{"id":"https://openalex.org/W2155582899","doi":"https://doi.org/10.1016/j.jtbi.2014.02.025","title":"Evolution of acquired resistance to anti-cancer therapy","display_name":"Evolution of acquired resistance to anti-cancer therapy","publication_year":2014,"publication_date":"2014-03-25","ids":{"openalex":"https://openalex.org/W2155582899","doi":"https://doi.org/10.1016/j.jtbi.2014.02.025","mag":"2155582899","pmid":"https://pubmed.ncbi.nlm.nih.gov/24681298","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4058397"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtbi.2014.02.025","doi":"https://doi.org/10.1016/j.jtbi.2014.02.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jtbi.2014.02.025","pdf_url":null,"source":{"id":"https://openalex.org/S109682412","display_name":"Journal of Theoretical Biology","issn_l":"0022-5193","issn":["0022-5193","1095-8541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Theoretical Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4058397","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035234146","display_name":"Jasmine Foo","orcid":"https://orcid.org/0000-0001-8238-325X","observed_orcids":["https://orcid.org/0000-0001-8238-325X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasmine Foo","raw_affiliation_strings":["School of Mathematics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: jyfoo@umn.edu","School of Mathematics, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: jyfoo@umn.edu","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]},{"raw_affiliation_string":"School of Mathematics, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091861581","display_name":"Franziska Michor A","orcid":"https://orcid.org/0000-0003-4869-8842","observed_orcids":["https://orcid.org/0000-0003-4869-8842","https://orcid.org/0009-0003-8552-7767"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Franziska Michor","raw_affiliation_strings":["Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02215, USA. Electronic address: michor@jimmy.harvard.edu","Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","Department of Biostatistics, Harvard School of Public Health, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02215, USA. Electronic address: michor@jimmy.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Biostatistics, Harvard School of Public Health, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5091861581"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":null,"fwci":3.5569,"has_fulltext":false,"cited_by_count":252,"citation_normalized_percentile":{"value":0.9375,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"355","issue":null,"first_page":"10","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.3546999990940094,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.3546999990940094,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.33980000019073486,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.1843000054359436,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.4339999854564667},{"id":"https://openalex.org/keywords/evolutionary-dynamics","display_name":"evolutionary dynamics","score":0.8230000138282776},{"id":"https://openalex.org/keywords/resistance-mutations","display_name":"resistance mutations","score":0.8489999771118164},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4790000021457672},{"id":"https://openalex.org/keywords/timing-of-drug-administration","display_name":"timing of drug administration","score":0.7609999775886536},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tumor-cell-populations","display_name":"tumor cell populations","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6989442706108093},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.6967988014221191},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5900847911834717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5542365312576294},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.5414824485778809},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5113267302513123},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.502263069152832},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32492828369140625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27501487731933594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26572340726852417},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.17076346278190613},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12677419185638428},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jtbi.2014.02.025","doi":"https://doi.org/10.1016/j.jtbi.2014.02.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jtbi.2014.02.025","pdf_url":null,"source":{"id":"https://openalex.org/S109682412","display_name":"Journal of Theoretical Biology","issn_l":"0022-5193","issn":["0022-5193","1095-8541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Theoretical Biology","raw_type":"journal-article"},{"id":"pmid:24681298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24681298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of theoretical biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3515417","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4058397","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4058397","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4058397","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Theor Biol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.650.55","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.650.55","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://michorlab.dfci.harvard.edu/publications/JTheorBiol2014.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3515417","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4058397","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7243535510","display_name":"Evolutionary Dynamics of Brain, Lung, and Hematopoietic Tumors","funder_award_id":"U54CA143798","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W58756698","https://openalex.org/W159040841","https://openalex.org/W200447247","https://openalex.org/W284120598","https://openalex.org/W327468101","https://openalex.org/W610388639","https://openalex.org/W1415527769","https://openalex.org/W1545401674","https://openalex.org/W1567204338","https://openalex.org/W1644299043","https://openalex.org/W1824301619","https://openalex.org/W1863712471","https://openalex.org/W1876684013","https://openalex.org/W1922160368","https://openalex.org/W1925209866","https://openalex.org/W1966001093","https://openalex.org/W1966963129","https://openalex.org/W1969702239","https://openalex.org/W1975177536","https://openalex.org/W1977231128","https://openalex.org/W1978450356","https://openalex.org/W1979319210","https://openalex.org/W1985090267","https://openalex.org/W1987609716","https://openalex.org/W1988150423","https://openalex.org/W1988414899","https://openalex.org/W1988726104","https://openalex.org/W1989183527","https://openalex.org/W1989462530","https://openalex.org/W1989669878","https://openalex.org/W1992838975","https://openalex.org/W1995204992","https://openalex.org/W1996417425","https://openalex.org/W1998971866","https://openalex.org/W1999614615","https://openalex.org/W2002937040","https://openalex.org/W2004802243","https://openalex.org/W2005602906","https://openalex.org/W2006434892","https://openalex.org/W2007494957","https://openalex.org/W2009465554","https://openalex.org/W2011243518","https://openalex.org/W2011634072","https://openalex.org/W2013735712","https://openalex.org/W2014042122","https://openalex.org/W2014249275","https://openalex.org/W2014268112","https://openalex.org/W2016908937","https://openalex.org/W2018106070","https://openalex.org/W2020299413","https://openalex.org/W2022101765","https://openalex.org/W2029996517","https://openalex.org/W2033222884","https://openalex.org/W2033671436","https://openalex.org/W2034125992","https://openalex.org/W2034967857","https://openalex.org/W2039766809","https://openalex.org/W2043683964","https://openalex.org/W2046602791","https://openalex.org/W2047549748","https://openalex.org/W2048217586","https://openalex.org/W2053432271","https://openalex.org/W2053822327","https://openalex.org/W2058276116","https://openalex.org/W2058743530","https://openalex.org/W2063131697","https://openalex.org/W2063557699","https://openalex.org/W2064078476","https://openalex.org/W2066330900","https://openalex.org/W2075672121","https://openalex.org/W2076532400","https://openalex.org/W2077393203","https://openalex.org/W2080000401","https://openalex.org/W2081116284","https://openalex.org/W2081834615","https://openalex.org/W2082343402","https://openalex.org/W2087196378","https://openalex.org/W2091198609","https://openalex.org/W2091805286","https://openalex.org/W2094556422","https://openalex.org/W2094769592","https://openalex.org/W2098560585","https://openalex.org/W2099449559","https://openalex.org/W2100614336","https://openalex.org/W2101760255","https://openalex.org/W2105054044","https://openalex.org/W2106391833","https://openalex.org/W2111403860","https://openalex.org/W2112858108","https://openalex.org/W2115076532","https://openalex.org/W2116731538","https://openalex.org/W2118829564","https://openalex.org/W2122947245","https://openalex.org/W2134903919","https://openalex.org/W2135594199","https://openalex.org/W2136849860","https://openalex.org/W2141635226","https://openalex.org/W2143429228","https://openalex.org/W2145980885","https://openalex.org/W2149283799","https://openalex.org/W2150948144","https://openalex.org/W2152261022","https://openalex.org/W2154856176","https://openalex.org/W2159081397","https://openalex.org/W2161225385","https://openalex.org/W2165836181","https://openalex.org/W2169302611","https://openalex.org/W2170343590","https://openalex.org/W2171133933","https://openalex.org/W2171280873","https://openalex.org/W2265160193","https://openalex.org/W2315323580","https://openalex.org/W2325135001","https://openalex.org/W2328999771","https://openalex.org/W2416408618","https://openalex.org/W2417902677","https://openalex.org/W2488367146","https://openalex.org/W2501245056","https://openalex.org/W2585593151","https://openalex.org/W2905349247","https://openalex.org/W4230519922"],"related_works":["https://openalex.org/W7097970944","https://openalex.org/W3045230440","https://openalex.org/W2140544199","https://openalex.org/W7160401103","https://openalex.org/W7097253562","https://openalex.org/W3036886506","https://openalex.org/W4362633294","https://openalex.org/W4381855487","https://openalex.org/W2465704771","https://openalex.org/W4400342281"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":35},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}