{"id":"https://openalex.org/W2155605080","doi":"https://doi.org/10.1016/s0168-3659(02)00360-7","title":"Targeted cancer gene therapy: the flexibility of adenoviral gene therapy vectors","display_name":"Targeted cancer gene therapy: the flexibility of adenoviral gene therapy vectors","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W2155605080","doi":"https://doi.org/10.1016/s0168-3659(02)00360-7","mag":"2155605080","pmid":"https://pubmed.ncbi.nlm.nih.gov/12618032"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-3659(02)00360-7","doi":"https://doi.org/10.1016/s0168-3659(02)00360-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-3659(02)00360-7","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052333223","display_name":"Marianne G. Rots","orcid":"https://orcid.org/0000-0002-7416-2788","observed_orcids":["https://orcid.org/0000-0002-7416-2788"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"M.G. Rots","raw_affiliation_strings":["Department of Therapeutic Gene Modulation, University Center for Pharmacy, University of Groningen, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands. m.g.rots@farm.rug.nl","Department of Therapeutic Gene Modulation, University Center for Pharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Therapeutic Gene Modulation, University Center for Pharmacy, University of Groningen, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands. m.g.rots@farm.rug.nl","institution_ids":["https://openalex.org/I169381384"]},{"raw_affiliation_string":"Department of Therapeutic Gene Modulation, University Center for Pharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022987623","display_name":"David T. Curiel","orcid":"https://orcid.org/0000-0003-3802-6014","observed_orcids":["https://orcid.org/0000-0003-3802-6014"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.T. Curiel","raw_affiliation_strings":["Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039709555","display_name":"Winald R. Gerritsen","orcid":"https://orcid.org/0000-0003-1110-9119","observed_orcids":["https://orcid.org/0000-0003-1110-9119"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W.R. Gerritsen","raw_affiliation_strings":["Division of Gene Therapy, Department of Medical Oncology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gene Therapy, Department of Medical Oncology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021729725","display_name":"Hidde J. Haisma","orcid":"https://orcid.org/0000-0003-3997-9052","observed_orcids":["https://orcid.org/0000-0003-3997-9052"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H.J. Haisma","raw_affiliation_strings":["Department of Therapeutic Gene Modulation, University Center for Pharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Therapeutic Gene Modulation, University Center for Pharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052333223"],"corresponding_institution_ids":["https://openalex.org/I169381384"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":4.7561,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.95542058,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"87","issue":"1-3","first_page":"159","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cancer-gene-therapy","display_name":"cancer gene therapy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/targeted-gene-delivery","display_name":"targeted gene delivery","score":0.7139999866485596},{"id":"https://openalex.org/keywords/transgene-targeting","display_name":"transgene targeting","score":0.9490000009536743},{"id":"https://openalex.org/keywords/transcriptional-targeting","display_name":"transcriptional targeting","score":0.8799999952316284},{"id":"https://openalex.org/keywords/in-vivo-gene-transfer","display_name":"in vivo gene delivery","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.8086100816726685},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6646918654441833},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.6540232300758362},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5556855201721191},{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.5234103798866272},{"id":"https://openalex.org/C43953973","wikidata":"https://www.wikidata.org/wiki/Q7917858","display_name":"Vectors in gene therapy","level":5,"score":0.5183064341545105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5141146779060364},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5062474608421326},{"id":"https://openalex.org/C111829913","wikidata":"https://www.wikidata.org/wiki/Q211083","display_name":"Gene targeting","level":3,"score":0.4918839931488037},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.48856672644615173},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48431268334388733},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4616609215736389},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4545409679412842},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4163469970226288},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.2184019386768341},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21214833855628967},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.13050535321235657},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1126660704612732}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018583","descriptor_name":"Pliability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0168-3659(02)00360-7","doi":"https://doi.org/10.1016/s0168-3659(02)00360-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-3659(02)00360-7","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:12618032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12618032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/4febc575-8922-4da4-b883-dafb1b0d187d","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/4febc575-8922-4da4-b883-dafb1b0d187d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rots, MG, Curiel, DT, Gerritsen, WR & Haisma, HJ 2003, 'Targeted cancer gene therapy : The flexibility of adenoviral gene therapy vectors', J.Control Release, vol. 87, no. 1-3, pp. 159-165. https://doi.org/10.1016/S0168-3659(02)00360-7","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/4febc575-8922-4da4-b883-dafb1b0d187d","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/4febc575-8922-4da4-b883-dafb1b0d187d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J.Control Release, 87(1-3), 159 - 165. Elsevier Bedrijfsinformatie b.v.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1539803330","https://openalex.org/W1969496633","https://openalex.org/W1975528602","https://openalex.org/W1982334259","https://openalex.org/W1991711054","https://openalex.org/W2010932845","https://openalex.org/W2016138321","https://openalex.org/W2018538802","https://openalex.org/W2043852940","https://openalex.org/W2051758487","https://openalex.org/W2065424348","https://openalex.org/W2107626424","https://openalex.org/W2107985871","https://openalex.org/W2114713912","https://openalex.org/W2116071714","https://openalex.org/W2130944545","https://openalex.org/W2143729842","https://openalex.org/W2158071204","https://openalex.org/W2158691858","https://openalex.org/W2172477250","https://openalex.org/W2317651908","https://openalex.org/W2319203375","https://openalex.org/W2330642552","https://openalex.org/W2415322590","https://openalex.org/W6679394079"],"related_works":["https://openalex.org/W2328616569","https://openalex.org/W2183650544","https://openalex.org/W2102167835","https://openalex.org/W2029835433","https://openalex.org/W97066210","https://openalex.org/W2495544870","https://openalex.org/W2357718502","https://openalex.org/W2350416626","https://openalex.org/W2106265979","https://openalex.org/W106173202"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}