{"id":"https://openalex.org/W2155559959","doi":"https://doi.org/10.1016/s0022-2275(20)42621-5","title":"Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.","display_name":"Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.","publication_year":1990,"publication_date":"1990-08-01","ids":{"openalex":"https://openalex.org/W2155559959","doi":"https://doi.org/10.1016/s0022-2275(20)42621-5","mag":"2155559959","pmid":"https://pubmed.ncbi.nlm.nih.gov/2280190"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-2275(20)42621-5","doi":"https://doi.org/10.1016/s0022-2275(20)42621-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)42621-5","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0022-2275(20)42621-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110083694","display_name":"Karl Heinrich Weisgraber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I3019692003","display_name":"Cardiovascular Institute Hospital","ror":"https://ror.org/032qqvq76","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3019692003"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"K H Weisgraber","raw_affiliation_strings":["Department of Pathology, University of California, San Francisco, CA 94140-0608","Gladstone Foundation Laboratories for Cardiovascular Disease, Cardiovascular Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, San Francisco, CA 94140-0608","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Gladstone Foundation Laboratories for Cardiovascular Disease, Cardiovascular Research Institute,","institution_ids":["https://openalex.org/I3019692003"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110083694"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I3019692003"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":9.8368,"has_fulltext":false,"cited_by_count":304,"citation_normalized_percentile":{"value":0.98514099,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"31","issue":"8","first_page":"1503","last_page":"1511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.48069998621940613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.48069998621940613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.4507000148296356,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9729999899864197},{"id":"https://openalex.org/keywords/apolipoprotein-e-isoforms","display_name":"apolipoprotein E isoforms","score":0.925000011920929},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.746999979019165},{"id":"https://openalex.org/keywords/apoe3","display_name":"APOE3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoe2","display_name":"APOE2","score":0.8830000162124634},{"id":"https://openalex.org/keywords/plasma-lipoproteins","display_name":"serum lipoproteins","score":0.8199999928474426},{"id":"https://openalex.org/keywords/high-density-lipoprotein","display_name":"high-density lipoprotein","score":0.9229999780654907},{"id":"https://openalex.org/keywords/very-low-density-lipoprotein","display_name":"VLDL","score":0.9929999709129333},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.800000011920929},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.4690000116825104},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.8727853298187256},{"id":"https://openalex.org/C2776515853","wikidata":"https://www.wikidata.org/wiki/Q2191895","display_name":"Iodoacetamide","level":4,"score":0.6957623362541199},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.6833701729774475},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6766929030418396},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6011980772018433},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.5594555139541626},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.5435630083084106},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.5049174427986145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46233034133911133},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.44402438402175903},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.42415666580200195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18267399072647095},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.15278339385986328},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10889580845832825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008079","descriptor_name":"Lipoproteins, VLDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008079","descriptor_name":"Lipoproteins, VLDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053329","descriptor_name":"Apolipoprotein E2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053419","descriptor_name":"Lipoproteins, IDL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-2275(20)42621-5","doi":"https://doi.org/10.1016/s0022-2275(20)42621-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)42621-5","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:2280190","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2280190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:43a3280cdc254afb8d6c8144585baa9f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/43a3280cdc254afb8d6c8144585baa9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 31, Iss 8, Pp 1503-1511 (1990)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/s0022-2275(20)42621-5","doi":"https://doi.org/10.1016/s0022-2275(20)42621-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)42621-5","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3786833126","display_name":"LIPOPROTEIN STRUCTURE/FUNCTION IN CHOLESTEROL METABOLISM","funder_award_id":"P01HL041633","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W134453782","https://openalex.org/W149726692","https://openalex.org/W182198897","https://openalex.org/W1255346594","https://openalex.org/W1483795916","https://openalex.org/W1490077018","https://openalex.org/W1529259401","https://openalex.org/W1546262989","https://openalex.org/W1567308646","https://openalex.org/W1593464696","https://openalex.org/W1603930029","https://openalex.org/W1736154854","https://openalex.org/W1920171370","https://openalex.org/W1990170200","https://openalex.org/W2003854546","https://openalex.org/W2017640755","https://openalex.org/W2024118357","https://openalex.org/W2034968148","https://openalex.org/W2065510904","https://openalex.org/W2066644955","https://openalex.org/W2079917977","https://openalex.org/W2093662767","https://openalex.org/W2188938709","https://openalex.org/W2259265492","https://openalex.org/W2285849357","https://openalex.org/W2337486967"],"related_works":["https://openalex.org/W2093662767","https://openalex.org/W1559121591","https://openalex.org/W2032132732","https://openalex.org/W1841798962","https://openalex.org/W2081151510","https://openalex.org/W7097885566","https://openalex.org/W7098164739","https://openalex.org/W2138870569","https://openalex.org/W2063987466","https://openalex.org/W2056451248"],"abstract_inverted_index":{"Human":[0,125],"apolipoprotein":[1],"(apo)":[2],"E":[3],"occurs":[4],"as":[5],"three":[6],"common":[7],"isoforms":[8],"(apoE4,":[9],"E3,":[10],"and":[11,23,86,100,108,132,145,149,169,203],"E2),":[12],"all":[13],"of":[14,41,58,63,112,160,164,175,184,214],"which":[15],"influence":[16],"plasma":[17,42,106,126],"cholesterol":[18],"levels.":[19],"Although":[20],"both":[21],"apoE4":[22,44,64,80,99,118,201],"E3":[24,101],"bind":[25],"with":[26,38,45,51,129,147,152],"equal":[27],"effectiveness":[28],"to":[29,177,211],"the":[30,110,113,123,165,178,200,205,212],"low":[31,47],"density":[32,48,53,154,180],"lipoprotein":[33],"receptor,":[34],"they":[35],"associate":[36],"preferentially":[37],"different":[39],"classes":[40],"lipoproteins:":[43],"very":[46],"lipoproteins,":[49,107,155],"apoE3":[50,59,70,140,167,176,185],"high":[52,153,179],"lipoproteins.":[54,181],"The":[55,90],"primary":[56],"structure":[57,168],"differs":[60],"from":[61],"that":[62,141,157,192,204],"at":[65,76,83,196,216],"only":[66],"a":[67,158,193],"single":[68],"site;":[69],"has":[71],"its":[72],"sole":[73],"cysteine":[74],"residue":[75],"position":[77,84,197],"112,":[78],"while":[79],"contains":[81],"arginine":[82,215],"112":[85,198],"completely":[87],"lacks":[88],"cysteine.":[89],"present":[91],"study":[92],"investigated":[93],"how":[94],"this":[95,217],"structural":[96],"difference":[97],"between":[98],"determines":[102],"their":[103],"distribution":[104,174,202],"among":[105],"analyzed":[109],"role":[111],"disulfide-linked":[114],"heterodimer":[115],"apoE-A-II":[116,170],"(which":[117],"cannot":[119],"form)":[120],"in":[121,187],"determining":[122],"distribution.":[124],"was":[127,207],"incubated":[128],"125I-labeled":[130],"apoE,":[131],"lipoproteins":[133],"were":[134],"separated":[135],"by":[136],"agarose":[137],"chromatography.":[138],"Both":[139],"had":[142],"been":[143],"reduced":[144],"alkylated":[146],"iodoacetamide":[148],"apoE3-A-II":[150],"distributed":[151],"indicating":[156],"combination":[159],"an":[161,188],"inherent":[162],"property":[163],"monomeric":[166],"formation":[171],"account":[172],"for":[173],"Cysteamine":[182],"modification":[183],"resulted":[186],"apoE4-like":[189],"distribution,":[190],"demonstrating":[191],"positive":[194],"charge":[195],"determined":[199],"effect":[206],"not":[208],"exclusively":[209],"due":[210],"presence":[213],"position.(ABSTRACT":[218],"TRUNCATED":[219],"AT":[220],"250":[221],"WORDS)":[222]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
