{"id":"https://openalex.org/W2155607773","doi":"https://doi.org/10.1161/01.res.24.4.545","title":"Catecholamine Synthesis in Rabbits with Neurogenic Hypertension","display_name":"Catecholamine Synthesis in Rabbits with Neurogenic Hypertension","publication_year":1969,"publication_date":"1969-04-01","ids":{"openalex":"https://openalex.org/W2155607773","doi":"https://doi.org/10.1161/01.res.24.4.545","mag":"2155607773","pmid":"https://pubmed.ncbi.nlm.nih.gov/4305369"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.24.4.545","doi":"https://doi.org/10.1161/01.res.24.4.545","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.24.4.545","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.24.4.545","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.24.4.545","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090960576","display_name":"Vincent L. DeQuattro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. DEQUATTRO","raw_affiliation_strings":["VINCENT DEQUATTRO  Departments of Medicine and Physiology, University of Southern California School of Medicine, Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VINCENT DEQUATTRO  Departments of Medicine and Physiology, University of Southern California School of Medicine, Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113436856","display_name":"Toshiharu Nagatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. NAGATSU","raw_affiliation_strings":["TOSHIHARU NAGATSU  Departments of Medicine and Physiology, University of Southern California School of Medicine, Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TOSHIHARU NAGATSU  Departments of Medicine and Physiology, University of Southern California School of Medicine, Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111711593","display_name":"Robert F. Maronde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. MARONDE","raw_affiliation_strings":["ROBERT MARONDE  Departments of Medicine and Physiology, University of Southern California School of Medicine, Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ROBERT MARONDE  Departments of Medicine and Physiology, University of Southern California School of Medicine, Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":null,"display_name":"N. ALEXANDER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. ALEXANDER","raw_affiliation_strings":["NATALIE ALEXANDER  Departments of Medicine and Physiology, University of Southern California School of Medicine, Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NATALIE ALEXANDER  Departments of Medicine and Physiology, University of Southern California School of Medicine, Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":8.0687,"has_fulltext":true,"cited_by_count":90,"citation_normalized_percentile":{"value":0.97344133,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"4","first_page":"545","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.5859000086784363,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.5859000086784363,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.05460000038146973,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catecholamine-biosynthesis","display_name":"catecholamine synthesis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neurogenic-hypertension","display_name":"neurogenic hypertension","score":0.9129999876022339},{"id":"https://openalex.org/keywords/baroreceptor-denervation","display_name":"baroreceptor denervation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/carotid-sinus","display_name":"carotid sinus","score":0.859000027179718},{"id":"https://openalex.org/keywords/aortic-arch","display_name":"aortic arch","score":0.8759999871253967},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.968999981880188},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/phenylethanolamine-n-methyltransferase","display_name":"phenylethanolamine N-methyltransferase","score":0.8889999985694885},{"id":"https://openalex.org/keywords/left-ventricle","display_name":"left ventricle","score":0.7680000066757202},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.8980000019073486},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.6470000147819519},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.7519999742507935},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5629812479019165},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.4224736988544464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3514034152030945},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.09290918707847595}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000637","descriptor_name":"Transaminases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002346","descriptor_name":"Carotid Sinus","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D003714","descriptor_name":"Denervation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011311","descriptor_name":"Pressoreceptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.res.24.4.545","doi":"https://doi.org/10.1161/01.res.24.4.545","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.24.4.545","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.24.4.545","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:4305369","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4305369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.857.2473","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.857.2473","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circres.ahajournals.org/content/24/4/545.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1161/01.res.24.4.545","doi":"https://doi.org/10.1161/01.res.24.4.545","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.24.4.545","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.24.4.545","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2155607773.pdf","grobid_xml":"https://content.openalex.org/works/W2155607773.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7096479755","https://openalex.org/W2001360416","https://openalex.org/W2138059850","https://openalex.org/W7098471414","https://openalex.org/W2088572917","https://openalex.org/W2107537045","https://openalex.org/W2398654666","https://openalex.org/W2014303290","https://openalex.org/W2394541282","https://openalex.org/W1989396335"],"abstract_inverted_index":{"Norepinephrine":[0],"synthesis":[1,42,54,76,197],"was":[2,23,116],"determined":[3,44],"in":[4,30,52,75,102,111,120,125,173,181,205,235,246,262,268],"the":[5,17,31,85,103,106,112,121,126,147,199,203,258],"heart":[6],"and":[7,20,133,146,192,201],"adrenals":[8],"of":[9,16,27,40,68,87,105,123,149,163,198,227],"rabbits":[10,114,165],"made":[11],"hypertensive":[12,164],"by":[13,45],"complete":[14],"denervation":[15,132,213],"carotid":[18,215],"sinuses":[19],"aortic":[21,217],"arch.There":[22],"a":[24,72,94,117,134,171,247],"24%":[25],"reduction":[26,119,172],"norepinephrine":[28,63,176],"concentration":[29],"left":[32,174],"ventricle":[33],"3":[34,140,159],"weeks":[35],"after":[36,66,131],"denervation,":[37],"despite":[38],"evidence":[39,226],"enhanced":[41],"as":[43],"three":[46],"methods:":[47],"(1)":[48],"an":[49],"18%":[50],"increase":[51,74,96,204],"apparent":[53],"rates":[55,65,77],"(from":[56,78,97],"0.76":[57],"to":[58,80,99,136,183,189,195],"0.90":[59],"m^imoles/g/hour)":[60],"calculated":[61],"from":[62,84,89,151],"turnover":[64],"infusion":[67],"DL-norepinephrine-3":[69],"H;":[70,92],"(2)":[71],"124%":[73],"2.1":[79],"4.7":[81],"m^moles/g/hour)":[82],"estimated":[83],"incorporation":[86,148],"label":[88,150],"infused":[90],"tyrosine-3":[91],"(3)":[93],"50%":[95],"4.0":[98],"6.0":[100],"mju.moles/g/hour)":[101],"activity":[104],"regulatory":[107],"enzyme":[108],"tyrosine":[109,142,222],"hydroxylase.Additionally,":[110],"denervated":[113],"there":[115],"43%":[118],"amount":[122],"epinephrine":[124,155],"adrenal":[127],"gland":[128],"2":[129,168],"days":[130,169],"return":[135],"normal":[137],"values":[138],"at":[139,158,167],"weeks.Adrenal":[141],"hydroxylase,":[143],"phenylethanolamine-N-methyl":[144,220],"transferase,":[145],"tyrosine-8":[152],"!!":[153],"into":[154],"were":[156],"increased":[157,190],"weeks.A":[160],"smaller":[161],"number":[162],"studied":[166],"showed":[170],"ventricular":[175],"concentration.Catecholamine":[177],"reductions,":[178],"due":[179],"only":[180],"part":[182],"dilutional":[184],"hypertrophy,":[185],"may":[186,193],"be":[187],"related":[188],"utilization":[191],"serve":[194],"enhance":[196],"neurotransmitter":[200,240],"maintain":[202],"blood":[206],"pressure.":[207],"ADDITIONAL":[208],"KEY":[209],"WORDS":[210],"biosynthesis":[211],"baroreceptor":[212],"catecholamines":[214],"sinus":[216],"pressure":[218],"receptors":[219],"transferase":[221],"hydroxylase":[223],"hypertension\u2022":[224],"Biochemical":[225],"altered":[228],"sympathetic":[229],"nerve":[230],"function":[231],"has":[232,242],"been":[233,244],"reported":[234],"essential":[236,269],"hypertension":[237,256],"(1,":[238],"2).Defective":[239],"storage":[241],"also":[243],"demonstrated":[245],"salt-loaded,":[248],"DOCA-treated,":[249],"uninephrectomized":[250],"animal":[251],"model":[252,264],"with":[253],"experimental":[254],"arterial":[255],"(3).However,":[257],"pathophysiologic":[259],"conditions":[260],"induced":[261],"that":[263],"are":[265],"not":[266],"present":[267],"hyperten-":[270]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
