent":[50,118],"molecular":[51,109],"profiles":[52,110],"across":[53],"patients.":[54],"Multidimensional":[55],"scaling":[56],"plots":[57],"visually":[58],"distinguished":[59],"cases":[60,95,125],"by":[61],"family":[62,90],"history":[63,91],"status,":[64],"which":[65,83],"was":[66],"confirmed":[67],"statistically":[68],"using":[69],"global":[71],"permutation":[72],"test":[73],"=":[75],"0.007);":[76],"we":[77],"then":[78],"identified":[79],"152":[80],"the":[84],"expression":[85,121],"differed":[86],"in":[87,111,123,129],"tumors":[88],"positive":[92],"versus":[93],"negative":[94],"(55":[96],"97":[99],"underexpressed":[100],"at":[101],"P":[102],"0.001).":[104],"These":[105],"data":[106],"indicate":[107],"that":[108,120],"are":[116],"highly":[117],"patterns":[122],"familial":[124],"differ":[126],"those":[128],"sporadic":[130],"cases.":[131]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
